scholarly journals Wound healing properties of green (using Lawsonia inermis leaf extract) and chemically synthesized ZnO nanoparticles in albino rats

2021 ◽  
Author(s):  
Asmaa A. Metwally ◽  
Abdel-Nasser A. A. Abdel-Hady ◽  
Mohie A. M. Haridy ◽  
Khaled Ebnalwaled ◽  
AbdulRahman A. Saied ◽  
...  
Keyword(s):  
Wound Healing ◽  
Zno Nanoparticles ◽  
Leaf Extract ◽  
Albino Rats ◽  
Lawsonia Inermis

scholarly journals Wound-Healing Properties of Green (Using Lawsonia Inermis Leaf Extract) and Chemically Synthesized Zno Nanoparticles in Albino Rats

2021 ◽  
Author(s):  
Asmaa A. Metwally ◽  
Abdel-Nasser A.A. Abdel-Hady ◽  
Mohie A.M. Haridy ◽  
Khaled Ebnalwaled ◽  
AbdulRahman A Saied ◽  
...  
Keyword(s):  
Wound Healing ◽  
Leaf Extract ◽  
Healing Time ◽  
Control Group ◽  
Albino Rats ◽  
Tissue Formation ◽  
Lawsonia Inermis ◽  
Zno Nps ◽  
Medical Issues ◽  
Good Crystallinity

Abstract Wound healing is one of the utmost medical issues in human and veterinary medicine, which explains the urgent need for developing new agents that possess wound-healing activities. The present study aimed to assess the effectiveness of green and chemical ZnO-NPs for wound healing. ZnO-NPs (chemical and green using Lawsonia inermis leaf extract) were synthesized and characterized by XRD; FTIR, and HRTEM. The gels containing the nanomaterials were prepared and inspected. Forty-five albino rats were divided into three groups, the control group was treated with normal saline 0.9 % and the other two groups were treated with gels containing green and chemical ZnO-NPs, respectively. On the 3rd, 7th, 14th, and 21st dpt, the wounds were clinical and histologically examined. Both nanomaterials have good crystallinity and high purity, but green ZnO-NPs have a longer nanowire length and diameter than chemical ZnO-NPs. The formed gels were highly viscous with a pH of 6.5 to 7. Both prepared gels showed clinical improvements, such as a decrease in WSA and WSA%, increase in WC%, and reduced healing time (P < 0.05) in both treated groups when compared with control group. The histological scoring of this study showed that the epithelization score was significantly higher at 21st dpt in treated groups than in the control group (P < 0.05), but the vasculature, necrosis, connective tissue formation, and collagen synthesis scores were mostly similar. The green and chemical ZnO-NPs gels showed promising wound healing properties however, the LI mediated-ZnO-NPs were more effective.

scholarly journals Wound-healing Activity of the Aqueous Leaf Extract and Fractions of Ficus exasperata (Moraceae) and its Safety Evaluation on Albino Rats

2014 ◽  
Vol 4 (4) ◽  
pp. 246-252 ◽  
Author(s):  
Victoria Nonyelum Umeh ◽  
Emmanuel Emeka Ilodigwe ◽  
Daniel Lotanna Ajaghaku ◽  
Earnest Oghenesuvwe Erhirhie ◽  
Goodies Emuesiri Moke ◽  
...  
Keyword(s):  
Wound Healing ◽  
Leaf Extract ◽  
Safety Evaluation ◽  
Albino Rats ◽  
Aqueous Leaf Extract ◽  
Wound Healing Activity

scholarly journals Evaluation of wound healing potentials of neem (Azadirachtaindica) leaf extract on excision wounds in Wistar albino rats

2020 ◽  
Vol 45 (4) ◽  
Author(s):  
R. A. Olorunsola ◽  
F. Oke ◽  
A. S. Bagbe ◽  
O. A. Ayeyinbo
Keyword(s):  
Wound Healing ◽  
Azadirachta Indica ◽  
Leaf Extract ◽  
Wound Closure ◽  
Albino Rats ◽  
Orthodox Medicine ◽  
Procaine Penicillin ◽  
Group A ◽  
Wistar Albino Rats ◽  
Group B

This study was carried out to evaluate the wound healing ability of ethanoic leaf extract of Azadirachta indica, incorporated into the feed of albino rats. Twenty-four (24) albino rats of both sexes weighing between 90 to 125g were randomly selected and divided into three (3) groups of 8 rats each. Animals in each group were divided into four (4) replicates of two (2) rats per replicate. Group A had penicillin, group B had neem ointment and group C had Neem incorporated in the feed. The ethanoic leaf extract of Azadirachta indica showed a significantly higher (p<0.05) contraction rate and shortened wound closure time. The healing was 92% (p<0.05) on 10th day compared to 75% and 82% of healing with ground leaf of A. indica incorporated into the feed (neem + feed) and procaine penicillin, respectively. The complete wound closure took place on the 12th day in the case of ethanoic leaf extract of Azadirachta indica while, neem + feed and procaine penicillin the wounds persisted than12th day. The study concluded that the ethanoic leaf extract of A. indica had better potential wound healing activity for excision wounds; justifying its use in the traditional and orthodox medicine.

Wound Healing Activity of Ten Indigenous Plants in Incision and Excision Wound Models in Albino Rats

2012 ◽  
Vol 2 (9) ◽  
pp. 56-58
Author(s):  
Vasanthalaxmi K Vasanthalaxmi K ◽  
◽  
Saraswathi Udupa ◽  
Laximinarayana Udupa
Keyword(s):  
Wound Healing ◽  
Albino Rats ◽  
Indigenous Plants ◽  
Excision Wound ◽  
Wound Healing Activity

Acute Toxicity Assessment of Ethanolic Leaf Extract of Macrotyloma uniflorum L. on Wistar Albino Rats

2017 ◽  
Vol 24 (1) ◽  
pp. 22 ◽  
Author(s):  
S. Priyanga ◽  
S. Hemmalakshmi ◽  
B. Vidya ◽  
P. Chella Perumal ◽  
V. K. Gopalakrishnan ◽  
...  
Keyword(s):  
Acute Toxicity ◽  
Leaf Extract ◽  
Toxicity Assessment ◽  
Albino Rats ◽  
Macrotyloma Uniflorum ◽  
Wistar Albino Rats ◽  
Ethanolic Leaf Extract

Potential Antiseptic of Rhodomyrtus tomentosa leaves extract on Healing wound in Male Wistar rats

2021 ◽  
pp. 3143-3149
Author(s):  
Endang Sri Purwanti Ningsih ◽  
Noorlaila Noorlaila ◽  
Ikhwan Rizki Muhammad ◽  
Windy Yuliana Budianto
Keyword(s):  
Wound Healing ◽  
Wistar Rats ◽  
Leaf Extract ◽  
Wound Care ◽  
Positive Control ◽  
Negative Control ◽  
Control Group ◽  
Significant Difference ◽  
Male Wistar Rats ◽  
Rhodomyrtus Tomentosa

Background: The process of wound healing is influenced by various factors such as age, hormones, and wound care. Wound care is done to accelerate wound healing which can be done by various methods, one of them is traditional care. Traditional wound care can use medicinal plants. Rhodomyrtus tomentosa is a medicinal plant that has an antioxidant, anti-inflammatory, antitumor and antibacterial content. Thus this study aims to evaluate the effectiveness of the antiseptic solution of the Rodhomyrtus tomentosa leaf extract on wound healing in male Wistar rats. Method: this research is pure experimental research with post test only control group design. Thirty male white rats were divided into five groups, namely negative control, positive control, Rhodomyrtus tomentosa leaf extract 15%, 30%, and 60%. Rhodomyrtus tomentosa leaf extraction was carried out by maceration method with 70% ethano solvent. The extraction results are divided into 3 concentrations (15%, 30% and 60%). The wound healing process was evaluated by measuring the length of the wound manually from 0 to 10 days in each group. Meanwhile, the number of fibroblast cells was calculated through hematoxylin eosin (HE) staining and observed using an Olympus CX41 microscope with a 10x magnification and objective lens magnification in 3 fields. Result: There was a significant difference in the reduction in wound length (p =< 0,000) between the five experimental groups (Rhodomyrtus tomentosa leaf extract solution 15%, 30% and 60%, negative control and positive control. Solution of rhodomyrtus tomentosa leaf extract accelerated the increase in the number of fibroblasts compared to the negative control group (p = 0.003), but did not make a difference (p = 0.403) with the positive control group. Rhodomyrtus tomentosa leaf extraction solution had the same microscopic effect on the number of fibroblasts with a positive control group given 0.9% NaCl solution. Conclusion: There was a significant difference in the number of fibroblasts between all groups, but no difference in wound healing length.

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