Determinants of High Parathyroid Hormone Levels in Patients With Severe Obesity and Their Relationship With the Cardiometabolic Risk Factors, Before and After a Laparoscopic Sleeve Gastrectomy Intervention

OBJECTIVE: To investigate the relationship between ultrasensitive C-reactive protein and cardiometabolic risk factors in overweight or obese childrenand adolescents. METHODS: Cross-sectional study conducted at the Center for Childhood Obesity in the period from April 2009 to April 2010, involving 185 overweight children and adolescents aged 2 to 18 years. Measures of ultrasensitive C-reactive protein according to age, nutritional status, gender, race, cardiometabolic risk factors (waist circumference, lipid profile, impaired fasting glucose, high blood pressure and presence of insulin resistance) were compared through the Chi-square test and analysis of variance. All analyses were performed using the Statistical Package for the Social Sciences software version 17.0, adopting a significance level of 5%. RESULTS: Altered high-density lipoprotein was the most frequent cardiometabolic risk factor, and there was a significant association between altered ultrasensitive C-reactive protein values and severe obesity (p=0.005), high waist circumference (p<0.001), hypertriglyceridemia (p=0.037) and insulin resistance (p=0.002), as well as significantly higher body mass index (p=0.000), waist circumference (p=0.001), insulin (p=0.005) and index of glucose homeostasis values(p=0.005). CONCLUSION: High prevalence of altered ultrasensitive C-reactive protein and significant association with severe obesity, waist circumference, hypertriglyceridemia and insulin resistance were observed.

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Gender-related differences in cardiometabolic risk factors and lifestyle behaviors in treatment-seeking adolescents with severe obesity

BMC Pediatrics ◽

10.1186/s12887-018-1057-3 ◽

2018 ◽

Vol 18 (1) ◽

Cited By ~ 13

Author(s):

Lisa Ha Barstad ◽

Pétur B. Júlíusson ◽

Line Kristin Johnson ◽

Jens Kristoffer Hertel ◽

Samira Lekhal ◽

...

Keyword(s):

Risk Factors ◽

Cardiometabolic Risk ◽

Severe Obesity ◽

Cardiometabolic Risk Factors ◽

Treatment Seeking ◽

Lifestyle Behaviors

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Correlations between obesity indices and cardiometabolic risk factors in obese subgroups in women with severe obesity: A multicenter, cross-sectional study

Obesity Research & Clinical Practice ◽

10.1016/j.orcp.2016.03.014 ◽

2017 ◽

Vol 11 (2) ◽

pp. 167-176 ◽

Cited By ~ 4

Author(s):

Seung Hun Lee ◽

Young Jin Tak ◽

Yu Hyeon Yi ◽

Sang Yeoup Lee ◽

Young Hye Cho ◽

...

Keyword(s):

Risk Factors ◽

Cardiometabolic Risk ◽

Severe Obesity ◽

Cross Sectional Study ◽

Cardiometabolic Risk Factors ◽

Sectional Study ◽

Cross Sectional ◽

Obesity Indices

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Hypovitaminosis D and Cardiometabolic Risk Factors in Adolescents with Severe Obesity

Children ◽

10.3390/children7020010 ◽

2020 ◽

Vol 7 (2) ◽

pp. 10 ◽

Cited By ~ 1

Author(s):

Teodoro Durá-Travé ◽

Fidel Gallinas-Victoriano ◽

Diego Mauricio Peñafiel-Freire ◽

María Urretavizcaya-Martinez ◽

Paula Moreno-González ◽

...

Keyword(s):

Risk Factors ◽

Blood Pressure ◽

Vitamin D ◽

Total Cholesterol ◽

Fat Mass ◽

Cardiometabolic Risk ◽

Severe Obesity ◽

Cardiometabolic Risk Factors ◽

Z Score ◽

Fat Mass Index

Background/Objectives. Obesity is associated with cardiometabolic risk factors and with Vitamin D deficiency. The aim of this study was to examine the relationship between 25(OH)D concentrations and cardiometabolic risk factors in adolescents with severe obesity. Subjects/Methods. A cross-sectional clinical assessment (body mass index, fat mass index, fat-free mass index, waist-to-height ratio, and blood pressure) and metabolic study (triglycerides, total cholesterol, HDL-C, LDL-C, glucose, insulin, HOMA-IR, leptin, calcium, phosphorous, calcidiol, and PTH) were carried out in 236 adolescents diagnosed with severe obesity (BMI z-score > 3.0, 99th percentile), aged 10.2–15.8 years. The criteria of the US Endocrine Society were used for the definition of Vitamin D status. Results. Subjects with Vitamin D deficiency had significantly elevated values (p < 0.05) for BMI z-score, waist circumference, waist z-score, body fat percentage, fat mass index, systolic and diastolic blood pressure, total cholesterol, triglycerides, LDL-C, insulin, HOMA-IR, leptin, and PTH than subjects with normal Vitamin D status. There was a significant negative correlation (p < 0.05) of serum 25(OH)D levels with body fat percentage, FMI, systolic BP, total cholesterol, triglyceride, LDL-C, glucose, insulin, HOMA-IR, leptin, and PTH. Conclusions. Low Vitamin D levels in adolescents with severe obesity were significantly associated with some cardiometabolic risk factors, including body mass index, waist circumference, fat mass index, high blood pressure, impaired lipid profile, and insulin resistance.

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Relationship Between the Bertin Index to Estimate Visceral Adipose Tissue From Dual-Energy X-Ray Absorptiometry and Cardiometabolic Risk Factors Before and After Weight Loss

Obesity ◽

10.1038/oby.2011.273 ◽

2012 ◽

Vol 20 (4) ◽

pp. 886-890 ◽

Cited By ~ 5

Author(s):

Antony D. Karelis ◽

Rémi Rabasa-Lhoret ◽

Roseline Pompilus ◽

Virginie Messier ◽

Irene Strychar ◽

...

Keyword(s):

Risk Factors ◽

Weight Loss ◽

Adipose Tissue ◽

Visceral Adipose Tissue ◽

Cardiometabolic Risk ◽

Dual Energy ◽

Cardiometabolic Risk Factors ◽

X Ray ◽

Before And After ◽

Visceral Adipose

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The impact of the March 2020 lockdown on the cardiometabolic risk factors of male forensic and rehabilitation patients

BJPsych Open ◽

10.1192/bjo.2021.658 ◽

2021 ◽

Vol 7 (S1) ◽

pp. S246-S247

Author(s):

Nicholas Dodough ◽

Jaspreet Phull ◽

Jaswant Singh ◽

Jackie Sendell

Keyword(s):

Risk Factors ◽

Cardiometabolic Risk ◽

Dietary Habits ◽

Antihypertensive Agents ◽

Cardiometabolic Risk Factors ◽

List Type ◽

Serum Triglycerides ◽

Number Of Patients ◽

Before And After ◽

The Impact

AimsTo explore the impact of the March 2020 lockdown restrictions on the cardiometabolic risk factors of male forensic and rehabilitation inpatients in one NHS trust in the United Kingdom.MethodRetrospective data from September 2019 to September 2020 (six months before and after the 23 March 2020 lockdown) was collected by evaluating the health records of male patients in a low secure forensic ward and two rehabilitation units.ResultThe number of patients with BMI values within the study period was 34 while the number of patients with blood results was 26. This study showed that the average BMI six months before the start of the March lockdown was 29.8 kg/m2 while the average BMI at the end of six months after the lockdown was 31.8 kg/m2.The results from the 6-month interval before the March 2020 lockdown (M = 0, SD = 0) and the 6- month interval after the March 2020 lockdown (M = 0.9, SD = 4.16) indicate that the March 2020 lockdown resulted in an increase of BMI, t (5) = 2.42, P = 0.036. The result is significant at p < 0.058.8% of patients had an increase in their doses of antihypertensive agents after the lockdown whereas no patients had an increase of dose before the lockdown. 7.7% of patients had an HBA1c of more than 48 mmol/L after the lockdown compared to 3.8% before the lockdown. The serum triglycerides and total cholesterol levels also increased after the lockdown with an average increase of 0.17 mmol/L and 0.25 mmol/L respectively. The average serum HDL levels decreased after the lockdown with an average decrease of 0.06 mmol/L.ConclusionThere appears to be a positive correlation between the onset of the March 2020 lockdown and an increase of BMI, worsening of blood pressure, glycemic control and lipid metabolism.Limitations (1)Waist circumference was not measured during the study period preventing us from examining all of the features of metabolic syndrome.(2)This study did not look at the levels of physical activity (such as access to section 17 leave) and dietary habits before and after the March 2020 lockdown which may explain the results found.RecommendationsTo raise metabolic awareness of the impact of the lockdown restrictions on cardiometabolic risk in people with SMI and the general public.

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