Markedly raised intake of saturated and monounsaturated fatty acids in rats on a high-fat ketogenic diet does not inhibit carbon recycling of13C-α-linolenate

Lipids ◽  
2006 ◽  
Vol 41 (10) ◽  
pp. 933-935 ◽  
Author(s):  
Ameer Y. Taha ◽  
Mary Ann Ryan ◽  
Stephen C. Cunnane
Keyword(s):  
Fatty Acids ◽  
Ketogenic Diet ◽  
Monounsaturated Fatty Acids ◽  
High Fat ◽  
Carbon Recycling

scholarly journals High fat diet enriched with saturated, but not monounsaturated fatty acids adversely affects femur, and both diets increase calcium absorption in older female mice

2016 ◽  
Vol 36 (7) ◽  
pp. 742-750 ◽  
Author(s):  
Yang Wang ◽  
Peter Dellatore ◽  
Veronique Douard ◽  
Ling Qin ◽  
Malcolm Watford ◽  
...  
Keyword(s):  
Fatty Acids ◽  
High Fat Diet ◽  
Calcium Absorption ◽  
Monounsaturated Fatty Acids ◽  
High Fat ◽  
Female Mice

Monounsaturated Fatty Acids in a High‐Fat Diet and Niacin Protect from White Fat Dysfunction in the Metabolic Syndrome

2019 ◽  
Vol 63 (19) ◽  
pp. 1900425 ◽  
Author(s):  
Sergio Montserrat‐de la Paz ◽  
Maria C. Naranjo ◽  
Maria C. Millan‐Linares ◽  
Sergio Lopez ◽  
Rocio Abia ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Fatty Acids ◽  
High Fat Diet ◽  
Monounsaturated Fatty Acids ◽  
High Fat ◽  
The Metabolic Syndrome ◽  
White Fat

scholarly journals Fatty Acid Diets: Regulation of Gut Microbiota Composition and Obesity and Its Related Metabolic Dysbiosis

2020 ◽  
Vol 21 (11) ◽  
pp. 4093 ◽  
Author(s):  
David Johane Machate ◽  
Priscila Silva Figueiredo ◽  
Gabriela Marcelino ◽  
Rita de Cássia Avellaneda Guimarães ◽  
Priscila Aiko Hiane ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Health Promotion ◽  
Fatty Acid ◽  
Gut Microbiota ◽  
Human Subjects ◽  
Monounsaturated Fatty Acids ◽  
Microbiota Composition ◽  
High Fat ◽  
Gut Microbiota Composition ◽  
Chain Fatty Acids

Long-term high-fat dietary intake plays a crucial role in the composition of gut microbiota in animal models and human subjects, which affect directly short-chain fatty acid (SCFA) production and host health. This review aims to highlight the interplay of fatty acid (FA) intake and gut microbiota composition and its interaction with hosts in health promotion and obesity prevention and its related metabolic dysbiosis. The abundance of the Bacteroidetes/Firmicutes ratio, as Actinobacteria and Proteobacteria species are associated with increased SCFA production, reported high-fat diet rich in medium-chain fatty acids (MCFAs), monounsaturated fatty acids (MUFAs), and n–3 polyunsaturated fatty acids (PUFAs) as well as low-fat diets rich in long-chain fatty acids (LCFAs). SCFAs play a key role in health promotion and prevention and, reduction and reversion of metabolic syndromes in the host. Furthermore, in this review, we discussed the type of fatty acids and their amount, including the administration time and their interplay with gut microbiota and its results about health or several metabolic dysbioses undergone by hosts.

Minireview: Effect of the ketogenic diet in excitable tissues

2021 ◽  
Author(s):  
Carmen Murano ◽  
Anna Binda ◽  
Paola Palestini ◽  
Mirko Baruscotti ◽  
Jacopo C DiFrancesco ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Ketogenic Diet ◽  
Metabolic Disorders ◽  
Ketone Bodies ◽  
Systemic Circulation ◽  
Potential Treatment ◽  
Single Patient ◽  
High Fat ◽  
Wide Range ◽  
Extrahepatic Tissues

In the last decade Ketogenic Diet (KD) came to light as a potential treatment for a wide range of diseases, from neurological to metabolic disorders, thanks to a beneficial role mainly related to its anti-inflammatory properties. The high-fat, carbohydrate-restricted regimen causes changes in the metabolism leading, through the β-oxidation of fatty acids, to the hepatic production of ketone bodies (KBs), used by many extrahepatic tissues as energy fuels. Once synthetized, KBs move through the systemic circulation and reach all the tissues of the organism, affecting their functions and playing pleiotropic roles acting directly and indirectly on various targets as ion channels and neurotransmitters. Moreover, they can operate as signalling metabolites and epigenetic modulators. Therefore, it is limiting to consider that the clinical condition of each single patient could improve after a KD regimen based on its localized effects; rather it is more complete to think about how KBs might affect the organism as a whole. In this minireview, we tried to summarize the recent knowledge of the effects of KBs on various tissues, with a particular attention to the excitable ones, namely the nervous system, heart and muscles.

scholarly journals Anethole dithiolethione improves liver fatty acid metabolism in hamster fed high-fat diets

2020 ◽  
Author(s):  
Chengcheng Zhao ◽  
Nannan Yu ◽  
Wenqun Li ◽  
Hualin Cai ◽  
Mouze Liu ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Metabolic Diseases ◽  
Monounsaturated Fatty Acids ◽  
Lipid Lowering ◽  
High Fat ◽  
Nonalcoholic Fatty Liver ◽  
Syrian Golden Hamsters ◽  
Liver Injuries ◽  
Fat Diets ◽  
Excessive Accumulation

Abstract“Lipotoxicity” induced by excessive accumulation of free fatty acids (FFAs) in the liver, especially saturated FAs and their toxic metabolites, is closely related to metabolic diseases such as nonalcoholic fatty liver disease (NAFLD). Hydrogen sulfide (H2S), a novel gaseous signaling molecule, has been reported to have lipid-lowering effects, but its effect on FAs metabolism remains unclear. The purpose of this study was to investigate the effect and mechanisms of anethole dithiolethione (ADT, a sustained-release H2S donor) on hepatic FAs metabolism. ADT was administered daily for 4 weeks in male Syrian golden hamsters fed a high fat diet (HFD), and FAs profiles of liver tissues were analyzed using GC-MS. The results showed that in HFD-fed hamsters, ADT treatment significantly reduced the accumulation of saturated and monounsaturated fatty acids (C16:0, C18:0, C16:1, and C18:1n9), while increased the content of n-6 and n-3 series polyunsaturated fatty acids (C20:3n6, C20:4n6, and C22:6n3). Mechanistically, ADT obviously inhibited the overexpression of ACC1, FAS and SCD1, and up-regulated the levels of FATPs, L-FABP, CPT1α, FADS1 and FADS2. Notably, ADT evidently induced Mitofusin1 to facilitate mitochondrial fusion and optimize β-oxidation. These findings suggest that ADT plays a beneficial role by regulating the synthesis, desaturation, β-oxidation, uptake, binding/isolation, and transport of FAs. In conclusion, ADT is effective in improving liver FAs metabolic disorders and liver injuries caused by HFD.

scholarly journals The degree of saturation of fatty acids influences post-ingestive satiety

2000 ◽  
Vol 83 (5) ◽  
pp. 473-482 ◽  
Author(s):  
Clare L. Lawton ◽  
Helen J. Delargy ◽  
Justine Brockman ◽  
Fiona C. Smith ◽  
John E. Blundell
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Chain Length ◽  
Saturated Fatty Acids ◽  
Monounsaturated Fatty Acids ◽  
Normal Weight ◽  
Degree Of Saturation ◽  
High Fat ◽  
Short Term ◽  
Fixed Energy

Two studies were designed to compare the effects on post-ingestive satiety of manipulating the degree of saturation of fatty acids, at a fixed chain length (18 C atoms), in a fixed energy (5·68 MJ for males; 3·97 MJ for females), high-fat (55 % energy) lunch meal. Two different groups of twenty subjects (ten males and ten females) took part in each study. All forty subjects were of normal weight and aged between 18 and 36 years. Study 1 compared the effects of fat A (oleic blend, high in monounsaturated fatty acids (MUFA)) with those of fat B (linoleic blend, high in polyunsaturated fatty acids (PUFA)) and fat C (stearic–oleic blend, high in saturated fatty acids (SFA)). Study 2, which was designed to confirm and extend the findings of Study 1, compared the effects of fats A, B and C with those of fat D (a linoleic–oleic blend). Energy and nutrient intakes were monitored for the rest of the day and for the following day. Profiles of hunger, fullness and other sensations were monitored by continuous tracking and end-of-day questionnaires. In each meal the fat content was exclusively composed of one particular type (A, B, C or D) and was divided equally between the main course and dessert. Study 1 revealed a significant effect of fat type (degree of saturation) on intake of nutrients at the following (dinner) meal (smallest F[2,36] 3·38, P < 0·05), on post-ingestive ratings of motivation to eat (smallest F[2,36] 4·18, P = 0·02) and on energy intake over the whole test day (F[2,36] 3·39, P < 0·01). Subjects consumed significantly more energy after consumption of the lunch containing fat A than after the lunches containing fats B or C and there was a trend for these effects to continue into the second day. In Study 2, fat C produced more similar effects on appetite to fat A and there was a tendency for subjects to consume more over the whole test day when they had consumed the lunch containing fat A than when they had consumed the lunch containing fat B. Furthermore, when the data from fat conditions A and B in both studies were combined (n 40) the results of Study 1 were confirmed. Overall, the results of these short-term studies indicate that PUFA may exert a relatively stronger control over appetite than MUFA and SFA.

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