Effects of gold core size on regulating the performance of doxorubicin-conjugated gold nanoparticles

Nano Research ◽  
2018 ◽  
Vol 11 (6) ◽  
pp. 3396-3410 ◽  
Author(s):  
Dongyan Wu ◽  
Huaisong Wang ◽  
Xiaoshuang Hou ◽  
Huan Chen ◽  
Yu Ma ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Core Size ◽  
Gold Core

Thermoresponsive Properties ofN-Isopropylacrylamide Oligomer Brushes Grafted to Gold Nanoparticles: Effects of Molar Mass and Gold Core Size

2009 ◽  
Vol 42 (7) ◽  
pp. 2696-2701 ◽  
Author(s):  
Jun Shan ◽  
Yiming Zhao ◽  
Niko Granqvist ◽  
Heikki Tenhu
Keyword(s):  
Gold Nanoparticles ◽  
Molar Mass ◽  
Core Size ◽  
Gold Core

Remarkable high-yielding chemical modification of gold nanoparticles using uncatalyzed click-type 1,3-dipolar cycloaddition chemistry and hyperbaric conditions

2009 ◽  
Vol 87 (12) ◽  
pp. 1708-1715 ◽  
Author(s):  
Hossein Ismaili ◽  
Abdolhamid Alizadeh ◽  
Kristen E. Snell ◽  
Mark S. Workentin
Keyword(s):  
Gold Nanoparticles ◽  
High Pressure ◽  
Dipolar Cycloaddition ◽  
Core Size ◽  
Tem Analysis ◽  
H Nmr ◽  
Gold Core ◽  
High Yields ◽  
Hyperbaric Conditions ◽  
Model Reactions

Azide-terminated alkyl thiolate monolayer-protected gold nanoparticles (1-C12MPN) with a core size of 1.8 ± 0.2 nm were prepared. 1-C12MPN was modified in high yields via an uncatalyzed 1,3-dipolar cycloaddition (click-type reaction) with a variety of terminal acyl–alkynes under hyperbaric conditions at 11 000 atm. The resulting 1,2,3-triazole modified MPNs (2-C12MPN) were characterized using 1H NMR spectroscopy and were verified by comparison of the spectra to those obtained for the products of the model reactions of 1-azidododecane with the same alkynes. TEM analysis showed that the high-pressure conditions did not affect the size of the gold core, suggesting that the only effect is to facilitate the chemical reaction on the particles.

Applications of Gold Nanoparticles in Cancer

2017 ◽  
pp. 194-229
Author(s):  
Solaimuthu Balakrishnan ◽  
Firdous Ahmad Bhat ◽  
Arunakaran Jagadeesan
Keyword(s):  
Drug Delivery ◽  
Gold Nanoparticles ◽  
Drug Delivery Systems ◽  
Protein Detection ◽  
Local Environment ◽  
Controlled Drug Release ◽  
Cell Types ◽  
The Novel ◽  
Gold Core ◽  
Novel Drug

This chapter deals with the applications of gold nanoparticle in cancer and various strategies to target cancer cells by using gold nanoparticles. They are in great demand for biomedical applications such as DNA/Protein detection, bimolecular regulators, cell imaging and cancer cell diagnostics. The ability to tune the surface of the particle provides access to cell –specific targeting and controlled drug release. Depending on their size, shape, degree of aggregation, and local environment, gold nanoparticles can appear red, blue, or other colors. The novel drug delivery systems offer the opportunity to improve poor solubility, limited stability, bio distribution, and pharmacokinetics of drug as well as offering the potential ability to target specific tissues and cell types. The multifunctional gold nanoparticles are attractive organic –inorganic hybrid material composed of an inorganic metallic gold core surrounded by an organic or bimolecular monolayer they provide desirable attributes for the creation of drug delivery in cancer.

scholarly journals Functionalized Gold Nanoparticles as Contrast Agents for Proton and Dual Proton/Fluorine MRI

Nanomaterials ◽  
2019 ◽  
Vol 9 (6) ◽  
pp. 879 ◽  
Author(s):  
Maria Şologan ◽  
Francesco Padelli ◽  
Isabella Giachetti ◽  
Domenico Aquino ◽  
Mariangela Boccalon ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Gold Nanoparticles ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
High Sensitivity ◽  
Mri Contrast Agents ◽  
Resonance Imaging ◽  
Mri Contrast ◽  
Gold Core ◽  
19F Magnetic Resonance Imaging

Gold nanoparticles carrying fluorinated ligands in their monolayer are, by themselves, contrast agents for 19F magnetic resonance imaging displaying high sensitivity because of the high density of fluorine nuclei achievable by grafting suitable ligands on the gold core surface. Functionalization of these nanoparticles with Gd(III) chelates allows adding a further functional activity to these systems, developing materials also acting as contrast agents for proton magnetic resonance imaging. These dual mode contrast agents may allow capitalizing on the benefits of 1H and 19F magnetic resonance imaging in a single diagnostic session. In this work, we describe a proof of principle of this approach by studying these nanoparticles in a high field preclinical scanner. The Gd(III) centers within the nanoparticles monolayer shorten considerably the 19F T1 of the ligands but, nevertheless, these systems display strong and sharp NMR signals which allow recording good quality 19F MRI phantom images at nanoparticle concentration of 20 mg/mL after proper adjustment of the imaging sequence. The Gd(III) centers also influence the T1 relaxation time of the water protons and high quality 1H MRI images could be obtained. Gold nanoparticles protected by hydrogenated ligands and decorated with Gd(III) chelates are reported for comparison as 1H MRI contrast agents.

scholarly journals Functionalization of Gold Nanoparticles by Inorganic Entities

Nanomaterials ◽  
2020 ◽  
Vol 10 (3) ◽  
pp. 548 ◽  
Author(s):  
Frédéric Dumur ◽  
Eddy Dumas ◽  
Cédric R. Mayer
Keyword(s):  
Gold Nanoparticles ◽  
Rapid Development ◽  
Gold Surface ◽  
Intrinsic Properties ◽  
Au Nps ◽  
Gold Core ◽  
Inorganic Systems ◽  
Wide Range ◽  
Different Types ◽  
Electron Donating Groups

The great affinity of gold surface for numerous electron-donating groups has largely contributed to the rapid development of functionalized gold nanoparticles (Au-NPs). In the last years, a new subclass of nanocomposite has emerged, based on the association of inorganic molecular entities (IME) with Au-NPs. This highly extended and diversified subclass was promoted by the synergy between the intrinsic properties of the shell and the gold core. This review—divided into four main parts—focuses on an introductory section of the basic notions related to the stabilization of gold nanoparticles and defines in a second part the key role played by the functionalizing agent. Then, we present a wide range of inorganic molecular entities used to prepare these nanocomposites (NCs). In particular, we focus on four different types of inorganic systems, their topologies, and their current applications. Finally, the most recent applications are described before an overview of this new emerging field of research.

Carbon–gold core–shell structures: formation of shells consisting of gold nanoparticles

2012 ◽  
Vol 48 (33) ◽  
pp. 3972 ◽  
Author(s):  
Jerzy Choma ◽  
Dominik Jamioła ◽  
Katarzyna Augustynek ◽  
Michal Marszewski ◽  
Mietek Jaroniec
Keyword(s):  
Gold Nanoparticles ◽  
Shell Structures ◽  
Core Shell ◽  
Gold Core

Self-Assembly of Gold Nanoparticles on Gold Core-Induced Polypyrrole Nanohybrids for Electrochemical Sensor of Dopamine

NANO ◽  
2015 ◽  
Vol 10 (08) ◽  
pp. 1550115 ◽  
Author(s):  
Junwei Ding ◽  
Kai Zhang ◽  
Wei Xu ◽  
Zhiqiang Su
Keyword(s):  
Electron Microscopy ◽  
Gold Nanoparticles ◽  
Self Assembly ◽  
Chemical Oxidation ◽  
X Ray Diffraction ◽  
Detection Range ◽  
In Situ Chemical Oxidation ◽  
Gold Core ◽  
Transmission Electron ◽  
Chemical Oxidation Polymerization

Gold core-induced polypyrrole nanohybrids (Au–PPyNHs) were successfully synthesized via in situ chemical oxidation polymerization of pyrrole molecules, and their structure was directly confirmed and characterized by scanning electron microscopy, transmission electron microscopy, Fourier transform infrared spectroscopy and X-ray diffraction. Furthermore, gold nanoparticles (AuNPs) were assembled onto the as-prepared Au–PPyNHs by electrostatic interaction to fabricate the nanohybrids of Au–PPyNH–Au. The created Au–PPyNH–Au nanohybrids was immobilized onto glassy carbon electrode and applied to construct dopamine (DA) sensor. We found that the fabricated sensor with Au–PPyNH–Au nanohybrids is highly specific probe for sensing DA. The Au–PPyNH–Au based DA sensor has a linear detection range from 1[Formula: see text][Formula: see text]M to 0.321 mM and a detection limit of 0.32[Formula: see text][Formula: see text]M.

Sign in / Sign up

Export Citation Format

Share Document