Pre-clinical investigation of anti-diarrheal and CNS depressant effect of Wedelia trilobata in Swiss albino mice

2019 ◽  
Vol 19 (4) ◽  
pp. 435-444
Author(s):  
Md. Al Foyjul Islam ◽  
Anindya Barua ◽  
Maksud Hassan Binoy ◽  
Md. Jahir Alam ◽  
Md. Ershad ◽  
...  
Keyword(s):  
Clinical Investigation ◽  
Depressant Effect ◽  
Swiss Albino Mice ◽  
Wedelia Trilobata ◽  
Cns Depressant ◽  
Albino Mice

Methanolic Extract of Peel of Citrus maxima Fruits Exhibit Analgesic, CNS Depressant and Anti-inflammatory Activities in Swiss Albino Mice

2018 ◽  
Vol 4 (1) ◽  
pp. 07-11 ◽  
Author(s):  
Ibrahim Md. Ibrahim ◽  
Mohammad Nurul Amin ◽  
Md. Shalahuddin Millat ◽  
Jahangir Alam Raju ◽  
Md. Saddam Hussain ◽  
...  
Keyword(s):  
Methanolic Extract ◽  
Swiss Albino Mice ◽  
Cns Depressant ◽  
Citrus Maxima ◽  
Albino Mice ◽  
Anti Inflammatory

scholarly journals The Motor Coordination Activity Of Aqueous Extract Of Withania Coagulans Fruits In Swiss Albino Mice By Rota Rod Test

2020 ◽  
Vol 2 (3) ◽  
Author(s):  
Amit Shankarrao Kamdi ◽  
Devesh D. Gosavi ◽  
Suvarna M. Kalambe ◽  
Pankaj N. Bohra
Keyword(s):  
Aqueous Extract ◽  
Motor Coordination ◽  
P Value ◽  
Endurance Time ◽  
Swiss Albino Mice ◽  
Cns Depressant ◽  
Withania Coagulans ◽  
Rota Rod Test ◽  
Albino Mice ◽  
Cns Depressant Activity

Background: The various sedative and hypnotic medications used today have the central nervous system (CNS) depressant effects. A very little work has been done on the Withania coagulans – a vulnerable species as it is not found rampant in the world except in late seventies. Therefore, it was important to explore the CNS depressant activities of aqueous extract of Withania coagulans fruits in Swiss albino mice by using rota rod test. Methods: Motor coordination was assessed by using the Rota Rod Test. The CNS depressant drugs decrease the endurance time of mice on the rota rod as they impair the motor coordination so that mice fall early on the rotating rod. This endurance time is statistically correlated among the control, standard and the test drugs. Results: There was statistically highly significant (p-value < 0.001) association observed between aqueous extract of Withania coagulans fruits with endurance time in Swiss albino mice on rota rod test. Conclusion: The aqueous extract of Withania coagulans fruits demonstrated the CNS depressant activity in Swiss albino mice by rota rod test.

scholarly journals The spontaneous motor activity of aqueous extract of Withania coagulans fruits in Swiss albino mice by actophotometer

2020 ◽  
Vol 9 (9) ◽  
pp. 1440
Author(s):  
Devesh D. Gosavi ◽  
Amit S. Kamdi ◽  
Suvarna M. Kalambe ◽  
Pankaj N. Bohra
Keyword(s):  
Locomotor Activity ◽  
Aqueous Extract ◽  
Motor Coordination ◽  
Spontaneous Locomotor Activity ◽  
P Value ◽  
Swiss Albino Mice ◽  
Cns Depressant ◽  
Withania Coagulans ◽  
Albino Mice ◽  
Cns Depressant Activity

Background: People spend about one third of their time in sleep every day. The various sedative and hypnotic medications used today have numerous side effects. In the late seventies a very little work was done on the Withania coagulans - a vulnerable species that is found scattered in the world. Therefore, it was essential to discover the CNS depressant activities of aqueous extract of Withania coagulans fruits in swiss albino mice by using actophotometer.Methods: The spontaneous locomotor activity was evaluated by using the actophotometer. The CNS depressant drugs decrease the locomotor activity in mice as they impair the motor coordination so that mice stay at one place for the longer time. Therefore, there is less disruption of the beams of light. This spontaneous locomotor activity time is statistically correlated among the control, standard and the test drugs.Results: There was statistically highly significant (p value <0.001) association observed between aqueous extract of Withania coagulans fruits with spontaneous locomotor activity in swiss albino mice on the actophotometer.Conclusions: The aqueous extract of Withania coagulans fruits demonstrated the CNS depressant activity in swiss albino mice by actophotometer.

Protective Effects of Prunus Avium Extract on 10 Ghz Induced Damages in the Spleen of Swiss Albino Mice

2011 ◽  
Vol 3 (8) ◽  
pp. 680-684 ◽  
Author(s):  
Faiza Rifat ◽  
◽  
Archana Sharma ◽  
Preeti Srivastava ◽  
Shikha Patni ◽  
...  
Keyword(s):  
Prunus Avium ◽  
Protective Effects ◽  
Swiss Albino Mice ◽  
Albino Mice

PROTECTIVE EFFECT OF ROSEMARY (ROSMARINUS OFFICINALIS L.) EXTRACT OVER THE GENOTOXICITY INDUCED BY CYCLOPHOSPHAMIDE IN SWISS ALBINO MICE

2016 ◽  
Vol 72 (9) ◽  
Author(s):  
Dr. Ayman Salah El-Seedy ◽  
Hany George Shalaby ◽  
Mohamed Ahmed El-Sehrigy ◽  
Madiha Mohiy El-Dein Ghoneim
Keyword(s):  
Protective Effect ◽  
Rosmarinus Officinalis ◽  
Swiss Albino Mice ◽  
Albino Mice ◽  
Rosmarinus Officinalis L

HAEMATO-BIOCHEMICAL AND IMMUNOLOGICAL CHANGES IN EXPERIMENTALLY INDUCED ACETAMIPRID TOXICITY IN SWISS ALBINO MICE

2016 ◽  
Vol 12 (1) ◽  
Author(s):  
D.T. Fefar ◽  
Ankita N. Brahmbhatt ◽  
B.P. Joshi ◽  
D.J. Ghodasara
Keyword(s):  
Dose Level ◽  
Significant Rise ◽  
High Dose ◽  
Cell Mediated Immunity ◽  
Swiss Albino Mice ◽  
Mean Values ◽  
Group Iii ◽  
Treatment Groups ◽  
Immunological Effects ◽  
Albino Mice

A study was conducted on 5 weeks old 64 (32 male and 32 female) Swiss albino mice to assess the haemato-biochemical and immunological effects of acetamiprid. All the male and female mice were randomly divided into eight different groups. The groups I (male) and II (female) served as controls whereas remaining groups served as treatment groups and were administered acetamiprid at the daily dose rate of 20, 10, 5 mg/kg body weight in males(Group III, V, VII) and females (Group IV, VI,VIII),respectively for 28 days. After 28 days treatment, blood samples were collected for hematological, biochemical as well as immunological analysis. There was significant decrease in haematological parameters like Hb, TEC, TLC, neutrophils and lymphocytes count in high dose groups and revealed potential adversity of acetamiprid at rates of 20 mg/kg/day on haematopoetic system of mice. A dose dependent significant rise in mean values of AST and ALT was observed in treatment groups, whereas there was significant decrease in total protein and albumin and increase in BUN in high and mid dose treated groups, irrespective of sex of mice. Dinitroflurobenzene (DNFB) test conducted to assess the cell mediated immunity revealed the toxic effect of acetamiprid on cell mediated immunity of mice at dose level of 10 mg/kg/day. The mice of high dose group revealed a significant decrease in HA titer and indicated the immunotoxic potential of acetamiprid at dose level of 20 mg/kg/day.

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