scholarly journals Tangutidines A–C, Three Amphoteric Diterpene Alkaloids from Aconitum tanguticum

2021 ◽  
Author(s):  
Hao-Yi Li ◽  
Bing-Chao Yan ◽  
Li-Xin Wei ◽  
Han-Dong Sun ◽  
Pema-Tenzin Puno
Keyword(s):  
Spectroscopic Data ◽  
Cytotoxic Activities ◽  
Diterpene Alkaloids ◽  
Nmr Data ◽  
Whole Plant ◽  
Detailed Interpretation ◽  
First Time

AbstractThree new diterpene alkaloids, tangutidines A–C (1–3), and four known alkaloids (4–7) were isolated from the whole plant of Aconitum tanguticum, from which amphoteric diterpene alkaloids (1–3) were obtained for the first time. The structures of 1–3 were elucidated by detailed interpretation of spectroscopic data, including MS and NMR data. All of them were evaluated for their cytotoxic activities. Graphic Abstract

Two Rare Hydroazulene-type Sesquiterpenes from the Roots of Aristolochia yunnanensis

2014 ◽  
Vol 69 (6) ◽  
pp. 742-746 ◽  
Author(s):  
Zhuo Du ◽  
Feng-Ni Wen ◽  
Ji-Ping Zhang ◽  
Jian-Feng Wua ◽  
Fang Liu ◽  
...  
Keyword(s):  
Circular Dichroism ◽  
Cell Lines ◽  
Spectroscopic Data ◽  
Cytotoxic Activities ◽  
Moderate Activity ◽  
Electronic Circular Dichroism ◽  
The Third ◽  
The Absolute ◽  
First Time ◽  
Circular Dichroïsm

Two new sesquiterpenes, named aristoyunnolin I (1) and J (2), together with eight known compounds (3 - 10) were isolated from the roots of Aristolochia yunnanensis. Compounds 1 and 2 feature a rare hydroazulene-type sesquiterpene skeleton and represent the third and fourth examples of this kind found in nature. The structures were determined from spectroscopic data, and the absolute configurations of 1 - 3 were assigned by comparing experimental with simulated electronic circular dichroism (ECD) spectra. Compounds 1, 2, 6 - 10 were isolated from this plant for the first time. The cytotoxic activities of 1 - 10 were evaluated against P-388 and A-549 cell lines. Only compounds 4 and 5 showed moderate activity with IC50 values ranging from 12.0 to 18.2 μM.

scholarly journals Microbial Transformation of neo-Clerodane Diterpenoid, Scutebarbatine F, by Streptomyces sp. CPCC 205437

2021 ◽  
Vol 12 ◽  
Author(s):  
Dewu Zhang ◽  
Xiaoyu Tao ◽  
Guowei Gu ◽  
Yujia Wang ◽  
Wenxia Zhao ◽  
...  
Keyword(s):  
Influenza A ◽  
Microbial Transformation ◽  
Cancer Cell Line ◽  
Antibacterial Activities ◽  
Positive Control ◽  
Cytotoxic Activities ◽  
Ionization Mass ◽  
Nmr Data ◽  
First Time ◽  
New Metabolites

Biotransformation of the neo-clerodane diterpene, scutebarbatine F (1), by Streptomyces sp. CPCC 205437 was investigated for the first time, which led to the isolation of nine new metabolites, scutebarbatine F1–F9 (2–10). Their structures were determined by extensive high-resolution electrospray ionization mass spectrometry (HRESIMS) and NMR data analyses. The reactions that occurred included hydroxylation, acetylation, and deacetylation. Compounds 2–4 and 8–10 possess 18-OAc fragment, which were the first examples of 13-spiro neo-clerodanes with 18-OAc group. Compounds 7–10 were the first report of 13-spiro neo-clerodanes with 2-OH. Compounds 1–10 were biologically evaluated for the cytotoxic, antiviral, and antibacterial activities. Compounds 5, 7, and 9 exhibited cytotoxic activities against H460 cancer cell line with inhibitory ratios of 46.0, 42.2, and 51.1%, respectively, at 0.3 μM. Compound 5 displayed a significant anti-influenza A virus activity with inhibitory ratio of 54.8% at 20 μM, close to the positive control, ribavirin.

scholarly journals Chemical constituents of the lichen Roccella sinensis growing in Binh Thuan province

2019 ◽  
Vol 2 (5) ◽  
pp. 63-67
Author(s):  
Huy Thuc Duong ◽  
Hao Xuan Bui
Keyword(s):  
Spectroscopic Analysis ◽  
Chemical Constituents ◽  
Human Lung Cancer ◽  
Cytotoxic Activities ◽  
Human Breast ◽  
Nmr Data ◽  
Liver Hepatocellular Carcinoma ◽  
First Time ◽  
Layer Chromatography ◽  
Mcf 7

The lichen Roccella sinensis has not been studied chemically. This research described the isolation and elucidation of compounds isolated from the lichen Roccella sinensis collected in Binh Thuan. Phytochemistry investigation of this lichen was carried out by using normal phase silica gel column chromatography and thin-layer chromatography. Six compounds was isolated. Their structures were established by extensively spectroscopic analysis as well as comparison with NMR data in the literatures. They are (+)-D-montagnetol (1), (+)-D-erythrin (2), lecanorin (3), 1-acetylerythritol (4), (E)-nostodione A (5), and 2,4-dihydroxyphthalide (6). This is the first time compounds 3 6 were found in the Roccella genus. Compounds 1, 2, and 6 were evaluated for their cytotoxic activities against HepG2 (liver hepatocellular carcinoma), NCI-H460 (human lung cancer), MCF-7 (human breast cancer), and HeLa (human epithelial cancer) and all of them showed no activity.

scholarly journals Oleanane-type Triterpene Glycosides from Glycyrrhiza Uralensis

2007 ◽  
Vol 2 (3) ◽  
pp. 1934578X0700200 ◽  
Author(s):  
Jinwei Li-Yang ◽  
Jun-ichiro Nakajima ◽  
Nobuhito Kimura ◽  
Kazuki Saito ◽  
Shujiro Seo
Keyword(s):  
Natural Products ◽  
Spectroscopic Data ◽  
2D Nmr ◽  
Mass Spectrometric ◽  
Triterpene Glycosides ◽  
Glycyrrhiza Uralensis ◽  
Nmr Data ◽  
Nmr Methods ◽  
First Time ◽  
C Nmr

Chemical investigation of the roots of Glycyrrhiza uralensis resulted in the isolation of six oleanane-type triterpene glycosides (1 – 6), including one new saponin (1) and two (2 and 3) obtained as natural products for the first time. The new licorice saponin (1) was identified as 22β–acetoxylglycyrrhizin from [α]D, mass spectrometric, and UV, IR, and NMR spectroscopic data.. Full assignments of 1H and 13C-NMR data for compounds 2, 3, 4, 5 and 6 were made for the first time according to 2D NMR methods.

scholarly journals Dihydroisocoumarins and Dihydroisoflavones from the Rhizomes of Dioscorea collettii with Cytotoxic Activity and Structural Revision of 2,2′-Oxybis(1,4-di-tert-butylbenzene)

Molecules ◽  
2021 ◽  
Vol 26 (17) ◽  
pp. 5381
Author(s):  
Songsong Jing ◽  
Zhuo Qu ◽  
Chengcheng Zhao ◽  
Xia Li ◽  
Long Guo ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
13C Nmr ◽  
The Other ◽  
Cytotoxic Activities ◽  
Spectroscopic Methods ◽  
1H And 13C Nmr ◽  
Structural Revision ◽  
Nmr Data ◽  
H460 Cell ◽  
First Time

The investigation of the constituents of the rhizomes of Dioscorea collettii afforded one new dihydroisocoumarin, named (−)-montroumarin (1a), along with five known compounds—montroumarin (1b), 1,1′-oxybis(2,4-di-tert-butylbenzene) (2), (3R)-3′-O-methylviolanone (3a), (3S)-3′-O-methylviolanone (3b), and (RS)-sativanone (4). Their structures were elucidated using extensive spectroscopic methods. To the best of our knowledge, compound 1a is a new enantiomer of compound 1b. The NMR data of compound 2 had been reported but its structure was erroneous. The structure of compound 2 was revised on the basis of a reinterpretation of its NMR data (1D and 2D) and the assignment of the 1H and 13C NMR data was given rightly for the first time. Compounds 3a–4, three dihydroisoflavones, were reported from the Dioscoreaceae family for the first time. The cytotoxic activities of all the compounds were tested against the NCI-H460 cell line. Two dihydroisocoumarins, compounds 1a and 1b, displayed moderate cytotoxic activities, while the other compounds showed no cytotoxicity.

scholarly journals Secondary Metabolites from Astragalus lycius and Their Cytotoxic Activities

2016 ◽  
Vol 11 (12) ◽  
pp. 1934578X1601101 ◽  
Author(s):  
Ibrahim Horo ◽  
Fatma Kocabaş ◽  
Özgen Alankuş-Çalışkan ◽  
Fevzi Özgökçe ◽  
Ihlas A. Khan ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Methanolic Extract ◽  
Human Colon ◽  
Cytotoxic Activities ◽  
Significant Activity ◽  
Human Colon Carcinoma ◽  
Whole Plant ◽  
First Time ◽  
Ht 29 ◽  
C Nmr

Eight known secondary metabolites were isolated from the methanolic extract of the whole plant of Astragalus lycius Boiss. They were identified as 5,5′-dihydroxy-3′-methoxy-isoflavone-7- O-β-D-glucoside (1), genistin (2), sissotrin (3), 5,4′-dimethoxy-isoflavone-7- O-β-D-glucopyranoside (4), (7 S,8 R)-5-methoxydehydrodiconiferyl alcohol-4- O-β-D-glucopyranoside (5), 4- O-lariciresinol-glucoside (6), 2-phenylethyl-β-D-glucopyranoside (7) and β-sitosterol-3- O-β-D-glucopyranoside (8) by spectroscopic methods including 1H- and 13C-NMR and HR-MS experiments, and by comparison with literature values. Compounds 1–7 are reported for the first time from Astragalus taxa. All of the compounds were tested for their cytotoxic activities against a number of cancer cell lines. Among them, only 6 exhibited significant activity against human colon carcinoma (HT-29) at 2.69 μM concentration.

scholarly journals Stereochemistry and NMR Data Assignment of Cyclopeptide Alkaloids from Zizyphus Oxyphylla

2010 ◽  
Vol 5 (8) ◽  
pp. 1934578X1000500
Author(s):  
Muhammad Nisar ◽  
Waqar Ahmad Kaleem ◽  
Achyut Adhikari ◽  
Zulfiqar Ali ◽  
Nusrat Hussain ◽  
...  
Keyword(s):  
Spectroscopic Data ◽  
Mass Spectrometric ◽  
Mass Spectrometric Data ◽  
Spectrometric Data ◽  
Nmr Data ◽  
Cyclopeptide Alkaloids ◽  
First Time ◽  
C Nmr

The structures of (3 S,7 R,13 S)-6-[2-(dimethylamino)-3-phenylpropanoyl]-19-methoxy-2-oxa-6,9,15-triazatetracyclo[16.3.1.03,7. 09,13]docosa-1-(22),16,18,20-tetraene-8,14-dione (1), nummularin-C (2) and nummularin-R (3) have been previously determined mainly based on mass spectrometric data. Stereochemistry and complete 1H and 13C NMR spectroscopic data assignments of these compounds are now described. Compounds 1 and 2 are reported for the first time from

scholarly journals A Novel Cytotoxic Physalin from Physalis angulata

2017 ◽  
Vol 12 (10) ◽  
pp. 1934578X1701201
Author(s):  
Jia-Jia Fan ◽  
Xia Liu ◽  
Xi-Long Zheng ◽  
Hai Yu Zhao ◽  
Huan Xia ◽  
...  
Keyword(s):  
Spectroscopic Data ◽  
Hepatoma Cells ◽  
Cytotoxic Activities ◽  
Mammary Cells ◽  
Human Hepatoma ◽  
Human Hepatoma Cells ◽  
Whole Plant ◽  
Bioassay Guided Fractionation ◽  
Physalis Angulata ◽  
Mcf 7

Bioassay-guided fractionation from the whole plant of Physalis angulata led to the isolation of a novel physalin, 25-hydroxylisophysalin B (1), together with three megastigmane glucosides (2-4) and eight known physalins (5-12). The structure of compound 1 was elucidated by analysis of spectroscopic data. All of the compounds exhibited cytotoxic activities against MCF-7 human mammary cells and HepG2 human hepatoma cells.

scholarly journals SOME TRITERPENOIDS AND STEROIDS FROM THE LICHEN LOBARIA ORIENTALIS, LOBARIACEAE.

2018 ◽  
Vol 54 (2C) ◽  
pp. 313
Author(s):  
Nguyen Thi My Dung
Keyword(s):  
Spectroscopic Data ◽  
Human Lung ◽  
Ethyl Acetate Extract ◽  
Cancer Cell Line ◽  
Human Lung Cancer ◽  
Cytotoxic Activities ◽  
Ic50 Value ◽  
Liver Hepatocellular Carcinoma ◽  
First Time ◽  
Mcf 7

Chemical investigation of the ethyl acetate extract of the lichen Lobaria orientalis,Lobariaceae, collected in Vietnam, afforded six known compounds, including four triterpenoids,zeorin (1), 16β-acetoxyhopane-6α,22-diol (2), retigeric acid A (3), retigeric acid B (4), togetherwith two steroids, ergosterol-5α,8α-peroxide (5) and cerevisterol (6). Their chemical structureswere elucidated by spectroscopic data analysis and comparison with those reported in theliterature. The cytotoxic activities of some compounds against liver hepatocellular carcinoma(HepG2), human lung cancer (NCI-H460), human epithelial carcinoma (HeLa) and humanbreast cancer (MCF-7) cell lines were evaluated. Compound 2 exhibited good cytotoxicityagainst MCF-7 cancer cell line with IC50 value of 21.10 μg/mL. This is the first time compounds(1), (2), (6) are reported in the Lobaria genus.

scholarly journals Chemical constituents of the whole plant of PHLOGACANTHUS TURGIDUS (FUA EX HOOK.F.) LINDAU

2021 ◽  
Vol 5 (3) ◽  
pp. first
Author(s):  
Nguyen Tan Phat ◽  
Mai Thanh Chi ◽  
Phan Nhat Minh ◽  
Dang Chi Hien ◽  
Mai Dinh Tri
Keyword(s):  
Biological Activities ◽  
Chemical Constituents ◽  
Ethanolic Extract ◽  
2D Nmr ◽  
Published Data ◽  
Cytotoxic Activities ◽  
Phenylethanoid Glycosides ◽  
Whole Plant ◽  
The Family ◽  
First Time

The genus Phlogacanthus belongs to the family Acanthaceae and consists of more than 49 species, These species are widespread in tropical and subtropical zones such as Bangladesh, Bhutan, China, Indonesia, India, Myanmar and Vietnam. In Vietnam, the genus contains about 06 species. The extracts from some species in this genus have been evaluated for biological activities as analgesic, antiinflammatory, antimicrobial, antioxidant, antihyperglycemic and cytotoxic activities. In this study, the whole plant of Phlogacanthus turgidus was collected, dried, cut into small species, and extracted with ethanol to yield the ethanolic extract. Isolation of chemical constituents was performed using column chromatography on silica gel; their structures were elucidated by HRESI-MS, 1D & 2D-NMR and compared with published data. Six compounds, including two nor-isoprenoids: (+)-dehydrovomifoliol (1), (3S,5R,6R,7E,9S)-megastiman-7-ene-3,5,6,9-tetrol (2), two steroids b - sitosterol (3), daucosterol (4), one lignan (+)-syringaresinol (5), a derivative of phenylethanoid glycosides: martynoside (6) were isolated from the ethyl acetate extract of the whole plant of P. turgidus. Among them, 1, 2 were reported for the first time from the genus Phlogacanthus, while 3, 4, 5, 6, were found for the first time from this species.

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