Sinapic acid restores blood parameters, serum antioxidants, and liver and kidney functions in obesity

Introduction.Nanoparticles of NiO pollute air of workplace in metallurgic production of nickel and alloyed steel (during their use in electric welding). Toxicity of NiO nanoparticles was studied in some experiments, but mechanisms underlying their toxic eff ects are not understood and require wider base of experimental data.Objective. To study toxic eff ects of NiO nanoparticles in chronic inhalation exposure.Materials and methods.Outbred female rats were subjected to repeated low-level inhalation exposure to NiO nanoparticles of 99.99% purity, measured 23±5 nm, 4 hours per day, 5 days per week, up to 10-month duration in an “only nose” device with concentration 0.2±0.01 mg/m3. To select this concentration, preliminary pilot experiment included 5-fold exposure with concentration 1.00±0.12 mg/m3.Results.NiO nanoparticles in short-term and chronic inhalation exposure aff ect lipids peroxidation, red blood parameters, liver and kidney functions, oxidation-reduction balance. All three terms of chronic inhalation experiment cause active alveolar phagocytosis reaction, and their high cytotoxicity is proved by relation of neutrophils to alveolar macrophages and by enzymes levels in bronchoalveolar lavage.Conclusions.NiO nanoparticles if inhaled in concentration 0.2 mg/m3 cause moderate toxic eff ect in experimental animals.

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Clinical manifestations of Liver and Renal impairments in asymptomatic, moderate and severe COVID-19 patients of Madinah city of Saudi Arabia: a retrospective analysis (Preprint)

10.2196/preprints.23629 ◽

2020 ◽

Author(s):

Firdous Beigh ◽

Nidda Syeed ◽

Walaa Saeed ◽

Ziab Alahmadey ◽

Ibrahim Seedi

Keyword(s):

Saudi Arabia ◽

Clinical Status ◽

Clinical Manifestations ◽

Normal Liver ◽

Significant Percentage ◽

Renal Functions ◽

Moderate Disease ◽

Novel Association ◽

Liver And Kidney ◽

Kidney Functions

BACKGROUND Coronavirus disease (COVID-19) is a budding infectious disease that has affected various countries globally. OBJECTIVE The aim of this study was to analyze the effect of COVID-19 disease on liver and kidney functions and to determine their association with the severity and mortality of disease METHODS A total of 100 confirmed COVID-19 adult patients from Madinah city of Saudi Arabia hospitalized between April 28, and June 30, 2020 were included,and categorized into asymptomatic,mild to moderate and severely ill patients.We analyzed the clinical status of liver and renal functioning in all of the three groups. RESULTS The majority of patients (51%) were diagnosed with mild to moderate disease, 27% of patients were severely ill and 22% of patients were asymptomatic.The liver and renal functional analysis showed that the severity of the COVID-19 patients were significantly associated with the kidney and renal impairments exhibiting higher levels of ALT, AST, Creatinine, Urea levels (P < 0.05). Furthermore, in this study, a novel association is found between high Na and Cl levels with the severely ill COVID-19 patients. CONCLUSIONS We concluded from the present study that a significant percentage of COVID-19 patients continued to have a normal liver and renal function during the course of their disease. Nevertheless, severely ill COVID-19 patients were more prone to have abnormal liver and renal functions. During the course of treatment, the patients had a gradual normalization of their liver and kidney parameters and subsequently achieved a complete normal liver and renal functions upon discharge with no mortality.

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Effect of dietary calcium and phosphorus levels on growth, carcass characteristics and liver and kidney functions of growing Egyptian geese

Poultry Science ◽

10.1016/j.psj.2021.101244 ◽

2021 ◽

pp. 101244

Author(s):

Mahmoud Alagawany ◽

Elwy Ali Ashour ◽

Mohamed Soliman El-Kholy ◽

Laila Ali Mohamed ◽

Mohamed Ezzat Abd El-Hack

Keyword(s):

Carcass Characteristics ◽

Dietary Calcium ◽

Liver And Kidney ◽

Calcium And Phosphorus ◽

Kidney Functions ◽

Phosphorus Levels

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The effect of antioxidant properties of aqueous garlic extract and Nigella sativa as anti-schistosomiasis agents in mice

Revista do Instituto de Medicina Tropical de São Paulo ◽

10.1590/s0036-46652008000100007 ◽

2008 ◽

Vol 50 (1) ◽

pp. 29-36 ◽

Cited By ~ 65

Author(s):

Nahla S. EL Shenawy ◽

Maha F. M. Soliman ◽

Shimaa I. Reyad

Keyword(s):

Nigella Sativa ◽

Antioxidant Properties ◽

Specific Treatment ◽

Garlic Extract ◽

Serum Total Protein ◽

Treatment Regimens ◽

Liver And Kidney ◽

Hematological And Biochemical Parameters ◽

Kidney Functions ◽

Remarkable Reduction

The aim of this study was to assess the antioxidant and anti-schistosomal activities of the garlic extract (AGE) and Nigella sativa oil (NSO) on normal and Schistosoma mansoni-infected mice. AGE (125 mg kg-1, i.p.) and NSO (0.2 mg kg-1, i.p.) were administrated separately or in combination for successive 28 days, starting from the 1st day post infection (pi). All mice were sacrificed at weeks 7 pi. Hematological and biochemical parameters including liver and kidney functions were measured to assess the progress of anemia, and the possibility of the tissue damage. Serum total protein level, albumin, globulin and cholesterol were also determined. Malondialdehyde (MDA) and glutathione (GSH) levels were determined in the liver tissues as biomarkers for oxidative and reducing status, respectively. The possible effect of the treatment regimens on Schistosoma worms was evaluated by recording percentage of the recovered worms, tissue egg and oogram pattern. Result showed that, protection with AGE and NSO prevented most of the hematological and biochemical changes and markedly improved the antioxidant capacity of schistosomiasis mice compared to the infected-untreated ones. In addition, remarkable reduction in worms, tissue eggs and alteration in oogram pattern were recorded in all the treated groups. The antioxidant and antischistosomal action of AGE and NSO was greatly diverse according to treatment regimens. These data point to these compounds as promising agents to complement schistosomiasis specific treatment.

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Safety and persistence of orally administered human Lactobacillus sp. strains in healthy adults

Beneficial Microbes ◽

10.3920/bm2010.0023 ◽

2011 ◽

Vol 2 (1) ◽

pp. 79-90 ◽

Cited By ~ 13

Author(s):

P. Hütt ◽

P. Kõll ◽

J. Stsepetova ◽

B. Alvarez ◽

R. Mändar ◽

...

Keyword(s):

Denaturing Gradient Gel Electrophoresis ◽

Blood Parameters ◽

Second Phase ◽

Biotechnological Applications ◽

Gut Health ◽

Blood Indices ◽

Day Range ◽

Gradient Gel Electrophoresis ◽

Liver And Kidney ◽

High Doses

The aim of the study was to evaluate the safety and persistence of selected Lactobacillus strains in the gastrointestinal tract (GIT) of healthy adult volunteers after oral consumption of high doses of lactobacilli to identify potential candidates for probiotic and biotechnological applications. In the first phase of the study, nine individuals consumed capsules containing Lactobacillus gasseri 177 and E16B7, Lactobacillus acidophilus 821-3, Lactobacillus paracasei 317 and Lactobacillus fermentum 338-1-1 (each daily dose 1×1010 cfu) for 5 consecutive days. Data on gut health, blood parameters, and liver and kidney function were collected. The persistence of Lactobacillus strains was assessed by culturing combined with arbitrarily primed polymerase chain reaction (AP-PCR) and PCR-denaturing gradient gel electrophoresis (PCR-DGGE) on days 0, 5, 8, 10 and 20 from faecal samples. All strains survived gastrointestinal passage and were detected on the 5th day. L. acidophilus 821-3 was detected in four volunteers on the 8th day (4.3 to 7.0 log10 cfu/g) and in two on the 10th day (8.3 and 3.9 log10 cfu/g, respectively). In the second phase of the study, five additional volunteers consumed L. acidophilus 821-3 (daily 1×1010 cfu) for 5 consecutive days. The strain was subsequently detected in faeces of all individuals using real-time PCR on the 10th day (range 4.6-6.7; median 6.0 log10 cell/g) in both phases of the study for at least 5 days after discontinuation of consumption. The administration of high doses of different Lactobacillus strains did not result in any severe adverse effects in GIT and/or abnormal values of blood indices. Thus, the strain L. acidophilus 821-3 is a promising candidate for probiotic and biotechnological applications. Further studies will be performed to confirm the strain persistence and safety in a larger number of individuals.

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Acute and Sub-Acute Oral Toxicity Profile of Purified Tomato Extract on the Liver and Kidney Functions of Male Wistar Rats

10.26538/tjnpr/v5i11.12 ◽

2021 ◽

Vol 5 (11) ◽

pp. 1962-1965

Keyword(s):

Wistar Rats ◽

Acute Oral Toxicity ◽

Toxicity Profile ◽

Oral Toxicity ◽

Tomato Extract ◽

Male Wistar Rats ◽

Liver And Kidney ◽

Kidney Functions

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Evaluation of Some Biochemical Parameters and Hormones In Patients with Acute Myeloid Leukemia in Iraq

Iraqi Journal of Science ◽

10.24996/ijs.2021.62.5.9 ◽

2021 ◽

pp. 1460-1466

Author(s):

Hind Mahmood Jumaah ◽

Jabbar H. Yenzeel ◽

Mohammad G. Mehdi

Keyword(s):

Acute Myeloid Leukemia ◽

Liver Function ◽

Kidney Function ◽

Myeloid Leukemia ◽

Biochemical Parameters ◽

Serum Levels ◽

Newly Diagnosed ◽

Liver And Kidney ◽

Kidney Functions ◽

Acute Myeloid

The effect of myeloid leukemia, especially cute myeloid leukemia (AML), has been widely noticed on the parameters of liver and kidney functions and the levels of certain hormones. This study aimed to evaluate a number of biochemical parameters of liver and kidney functions and hormones in Iraqi subjects with newly diagnosed acute myeloid leukemia. Eighty newly diagnosed AML adult patients (40 males and 40 females) and forty healthy individuals (20 males and 20 females) with an age range of 16-75 years were involved in this study during their attendance at the Hematology Department of Baghdad Teaching Hospital/ Medical city in Baghdad province from March 2019 to February 2020. Blood samples were collected from all subjects for the determination of serum levels of the parameters of liver function parameters., kidney function , lactate dehydrogenase (LDH), and Erythropoietin (EPO). The results showed that the serum levels of liver function parameters (alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) had highly significant increases (p< 0.01) in AML patients (85.87±2.49 , 53.93±1.76, 150.87±7.04 U/L, respectively) as compared to the control (30.58 ±2.04, 22.89 ±0.97, 75.51 ±2.12 U/L, respectively ). Also, the level of kidney function parameters (blood urea, creatinine and uric acid) showed highly significant increases (p< 0.01) in AML patients (58.82 ±1.49, 1.831 ±0.05, 8.34 ±0.15 mg/dl, respectively) as compared to the control (31.10 ±1.03, 0.850 ±0.02, 4.81 ±0.14 mg/dl, respectively). In addition, the level of LDH showed a highly significant increase (p< 0.01) in the patients with AML (657.72 ±80.76 U/L) as compared to the control (166.05 ±6.15 U/L). Moreover, the level of EPO showed a highly significant increase (p<0.01) in the patients with AML (11763.80 ±329.46 pg/ml ) as compared to the control (316.94 ±34.42 pg/ml).

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Berberine Phospholipid Is an Effective Insulin Sensitizer and Improves Metabolic and Hormonal Disorders in Women with Polycystic Ovary Syndrome: A One-Group Pretest–Post-Test Explanatory Study

Nutrients ◽

10.3390/nu13103665 ◽

2021 ◽

Vol 13 (10) ◽

pp. 3665

Author(s):

Mariangela Rondanelli ◽

Antonella Riva ◽

Giovanna Petrangolini ◽

Pietro Allegrini ◽

Attilio Giacosa ◽

...

Keyword(s):

Polycystic Ovary Syndrome ◽

Polycystic Ovary ◽

Sex Hormone ◽

Model Assessment ◽

Ovary Syndrome ◽

Insulin Sensitizer ◽

Tnf Α ◽

Post Test ◽

Liver And Kidney ◽

Kidney Functions

Polycystic Ovary Syndrome (PCOS) is the most frequent endocrine disease in females of reproductive age and is characterized by multifactorial unhealthy conditions related to hormonal unbalance and also to dysmetabolism and inflammation. Recently, increasing evidence has shown that natural plant-based products may play a role in PCOS management. The aim of this one-group pretest–post-test explanatory study was to evaluate, in normal–overweight PCOS women with normal menses, the effectiveness of berberine on: Insulin resistance (IR) by Homeostasis Model Assessment (HOMA); Inflammation by C-Reactive Protein (CRP), Tumor Necrosis Factor α (TNF-α); Lipid metabolism; Sex hormone profile and symptoms correlated to hyperandrogenism, such as acne, by Global Acne Grading System (GAGS) and Cardiff Acne Disability Index (CADI); Body composition by DXA. Finally, adverse effects were assessed by liver and kidney functions and creatine phosphokinase (CPK). All these parameters were collected at baseline and 60 days after supplementation with a new bioavailable and safe berberine formulation. Twelve females (aged 26.6 ± 4.9, BMI 25.3 ± 3.6) were supplied for 60 days with two tablets/day (550 mg/table) of the bioavailable berberine. Results showed a statistically significant decrease in HOMA, CRP, TNF-α, Triglycerides, testosterone, Body Mass Index (BMI), Visceral Adipose Tissue (VAT), fat mass, GAGS and CADI scores, and a statistically significant increase in sex hormone-binding globulin (SHBG). Liver and kidney functions and CPK are not statistically significantly different. Therefore, berberine can represent a safe novel dietary supplement, helpful in treatment strategy for PCOS.

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