scholarly journals Advances on marine-derived natural radioprotection compounds: historic development and future perspective

2021 ◽  
Author(s):  
Reinu E. Abraham ◽  
Mousa Alghazwi ◽  
Qi Liang ◽  
Wei Zhang
Keyword(s):  
Future Perspective ◽  
X Rays ◽  
Marine Plants ◽  
The Past ◽  
Damage Repair ◽  
Comprehensive Survey ◽  
Γ Rays ◽  
Historic Development ◽  
Free Radicals Scavenging ◽  
Uv Rays

AbstractNatural extracts and compounds from marine resources have gained intensive scientific and industry attention for radioprotective activities in the past ten years. However, the marine-derived radioprotectants have been studied against UV-rays, gamma (γ)-rays and X-rays for more than 30 years. This review aims to identify key marine-derived extracts/compounds and their modes of action studied for radioprotective activities from 1986 to 2019. A comprehensive survey was conducted to establish the trend in terms of the publications each year and the countries of origin. A total of 40 extracts and 34 natural compounds showing radioprotective activities against UV-rays, gamma (γ)-rays and X-rays were identified from a range of marine plants and animals. These extracts and compounds are broadly categorized into polysaccharides, phlorotannins, carotenoids and mycosporine-like amino acids (MAAs). Macroalgae and microalgae were found to be the dominant sources of polysaccharides, phlorotannins and carotenoids. MAAs were mainly identified in algae, sponges, sea cucumber and corals that showed significant UV-absorbing activities. A number of radioprotective mechanisms were shown by these compounds, predominantly free radicals scavenging, inhibition of apoptosis, UV-ray absorption and DNA damage-repair signaling pathways. While these bio-discoveries warrant further investigation and development of radioprotective therapeutics, however, the lack of clinical studies is a major obstacle to be tackled in the future.

scholarly journals The `quasi-mosaic' effect in crystals and its applications in modern physics

2015 ◽  
Vol 48 (4) ◽  
pp. 977-989 ◽  
Author(s):  
Riccardo Camattari ◽  
Vincenzo Guidi ◽  
Valerio Bellucci ◽  
Andrea Mazzolari
Keyword(s):  
Hadron Collider ◽  
Proton Synchrotron ◽  
X Rays ◽  
Super Proton Synchrotron ◽  
Charged Particle Beams ◽  
Modern Physics ◽  
Volume Reflection ◽  
Comprehensive Survey ◽  
Γ Rays ◽  
Crystallographic Planes

`Quasi-mosaicity' is an effect of anisotropy in crystals that permits one to obtain a curvature of internal crystallographic planes that would be flat otherwise. The term `quasi-mosaicity' was introduced by O. Sumbaev in 1957. The concept of `quasi-mosaicity' was then retrieved about ten years ago and was applied to steering of charged-particle beams at the Super Proton Synchrotron at CERN. Beams were deviated by exploiting channeling and volume reflection phenomena in curved crystals that show the `quasi-mosaic' effect. More recently, a crystal of this kind was installed in the Large Hadron Collider at CERN for beam collimation by the UA9 collaboration. Since 2011, another important application involving the `quasi-mosaic' effect has been the focalization of hard X-rays and soft γ-rays. In particular, the possibility of obtaining both high diffraction efficiency and the focalization of a diffracted beam has been proved, which cannot be obtained using traditional diffracting crystals. A comprehensive survey of the physical properties of `quasi-mosaicity' is reported here. Finally, experimental demonstrations for adjustable values of the `quasi-mosaic' curvature are provided.

scholarly journals POS1280 SPINAL LOCATION OF TUBERCULOSIS: WHAT HAS CHANGED OVER THE LAST YEARS?

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 923.3-923
Author(s):  
S. Boussaid ◽  
M. Mrabet ◽  
S. Jemmali ◽  
H. Sahli ◽  
H. Ajlani ◽  
...  
Keyword(s):  
Neurological Complications ◽  
Developing Nations ◽  
Lumbar Pain ◽  
X Rays ◽  
Resonance Imaging ◽  
Vertebral Collapse ◽  
The Past ◽  
Significant Difference ◽  
Tuberculous Spondylodiscitis ◽  
Different Parts

Background:Tuberculosis (TB) is no longer a disease limited to developing nations and is still a major cause of significant morbidity and mortality worldwide. It can affect the different parts of the spine.Objectives:The aim of this study was to determine the preferred spinal location of TB.Methods:We conduct a retrospective and descriptive study in a single rheumatology department. Data were collected from observations of patients hospitalized in the past 20 years (2000-2020) who have been diagnosed with tuberculous spondylodiscitis (TS).Results:Fifty-two patients were included (37F/15M). Their mean age was 55.21 years ± 17.79 [19-91]. TS was more frequently unifocal (75%) than multifocal (25%). Lumbar spine involvement was the most common (57.7%) and more frequent in women (63.3%) but with no statistically significant difference (p = 0.2). Other localizations were described such as: dorso-lumbar (21.2%), dorsal (15.4%), lumbosacral (3.8%) and cervical (1.9%). Lumbar pain was present in 34 patients (65.4%) and 29 patients (55.8%) suffered from segmental lumbar stiffness. Imaging was contributive by showing the vertebral location using standard X-rays, computed tomography and magnetic resonance imaging. Disc pinch, erosion of vertebral plateaus and vertebral collapse were the major signs (82.7%, 65.4% and 67.3%, respectively).Conclusion:TS is a rare but serious clinical condition which may lead to severe deformity and early or late neurological complications. Spinal involvement is often unifocal and mostly diagnosed with lumbar pain or stiffness. Multifocal forms, touching several parts of the spine, however remain rare. Our findings remain consistent with those of the literature.Disclosure of Interests:None declared

scholarly journals A review on the electric vehicle routing problems: Variants and algorithms

2021 ◽  
Author(s):  
Hu Qin ◽  
Xinxin Su ◽  
Teng Ren ◽  
Zhixing Luo
Keyword(s):  
Vehicle Routing ◽  
Vehicle Routing Problems ◽  
Location Routing Problem ◽  
Routing Problems ◽  
Routing Problem ◽  
Delivery Problem ◽  
Pickup And Delivery Problem ◽  
The Past ◽  
Location Routing ◽  
Comprehensive Survey

AbstractOver the past decade, electric vehicles (EVs) have been considered in a growing number of models and methods for vehicle routing problems (VRPs). This study presents a comprehensive survey of EV routing problems and their many variants. We only consider the problems in which each vehicle may visit multiple vertices and be recharged during the trip. The related literature can be roughly divided into nine classes: Electric traveling salesman problem, green VRP, electric VRP, mixed electric VRP, electric location routing problem, hybrid electric VRP, electric dial-a-ride problem, electric two-echelon VRP, and electric pickup and delivery problem. For each of these nine classes, we focus on reviewing the settings of problem variants and the algorithms used to obtain their solutions.

scholarly journals Advances in the Development Ubiquitin-Specific Peptidase (USP) Inhibitors

2021 ◽  
Vol 22 (9) ◽  
pp. 4546
Author(s):  
Shiyao Chen ◽  
Yunqi Liu ◽  
Huchen Zhou
Keyword(s):  
Signaling Pathways ◽  
Transforming Growth Factor ◽  
Regulatory System ◽  
Transforming Growth Factor Β ◽  
Molecular Signaling ◽  
Post Translational Modification ◽  
The Past ◽  
Damage Repair ◽  
Wide Range ◽  
Cancer And Inflammation

Ubiquitylation and deubiquitylation are reversible protein post-translational modification (PTM) processes involving the regulation of protein degradation under physiological conditions. Loss of balance in this regulatory system can lead to a wide range of diseases, such as cancer and inflammation. As the main members of the deubiquitinases (DUBs) family, ubiquitin-specific peptidases (USPs) are closely related to biological processes through a variety of molecular signaling pathways, including DNA damage repair, p53 and transforming growth factor-β (TGF-β) pathways. Over the past decade, increasing attention has been drawn to USPs as potential targets for the development of therapeutics across diverse therapeutic areas. In this review, we summarize the crucial roles of USPs in different signaling pathways and focus on advances in the development of USP inhibitors, as well as the methods of screening and identifying USP inhibitors.

Surface and Adhesive Properties of Low-Density Polyethylene after Radiation Cross-Linking

2014 ◽  
Vol 606 ◽  
pp. 265-268 ◽  
Author(s):  
Martin Bednarik ◽  
David Manas ◽  
Miroslav Manas ◽  
Martin Ovsik ◽  
Jan Navratil ◽  
...  
Keyword(s):  
Electron Beam ◽  
High Performance ◽  
Chemical Properties ◽  
Low Density Polyethylene ◽  
Cross Linking ◽  
Low Density ◽  
X Rays ◽  
Radiation Processing ◽  
Adhesive Properties ◽  
Γ Rays

Radiation cross-linking gives inexpensive commodity plastics and technical plastics the mechanical, thermal, and chemical properties of high-performance plastic. This upgrading of the plastics enables them to be used in conditions which they would not be able to with stand otherwise. The irradiation cross-linking of thermoplastic materials via electron beam or cobalt 60 (gammy rays) is performed separately, after processing. Generally, ionizing radiation includes accelerated electrons, gamma rays and X-rays. Radiation processing with an electron beam offers several distinct advantages when compared with other radiation sources, particularly γ-rays and x-rays. The process is very fast, clean and can be controlled with much precision. There is no permanent radioactivity since the machine can be switched off. In contrast to γ-rays and x-rays, the electron beam can steered relatively easily, thus allowing irradiation of a variety of physical shapes. The energy-rich beta rays trigger chemical reactions in the plastics which results in networking of molecules (comparable to the vulcanization of rubbers which has been in industrial use for so long). The energy from the rays is absorbed by the material and cleavage of chemical bonds takes place. This releases free radicals which in next phase from desired molecular bonds. This article describes the effect of radiation cross-linking on the surface and adhesive properties of low-density polyethylene.

Measurements of workplace productivity in the office context: A systematic review and current industry insights

2021 ◽  
Author(s):  
B. Bortoluzzi ◽  
D. Carey ◽  
J.J. McArthur ◽  
C. Menassa
Keyword(s):  
Systematic Review ◽  
Performance Indicators ◽  
Knowledge Worker ◽  
Key Performance Indicators ◽  
Expert Interviews ◽  
Structured Interviews ◽  
Productivity Measurement ◽  
The Past ◽  
Workplace Productivity ◽  
Comprehensive Survey

Purpose – The aim of this paper is to present a comprehensive survey of workplace productivity key performance indicators used in the office context. Academic literature from the past ten years is systematically reviewed and contextualized through a series of expert interviews. Design/methodology/approach – The authors present a systematic review of literature to identify Key Performance Indicators (KPIs) and methods of workplace productivity measurement, complemented by insights semi-structured interviews to inform a framework for a benchmarking tool. 513 papers published since 2007 were considered, of which 98 full-length papers were reviewed, and 20 were found to provide significant insight and are summarized herein. Findings – Currently, no consensus exists on a single KPI suitable for measuring workplace productivity in an office environment, though qualitative questionnaires are more widely adopted than quantitative tools. The diversity of KPIs used in published studies indicates that a multidimensional approach would be most appropriate for knowledge-worker productivity measurement. Expert interviews further highlighted a shift from infrequent, detailed evaluation to frequent, simplified reporting across human resource functions and this context is important for future tool development. Originality/value – This paper provides a summary of significant work on workplace productivity measurement and KPI development over the past ten years. This follows up on the comprehensive review by B. Haynes (2007a), providing an updated perspective on research in this field with additional insights from expert interviews.

Perspectives on the active volcanoes of China

2021 ◽  
pp. SP510-2021-87
Author(s):  
Jiandong Xu ◽  
Clive Oppenheimer ◽  
James O. S. Hammond ◽  
Haiquan Wei
Keyword(s):  
Hainan Island ◽  
Special Volume ◽  
Quarter Century ◽  
The Past ◽  
Special Publication ◽  
Current State ◽  
International Collaborations ◽  
Comprehensive Survey ◽  
Natural Laboratory ◽  
Active Volcanoes

AbstractChina ishas a rich record of Holocene volcanism that is relatively little known outside the country. It is encountered in home to a number of volcanoes that have erupted in the Holocene. These range from large stratovolcanoes in the northeast, linked to subduction of the pPacific plate (e.g., Changbaishan); in , more diffuse volcanismsmaller volcanoes on the edges of the TibetTibetan margin, linked toassociated with the collision of India and AEurasia (e.g., Tengchong, Ashishan), and more isolated regions of volcanismcentres possibly linked topossibly resulting from mantle upwelling (e.g., volcanoes in Hainan island). This makes China a natural laboratory for studyingstudies of intraplate volcanism, yet the study of volcanology in China is young, with a significant increase in research only over the last 25 yearsand significant progress in understanding its nature and origins has been made over the past quarter century. To highlight recent advances and the current state of knowledge, thisHere, we introduce the first publication in English to provide a comprehensive survey of the state of knowledge and research highlights. special volume presents the first compilation of research on the active volcanoes of China in English. This first paper introduces the book, which coversAccordingly, we provide an overview of the dynamics, geology, geochemistry, volcanic histories and geophysical studies of the 14 volcanoesvolcanic areas that have erupted in theassociated with Holocene documented thus far. Our hope is that this special publication acts as The special publication represents a benchmark reference on the topic but, as importantly, we hope it will stimulatea resource to allow new, international collaborations to be developed to help understandaimed at deepening our understanding of the origins, history, hazards and associated risks from future eruptions of China's volcanoes.

scholarly journals Measurements of workplace productivity in the office context

2018 ◽  
Vol 20 (4) ◽  
pp. 281-301 ◽  
Author(s):  
Brandon Bortoluzzi ◽  
Daniel Carey ◽  
J.J. McArthur ◽  
Carol Menassa
Keyword(s):  
Knowledge Worker ◽  
Expert Interviews ◽  
Structured Interviews ◽  
Productivity Measurement ◽  
Worker Productivity ◽  
Content Type ◽  
The Past ◽  
Workplace Productivity ◽  
Detailed Evaluation ◽  
Comprehensive Survey

Purpose The purpose of this paper is to present a comprehensive survey of workplace productivity key performance indicators (KPIs) used in the office context. Academic literature from the past 10 years has been systematically reviewed and contextualized through a series of expert interviews. Design/methodology/approach The authors present a systematic review of the literature to identify KPIs and methods of workplace productivity measurement, complemented by insights semi-structured interviews to inform a framework for a benchmarking tool. In total, 513 papers published since 2007 were considered, of which 98 full-length papers were reviewed, and 20 were found to provide significant insight and are summarized herein. Findings Currently, no consensus exists on a single KPI suitable for measuring workplace productivity in an office environment, although qualitative questionnaires are more widely adopted than quantitative tools. The diversity of KPIs used in published studies indicates that a multidimensional approach would be the most appropriate for knowledge-worker productivity measurement. Expert interviews further highlighted a shift from infrequent, detailed evaluation to frequent, simplified reporting across human resource functions and this context is important for future tool development. Originality/value This paper provides a summary of significant work on workplace productivity measurement and KPI development over the past 10 years. This follows up on the comprehensive review by B. Haynes (2007a), providing an updated perspective on research in this field with additional insights from expert interviews.

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