High temperature pressure pipes are widely used in power stations, nuclear power plants, and petroleum refinery, which always bear combined effects of high temperature, high pressure, and corrosive media, so the local pits are the most common volume defects in pressure pipe. Due to various reasons, the defects usually appear on the internal or external wall of pipe. In this paper, the dimensions of a defect were characterized as three dimensionless factors: relative depth, relative gradient and relative length. The main objects of study were the pipe with an internal pit and pipe with an external pit. Orthogonal array testing of three factors at four different levels was applied to analyze the sequence of the influence of three parameters. In present study, when the maximum principal strain nearby the location of the defects reaches 2%, the corresponding load is defined as the limit load, which is classified as two kinds of load type: limit pressure and limit bending moment. According to this strain criterion and isochronous stress strain data of P91 steel, the limit load of high temperature pipe with a local pit was determined by using ABAQUS. And in the same load condition of the pipe with the same dimensionless factors, the limit load of the internal defected pipe was compared with that of the external defected pipe. The results of this study can provide a reference for safety assessment and structural integrity analysis of high temperature creep pressure pipe with pit defects.