Plasma metabolites and food intake reduction following heparinoid injection in rats

1983 ◽  
Vol 30 (1) ◽  
pp. 113-119 ◽  
Author(s):  
W. Langhans ◽  
F. Wiesenreiter ◽  
E. Scharrer
Keyword(s):  
Food Intake ◽  
Plasma Metabolites

A comparison of the effects of infection with Eimeria maxima and dietary restriction on weight gain, plasma metabolites and liver glycogen in the immature fowl, Gallus domesticus

Parasitology ◽  
1982 ◽  
Vol 84 (2) ◽  
pp. 205-213 ◽  
Author(s):  
H. D. Chapman ◽  
D. L. Fernandes ◽  
T. F. Davison
Keyword(s):  
Growth Rate ◽  
Body Weight ◽  
Uric Acid ◽  
Weight Gain ◽  
Food Intake ◽  
Acute Phase ◽  
Plasma Glucose ◽  
Liver Glycogen ◽  
Plasma Metabolites ◽  
Eimeria Maxima

SUMMARYThe effects of Eimeria maxima or restricted pair-feeding on weight gain, plasma concentrations of protein, glucose, free fatty acids (FFA) and uric acid and liver glycogen were compared in immature fowl. Food intake/kg body weight and weight gain decreased during the acute phase of infection (days 5–7) while weight loss was prolonged for an extra day compared with pair-fed birds. During recovery, food intake/kg body weight of infected birds was greater than that of non-infected controls but there was no evidence for an increase in growth rate compared with controls when body weight was considered. Growth rate of pair-fed birds was greater than that of infected birds during recovery, indicating their better use of ingested food. Liver glycogen and plasma protein concentration were decreased during the acute phase of infection but the concentrations of plasma glucose, free fatty acid (FFA) and uric acid were not affected. In pair-fed birds liver glycogen was depleted, concentrations of plasma glucose and uric acid decreased and FFA increased, and these changes persisted for the remainder of the experiment. The findings are similar to those in birds whose food has been withheld and were probably due to the pattern of food intake imposed by the experimental protocol. It is concluded that the metabolic differences between infected and pair-fed birds are of doubtful significance.

Abstract MP17: Time Restricted Feeding Improves Cardiovascular Rhythms And Vascular Metabolism In Mice On A Chronic High Fat Diet

Hypertension ◽  
2020 ◽  
Vol 76 (Suppl_1) ◽  
Author(s):  
Paramita Pati ◽  
Dingguo Zhang ◽  
Jackson Colson ◽  
Shannon M Bailey ◽  
Karen L Gamble ◽  
...  
Keyword(s):  
Locomotor Activity ◽  
Food Intake ◽  
High Fat Diet ◽  
Disease Risk ◽  
Plasma Metabolites ◽  
Diurnal Changes ◽  
Restricted Feeding ◽  
High Fat ◽  
Inactive Period ◽  
Cardiovascular Rhythms

Irregular timing of food intake increases hypertension and cardiometabolic disease risk. A chronic high fat diet (HFD) also disrupts circadian rhythms. We hypothesized that active period time restricted feeding (TRF) during the last 2 weeks in mice on a chronic HFD will improve blood pressure rhythm, diurnal variation of circulating plasma factors, and vascular metabolism. Mice (male 8-week old, C57BL/6J) were fed a normal diet (ND; 10% fat) or HFD (45% fat) for 20 weeks ad libitum. For the final 2 weeks, half of the HFD mice were subjected to TRF. Mean arterial pressure (MAP), heart rate (HR), and locomotor activity were assessed by telemetry. TRF significantly increased the active-inactive period difference in MAP and HR in in mice fed a HFD (ΔMAP: ND: 16±0.7 mmHg, HFD: 15±0.8 mmHg, HFD+TRF: 18±0.9 mmHg, n=6-8, p=0.01; ΔHR: ND: 68±5.1 bpm, HFD: 69±6.5 bpm, HFD+TRF: 113±7.9 bpm, n=6-8, p<0.01). Diurnal changes in locomotor activity are not different between groups. At the end of the study, plasma was collected at 4 hour intervals over a 24 hour period (ZT0 at 7AM; ZT12 at 7PM). Circulating levels of liver-derived mediators β-hydroxybutyrate (βHB) and insulin-like growth factor-1 (IGF-1) showed significant differences due to diet but not TRF (βHB, ZT21: ND: 0.16±0.01 mM, HFD: 0.20±0.02 mM, HFD+TRF: 0.19±0.01 mM, n=5-6, p=0.02; IGF-1, ZT5: ND: 232±18 ng/mL, HFD: 292±34 ng/mL , HFD+TRF: 371±14 ng/mL, n=5-6, p<0.01). Plasma leptin was significantly higher in mice on HFD and reduced by TRF at ZT12 (ND: 5.3±1.3 ng/mL, HFD: 22.5±2.9 ng/mL, HFD+TRF: 10.3±3.5ng/mL, n=5-6, p<0.01) and ZT17 (ND: 6.7±1.1 ng/mL, HFD: 32.5±3.0 ng/mL, HFD+TRF: 25.0±1.3 ng/mL, n=5-6, p<0.01). Plasma adiponectin was unchanged between all groups. TRF in HFD mice increased NAD + , important for metabolism, in renal vessels at ZT17 (HFD: 0.10±0.02 pmol/μg; HFD+TRF: 0.19±0.03 pmol/μg; n=5, p=0.03). Aortic NAD + at ZT1 was not affected by TRF in HFD mice (HFD: 1.83±0.35 pmol/μg, HFD+TRF: 1.35±0.35 pmol/μg, n=4, p=0.37). Our results indicate that TRF in mice on HFD increases the active-inactive period difference in MAP and HR and alters plasma metabolites, suggesting the timing of food intake on a chronic HFD improves cardiovascular rhythms with increased renal vascular metabolism and reduced leptin levels.

scholarly journals Charged metabolite biomarkers of food intake assessed via plasma metabolomics in a population-based observational study in Japan

PLoS ONE ◽  
2021 ◽  
Vol 16 (2) ◽  
pp. e0246456
Author(s):  
Eriko Shibutami ◽  
Ryota Ishii ◽  
Sei Harada ◽  
Ayako Kurihara ◽  
Kazuyo Kuwabara ◽  
...  
Keyword(s):  
Cohort Study ◽  
Food Intake ◽  
Community Dwelling ◽  
Partial Least Square ◽  
Least Square ◽  
Assessment Tools ◽  
Plasma Metabolites ◽  
Baseline Survey ◽  
Accurate Estimation ◽  
Potential Food

Food intake biomarkers can be critical tools that can be used to objectively assess dietary exposure for both epidemiological and clinical nutrition studies. While an accurate estimation of food intake is essential to unravel associations between the intake and specific health conditions, random and systematic errors affect self-reported assessments. This study aimed to clarify how habitual food intake influences the circulating plasma metabolome in a free-living Japanese regional population and to identify potential food intake biomarkers. To achieve this aim, we conducted a cross-sectional analysis as part of a large cohort study. From a baseline survey of the Tsuruoka Metabolome Cohort Study, 7,012 eligible male and female participants aged 40–69 years were chosen for this study. All data on patients’ health status and dietary intake were assessed via a food frequency questionnaire, and plasma samples were obtained during an annual physical examination. Ninety-four charged plasma metabolites were measured using capillary electrophoresis mass spectrometry, by a non-targeted approach. Statistical analysis was performed using partial-least-square regression. A total of 21 plasma metabolites were likely to be associated with long-term food intake of nine food groups. In particular, the influential compounds in each food group were hydroxyproline for meat, trimethylamine-N-oxide for fish, choline for eggs, galactarate for dairy, cystine and betaine for soy products, threonate and galactarate for carotenoid-rich vegetables, proline betaine for fruits, quinate and trigonelline for coffee, and pipecolate for alcohol, and these were considered as prominent food intake markers in Japanese eating habits. A set of circulating plasma metabolites was identified as potential food intake biomarkers in the Japanese community-dwelling population. These results will open the way for the application of new reliable dietary assessment tools not by self-reported measurements but through objective quantification of biofluids

Determination of the Optimum Dietary Proportions of Lysine and Tryptophan for Growing Pigs Based on Growth, Food Intake and Plasma Metabolites

1977 ◽  
Vol 107 (8) ◽  
pp. 1369-1376 ◽  
Author(s):  
A. J. Lewis ◽  
E. R. Peo ◽  
P. J. Cunningham ◽  
B. D. Moser
Keyword(s):  
Food Intake ◽  
Growing Pigs ◽  
Plasma Metabolites

The changes in body weight and plasma metabolite levels during leptin injection are caused by the reduction of food intake in sheep

2000 ◽  
Vol 70 (2) ◽  
pp. 343-348 ◽  
Author(s):  
T. Tokuda ◽  
T. Matsui ◽  
J. Ito ◽  
S Torii ◽  
H. Yano
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Plasma Metabolites ◽  
Free Access ◽  
Glucose Levels ◽  
Important Regulator ◽  
The Central Nervous System ◽  
Plasma Metabolite ◽  
Phosphate Buffered Saline ◽  
Normal Food

AbstractLeptin is thought to act on the central nervous system as an important regulator of food intake and body weight in mice. To examine the actions of leptin in sheep, we injected recombinant mouse leptin into the lateral cerebral ventricle of ewes. Six ewes were intracerebroventricularly cannulated and given free access to forage and water. The ewes were injected with phosphate-buffered saline (PBS) as a vehicle for 5 days through the cannula and then with PBS + leptin for 7 days consecutively. Although food intake and body weight did not change during PBS injection, the administration of leptin decreased food intake and body weight. Plasma glucose levels decreased and plasma non-esterified fatty acid levels increased on the last few days of leptin administration. Approximately 2 weeks after normal food intake was recovered, the amount of diet was individually reduced in accordance with the recorded food intake during the leptin administration in each sheep. During food restriction, body weight and plasma metabolite concentrations were similarly changed as during the leptin-administration period. These results indicate that leptin decreases food intake in sheep. Moreover, it is likely that the changes in body weight and plasma metabolites were mainly induced by the suppression of food intake during leptin injection.

Determination of the Optimum Dietary Proportions of Lysine and Tryptophan for Growing Rats Based on Growth, Food Intake and Plasma Metabolites

1977 ◽  
Vol 107 (8) ◽  
pp. 1361-1368 ◽  
Author(s):  
A. J. Lewis ◽  
E. R. Peo ◽  
P. J. Cunningham ◽  
B. D. Moser
Keyword(s):  
Food Intake ◽  
Plasma Metabolites ◽  
Growing Rats

scholarly journals Corticosterone Inhibits the Lipid-Mobilizing Effects of Oleoyl-Estrone in Adrenalectomized Rats

Endocrinology ◽  
2007 ◽  
Vol 148 (8) ◽  
pp. 4056-4063 ◽  
Author(s):  
Maria del Mar Grasa ◽  
Marta Serrano ◽  
José Antonio Fernández-López ◽  
Marià Alemany
Keyword(s):  
Insulin Resistance ◽  
Insulin Sensitivity ◽  
Food Intake ◽  
Energy Expenditure ◽  
Slow Release ◽  
Status Quo ◽  
Female Rats ◽  
Plasma Metabolites ◽  
Body Lipid ◽  
Body Energy

Oleoyl-estrone (OE) is an adipose-derived signal that decreases energy intake and body lipid, maintaining energy expenditure and glycemic homeostasis. Glucocorticoids protect body lipid and the metabolic status quo. We studied the combined effects of OE and corticosterone in adrenalectomized female rats: daily OE gavages (0 or 10 nmol/g) and slow-release corticosterone pellets at four doses (0, 0.5, 1.7, and 4.8 mg/d). Intact and sham-operated controls were also included. After 8 d, body composition and plasma metabolites and hormones were measured. OE induced a massive lipid mobilization (in parallel with decreased food intake and maintained energy expenditure). Corticosterone increased fat deposition and inhibited the OE-elicited mobilization of body energy, even at the lowest dose. OE enhanced the corticosterone-induced rise in plasma triacylglycerols, and corticosterone blocked the OE-induced decrease in leptin. High corticosterone and OE increased insulin resistance beyond the effects of corticosterone alone. The presence of corticosterone dramatically affected OE effects, reversing its decrease of body energy (lipid) content, with little or no change on food intake or energy expenditure. The maintenance of glycemia and increasing insulin in parallel to the dose of corticosterone indicate a decrease in insulin sensitivity, which is enhanced by OE. The reversal of OE effects on lipid handling, insulin resistance, can be the consequence of a corticosterone-induced OE resistance. Nevertheless, OE effects on cholesterol were largely unaffected. In conclusion, corticosterone administration effectively blocked OE effects on body lipid and energy balance as well as insulin sensitivity and glycemia.

scholarly journals Metabolomic profiles associated with a mouse model of antipsychotic-induced food intake and weight gain

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Rizaldy C. Zapata ◽  
Sara Brin Rosenthal ◽  
Kathleen Fisch ◽  
Khoi Dao ◽  
Mohit Jain ◽  
...  
Keyword(s):  
Weight Gain ◽  
Side Effects ◽  
Food Intake ◽  
Palmitoleic Acid ◽  
Antipsychotic Drugs ◽  
Plasma Metabolites ◽  
Plasma Citrulline ◽  
Metabolic Side Effects ◽  
Psychiatric Conditions ◽  
Underlying Mechanisms

Abstract Antipsychotic drugs (AP) are used to treat a multitude of psychiatric conditions including schizophrenia and bipolar disorder. However, APs also have metabolic side effects including increased food intake and body weight, but the underlying mechanisms remain unknown. We previously reported that minocycline (MINO) co-treatment abrogates olanzapine (OLZ)-induced hyperphagia and weight gain in mice. Using this model, we investigated the changes in the pharmacometabolome in the plasma and hypothalamus associated with OLZ-induced hyperphagia and weight gain. Female C57BL/6 mice were divided into groups and fed either i) control, CON (45% fat diet) ii) CON + MINO, iii) OLZ (45% fat diet with OLZ), iv) OLZ + MINO. We identified one hypothalamic metabolite indoxylsulfuric acid and 389 plasma metabolites (including 19 known metabolites) that were specifically associated with AP-induced hyperphagia and weight gain in mice. We found that plasma citrulline, tricosenoic acid, docosadienoic acid and palmitoleic acid were increased while serine, asparagine and arachidonic acid and its derivatives were decreased in response to OLZ. These changes were specifically blocked by co-treatment with MINO. These pharmacometabolomic profiles associated with AP-induced hyperphagia and weight gain provide candidate biomarkers and mechanistic insights related to the metabolic side effects of these widely used drugs.

Sign in / Sign up

Export Citation Format

Share Document