A comparison of the effects of infection with Eimeria maxima and dietary restriction on weight gain, plasma metabolites and liver glycogen in the immature fowl, Gallus domesticus

Parasitology ◽  
1982 ◽  
Vol 84 (2) ◽  
pp. 205-213 ◽  
Author(s):  
H. D. Chapman ◽  
D. L. Fernandes ◽  
T. F. Davison
Keyword(s):  
Growth Rate ◽  
Body Weight ◽  
Uric Acid ◽  
Weight Gain ◽  
Food Intake ◽  
Acute Phase ◽  
Plasma Glucose ◽  
Liver Glycogen ◽  
Plasma Metabolites ◽  
Eimeria Maxima

SUMMARYThe effects of Eimeria maxima or restricted pair-feeding on weight gain, plasma concentrations of protein, glucose, free fatty acids (FFA) and uric acid and liver glycogen were compared in immature fowl. Food intake/kg body weight and weight gain decreased during the acute phase of infection (days 5–7) while weight loss was prolonged for an extra day compared with pair-fed birds. During recovery, food intake/kg body weight of infected birds was greater than that of non-infected controls but there was no evidence for an increase in growth rate compared with controls when body weight was considered. Growth rate of pair-fed birds was greater than that of infected birds during recovery, indicating their better use of ingested food. Liver glycogen and plasma protein concentration were decreased during the acute phase of infection but the concentrations of plasma glucose, free fatty acid (FFA) and uric acid were not affected. In pair-fed birds liver glycogen was depleted, concentrations of plasma glucose and uric acid decreased and FFA increased, and these changes persisted for the remainder of the experiment. The findings are similar to those in birds whose food has been withheld and were probably due to the pattern of food intake imposed by the experimental protocol. It is concluded that the metabolic differences between infected and pair-fed birds are of doubtful significance.

Multibreed comparisons of British cattle. Variation in body weight, growth rate and food intake

1984 ◽  
Vol 38 (3) ◽  
pp. 323-340 ◽  
Author(s):  
R. B. Thiessen ◽  
Eva Hnizdo ◽  
D. A. G. Maxwell ◽  
D. Gibson ◽  
C. S. Taylor
Keyword(s):  
Growth Rate ◽  
Body Weight ◽  
Genetic Variation ◽  
Weight Gain ◽  
Food Intake ◽  
Daily Weight Gain ◽  
Daily Food Intake ◽  
Daily Food ◽  
Breed Selection ◽  
Voluntary Food Intake

ABSTRACTA multibreed cattle experiment involving 25 British breeds was set up to study genetic variation between breeds and genetic inter-breed relationships for a wide spectrum of traits in order to examine the problems of between-breed testing and selection. The experimental design is described and results on between-breed variation are presented for four traits.All animals were housed indoors and from 12 weeks of age were given a single complete pelleted diet ad libitum through a system of Calan-Broadbent electronic gates. Females were mated to produce one purebred and three crossbred calves, which were reared to slaughter in order to measure the efficiency of the cow-calf unit of production.Results based on a total of 292 animals, with an average of 12 per breed, are presented for body weight, cumulated voluntary food intake, daily weight gain and daily food intake over the age range from 12 to 72 weeks. The 25 breed-mean curves for body weight and cumulated food intake displayed a remarkably uniform pattern of rankings at all ages and the rankings were very similar for both traits.The multibreed design used was effective in estimating between-breed variation as a proportion of total variation for the four traits examined. After approximately 1 year of age, the proportion of variation between breeds was approximately 0·70 for body weight and 0·60 for cumulated voluntary food intake. Changes in these traits could therefore be brought about more effectively by selection between breeds rather than within breeds. For average daily weight gain measured over 12-week intervals, between-breed selection was estimated to be most effective in the period of maximum growth rate between 6 and 9 months of age, when between-breed variation was 0·52 of the total. For average daily food intake, measured over 12-week intervals, between-breed selection was likely to be effective beyond 6 months of age, when the proportion of between-breed variation plateaued at 0·48.At all ages, the coefficient of genetic variation between breeds was approximately 0·14 for body weight and daily gain, and remarkably constant at approximately 0·12 for both daily and cumulated food intake. It is suggested that, for growth and intake traits, the genetic variances within and between breeds remain proportional to each other at all ages.

scholarly journals Pasta supplemented with isolated lupin protein fractions reduces body weight gain and food intake of rats and decreases plasma glucose concentration upon glucose overload trial

2014 ◽  
Vol 5 (2) ◽  
pp. 375-380 ◽  
Author(s):  
Jessica Capraro ◽  
Chiara Magni ◽  
Alessio Scarafoni ◽  
Rosita Caramanico ◽  
Filippo Rossi ◽  
...  
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Food Intake ◽  
Plasma Glucose ◽  
Body Weight Gain ◽  
Seed Proteins ◽  
Well Being ◽  
Biologically Active ◽  
Lupin Protein ◽  
Powerful Approach

The supplementation of foods with biologically active seed proteins can be a powerful approach for controlling body weight gain and glycaemia, thus improving well being.

Food intake controls in the suckling pig: glucoprivation and gastrointestinal factors.

1977 ◽  
Vol 232 (5) ◽  
pp. E510
Author(s):  
K A Houpt ◽  
T R Houpt ◽  
W G Pond
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Energy Balance ◽  
Food Intake ◽  
Food Deprivation ◽  
Plasma Glucose ◽  
Corn Oil ◽  
Protein Hydrolysate ◽  
Body Weight Gain ◽  
Yorkshire Pigs

The energy balance of suckling Yorkshire pigs 1 day to 2 wk old was challenged by: food deprivation, glucoprivation, and caloric and noncaloric gastric loads delivered by intubation. tafter 2--4 h fasts, food intake greatly increased over nonfasted control intake during a 3-h refeeding period. This response occurred both when body weight gain was used as a measure of intake for pigs nursing on the sow and when intake was measured directly in bottle-fed pigs. Glucoprivation produced by 0.5--2 U/kg insulin did not stimulate food intake although plasma glucose fell to a mean of 49 mg/100 ml (43% of control) after 1 U/kg insulin. Gastric loads of water or 3% NACl depressed intake after 3-h fast, but 0.9% NaCl did not. All the caloric gastric loads depressed intake; in order of increasing effectiveness, they were: heavy cream, protein hydrolysate, corn oil, milk, 5% glucose, and 5% lactose. The carbohydrate loads were most effective, a result which indicates that the response was not to calories alone but to some specific nutrient, possibly glucose.

Subdiaphragmatic vagal deafferentation affects body weight gain and glucose metabolism in obese male Zucker (fa/fa) rats

2005 ◽  
Vol 289 (4) ◽  
pp. R1027-R1034 ◽  
Author(s):  
Bettina Ferrari ◽  
Myrtha Arnold ◽  
Richard D. Carr ◽  
Wolfgang Langhans ◽  
Giovanni Pacini ◽  
...  
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Insulin Sensitivity ◽  
Food Intake ◽  
Plasma Glucose ◽  
Body Weight Gain ◽  
Zucker Rats ◽  
Sensitivity Index ◽  
Insulin Sensitivity Index ◽  
Obese Rats

We investigated the effect of subdiaphragmatic vagal deafferentation (SDA) on food intake, body weight gain, and metabolism in obese ( fa/ fa) and lean ( Fa/?) Zucker rats. Before and after recovery from surgery, food intake and body weight gain were recorded, and plasma glucose and insulin were measured in tail-prick blood samples. After implantation of a jugular vein catheter, an intravenous glucose tolerance test (IVGTT) was performed, followed by minimal modeling to estimate the insulin sensitivity index. Food intake relative to metabolic body weight (g/kg0.75) and daily body weight gain after surgery were lower ( P < 0.05) in SDA than in sham obese but not lean rats. Before surgery, plasma glucose and insulin concentrations were lower ( P < 0.05) in lean than in obese rats but did not differ between surgical groups within both genotypes. Four weeks after surgery, plasma glucose and insulin were still similar in SDA and sham lean rats but lower ( P < 0.05) in SDA than in sham obese rats. IVGTT revealed a downward shift of the plasma insulin profile by SDA in obese but not lean rats, whereas the plasma glucose profile was unaffected. SDA decreased ( P < 0.05) area under the curve for insulin but not glucose in obese rats. The insulin sensitivity index was higher in lean than in obese rats but was not affected by SDA in both genotypes. These results suggest that elimination of vagal afferent signals from the upper gut reduces food intake and body weight gain without affecting the insulin sensitivity index measured by minimal modeling in obese Zucker rats.

Improvement of mild hypoinsulinaemic diabetes in the rat by low non-toxic doses of vanadate

1994 ◽  
Vol 142 (3) ◽  
pp. 555-561 ◽  
Author(s):  
J C Henquin ◽  
F Carton ◽  
L N Ongemba ◽  
D J Becker
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Food Intake ◽  
Glucose Homeostasis ◽  
Plasma Glucose ◽  
Body Weight Gain ◽  
Oral Glucose ◽  
Low Doses ◽  
Glucose Levels ◽  
Vanadium Salts

Abstract To exert their anti-diabetic effects in animals with overt alterations of glucose homeostasis, vanadium salts must be administered in high doses, which also cause decreases in food intake and body weight gain. In this study, we evaluated the effect of low doses of vanadate in rats made mildly diabetic (fed plasma glucose levels ∼11 mmol/l) and moderately hypoinsulinaemic by the injection of streptozotocin 4 days after birth. Vanadate was added to food and drinking water, at concentrations that led to the consumption of about 1 mg vanadium element per day (∼2·65 mg vanadium/kg per day in adult rats), i.e. three to fivefold less than in previous studies. The treatment was started at weaning and lasted 22 weeks (V rats), or was administered for 9 weeks only from the age of 3 months (C-V rats). Food intake and body weight gain were not affected in V rats and decreased by no more than 10% in C-V rats. In V rats, fasted and fed plasma glucose levels were decreased by about 0·5 and 2–3 mmol/l, respectively. The rises in glycaemia after three oral glucose tolerance tests were also clearly attenuated. These effects were not accompanied by any changes in plasma insulin levels. Pancreatic insulin reserves (decreased by two-thirds as compared with normal rats) were not affected by the treatment. A decrease in plasma glucose levels was also noted in C-V rats, and this improvement disappeared upon cessation of the treatment. In conclusion, oral vanadate improves glucose homeostasis in rats with moderate insulin deficiency and diabetes, even when the element is administered at low doses which have practically no repercussions on food intake and body weight gain. This indicates that vanadium salts have genuine beneficial effects on glucose metabolism in vivo. Journal of Endocrinology (1994) 142, 555–561

scholarly journals The influence of perinatal undernutrition of twin-bearing ewes on milk yields and lamb performance and the effects of postnatal nutrition on live weight gain and carcass composition

1981 ◽  
Vol 45 (3) ◽  
pp. 579-586 ◽  
Author(s):  
M. J. Lawlor ◽  
S. P. Hopkins
Keyword(s):  
Growth Rate ◽  
Body Weight ◽  
Weight Gain ◽  
Food Intake ◽  
Average Daily Gain ◽  
Live Weight ◽  
Carcass Composition ◽  
Milk Substitute ◽  
The Mean ◽  
Daily Gain

1. Studies were conducted to measure the influence of perinatal undernutrition of twin-bearing ewes on ewe milk yields and lamb performance in early lactation. Comparative studies were conducted with lambs to measure the effects of postnatal nutrition on lamb performance and carcass composition. The major objective of this work was to determine the extent of the influence of postnatal nutritional deprivation of lambs.2. From 8 weeks prepartum to 4 weeks postpartum each of forty twin-bearing ewes was given daily 0.30 MJ of ME/kg body-weight (W)0.75. Measurements were made of ewe body-weight changes, milk yields during the first 4 weeks of lactation, and of lamb performance.3. There were three postnatal experiments with lambs of ‘light’ and ‘normal’ birth weights, wcaned from the ewes at 72 h. One hundred and four lambs were used and they were individually reared on separate allowances of lamb milk-substitute for 8 weeks. They were subsequently given a lamb concentrate ration. In Expts 1 and 2 the lamb concentrate was fed ad lib. to ‘slaughter’ live weight. In Expt 3 the concentrate was restricted for 8 weeks post weaning and then fed ad lib. A carcass analysis (bone, muscle, fat content) was conducted on all lambs after slaughter. In the first experiment, half the lambs were slaughtered at 8 weeks of age on being weaned off the milk substitute, and a carcass analysis was carried out.4. The mean net body-weight loss per ewe from commencement of late pregnancy to 28 d post partum was 23.8 kg. The over-all mean daily milk yield was 843 g/d. The mean growth rate of the lambs was 97 g/d during the 4-week measurement of ewe milk yields.5. Live weight gain of lambs subjected to restricted milk-substitute allowance (125 g/dry matter (DM) per d) was low, irrespective of lamb birth weight. The average daily gain over the 8-week postnatal period was 86.5 g/d on restricted milk allowance compared with 244 g/d for those fed ad lib. Conversely, the food intake and growth rate of these lambs were almost identical during feeding on ad lib. concentrates. This clearly reflected a response to compensatory food intake which was independent of either birth weight or postnatal milk allowance. The average daily gain of lambs, before weaning, on the restricted milk allowance was very similar to that of the lambs being suckled by ewes subjected to perinatal undernutrition. The effects of postnatal undernutrition of lambs was particularly reflected in the time required to reach ‘slaughter’ live weight. The period of time varied from 117 d for those on ad lib. food intake to 169 d for lambs on restricted food intake.6. The major effect of postnatal undernutrition on carcass composition was evident in the lambs slaughtered at 8 weeks in Expt 1. The percentage carcass fat was 4.7 for those on the low milk allowance. The carcass composition of all lambs at ‘slaughter’ live weight was similar. It would appear that lambs on a restricted milk intake before weaning deposited more fat during the subsequent period of compensatory food intake.7. It is evident from the present results that postnatal growth retardation in lambs reflects either perinatal undernutrition of twin-bearing ewes, or postnatal undernutrition of the lambs due to inadequate milk availability from the dam.

scholarly journals Neonatal nutritional programming impairs adiponectin effects on energy homeostasis in adult life of male rats

2018 ◽  
Vol 315 (1) ◽  
pp. E29-E37 ◽  
Author(s):  
Mariana Peduti Halah ◽  
Paula Beatriz Marangon ◽  
Jose Antunes-Rodrigues ◽  
Lucila L. K. Elias
Keyword(s):  
Body Weight ◽  
Adipose Tissue ◽  
Weight Gain ◽  
Food Intake ◽  
White Adipose Tissue ◽  
Energy Homeostasis ◽  
Body Weight Gain ◽  
Adult Life ◽  
Male Rats ◽  
Nutritional Programming

Neonatal nutritional changes induce long-lasting effects on energy homeostasis. Adiponectin influences food intake and body weight. The aim of this study was to investigate the effects of neonatal nutritional programming on the central stimulation of adiponectin. Male Wistar rats were divided on postnatal (PN) day 3 in litters of 3 (small litter, SL), 10 (normal litter, NL), or 16 pups/dam (large litter, LL). We assessed body weight gain for 60 days, adiponectin concentration, and white adipose tissue weight. We examined the response of SL, NL, and LL rats on body weight gain, food intake, oxygen consumption (V̇o2), respiratory exchange ratio (RER), calorimetry, locomotor activity, phosphorylated-AMP-activated protein kinase (AMPK) expression in the hypothalamus, and uncoupling protein (UCP)-1 in the brown adipose tissue after central stimulus with adiponectin. After weaning, SL rats maintained higher body weight gain despite similar food intake compared with NL rats. LL rats showed lower body weight at weaning, with a catch up afterward and higher food intake. Both LL and SL groups had decreased plasma concentrations of adiponectin at PN60. SL rats had increased white adipose tissue. Central injection of adiponectin decreased body weight and food intake and increased V̇o2, RER, calorimetry, p-AMPK and UCP- 1 expression in NL rats, but it had no effect on SL and LL rats, compared with the respective vehicle groups. In conclusion, neonatal under- and overfeeding induced an increase in body weight gain in juvenile and early adult life. Unresponsiveness to central effects of adiponectin contributes to the imbalance of the energy homeostasis in adult life induced by neonatal nutritional programming.

scholarly journals The Gut Microbiome Derived From Anorexia Nervosa Patients Impairs Weight Gain and Behavioral Performance in Female Mice

Endocrinology ◽  
2019 ◽  
Vol 160 (10) ◽  
pp. 2441-2452 ◽  
Author(s):  
Tomokazu Hata ◽  
Noriyuki Miyata ◽  
Shu Takakura ◽  
Kazufumi Yoshihara ◽  
Yasunari Asano ◽  
...  
Keyword(s):  
Body Weight ◽  
Anorexia Nervosa ◽  
Weight Gain ◽  
Food Intake ◽  
Brain Stem ◽  
Body Weight Gain ◽  
Field Tests ◽  
Compulsive Behavior ◽  
The Brain ◽  
Poor Weight Gain

Abstract Anorexia nervosa (AN) results in gut dysbiosis, but whether the dysbiosis contributes to AN-specific pathologies such as poor weight gain and neuropsychiatric abnormalities remains unclear. To address this, germ-free mice were reconstituted with the microbiota of four patients with restricting-type AN (gAN mice) and four healthy control individuals (gHC mice). The effects of gut microbes on weight gain and behavioral characteristics were examined. Fecal microbial profiles in recipient gnotobiotic mice were clustered with those of the human donors. Compared with gHC mice, gAN mice showed a decrease in body weight gain, concomitant with reduced food intake. Food efficiency ratio (body weight gain/food intake) was also significantly lower in gAN mice than in gHC mice, suggesting that decreased appetite as well as the capacity to convert ingested food to unit of body substance may contribute to poor weight gain. Both anxiety-related behavior measured by open-field tests and compulsive behavior measured by a marble-burying test were increased only in gAN mice but not in gHC mice. Serotonin levels in the brain stem of gAN mice were lower than those in the brain stem of gHC mice. Moreover, the genus Bacteroides showed the highest correlation with the number of buried marbles among all genera identified. Administration of Bacteroides vulgatus reversed compulsive behavior but failed to exert any substantial effect on body weight. Collectively, these results indicate that AN-specific dysbiosis may contribute to both poor weight gain and mental disorders in patients with AN.

scholarly journals Effects of sleeve gastrectomy and ileal transposition, alone and in combination, on food intake, body weight, gut hormones, and glucose metabolism in rats

2013 ◽  
Vol 305 (4) ◽  
pp. E507-E518 ◽  
Author(s):  
S. Nausheen ◽  
I. H. Shah ◽  
A. Pezeshki ◽  
D. L. Sigalet ◽  
P. K. Chelikani
Keyword(s):  
Body Weight ◽  
Sleeve Gastrectomy ◽  
Weight Gain ◽  
Food Intake ◽  
Glucose Metabolism ◽  
Glucose Tolerance ◽  
Gut Hormones ◽  
Ileal Transposition ◽  
Gastric Restriction ◽  
Peripheral Tissues

Bariatric surgeries are hypothesized to produce weight loss and improve diabetes control by multiple mechanisms including gastric restriction and lower gut stimulation; the relative importance of these mechanisms remains poorly understood. We compared the effects of a typical foregut procedure, sleeve gastrectomy, (SG) with a primarily hindgut surgery, ileal transposition (IT), alone and together (SGIT), or sham manipulations, on food intake, body weight, gut hormones, glucose tolerance, and key markers of glucose homeostasis in peripheral tissues of adult male Sprague-Dawley rats (450–550 g, n = 7–9/group). SG, IT, and SGIT surgeries produced transient reduction in food intake and weight gain; the effects of SG and IT on intake and body weight were nonadditive. SG, IT, and SGIT surgeries resulted in increased tissue expression and plasma concentrations of the lower gut hormones glucagon-like peptide-1 and peptide YY and decreased plasma glucose-dependent insulinotropic peptide, insulin, and leptin concentrations. Despite transient effects on intake and weight gain, the SG, IT, and SGIT surgeries produced a significant improvement in glucose tolerance. In support of glycemic improvements, the protein abundance of key markers of glucose metabolism (e.g., GLUT4, PKA, IRS-1) in muscle and adipose tissue were increased, whereas the expression of key gluconeogenic enzyme in liver (G-6-Pase) were decreased following the surgeries. Therefore, our data suggest that enhanced lower gut stimulation following SG, IT, and SGIT surgeries leads to transient reduction in food intake and weight gain together with enhanced secretion of lower gut hormones and improved glucose clearance by peripheral tissues.

scholarly journals Altering Developmental Trajectories in Mice by Restricted Index Selection

Genetics ◽  
1997 ◽  
Vol 146 (2) ◽  
pp. 629-640
Author(s):  
William R Atchley ◽  
Shizhong Xu ◽  
David E Cowley
Keyword(s):  
Growth Rate ◽  
Body Weight ◽  
Weight Gain ◽  
Complex Traits ◽  
Body Weight Gain ◽  
Developmental Trajectories ◽  
Cell Number ◽  
Index Selection ◽  
Early Postnatal Development ◽  
Rate Of Development

A restricted index selection experiment on mice was carried out for 14 generations on rate of early postnatal development (growth rate from birth to 10 days of age) vs. rate of development much later in ontogeny (growth rate from 28 to 56 days of age). Early rate of development (E) approximates hyperplasia (changes in cell number) and later rate (L) reflects hypertropy (changes in cell size). The selection criteria were as follows: E+L0 was selected to increase early body weight gain while holding late body weight gain constant; E–L0 was selected to decrease early body gain while holding late gain constant; E0L+ was selected to increase late gain holding early gain constant; and E0L– was selected to decrease late gain holding early gain constant. After 14 generations of selection, significant divergence among lines has occurred and the changes in the growth trajectories are very close to expectation. The genetic and developmental bases of complex traits are discussed as well as the concept of developmental homoplasy.

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