The effect of hypercapnic hypoxia, accompanied by different levels of lung ventilation, on heart rate in the duck

1973 ◽  
Vol 19 (2) ◽  
pp. 176-187 ◽  
Author(s):  
P.J. Butler ◽  
E.W. Taylor
2021 ◽  
Author(s):  
S.E. Bebinov ◽  
O.N. Krivoshchekova ◽  
A.V. Nechaev

The research was carried out on two independent experimental groups of boys and girls. The first was observed in traffic conditions, the second during the period of auto-simulator training. The HRV indices were determined: HR - heart rate, IN - index of tension of regulatory systems, AMo - amplitude of the mode, LF/HF - index of vagosympathetic interaction. A pronounced sympathetic reaction of more prepared cadets to the training load with the subsequent restoration of the studied characteristics was revealed. Key words: heart rate variability, autonomic regulation, vagosympathetic interaction, driver training, level of preparedness.


1993 ◽  
Vol 265 (6) ◽  
pp. R1410-R1415 ◽  
Author(s):  
G. Dieguez ◽  
J. L. Garcia ◽  
N. Fernandez ◽  
A. L. Garcia-Villalon ◽  
L. Monge ◽  
...  

The role of nitric oxide (NO) in the cerebral circulation under basal conditions and after vasodilatation to hypercapnia or reactive hyperemias was studied in 17 anesthetized goats. The intravenous administration of NG-nitro-L-arginine methyl ester (L-NAME, 3-4 or 8-10 mg/kg), an inhibitor of nitric oxide production, reduced middle cerebral artery (MCA) flow (electromagnetically measured) by 19 and 30% and increased systemic arterial pressure by 21 and 26%, respectively, whereas heart rate did not significantly change; MCA resistance increased by 48 and 86%, respectively. These hemodynamic effects were reversed by L-arginine (200-300 mg/kg iv; 5 goats). Different levels of hypercapnia (PCO2 of 30-35, 40-45, and 55-65 mmHg) (12 goats) produced arterial PCO2-dependent increases in MCA flow that were similar under control and L-NAME treatment. Graded cerebral hyperemia occurred after 5, 10, and 20 s of MCA occlusion in 5 goats, but its magnitude was decreased during L-NAME treatment. It suggests that, in the cerebral circulation, nitric oxide 1) produces a basal vasodilator tone and 2) is probably not involved in the vasodilatation to hypercapnia but may mediate hyperemic responses after short brain ischemias.


1975 ◽  
Vol 63 (2) ◽  
pp. 367-380 ◽  
Author(s):  
W. W. Burggren

1. In both the turtle, Pseudemys scripta, and the tortoise, Testudo graeca, lung ventilation is closely accompanied by a tachycardia of predictable magnitude and duration. 2. Efferent vagal activity progressively decreases as heart rate increases with the onset of lung ventilation. Atropine decreases heart rate during apnoea to those levels observed during prolonged breathing series when the development, duration or magnitude of ventilation tachycardia. It is thus concluded that heart rate change during chelonian lung ventilation is mediated solely by alterations in vagal tone. 3. Peripheral sensory reflexes involving pulmonary stretch receptors, arterial chemoreceptors and baroreceptors, and receptors stimulated by water immersion do not affect heart rate during breathing. It is suggested that ventilation tachycardia in these chelonians is the result of the spread of activity between the respiratory and cardiac centres of the medulla.


1992 ◽  
Vol 263 (3) ◽  
pp. R602-R608
Author(s):  
W. W. Burggren ◽  
J. E. Bicudo ◽  
M. L. Glass ◽  
A. S. Abe

Systemic arterial blood pressure and heart rate (fH) were measured in unanesthetized, unrestrained larvae and adults of the paradoxical frog, Pseudis paradoxus from Sao Paulo State in Brazil. Four developmental groups were used, representing the complete transition from aquatic larvae to primarily air-breathing adults. fH (49-66 beats/min) was not significantly affected by development, whereas mean arterial blood pressure was strongly affected, being lowest in the stage 37-39 larvae (10 mmHg), intermediate in the stage 44-45 larvae (18 mmHg), and highest in the juveniles and adults (31 and 30 mmHg, respectively). Blood pressure was not significantly correlated with body mass, which was greatest in the youngest larvae and smallest in the juveniles. In the youngest larvae studied (stages 37-39), lung ventilation was infrequent, causing a slight decrease in arterial blood pressure but no change in heart rate. Lung ventilation was more frequent in stages 44-45 larvae and nearly continuous in juveniles and adults floating at the surface. Bradycardia during both forced and voluntary diving was observed in almost every advanced larva, juvenile, and adult but in only one of four young larvae. Developmentally related changes in blood pressure were not complete until metamorphosis, whereas diving bradycardia was present at an earlier stage.


Author(s):  
Dev S. Kochhar ◽  
Hatem M. Ali

A study was conducted to investigate the variation in speed of performance and decision making ability with age. The task performed involved decision making, hand movement, and positioning elements. The effects of age on decision and movement time were examined when information load, distance of move, and radial clearance (target width) were varied. In addition, heart rate was also monitored. Significant differences were detected in both decision and movement time for different levels of information load, distance of move, and radial clearance between the older (52 to 63 years) and younger (18 to 29 years) groups of subjects. Decision time differences between the two groups increased at higher levels of information load. The relationship between movement time and index of difficulty suggested that the older worker tends to exhibit a “start-up” lag in exercising movement control. Performance errors indicated that the slowing among the older workers was not observed at the expense of accuracy. The study provided no evidence that age has an effect on heart rate variability under different levels of information load and task difficulty.


Author(s):  
Tetiana Odinets

HUMAN HEALTH Open Journal Systems ipv6 ready Journal Help User Username Password Remember me Notifications View Subscribe Language Select Language Journal Content Search Search Scope Browse By Issue By Author By Title Other Journals Categories Font Size Make font size smaller Make font size default Make font size larger Home About Login Register Search Current Archives Announcements Editorial Board Home > No 1 (2019) > Odinets FACTOR STRUCTURE OF FUNCTIONAL PARAMETERS OF WOMEN WITH POST-MASTECTOMY SYNDROME WITH DIFFERENT LEVELS OF FUNCTIONAL STATE OF THE CARDIOVASCULAR SYSTEM Tetiana Odinets Abstract Modern approaches used in breast cancer treatment resulted in increasing survival rates. However, significant adverse events such as сardiotoxicity and cardiovascular complications remain high. A lot of women experienced fatigue, arrhythmias, heart failure, ischemic heart disease, and pulmonary side effects induced by breast cancer treatment. The objective: to determine the features of the factor structure of functional parameters in women with postmastectomy syndrome with different levels of functional state of the cardiovascular system. Methods: analysis of sources of literature and empirical data; rheography, spirography, analysis of heart rate variability; anthropometry; mathematical statistics methods. Results. a developed method for estimating the level of functional state of the cardiovascular system of women with postmastectomy syndrome based on age and objective indicators of central hemodynamics: heart rate, minute blood volume and left ventricular work, as well as their significant contribution to overall predicted level. Based on the values of the determined parameters and coefficients of multiple regression, criteria of levels of functional state of the cardiovascular system of patients with postmastectomy syndrome are determined. The proposed method allows to carry out rapid monitoring and with a high degree of probability to assess the functional state of the cardiovascular system of the patients with postmastectomy syndrome, as well as to determine the effectiveness of therapeutic, rehabilitation measures and make adjustments to the program of rehabilitation. Defined factors of the direction of the rehabilitation process with the integral account of the predicted level of the functional state of the cardiovascular system are in the manuscript. It has been identified that the hemodynamic factor has covered 22.37% of the dispersion in women with the low level of functional state, 21.24% – with the lower-than-average level, 22.06 – with the average level; expiratory – 17.15%, 16.74% and 17.48; vegetative – 11.21%, 13.29% and 12.97% at corresponding levels at outpatient rehabilitation stage. Conclusions. obtained results are the basis for choosing priority means of physical rehabilitation during developing a program for the rehabilitation of women with postmastectomy syndrome with various levels of the functional state of the cardiovascular system.


2013 ◽  
Vol 58 (No. 2) ◽  
pp. 87-95 ◽  
Author(s):  
Amarpal ◽  
RA Ahmad ◽  
P. Kinjavdekar ◽  
HP Aithal ◽  
AM Pawde ◽  
...  

A combination of drugs may be preferred over the use of a single agent to induce deep sedation. A synergistic interaction between the drugs reduces the dose requirements of the drugs thereby minimising the unwanted side effects associated with each drug and improving recovery. The present study was undertaken to evaluate the suitability of dexmedetomidine and dexmedetomidine in combination with midazolam-fentanyl or midazolam-fentanyl-ketamine for different levels of sedation, analgesia and anaesthesia in dogs. In a prospective, blinded, randomised clinical trial, 12 mixed breed dogs were divided into three groups. Animals of Group I were injected with dexmedetomidine 20 μg/kg. Animals of Group II received 20 μg/kg dexmedetomidine + 0.2 mg/kg midazolam + 4 μg/kg fentanyl and animals of Group III were administered with 20 μg/kg dexmedetomidine + 0.2 mg/kg midazolam + 4 μg/kg fentanyl + 10 mg/kgketamine. All the drugs were given simultaneously via the intramuscular route. Jaw relaxation, palpebral reflex, pedal reflex and response to intubation were recorded and graded on a numerical scale. Values of heart rate, respiratory rate, rectal temperature and mean arterial pressure were recorded at baseline and then at predetermined intervals up to 120 min. Onset of sedation time, onset of recumbency time, time to return of righting reflex, standing recovery time and complete recovery time were recorded. Maximal muscle relaxation, sedation and analgesia were observed in animals of Group III, which was followed in decreasing order by Groups II and I. Heart rate decreased significantly (P < 0.05) after administration of drugs in Groups I and II but a significant (P < 0.05) increase was recorded in Group III. Respiratory rate decreased significantly (P < 0.05) in all the groups. Rectal temperature decreased non-significantly in all the groups. Mean arterial pressure initially increased significantly (P < 0.01) in Groups I and III followed by a decrease in Group I, but in Group III it remained above the base line. In Group II, MAP decreased throughout the study period. Onset of sedation time and onset of recumbency time were significantly (P < 0.05) shorter in Group III as compared to Group I. Time to return of righting reflex, standing recovery time and complete recovery time did not differ significantly between the groups. It is concluded that dexmedetomidine provides a reliable moderate sedation and analgesia. Addition of midazolam and fentanyl enhances sedation, analgesia and muscle relaxation induced by dexmedetomidine. Addition of ketamine produced deep sedation and complete anaesthesia with lesser cardiopulmonary depression. Thus, dexmedetomidine can be used safely in combination with midazolam, fentanyl and ketamine for different levels of sedation, analgesia and anaesthesia in dogs.  


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