Role of different types of alcoholic beverages and ways of drinking in the ethanol-induced liver damage: Hints from the dionysos study

Hepatology ◽  
1994 ◽  
Vol 19 (4) ◽  
pp. I42
Author(s):  
S Bellentani
Keyword(s):  
Liver Damage ◽  
Alcoholic Beverages ◽  
Different Types

scholarly journals Cancer prevention and diet: oppourtunities in Europe

2001 ◽  
Vol 4 (2b) ◽  
pp. 475-484 ◽  
Author(s):  
Elio Riboli ◽  
Teresa Norat
Keyword(s):  
Dietary Habits ◽  
Epidemiological Studies ◽  
Red Meat ◽  
Alcoholic Beverages ◽  
Processed Meat ◽  
Consistent Finding ◽  
Different Types ◽  
Different Populations ◽  
Vegetables And Fruits

AbstractOver the past 20 years, a large number of epidemiological studies, particularly case-control and cohort studies, have been conducted to investigate the role of diet and the risk of developing different types of cancer. The most consistent finding so far is the association observed between consumption of vegetables and fruit and reduced risk of cancers of the digestive and respiratory tracts. More recently, evidence has accumulated indicating that high consumption of red meat (mainly beef, lamp and pork) and of preserved meat (‘charcuterie’) is specifically associated with a modest but significant increase in colorectal cancer risk. Finally, there is epidemiological evidence supporting an association between the risk of developing gastric cancer and the intake of salt and-preserved foods.Cancer incidence and dietary habits vary substantially across Europe, and the expected benefit of dietary changes may be somewhat difference in different populations. Despite some uncertainly, it is generally agreed that an increase in the consumption of vegetables and fruits and a decrease in the intake of red meat, processed meat, alcoholic beverages, salt and salt-preserved foods should contribute to a reduction in the incidence of cancers of the digestive and respiratory tract.

scholarly journals Mitochondrial Drug Delivery for the Liver Diseases: Comprehensive Review

2020 ◽  
Vol 11 (1) ◽  
pp. 1172-1181
Author(s):  
Famna Roohi N K ◽  
Mahendran Bhaskaran ◽  
Sathish Babu ◽  
Gowda D V
Keyword(s):  
Liver Damage ◽  
Polymeric Micelles ◽  
Ethanol Consumption ◽  
The Other ◽  
Oxygen Species ◽  
Mitochondrial Membranes ◽  
Passive Targeting ◽  
Tat Peptides ◽  
Different Types

The role of mitochondria in liver targeting has been reviewed, which mainly focuses on acute and chronic. This is due to ethanol consumption, which causes liver damage. And how ethanol consumption affects liver disease. Autophagy, which explains the ROS production, in oxygen species, the changes that take place in it have been reviewed below and also helps us to understand the methods and drugs used in targeting the mitochondria differently. The mainly 2 types of targeting has been focused upon that is the active and passive targeting. The other different types of targeting are Hepatic stellate cells (HSCs) targeting, Hepatocytes, the drug is targeted, Polymeric micelles, the mitochondrial membranes are affected by the proteins, and the Nanosystems used for the delivery. The other drugs used for the study are lipophilic cation, liposomes, and the TAT peptides. The herbal treatment can also be used for the treatment of liver damage. The herbal extracts that are based on the phytosomes and the anti-oxidants that target on the hepatocytes cells

Involvement of Toll-like receptor 4 in acetaminophen hepatotoxicity

2006 ◽  
Vol 290 (6) ◽  
pp. G1269-G1279 ◽  
Author(s):  
Herbert C. Yohe ◽  
Kimberley A. O'Hara ◽  
Jane A. Hunt ◽  
Tamar J. Kitzmiller ◽  
Sheryl G. Wood ◽  
...  
Keyword(s):  
Liver Damage ◽  
Alcoholic Beverages ◽  
Toll Like Receptor ◽  
Short Term ◽  
Toll Like Receptor 4 ◽  
Tnf Α ◽  
Subsequent Exposure ◽  
Acetaminophen Hepatotoxicity ◽  
Apap Hepatotoxicity

The objective of this study was to determine whether Toll-like receptor 4 (TLR4) has a role in alcohol-mediated acetaminophen (APAP) hepatotoxicity. TLR4 is involved in the inflammatory response to endotoxin. Others have found that ethanol-mediated liver disease is decreased in C3H/HeJ mice, which have a mutated TLR4 resulting in a decreased response to endotoxin compared with endotoxin-responsive mice. In the present study, short-term (1 wk) pretreatment with ethanol plus isopentanol, the predominant alcohols in alcoholic beverages, caused no histologically observed liver damage in either C3H/HeJ mice or endotoxin-responsive C3H/HeN mice, despite an increase in nitrotyrosine levels in the livers of C3H/HeN mice. In C3H/HeN mice pretreated with the alcohols, subsequent exposure to APAP caused a transient decrease in liver nitrotyrosine formation, possibly due to competitive interaction of peroxynitrite with APAP producing 3-nitroacetaminophen. Treatment with APAP alone resulted in steatosis in addition to congestion and necrosis in both C3H/HeN and C3H/HeJ mice, but the effects were more severe in endotoxin-responsive C3H/HeN mice. In alcohol-pretreated endotoxin-responsive C3H/HeN mice, subsequent exposure to APAP resulted in further increases in liver damage, including severe steatosis, associated with elevated plasma levels of TNF-α. In contrast, alcohol pretreatment of C3H/HeJ mice caused little to no increase in APAP hepatotoxicity and no increase in plasma TNF-α. Portal blood endotoxin levels were very low and were not detectably elevated by any of the treatments. In conclusion, this study implicates a role of TLR4 in APAP-mediated hepatotoxicity.

Construction of a binary evaluative taxonomy within a story

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Eric Hauser
Keyword(s):  
Ad Hoc ◽  
Cognitive Structure ◽  
Cultural Knowledge ◽  
Alcoholic Beverages ◽  
Specific Level ◽  
Neighborhood Organization ◽  
Different Types ◽  
Drinking Session ◽  
Inherent Part

Abstract Making use of Occasioned Semantics, I look at how a taxonomy of different types of alcoholic beverages is constructed within a story told during the closing of a meeting at a neighborhood organization. The data are in Japanese with English translation. The use of taxonomic analysis within Occasioned Semantics is discussed, with a separate example. The story is shown to be placed at a point in the closing routine where an invitation to join a post-meeting drinking session is expectable. Within the story, the teller, Kaicho, who is the head of the organization, constructs an occasioned inclusion taxonomy of alcoholic beverages. He then adds two binary evaluative contrasts to the more specific level of the taxonomy. What Kaicho accomplishes through telling the story, what he accomplishes through constructing the taxonomy with its evaluative contrasts, and how the constructed taxonomy cannot be seen simply as the reflection of an underlying cognitive structure are discussed. It is argued that an ad hoc element is an inherent part of any actually occurring taxonomy. The role of cultural knowledge in the analysis of meaning in interaction is discussed.

Potential Uses of Vinegar as a Medicine and Related in vivo Mechanisms

2016 ◽  
Vol 86 (3-4) ◽  
pp. 127-151 ◽  
Author(s):  
Zeshan Ali ◽  
Zhenbin Wang ◽  
Rai Muhammad Amir ◽  
Shoaib Younas ◽  
Asif Wali ◽  
...  
Keyword(s):  
Chemical Structure ◽  
Review Paper ◽  
Heart Diseases ◽  
Folk Medicine ◽  
Active Role ◽  
Current Review ◽  
Different Types ◽  
Positive Effect

While the use of vinegar to fi ght against infections and other crucial conditions dates back to Hippocrates, recent research has found that vinegar consumption has a positive effect on biomarkers for diabetes, cancer, and heart diseases. Different types of vinegar have been used in the world during different time periods. Vinegar is produced by a fermentation process. Foods with a high content of carbohydrates are a good source of vinegar. Review of the results of different studies performed on vinegar components reveals that the daily use of these components has a healthy impact on the physiological and chemical structure of the human body. During the era of Hippocrates, people used vinegar as a medicine to treat wounds, which means that vinegar is one of the ancient foods used as folk medicine. The purpose of the current review paper is to provide a detailed summary of the outcome of previous studies emphasizing the role of vinegar in treatment of different diseases both in acute and chronic conditions, its in vivo mechanism and the active role of different bacteria.

The Diagnosis of Lupus Anticoagulants by the Activated Partial Thromboplastin Time - The Central Role of Phosphatidyl Serine

1984 ◽  
Vol 52 (02) ◽  
pp. 172-175 ◽  
Author(s):  
P R Kelsey ◽  
K J Stevenson ◽  
L Poller
Keyword(s):  
Screening Method ◽  
Coagulation Factors ◽  
Phosphatidyl Serine ◽  
Test System ◽  
Specific Factor ◽  
Marginal Effect ◽  
Constant Composition ◽  
Lupus Anticoagulants ◽  
Different Types

SummaryLiposomes of pure phospholipids were used in a modified APTT test system and the role of phosphatidyl serine (PS) in determining the sensitivity of the test system to the presence of lupus anticoagulants was assessed. Six consecutive patients with lupus anticoagulants and seven haemophiliacs with anticoagulants directed at specific coagulation factors, were studied. Increasing the concentration of phospholipid in the test system markedly reduced the sensitivity to lupus anticoagulants but had marginal effect on the specific factor inhibitors. The same effect was achieved when the content of PS alone was increased in a vehicle liposome of constant composition.The results suggest that the lupus anticoagulants can best be detected by a screening method using an APTT test with a reagent of low PS content. The use of a reagent rich in PS will largely abolish the lupus anticoagulant’s effect on the APTT. An approach using the two different types of reagent may facilitate differentiation of lupus inhibitors from other types of anticoagulant.

The Role of Evaluative Tools in the Creation of the Memorial Media Portrait of Jacques Chirac (1932—2019)

2020 ◽  
pp. 97-110
Author(s):  
E. N. Mikhailova ◽  
V. A. Telegina
Keyword(s):  
Print Media ◽  
Political Elite ◽  
Systematic Analysis ◽  
Research Material ◽  
Political Orientations ◽  
Different Types ◽  
The Media ◽  
The Creation ◽  
Entire Text

The article is devoted to the study of evaluative tools used in modern French media in order to form the media image of a representative of the political elite. The techniques used in the creation of a memorial media portrait of Jacques Chirac (1932—2019), President of France from 1995 to 2007 are considered. The research material was the most prestigious French print media of various political orientations, published in late September — early October 2019 in connection with the death of the ex-President of the French Republic. The relevance of the research topic is dictated by the close attention of modern linguistics to axiological phenomena, differently presented in different types of discursive practices. The novelty of the study is due to the appeal to the analysis of the complex of evaluation tools used in the French print media when characterizing the former leader of the state during the nation’s farewell period. The estimated potential of the title of the article and its influence on the formation of the estimated vector of the entire text of the publication are shown. A systematic analysis of the assessment expression means, reflected in the memorial media portrait of the politician, is given. The factors that influenced the peculiarities of their use in this type of media portrait are revealed.

The influence of information relevance on the continued influence effect of misinformation

2020 ◽  
Author(s):  
Hua Jin ◽  
Lina Jia ◽  
Xiaojuan Yin ◽  
Shilin Wei ◽  
Guiping Xu
Keyword(s):  
Experimental Study ◽  
Questionnaire Survey ◽  
Personal Involvement ◽  
Influence Effect ◽  
Information Relevance ◽  
Different Types ◽  
Role Of Information

Misinformation often continues to influence people’s cognition even after corrected (the ‘continued influence effect of misinformation’, the CIEM). This study investigated the role of information relevance in the CIEM by questionnaire survey and experimental study. The results showed that information with higher relevance to the individuals had a larger CIEM, indicating a role of information relevance in the CIEM. Personal involvement might explain the effects of information relevance on the CIEM. This study provides insightful clues for reducing the CIEM in different types of misinformation and misinformation with varying relevance.

Classic and Novel Signaling Pathways Involved in Cancer: Targeting the NF-κB and Syk Signaling Pathways

2019 ◽  
Vol 14 (3) ◽  
pp. 219-225 ◽  
Author(s):  
Cong Tang ◽  
Guodong Zhu
Keyword(s):  
Cancer Therapy ◽  
Tyrosine Kinase ◽  
Signaling Pathways ◽  
Molecular Mechanisms ◽  
Therapeutic Potential ◽  
Cell Receptor ◽  
Transmembrane Receptors ◽  
Biological Responses ◽  
Different Types

The nuclear factor kappa B (NF-κB) consists of a family of transcription factors involved in the regulation of a wide variety of biological responses. Growing evidence support that NF-κB plays a major role in oncogenesis as well as its well-known function in the regulation of immune responses and inflammation. Therefore, we made a review of the diverse molecular mechanisms by which the NF-κB pathway is constitutively activated in different types of human cancers and the potential role of various oncogenic genes regulated by this transcription factor in cancer development and progression. We also discussed various pharmacological approaches employed to target the deregulated NF-κB signaling pathway and their possible therapeutic potential in cancer therapy. Moreover, Syk (Spleen tyrosine kinase), non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immune-receptors like the B-cell receptor (BCR), which can also activate the inflammasome and NF-κB-mediated transcription of chemokines and cytokines in the presence of pathogens would be discussed as well. The highlight of this review article is to summarize the classic and novel signaling pathways involved in NF-κB and Syk signaling and then raise some possibilities for cancer therapy.

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