The circannual variations in the total serum lipids and cholesterol with respect to body weight in the woodchuck (Marmota monax)

1973 ◽  
Vol 44 (2) ◽  
pp. 577-583 ◽  
Author(s):  
Gary M. Wenberg ◽  
Jack C. Holland
Keyword(s):  
Body Weight ◽  
Serum Lipids ◽  
Total Serum ◽  
Marmota Monax

scholarly journals Green Coffee Extract Modifies Body Weight, Serum Lipids and TNF-α in High-Fat Diet-Induced Obese Rats

2020 ◽  
Author(s):  
Cimi Ilmiawati ◽  
Fajar Fitri ◽  
Zelly Dia Rofinda ◽  
Mohamad Reza
Keyword(s):  
Body Weight ◽  
Effective Dose ◽  
High Fat Diet ◽  
Serum Lipids ◽  
Total Serum ◽  
Green Coffee ◽  
High Fat ◽  
Tnf Α ◽  
Obese Rats ◽  
Α Level

Abstract Objective: Currently, there are many efforts to find functional nutrients for obesity management, and the green coffee extract is a potential candidate. This study aimed to examine the effect of the green coffee extract on body weight, serum lipids, and TNF-α level in obese rats. Results: Administration of green coffee extract to high-fat diet-induced male Wistar rats (Rattus norvegicus) reduced body weight, total serum cholesterol, and triglyceride at the dose of 10, 20, and 40 mg/kg BW/day; lowered LDL-cholesterol at the treatment of 20 mg/kg BW/day (p<0.05). The effective dose to decrease serum TNF-α level was 40 mg/kg BW/day, while the effective dose to improve the lipid profile was 10 mg/kg BW/day. These results supported the potential use of green coffee extract as a functional nutrient in the management of obesity

scholarly journals Intermittent Fasting Ameliorated High-Fat Diet-Induced Memory Impairment in Rats via Reducing Oxidative Stress and Glial Fibrillary Acidic Protein Expression in Brain

Nutrients ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 10
Author(s):  
Suzan M. Hazzaa ◽  
Mabrouk A. Abd Eldaim ◽  
Amira A. Fouda ◽  
Asmaa Shams El Dein Mohamed ◽  
Mohamed Mohamed Soliman ◽  
...  
Keyword(s):  
Body Weight ◽  
Glial Fibrillary Acidic Protein ◽  
Brain Tissue ◽  
High Fat Diet ◽  
Serum Lipids ◽  
Memory Performance ◽  
Granular Cell ◽  
Intermittent Fasting ◽  
High Fat ◽  
Cell Layers

Intermittent fasting (IF) plays an important role in the protection against metabolic syndrome-induced memory defects. This study aimed to assess the protective effects of both prophylactic and curative IF against high-fat diet (HFD)-induced memory defects in rats. The control group received a normal diet; the second group received a HFD; the third group was fed a HFD for 12 weeks and subjected to IF during the last four weeks (curative IF); the fourth group was fed a HFD and subjected to IF simultaneously (prophylactic IF). A high-fat diet significantly increased body weight, serum lipids levels, malondialdehyde (MDA) concentration, glial fibrillary acidic protein (GFAP) and H score in brain tissue and altered memory performance. In addition, it significantly decreased reduced glutathione (GSH) concentration in brain tissue and viability and thickness of pyramidal and hippocampus granular cell layers. However, both types of IF significantly decreased body weight, serum lipids, GFAP protein expression and H score and MDA concentration in brain tissue, and improved memory performance, while it significantly increased GSH concentration in brain tissue, viability, and thickness of pyramidal and granular cell layers of the hippocampus. This study indicated that IF ameliorated HFD-induced memory disturbance and brain tissue damage and the prophylactic IF was more potent than curative IF.

scholarly journals Absence of antidiabetic and hypolipidemic effect of Gymnema sylvestre in non-diabetic and alloxan-diabetic rats

2004 ◽  
Vol 47 (4) ◽  
pp. 545-551 ◽  
Author(s):  
Ricardo Galletto ◽  
Vera Lúcia Dias Siqueira ◽  
Edilene Bega Ferreira ◽  
Arildo José Braz Oliveira ◽  
Roberto Barbosa Bazotte
Keyword(s):  
Body Weight ◽  
Blood Level ◽  
Serum Lipids ◽  
Body Weight Gain ◽  
Acute Effect ◽  
Diabetic Rats ◽  
The Body ◽  
Hypolipidemic Effect ◽  
Gymnema Sylvestre ◽  
Water Ingestion

In this study we investigated the antidiabetic and hypolipidemic potential of dried powdered leaves of Gymnema sylvestre (GS). The acute effect of GS administered by oral gavage on glucose blood level of and lipids in non-diabetic and alloxan-diabetic rats were investigated in the following conditions: a) after a balanced meal; b) after the ingestion of 1000 mg/kg amylose or 1000 mg/kg glucose; c) after the ingestion of a mixture of 12 mL/kg soybean oil + 1% cholesterol (SOC). In addition, the effect of the treatment with GS during two (sub-acute) or four weeks (chronic) on body weight, food and water ingestion, glucose blood level and lipids in non-diabetic and alloxan-diabetic rats were measured. The dose of GS utilized in the majority of the experiments, i.e., 30 mg/kg, corresponds to that given to treat diabetes in Brazil. GS acutely did not influence the elevation of glycemia promoted by a balanced meal or by the administration of amylose or glucose; but promoted more intense (P<0.05) elevation of serum lipids after the administration of SOC. Moreover, the sub-acute and chronic treatment with GS in non-diabetic and alloxan-diabetic rats did not change: a) the body weight gain; b) food and water ingestion; c) the blood level of glucose and lipids. Thus we concluded that GS, at least in the form commercialized in the Brazil, i.e., dried powdered leaves, require further experimental and clinical trials before being recommended to treat diabetes and hyperlipidemia.

GLYCOGEN DISEASE OF THE LIVER (VON GIERKE'S DISEASE) WITH HEPATOMATA

PEDIATRICS ◽  
1955 ◽  
Vol 16 (6) ◽  
pp. 785-800
Author(s):  
Howard H. Mason ◽  
Dorothy H. Andersen
Keyword(s):  
Lactic Acid ◽  
Blood Sugar ◽  
Terminal Illness ◽  
Serum Lipids ◽  
Right Heart Failure ◽  
Total Serum ◽  
Epinephrine Injection ◽  
Chemical Studies ◽  
Severity Of The Disease ◽  
Sugar Levels

A case of glycogen disease of the liver (von Gierke's disease), followed from the age of 6 months to death at 10½ years, is reported. The child was dwarfed and mentally retarded. The diagnosis is supported by blood sugar concentrations following the administration of monosaccharides and following epinephrine injection as well as by post-mortem anatomical and chemical studies. Hypoglycemia was controlled by frequent feedings which contained glucose or starch. Levulose and galactose were restricted because low tolerance tests suggested that these substances were rapidly removed from the blood by the liver; after phosphorylation and conversion in the liver their release as glucose was evidently blocked by the same mechanism that blocked the release of glucose from glycogen. Blood lactic acid was consistently elevated, the degree of elevation bearing an inverse relationship to blood sugar levels. It is suggested that excess blood lactic acid contributes to the acidosis and so therapy of the acidosis with lactates would be illogical. The concentration of total serum lipids was always high but fluctuated widely, reaching a peak of 7.45 gm./100 ml., higher during periods of prolonged hypoglycemia and probably reflecting the mobilization of body fat during these periods. The terminal illness was marked by 2 unexplained complications: multiple hepatomata and congestive right heart failure. The severity of the disease varies from patient to patient, in the present case appearing to decrease with advancing age.

Physical and behavioral postnatal development of woodchucks (Marmota monax)

1991 ◽  
Vol 69 (4) ◽  
pp. 1040-1047 ◽  
Author(s):  
J. Ferron ◽  
J.-P. Ouellet
Keyword(s):  
Growth Rate ◽  
Body Weight ◽  
Social Behavior ◽  
Postnatal Development ◽  
Tail Length ◽  
Postnatal Growth ◽  
Behavioral Development ◽  
Ground Squirrels ◽  
Behavioral Repertoire ◽  
Marmota Monax

The physical and behavioral postnatal development of woodchucks (Marmota monax) was analyzed from birth to 42 days of age, the age at which weaning begins. Postnatal growth was evaluated by means of daily measurements of body weight, body length, tail length, and length of hind foot. Data on length of ear pinnae, vibrissae, and fur, and on the timing of appearance of some events of physical development are also presented. We considered postnatal development of locomotion, alertness, exploratory behavior, feeding, and comfort and social behavior. Our results indicate no sexual dimorphism in body size in young woodchucks, despite its occurrence in adults. Intraspecific comparisons reveal that woodchucks from different populations show marked variation in growth rate. The high level of intraspecific variation in developmental rates of sciurid rodents provides a warning to those performing interspecific comparisons. The data also suggest that the ratio of growth rate to adult body weight is not related to environmental severity. Behavioral development in M. monax is similar to that of ground squirrels but faster than that of tree squirrels and flying squirrels. There is also no direct relationship between size and timing of behavioral development in sciurid rodents. The behavioral repertoire of young woodchucks is simpler than that of young Spermophilus lateralis, another asocial species. It is possible that specific differences in rates of development of social interactions led to such differentiation in the repertoire of social behavior.

scholarly journals Serum Level of Total Lipids and Telomere Length in the Male Population: A Cross-Sectional Study

2019 ◽  
Vol 13 (2) ◽  
pp. 155798831984297 ◽  
Author(s):  
Behrooz Karimi ◽  
Masud Yunesian ◽  
Ramin Nabizadeh ◽  
Parvin Mehdipour
Keyword(s):  
Serum Level ◽  
Telomere Length ◽  
Serum Lipids ◽  
Inverse Relationship ◽  
Repetitive Sequences ◽  
Initial Assessment ◽  
Total Serum ◽  
Cluster Sampling ◽  
Total Lipids ◽  
Age Related

Telomeres contain TTAGGG (T; Thymine, A; Adenine and G; Guanine) repetitive sequences and are placed at the end of human chromosomes. Telomere dysfunction is implicated in some age-related and chronic diseases, but its association with total serum lipids and obesity is unknown. Our objective was to determine influenced of total serum lipids on leukocyte telomere lengths (TLs). Participants were selected by cluster sampling from 22 districts of Tehran. The questionnaires were completed by 500 subjects and after the initial assessment in terms of lifestyle, nutrition, home, and job, 300 healthy people, aged 25–40 years were finally selected. TLs and serum level of total lipids were measured by quantitative real-time PCR and the Phillips method, respectively. The average telomere length (T/S) and total lipids were 1.05 ± 0.3 mg/dl and 643.3 ± 70.8 mg/dl, respectively. We found that a one unit difference in the following parameters were associated with kilo base pair differences in TL: Age −0.0002 (95% CI [−0.0022, −0.0018]), BMI −0.0019 (95% CI [−0.0003, −0.0034]), TC 0.0001 (95% CI [−0.0006, −0.0007]), TG −0.0010 (95% CI [−0.0015, −0.0004]), PL 0.0001 (95% CI [−0.0005, −0.0007]), and TSL −0.0003 (95% CI [−0.0008, 0.0001]). Spearman correlation analysis revealed an inverse relationship between TC (R = −0.53; 95% CI [−0.61, −0.44]), TG (R = −0.50; 95% CI [−0.58, −0.41]), PL (R = −0.46; 95% CI [−0.54−0.36]), and TSL (R = −0.63; 95% CI [−0.69, −0.56]) with T/S. Our research suggests that the inverse relationship was found between TL and weight, BMI, age, and TSL which were associated with obesity. High serum lipids concentration may be associated with systemic inflammation and atherosclerosis and may lead to oxidative stress, resulting in telomere shortening.

Evaluation of different methods to determine total serum lipids for normalization of circulating organochlorine compounds

2009 ◽  
Vol 82 (10) ◽  
pp. 1241-1247 ◽  
Author(s):  
Roberto Bergonzi ◽  
Giuseppe De Palma ◽  
Cesare Tomasi ◽  
Maria Cristina Ricossa ◽  
Pietro Apostoli
Keyword(s):  
Serum Lipids ◽  
Organochlorine Compounds ◽  
Total Serum

scholarly journals Effect of guar gum on body-weight, hunger ratings and metabolism in obese subjects

1984 ◽  
Vol 52 (1) ◽  
pp. 97-105 ◽  
Author(s):  
Marcin Krotkiewski
Keyword(s):  
Body Weight ◽  
Dietary Habits ◽  
Guar Gum ◽  
Term Treatment ◽  
Total Serum ◽  
Glucose Levels ◽  
Cholesterol Levels ◽  
Long Term Treatment ◽  
Obese Subjects

1. The effect of a palatable granulated guar-gum preparation (10 g twice daily) was studied in obese subjects. The acute effect of a single dose of guar gum to reduce the peak postprandial whole blood glucose levels (about 10%) was verified. Following long-term treatment, a further reduction was seen in the obese subjects with the highest postprandial glucose levels. Since the postprandial plasma insulin levels were essentially unchanged, this finding suggested an increased responsiveness to insulin. Total serum cholesterol levels were significantly reduced following long-term treatment but serum α-cholesterol levels, representing the high-density-lipoprotein fraction, was unchanged.2. Body-weight was significantly reduced during guar-gum treatment even though the patients were asked to maintain their normal dietary habits. Daily hunger ratings recorded for up to 10 weeks showed that guar gum reduced hunger significantly better than commercially available bran taken in the same way.3. Thus, guar gum seemed to influence carbohydrate and lipid metabolism in a beneficial way in obese subjects. The reduction in hunger would offer an additional benefit to these patients.

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