Multidisciplinary pain center follow-up study: Evaluation with a no-treatment control group

Pain ◽  
1985 ◽  
Vol 21 (3) ◽  
pp. 295-306 ◽  
Author(s):  
Thomas P. Guck ◽  
Miles F. Skultety ◽  
Philip W. Meilman ◽  
Thomas E. Dowd
1995 ◽  
Vol 6 (6) ◽  
pp. 343-351 ◽  
Author(s):  
Jane E. Gillham ◽  
Karen J. Reivich ◽  
Lisa H. Jaycox ◽  
Martin E.P. Seligman

After teaching cognitive and social-problem-solving techniques designed to prevent depressive symptoms, we followed 69 fifth- and sixth-grade children at risk for depression for 2 years We compared these children with 49 children in a matched no-treatment control group The prevention group reported fewer depressive symptoms through the 2-year followup, and moderate to severe symptoms were reduced by half Surprisingly, the effects of the prevention program grew larger after the program was over We suggest that psychological immunization against depression can occur by teaching cognitive and social skills to children as they enter puberty


1980 ◽  
Vol 47 (2) ◽  
pp. 567-574 ◽  
Author(s):  
Allan Markle ◽  
Roger C. Rinn ◽  
Brenda Goodwin

In an attempt to help underachieving students improve academic performance, an Achievement Motivation Training program was developed. Although similar to other programs focusing on achievement motivation, substantial differences exist, particularly since the present program is presented in an outpatient format rather than integrated into the classroom. 54 students (Grades 3 to 11), referred by their counselors, were subjects; half of these completed our Achievement Motivation Training program, the other half served as a no-treatment control group. The treated group showed a significant improvement in grades from before training to follow-up as well as significantly greater improvement than the control group. Also, a new methodology was offered and tested, demonstrating that a no-treatment group may not be necessary when grades are the primary dependent variable.


2019 ◽  
Vol 33 (8) ◽  
pp. 1298-1309 ◽  
Author(s):  
Priya Kannan ◽  
Stanley J Winser ◽  
Lam Choi Ho ◽  
Leung C Hei ◽  
Lam C Kin ◽  
...  

Objective:To determine the effectiveness of physiotherapy interventions for postprostatectomy erectile dysfunction and climacturia.Data sources:Multiple databases were searched from database inception to February 2019.Review methods:Randomized controlled trials comparing physiotherapy interventions to control were included.Results:The search yielded 127 potentially relevant articles; seven met the inclusion criteria and were included in the review. Meta-analysis of two studies revealed a statistically significant effect of pelvic floor muscle training (PFMT) plus biofeedback compared to the no treatment control group for erectile function at the12-month follow-up period (risk ratio (RR) = 3.65, 95% confidence interval (CI) = 1.02–13.05; P = 0.05). Data from one small study ( n = 31) identified a greater number of men reporting improved climacturia in the PFMT plus electrical stimulation group compared to the no treatment control group, and the overall effect was significant (RR = 15.60, 95% CI = 0.95–254.91; P = 0.05). Meta-analyses of two studies found no statistically significant differences between groups receiving PFMT and no treatment control for erectile function or climacturia at long-term follow-up.Conclusions:PFMT augmented with biofeedback improves erectile function after prostatectomy. Data from a single study found PFMT combined with electrical stimulation to be beneficial for postprostatectomy climacturia. However, electrical stimulation is recommended for terminally ill people only. The effect of PFMT alone on postprostatectomy erectile dysfunction and climacturia remains inconclusive. However, this is likely to be affected by the participant adherence and physiotherapy supervision. High-quality trials providing intensive supervision and due consideration of adherence factors are recommended.


1988 ◽  
Vol 67 (3) ◽  
pp. 597-601 ◽  
Author(s):  
C.J. Pierce ◽  
E.N. Gale

One hundred bruxers were evaluated for bruxing activity before, during, and after treatment with a portable electromyograph (EMG). A six-month post-treatment follow-up of bruxing activity was obtained. Experimental treatment groups consisted of diurnal biofeedback, nocturnal biofeedback, massed negative practice, and splint therapy. A no-treatment control group was included. The comparative efficacy of treatments was determined by analyses of variance. Both EMG-measured frequency of bruxing episodes and duration of bruxing activity decreased significantly for nocturnal biofeedback and splint therapy treatments but not for massed negative practice, diurnal biofeedback (relaxation), or the no-treatment control group. The two-week treatment effects were transient, and bruxing activity generally returned to baseline levels when treatment was withdrawn. These findings are consistent with the findings of previous researchers with regard to nocturnal biofeedback and splint therapy but differ from previous findings for massed negative practice therapy.


1987 ◽  
Vol 2 (3) ◽  
pp. 145-151 ◽  
Author(s):  
Winston C.V. Parris ◽  
Robert N. Jamison ◽  
Jennifer J. Vasterling

Author(s):  
Sen-Chi Yu ◽  
Kennon M. Sheldon ◽  
Wen-Ping Lan ◽  
Jia-Huei Chen

Research has demonstrated that positive interventions (PIs) can be effective in enhancing well-being. Our study used Facebook to conduct a PI based on savoring. Sixty-one university students in Taiwan were randomly assigned to undergo a three-week savoring PI, and 61 participants were assigned to a no-treatment control group. The results showed significantly enhanced positive affect in the treatment group compared to the control group, in both a post-test and a final follow-up, but no significant differences between the two groups in negative affect. The treatment group also displayed significantly lower depression in the post-test, which was not maintained at the follow-up. These results indicate that, for university students, a savoring intervention via Facebook can be an effective way of enhancing positive emotions.


2014 ◽  
Vol 306 (2) ◽  
pp. H286-H290 ◽  
Author(s):  
Calvin K. Chan ◽  
Song Yan Liao ◽  
Yue Lin Zhang ◽  
Aimin Xu ◽  
Hung Fat Tse ◽  
...  

In the porcine coronary artery, regenerated endothelium is dysfunctional as regards the responses to endothelium-dependent agonists. The current study aimed to determine the possible involvement of histamine in such dysfunction. Pigs were treated chronically with pyrilamine (H1 receptor inhibitor, 2 mg·kg−1·day−1) with part of their coronary endothelium and allowed to regenerate for 28 days after balloon denudation. The results showed a reduction in relaxation to bradykinin (Gq protein dependent) only in the pyrilamine-treated group (area under the curve, 269.7 ± 13.4 vs. 142.0 ± 31.0, native endothelium vs. regenerated endothelium) but not in the control group (253.0 ± 22.1 vs. 231.9 ± 29.5, native endothelium vs. regenerated endothelium). The differences in the relaxation to serotonin (Gi protein dependent) between native and regenerated endothelium were not affected by the pyrilamine treatment (control group, 106.3 ± 17.0 vs. 55.61 ± 12.7; and pyrilamine group, 106.0 ± 8.20 vs. 49.30 ± 6.31, native endothelium vs. regenerated endothelium). These findings indicate that during regeneration of the endothelium, the activation of H1 receptors by endogenous histamine may be required to maintain the endothelium-dependent Gq protein-mediated relaxation to bradykinin, suggesting a beneficial role of the monoamine in the process of endothelial regeneration.


2000 ◽  
Vol 10 (Supplement 1) ◽  
pp. 31S-37S ◽  
Author(s):  
Barbara Y. Whitman ◽  
Susan Myers ◽  
Aaron Carrel ◽  
David Allen

2022 ◽  
Author(s):  
Tobias Kube ◽  
Irving Kirsch ◽  
Julia Glombiewski ◽  
Philipp Herzog

After traumatic experiences, intrusive memories can flash back and evoke significant distress. Here, we investigated whether the occurrence of intrusions can be prevented by placebo. After the exposure to an experimental psychopathology model of psychological trauma, healthy participants (N=112) were randomised to deceptive placebo (DP), open-label placebo (OLP), or a no-treatment control group. The results show that one week later, the groups did not differ in the frequency of intrusive memories. However, participants receiving OLP reported the lowest intensity of intrusions. Participants receiving DP reported the lowest burden of intrusions. Across groups, the expectation that intrusions will be intense and hardly controllable was associated with a higher frequency of intrusions, higher distress, higher burden, and more negative appraisal. The results suggest that expectations play a crucial role in the emergence of intrusive memories and that at least some of the disabling aspects of intrusive memories can be reduced by placebo.


2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Xiulan Wang ◽  
Chun Chang ◽  
Wenjie Jin ◽  
Arun Arun ◽  
Sudunabuqi Sudunabuqi ◽  
...  

Background. Untreated nephropathy can progress to renal failure. The traditional Mongolian remedy Narenmandula regulates the kidney “yang.” This study aimed to identify key microRNAs (miRNAs) targeted by Narenmandula in a rat model of nephropathy. Methods. Fifteen rats exhibiting normal renal function were randomized to three study arms. Nephropathy was induced in n = 10 rats using doxorubicin hydrochloride, followed by either Narenmandula treatment (treatment group) or no treatment (control group). In n = 5 rats, no doxorubicin was given and renal function remained unchanged (healthy group). Microarray analysis identified miRNAs which were differentially expressed (DE-miRNAs) between groups. Target genes of DE-miRNAs were predicted using miRWalk version 2.0, followed by enrichment analysis using DAVID, and construction of the miRNA coregulatory network using Cytoscape. Results. Nephropathy was successfully induced, with doxorubicin resulting in differential expression of 3645 miRNAs (1324 upregulated and 2321 downregulated). Narenmandula treatment induced differential expression of a total of 159 miRNAs (102 upregulated and 57 downregulated). Upregulated DE-miRNAs (e.g., miR-497-5p, miR-195-5p, miR-181a-5p, miR-181c-5p, and miR-30e-5p) and downregulated DE-miRNAs (e.g., miR-330-3p and miR-214-3p) regulated a high number of target genes. Moreover, the miRNA pairs (e.g., miR-195-5p—miR-497-5p, miR-181a-5p—miR-181c-5p, and miR-30e-5p—miR-30a-5p) coregulated a high number of genes. Enrichment analysis indicated functional synergy between miR-30e-5p—miR-30a-3p, miR-34a-5p—miR-30e-5p, miR-30e-5p—miR-195-3p, and miR-30a-3p—miR-195-3p pairs. Conclusion. Narenmandula may modulate doxorubicin-induced nephropathy via targeting miR-497-5p, miR-195-5p, miR-181a-5p, miR-181c-5p, miR-30e-5p, miR-330-3p, miR-214-3p, miR-34a-5p, miR-30a-3p, and miR-30a-5p.


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