Response of whole blood glutathione peroxidase and selenium in chicks fed with sodium selenite, wheat and fish meal

1993 ◽  
Vol 41 (2) ◽  
pp. 103-111 ◽  
Author(s):  
S. Hassan ◽  
J. Hakkarainen ◽  
P. Lindberg ◽  
S. Sankari
Keyword(s):  
Glutathione Peroxidase ◽  
Whole Blood ◽  
Sodium Selenite ◽  
Fish Meal

scholarly journals Comparison of organic and inorganic forms of selenium in the mother and kid relationship in goats

2012 ◽  
Vol 57 (No. 8) ◽  
pp. 361-369 ◽  
Author(s):  
L. Pavlata ◽  
L. Mišurová ◽  
A. Pechová ◽  
R. Dvořák
Keyword(s):  
Glutathione Peroxidase ◽  
Whole Blood ◽  
Sodium Selenite ◽  
Dry Matter ◽  
Control Group ◽  
Individual Trial ◽  
Significant Difference ◽  
The Individual ◽  
Se Status

The goal of the experiment was to compare the effect of four different forms of selenium (Se) &minus; sodium selenite (SS), lactate-protein selenium complex (SL), selenium enriched yeast (SY), and selenium-proteinate (SP) supplemented to pregnant goats on Se concentration and glutathione peroxidase (GSH-Px) activity in the blood of goats on the day of delivery and also on Se concentration and GSH-Px activity in the blood of newborn kids. The experiment involved 33 pregnant goats of White Short-haired breed. The supplementation started 6 weeks before the parturition. The goats were divided into 5 groups: control group&nbsp;C, not supplemented, and 4 trial groups (SL, SP, SS, SY), which received Se in the above stated forms by the means of supplemented pellets (300 g per animal per day) at a rate 900 &mu;g Se/kg of dry matter. The average Se concentrations in the blood of the goats were 79.6 &mu;g/l in group C, 152.6 &mu;g/l in group SL, 167.1&nbsp;&mu;g/l in group SP, 144.9 &mu;g/l in group SS, and 152.9 &mu;g/l in group SY. Selenium concentrations in all 4 trial groups were significantly higher (P &lt; 0.01) than in control group, however no significant difference was found between individual trial groups. Likewise, the activity of GSH-Px in goat blood increased significantly in all supplemented groups compared to the controls; however we did not discover any significant differences in activity of GSH-Px between the individual selenium-supplemented groups. The Se concentrations in the blood of kids were significantly (P &lt; 0.01) higher in the selenium-supplemented groups (SL &ndash; 94.9&nbsp;&mu;g/l, <br />SP &ndash; 87.5 &mu;g/l, SS &ndash; 87.6 &mu;g/l, SY &ndash; 92.5 &mu;g/l) than in the control group (C &ndash; 49.4 &mu;g/l), but we did not discover any differences between the individual experimental groups. The activity of GSH-Px in the blood of the kids tended towards higher values in the supplemented groups than in the control group, but the values were significantly higher (P &lt; 0.05) only in groups SY and SL. We have found significant correlation between GSH-Px activity and Se concentration in the blood of goats (r = 0.86) and newborn kids (r = 0.95). Likewise, there was significant correlation between Se concentration in the blood of goats and their kids (r&nbsp;= 0.74). We discovered that the kids are reaching physiologically only about 60% of Se status in whole blood in comparison with their mothers. Our results are suggesting that all the above forms of Se were similarly utilised and transferred into the foetus in the goats. &nbsp;

scholarly journals The effect of inorganic and organically bound forms of selenium on glutathione peroxidase activity in the blood of goats

2011 ◽  
Vol 56 (No. 2) ◽  
pp. 75-81 ◽  
Author(s):  
L. Pavlata ◽  
L. Misurova ◽  
A. Pechova ◽  
R. Dvorak
Keyword(s):  
Glutathione Peroxidase ◽  
Lactobacillus Acidophilus ◽  
Whole Blood ◽  
Sodium Selenite ◽  
Complex Form ◽  
Biologically Active ◽  
Glutathione Peroxidase Activity ◽  
The Difference ◽  
Se Status

The goal of the experiment was to compare the effect of supplementation of inorganic and the new organically bound (lactate-protein selenium complex) form of selenium (Se) in feed for goats. The 31 goats were split into three groups: control (C) without Se supplementation, AN group administered sodium selenite, ORG group administered lactate-protein selenium complex (Selene Chelate, Agrobac, Czech Republic) produced by cultivation of Lactobacillus acidophilus on a substrate containing natrium selenite. The total Se intake in goats was 0.15 mg in group C, and 0.43 mg in the groups AN and ORG. The effect of Se supplementation was assessed based on the determination of Se concentration and the activity of glutathione peroxidase (GSH-Px) in whole blood. Samples were taken before the beginning of Se supplementation, 14 and 30 days after the start of supplementation, and then two and three months after the beginning of supplementation. Average Se concentrations in the blood of goats in individual groups (C, AN, ORG) before the start of supplementation were 109.6 &plusmn; 34.3, 117.5 &plusmn; 34.7, and 105.4 &plusmn; 43.6 &mu;g/l respectively, and the activity of GSH-Px in whole blood was 745.3 &plusmn; 289.2, 810.7 &plusmn; 280.4, and 791.0 &plusmn; 398.1 &mu;kat/l respectively. While in group C goats neither the Se concentration nor the GSH-Px activity changed substantially during the experiment, in the goats in the experimental groups there was a statistically significant increase (P &lt; 0.01) in both Se concentrations and the GSH-Px activities. At the end of the experiment Se concentrations in the blood of AN and ORG groups amounted to 168.5 &plusmn; 12.2 and 168.8 &plusmn; 26.8 &mu;g/l. The GSH-Px activities in goats supplemented with Se also increased significantly over the course of the experiment (at the end of the experiment it was 1178.0 &plusmn; 127.3 in the AN group and 1030.1 &plusmn; 152.3 &mu;kat/l in the ORG group), and the difference between the groups was significant (P = 0.038). Regarding the dynamics of GSH-Px activity changes during the monitored period, a markedly quicker increase in GSH-Px activity was recorded in the AN group &ndash; one month after the beginning of Se supplementation, compared to three months after the beginning of Se supplementation in the ORG group. The results thus show that the effects of supplementation with selenite and the lactate-protein selenium complex are similar with regard to Se status, but that the increase in GSH-Px activity occurred much faster with selenite, which therefore appears to be a more biologically available form of selenium for creation of biologically active selenoproteins.

Effect of selenium supplementation on survival, liveweight and wool weight of young sheep on Kangaroo Island, South Australia

1979 ◽  
Vol 19 (101) ◽  
pp. 689 ◽  
Author(s):  
SK Walker ◽  
GP Hall ◽  
DH Smith ◽  
RW Ponzoni ◽  
GJ Judson
Keyword(s):  
Total Dose ◽  
Whole Blood ◽  
Sodium Selenite ◽  
South Australia ◽  
Selenium Concentration ◽  
Mortality Rates ◽  
Selenium Supplementation ◽  
First Year ◽  
Weaning Weight ◽  
Fleece Weight

The responses in liveweight, wool weight and survival, to selenium supplementation, were studied in young sheep from weaning to yearling age. The experiment was conducted over three years. In the first year, one sodium selenite supplementation rate was used (total dose 46.5 mg). During the following two years two supplementation rates were administered (total doses 46.5 mg and 93 mg). Mean concentrations of selenium in whole blood in unsupplemented sheep varied from 0.19-0.56 pmol l-l and from 0.20-0.44 pmol l-1 in the two years in which concentrations were measured. Supplementation, which commenced at lamb marking, increased the selenium concentration in sheep at weaning and thereafter. Selenium supplementation improved the break-of-season weight (P < 0.01) and yearling weight (P < 0.01 ) but not weaning weight (0.05 < P < 0.1 ). Hogget fleece weight was improved (P < 0.01 ) and mortality reduced (P < 0.01) by selenium supplementation. There was a treatment x year interaction in mortality rates (P < 0.01 ). There were no significant differences between the two supplementation rates

Selenium and Glutathione Peroxidase Levels in Cystic Fibrosis

PEDIATRICS ◽  
1980 ◽  
Vol 65 (5) ◽  
pp. 1010-1012
Author(s):  
John D. Lloyd-Still ◽  
Howard E. Ganther
Keyword(s):  
Cystic Fibrosis ◽  
New Zealand ◽  
Glutathione Peroxidase ◽  
Whole Blood ◽  
Selenium Concentration ◽  
Selenium Level ◽  
Infants And Children ◽  
Healthy Children ◽  
Normal Range

Whole blood selenium and glutathione peroxidase levels were measured in 20 infants and children (aged 6 months to 15 years) with cystic fibrosis. The whole blood selenium concentration in cystic fibrosis was 0.122 ± 0.025 µg/gm. Although the levels of selenium in cystic fibrosis children were below the levels found in a study of healthy children (0.223 ± 0.007 µg/gm), they are comparable to those found in children with phenylketonuria treated dietetically and exceed the blood selenium level of healthy children in New Zealand. Levels of the selenoenzyme glutathione peroxidase in children with cystic fibrosis (0.042 ± 0.007 units/mg Hb) were in the normal range (0.035 ± 0.003 units/mg of Hb). These results do not support the hypothesis that deficiency of selenium is responsible for cystic fibrosis.

An Epidemiological Study of a Defined Area of N. Ireland: Whole Blood Glutathione Peroxidase (EC1.11.1.9)

1988 ◽  
pp. 517-518
Author(s):  
Dorothy McMaster ◽  
A. E. Evans ◽  
Evelyn McCrum ◽  
M. McF. Kerr ◽  
C. C. Patterson ◽  
...  
Keyword(s):  
Glutathione Peroxidase ◽  
Epidemiological Study ◽  
Whole Blood

Response of growing cattle to supplementation with organically bound or inorganic sources of selenium or yeast cultures

1991 ◽  
Vol 71 (3) ◽  
pp. 803-811 ◽  
Author(s):  
J. W. G. Nicholson ◽  
R. E. McQueen ◽  
R. S. Bush
Keyword(s):  
Glutathione Peroxidase ◽  
Whole Blood ◽  
Yeast Culture ◽  
Feed Conversion ◽  
Or Efficiency ◽  
Linear Rate ◽  
Beef Calves ◽  
Organic Selenium ◽  
Yeast Cultures ◽  
Holstein Calves

Bioavailability of organically bound and inorganic Se sources differ, the organic form being absorbed more efficiently. Dairy and beef calves (250 kg initial weight) were given a low Se diet alone or supplemented with sodium selenite (1 mg Se d−1; inorganic Se), a Se-enriched yeast (1.5 g yeast d−1 providing 1 mg of Se; organic Se), a live yeast culture (1.5 g d−1) or autoclaved yeast culture (1.5 g d−1). The latter treatments were included to determine the response to yeast per se. There were no treatment effects on rate of weight gain or efficiency of feed conversion by the calves. The Se souces had no effect on digestibility of the diet by sheep. The inorganic Se supplement increased the level of whole blood Se and glutathione peroxidase (GSH-Px) activity at a linear rate with time up to 3 mo from the start of supplementation. The effect of organic Se was sustained for 4 mo and both indices of Se status in blood were higher (P < 0.01) for calves fed the organic Se than for those fed inorganic Se after 4 mo (124 vs. 96 units of GSH-Px activity g−1 haemoglobin and 141 vs. 102 μg Se L−1 of whole blood). The values near the beginning of the trial were higher (P < 0.01) for Holstein calves than for beef calves but both groups showed the same response to source of Se. Subsequently, levels declined for Holstein and increased for beef calves given diets without supplemental Se. The results showed that Se supplementation for 4 mo had no effect on animal performance; that more than 4 mo are required to fully deplete or replete blood Se and GSH-Px; and, that supplemental organic Se gives higher (P < 0.01) blood Se and GSH-Px activity than does inorganic Se. Key words: Organic selenium, calves, glutathione peroxidase

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