Opportunistic Fungal Infections in a Hospital Pediatric Population: Risk Factors, Prevention, and Control

2008 ◽  
Vol 36 (5) ◽  
pp. E100-E101
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Thang Nguyen-Tien ◽  
Duy Cuong Do ◽  
Xuan Luat Le ◽  
Thi Hai Dinh ◽  
Mats Lindeborg ◽  
...  

Abstract Background Dengue is a mosquito-borne flavivirus present in many metropolitan cities of tropical countries. Methods During and after the dengue season (September 2018 to January 2019), we conducted a case-control study in order to determine the risk factors for dengue fever in Hanoi city, Vietnam. 98 dengue patients and 99 patients with other acute infections, such as Hepatitis B virus infection, were recruited at Department of Infectious Disease of Bach Mai national hospital in Hanoi. Patients were interviewed using a structured questionnaire covering demographic, housing, environmental factors and knowledge, attitude, and practice on dengue prevention and control. Univariate analysis and multivariable logistic regression were used to determine the risk factors of dengue status. Results The mean score of knowledge items and practice items was only 7.9 out of total 19 points and 3.9 out of total 17 points, respectively. While the mean score of attitude items was 4.8 out of total 6 points. Multivariable logistic regression indicated that older patients had lesser risk of getting dengue infection as compared to younger adults aged 16–30, and patients living in peri-urban districts were less likely to suffer of dengue fever than patients living in central urban districts (OR = 0.31; 95% CI 0.13–0.75). This study could not find any association with occupation, water storage habit, knowledge, attitude, or practice on dengue prevention. Conclusions All patients had a relatively low level of knowledge and practice on dengue prevention and control. However, the attitude of the participants was good. We found that age group and living district were the risk factors correlated with the dengue status. Communication programs on raising dengue awareness should be repeated all year round and target particular groups of adolescents, younger adults, landlords and migrants from other provinces to improve their knowledge and encourage them to implement preventive measures against dengue fever.


2020 ◽  
pp. 1-7
Author(s):  
Sharif S. Aly ◽  
Betsy M. Karle ◽  
Deniece R. Williams ◽  
Gabriele U. Maier ◽  
Sasha Dubrovsky

Abstract Bovine respiratory disease (BRD) is the leading natural cause of death in US beef and dairy cattle, causing the annual loss of more than 1 million animals and financial losses in excess of $700 million. The multiple etiologies of BRD and its complex web of risk factors necessitate a herd-specific intervention plan for its prevention and control on dairies. Hence, a risk assessment is an important tool that producers and veterinarians can utilize for a comprehensive assessment of the management and host factors that predispose calves to BRD. The current study identifies the steps taken to develop the first BRD risk assessment tool and its components, namely the BRD risk factor questionnaire, the BRD scoring system, and a herd-specific BRD control and prevention plan. The risk factor questionnaire was designed to inquire on aspects of calf-rearing including management practices that affect calf health generally, and BRD specifically. The risk scores associated with each risk factor investigated in the questionnaire were estimated based on data from two observational studies. Producers can also estimate the prevalence of BRD in their calf herds using a smart phone or tablet application that facilitates selection of a true random sample of calves for scoring using the California BRD scoring system. Based on the risk factors identified, producers and herd veterinarians can then decide the management changes needed to mitigate the calf herd's risk for BRD. A follow-up risk assessment after a duration of time sufficient for exposure of a new cohort of calves to the management changes introduced in response to the risk assessment is recommended to monitor the prevalence of BRD.


2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Zhijie Zhang ◽  
Yu Cao ◽  
Yanjian Li ◽  
Xufang Chen ◽  
Chen Ding ◽  
...  

Abstract Background Candida pelliculosa is an ecological fungal species that can cause infections in immunocompromised individuals. Numerous studies globally have shown that C. pelliculosa infects neonates. An outbreak recently occurred in our neonatal intensive care unit; therefore, we aimed to evaluate the risk factors in this hospital-acquired fungal infection. Methods We performed a case-control study, analysing the potential risk factors for neonatal infections of C. pelliculosa so that infection prevention and control could be implemented in our units. Isolated strains were tested for drug resistance and biofilm formation, important factors for fungal transmission that give rise to hospital-acquired infections. Results The use of three or more broad-spectrum antimicrobials or long hospital stays were associated with higher likelihoods of infection with C. pelliculosa. The fungus was not identified on the hands of healthcare workers or in the environment. All fungal isolates were susceptible to anti-fungal medications, and after anti-fungal treatment, all infected patients recovered. Strict infection prevention and control procedures efficiently suppressed infection transmission. Intact adhesin-encoding genes, shown by genome analysis, indicated possible routes for fungal transmission. Conclusions The use of three or more broad-spectrum antimicrobials or a lengthy hospital stay is theoretically associated with the risk of infection with C. pelliculosa. Strains that we isolated are susceptible to anti-fungal medications, and these were eliminated by treating all patients with an antifungal. Transmission is likely via adhesion to the cell surface and biofilm formation.


2017 ◽  
Vol 33 (12) ◽  
pp. 565
Author(s):  
Husni Husni ◽  
Th. B Rahayujati ◽  
S Supargiyono

Evaluation of malaria risk factors prevention and control program in Kulon Progo RegencyPurposeThe purpose of this research was to evaluate the program of prevention and control of malaria risk factors in Kulon Progo District in 2016 based on system approach.MethodThis research was evaluation program used mixed methods (sequential explanatory design). Data collected from 7 public health center of active focus malaria and district health office. Respondents were program managers and head of public health center, district program managers, head of control and eradication of communicable diseases, and head of district health offices. The instruments used structured questionnaires and in-depth interview guides. Quantitative data analysis was descriptive and qualitative data used Miles and Huberman model.Results Most of the availability of human resources, funds, facilities, materials, and methods already meet implementation needs except entomologists, allocation of funds activities other than IRS, time of the implementation of larval fish deployment. Most of the processes that started from the planning, implementation, monitoring, and evaluation have gone well except for planning other than IRS, preparation vector control without entomology database, implementation of environmental management, larviciding, and larval fish deployment. Coverage of LLINs, coverage of IRS, control of LLINs efficacy, and test of vector resistance have met the target, except coverage of larviciding and larval fish deployment was not available.ConclusionPrevention and control program of malaria risk factors has implemented but wasn’t based on entomological data. District health offices should recruit entomologist to support vector control activities.


2011 ◽  
Vol 139 (5-6) ◽  
pp. 304-310
Author(s):  
Dusica Rakic ◽  
Djordje Jakovljevic

Introduction. From 1984 to 2004, the city of Novi Sad participated in the international MONICA (Multinational MONItoring of trends and determinants in CArdiovascular disease) project, as one of the 38 research centres form 21 countries around the world and in CINDI (Countrywide Integrated Noncommunicable Disease Intervention Programme) programme. Objective. Objective was to indicate the advantages of the integrated approach to prevention and control of the cardiovascular disease (CVD) over mono-programmes and still present curative approach. Additional objective was the assessment of the vulnerability from the leading risk factors of the population of Novi Sad, based on the results and experience gained in realization of international projects. Methods. We analyzed the results obtained in the countries where MONICA project and CINDI programme have been applied. The results of their application in Novi Sad are analyzed (the trend of the prevalence of risk factors, the incidence of coronary and cerebrovascular events). Results. The prevalence of risk factors (except smoking), the incidence of coronary and cerebrovascular events are significantly increasing and are in positive correlation with the values of the linear trend. The decrease was only recorded in 1987 (the implementation of the intervention programme). Conclusion. The review of results and experiences in international projects and programs, clearly indicate the advantage of an integrated approach to prevention and control of CVD in relation to monoprograme. The great vulnerability of the population of Novi Sad of the risk factors of CVD points out the necessity of their reductions by the principles of integrated programmes of prevention and control.


Global Heart ◽  
2019 ◽  
Vol 14 (2) ◽  
pp. 109 ◽  
Author(s):  
Alemayehu Amberbir ◽  
Sabrina H. Lin ◽  
Joshua Berman ◽  
Adamson Muula ◽  
Darren Jacoby ◽  
...  

2018 ◽  
Vol 4 (2) ◽  
pp. 46-50
Author(s):  
Gyambo Sithey ◽  
Anne Marie Thow ◽  
Jayendra Sharma ◽  
Karma Lhazin ◽  
Mu Li

Noncommunicable diseases (NCDs) are major public health problem in Bhutan, accounting for 68% of total deaths. The growing epidemic of NCDs threatens the achievement of Gross National Happiness (GNH). NCDs are the results of complex interaction of social and economic risk factors and change in diet and lifestyle. Effective action to prevent and control these diseases requires a whole-of-government approach.In this paper we review new evidence to support political priority for NCDs in Bhutan. One third of the Bhutanese are overweight (33%) and hypertensive (35.7), and 6.4% are diabetic. The prevalence of modifiable risk factors is also very high. We also present the analysis of strategic policy opportunities for health sector to integrate the ‘Multisectoral national action plan for the prevention and control of NCDs, 2015-2020’ into policies across all relevant sectors. Our analysis has identified three specific opportunities for the health sector to engage strategically to strengthen action on NCDs and GNH, concurrently: 1) raising priority actions on NCDs within the existing GNH multisectoral committee, to achieve both health and happiness objectives; 2) identifying shared agenda between NCDs and GNH to achieve both health and happiness objectives; and 3) identifying shared GNH determinants between NCDs and GNH to enhance action on NCDs. Addressing NCDs aligns with the optimization of Gross National Happiness. It is imperative that the Government of Bhutan recognize that action on NCDs is an integral element for achieving GNH.


2016 ◽  
Vol 55 (4) ◽  
pp. 239-247 ◽  
Author(s):  
Irena Klavs ◽  
Jana Kolman ◽  
Tatjana Lejko Zupanc ◽  
Božena Kotnik Kevorkijan ◽  
Aleš Korošec ◽  
...  

Abstract Introduction In the second Slovenian national healthcare-associated infections (HAIs) prevalence survey, conducted within the European point prevalence survey of HAIs and antimicrobial use in acute-care hospitals, we estimated the prevalence of all types of HAIs and identified risk factors. Methods Patients from acute-care hospitals were enrolled into a one-day cross-sectional study in October 2011. Descriptive analyses were performed to describe the characteristics of patients, their exposure to invasive procedures and the prevalence of different types of HAIs. Univariate and multivariate analyses of association of having at least one HAI with possible risk factors were performed to identify risk factors. Results Among 5628 patients, 3.8% had at least one HAI and additional 2.6% were still being treated for HAIs on the day of the survey; the prevalence of HAIs was 6.4%. The prevalence of urinary tract infections was the highest (1.4%), followed by pneumoniae (1.3%) and surgical site infections (1.2%). In intensive care units (ICUs), the prevalence of patients with at least one HAI was 35.7%. Risk factors for HAIs included central vascular catheter (adjusted odds ratio (aOR) 4.0; 95% confidence intervals (CI): 2.9-5.7), peripheral vascular catheter (aOR 2.0; 95% CI: 1.5-2.6), intubation (aOR 2.3; 95% CI: 1.4-3.5) and rapidly fatal underlying condition (aOR 2.1; 95% CI: 1.4-3.3). Conclusions The prevalence of HAIs in Slovenian acute-care hospitals in 2011 was substantial, especially in ICUs. HAIs prevention and control is an important public health priority. National surveillance of HAIs in ICUs should be developed to support evidence-based prevention and control.


2021 ◽  
Author(s):  
Baohua Wang ◽  
Fengdie He ◽  
Yanan Hu ◽  
Yuting Sha ◽  
Dan Wang ◽  
...  

Abstract Background: We analyze the prevalence and risk factors of cancer in the member states of the “Belt and Road”, to explore the basis of health and medical cooperation between countries, and to provide a foundation for formulating cancer prevention and control policies for building the healthy "Belt and Road". Methods: We apply incidence, mortality, age-standardized rates, and population attributable fractions (PAFs) to measure the prevalence and risk factors of cancers in the “Belt and Road” countries. Results: Lung, breast, colorectal, stomach, liver, prostate, cervical, esophageal, thyroid, and uterine cancers are the most common and highest mortality cancers in the “Belt and Road” countries. For men, the highest cancer incidence and mortality is Hungary (ASR, 289.3 per 100,000 and ASR, 235.7 per 100,000, respectively), followed by Latvia (ASR, 288.6 per 100,000 and ASR, 196.5 per 100,000, respectively), the United Arab Emirates and Saudi Arabia enjoy the lowest (ASR, 34.3 per 100,000 and ASR, 36.1 per 100,000, respectively). The mortality and incidence rates of cancers in Greek and Brunei are highest in females (ASR, 238.7 per 100,000 and ASR, 192.3 per 100,000, respectively). Tobacco products, infectious factors, and ultraviolet rays are the three main cancer risk factors in the “Belt and Road” countries. Conclusion: The overall burden of cancer in the “Belt and Road” member states remains substantial, while the corresponding cancer prevention and control policies need to be improved. Enhancing health cooperation among the member countries will contribute to the joint response to the risks and challenges posed by cancer. (249 words)


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