The impact of psychological stress on mast cells

BACKGROUND: College students are a high-risk subpopulation of psychological disorders. The problem of various adverse phenomena and consequences caused by excessive pressure on college students has gradually become the focus of social and psychological academic circles. However, studies related to individual self-concept and psychological pressure are rare. OBJECTIVE: To explore the impact of sports dance exercises on college students’ psychological pressure and improve the psychological effects of their self-satisfaction. METHODS: College students were taken as research objects, randomly divided into a control group and an observation group. The observation group is intervened with sports dance exercises. The observation group was intervened with sports dance exercises. The stress response characteristic questionnaire and multidimensional self-satisfaction rating scale were utilized to measure college students’ conditions before and after the intervention. Finally, the obtained data were statistically analyzed. RESULTS: Generally, the psychological stress response of college students was mild, with self-satisfaction and various dimensions at a moderately higher level. No significant differences were discovered in the psychological stress response and self-satisfaction level between the control group and the observation group before intervention (P > 0.05), which were homogeneous. Compared with the data obtained before the intervention, after the intervention, the control group scores were slightly reduced in all dimensions of the psychological stress response and self-satisfaction. In contrast, the scores were significantly increased in the experimental group (P < 0.05). Psychological stress response could reliably explain 30.4%of the total self-satisfaction variance (P < 0.01). The negative self-evaluation was the most important variable affecting self-satisfaction, followed by poor interpersonal communication and poor sleeping quality. CONCLUSIONS: Sports dance exercises could alleviate the psychological stress of college students and improve their self-satisfaction. Colleges and universities should include sports dance in the content of optional public courses and encourage more college students to actively participate in sports dance exercises to improve their mental health.

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The impact of a 360° virtual tour on the reduction of psychological stress caused by COVID-19

Technology in Society ◽

10.1016/j.techsoc.2020.101514 ◽

2021 ◽

Vol 64 ◽

pp. 101514

Author(s):

Ting Yang ◽

Ivan Ka Wai Lai ◽

Zhao Bin Fan ◽

Qing Min Mo

Keyword(s):

Psychological Stress ◽

Virtual Tour ◽

The Impact

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The Impact of Psychological Stress on Wound Healing

Critical Care Nursing Clinics of North America ◽

10.1016/j.ccell.2012.03.006 ◽

2012 ◽

Vol 24 (2) ◽

pp. 201-213 ◽

Cited By ~ 30

Author(s):

Jean-Philippe Gouin ◽

Janice K. Kiecolt-Glaser

Keyword(s):

Wound Healing ◽

Psychological Stress ◽

The Impact

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Impact of COVID 19 pandemic on psychological wellbeing of oncology clinicians in MENA (Middle East and North Africa) region.

Journal of Clinical Oncology ◽

10.1200/jco.2021.39.15_suppl.e24105 ◽

2021 ◽

Vol 39 (15_suppl) ◽

pp. e24105-e24105

Author(s):

Muhammad Farooq Latif ◽

Faisal Azam ◽

Syed Hammad Tirmazy ◽

Shahid Bashir ◽

Fahad Ibnshamsah ◽

...

Keyword(s):

Public Sector ◽

Psychological Stress ◽

Female Gender ◽

Well Being ◽

Average Score ◽

Mena Region ◽

The Public ◽

Medical Oncologists ◽

Generalized Anxiety Disorders ◽

The Impact

e24105 Background: Cancer care has been severely affected by covid 19 pandemic leading to medical, ethical and organizational issues. Oncology healthcare professionals face challenges due to reorganization of cancer services and increasing health care requirements resulting in uncertainty and psychological stress. Aim of this study is to evaluate the impact of covid 19 pandemic on psychological well being of oncology clinicians in the MENA region. Methods: We randomly invited 1500 oncology clinicians including medical oncologists, clinical oncologists, radiation oncologists and surgical oncologists from 17 countries in the MENA region to complete a web based survey to determine the level of psychological stress during covid 19 pandemic from October 2020 to January 2021. The questionnaire was based on Perceived Stress Scale (PSS), Generalized Anxiety Disorders Scale (GAD-7) and WHO Well-being Index (WHO-5). The data was analyzed using SPSS version 21 and difference between groups was measured by T-test and ANOVA. Results: Overall 520 (35%) oncology clinicians including 368 (71%) males and 152 (29%) females participated in the survey. Most of the participants were medical oncologists (38%) from teaching institutions (76%) and the public sector (84%). 46% (n = 242) participants were 35-45 years of age. Majority of clinicians reported moderate (45.6%) to severe (42.3%) anxiety on GAD-7 scale. Females had statistically higher levels of anxiety (average score;15.46 ±4.87, p = 0.04). On PSS, the majority of participants reported higher stress with average scores (29.64 ±3.83) for males and (30.23 ±4.62) for females. Average score for WHO wellbeing index was 62.95 (±20.52) for males and 74.3 (±20.87) for females denoting a preservation of general well being, even in a higher stress and anxiety situation. Female gender was significantly associated with anxiety level on GAD-7 scale (p = 0.04), but this difference in stress level and well being was not observed on PSS (p = 0.134) and WHO well being index (p = 0.709). Clinicians of ages 25-35 years had significantly higher anxiety levels on GAD-7 scale (p = 0.004) and higher stress on PSS (p = 0.000). Age over 55 years was associated with lower levels of anxiety and stress on GAD-7 and PSS. Oncology clinicians working in public sector experienced significantly lower stress as compared to private sector on PSS scale (p = 0.041) Conclusions: Covid 19 pandemic has significantly increased the anxiety and stress levels among oncology clinicians in the MENA region. Anxiety and stress were higher in females and young clinicians. Clinicians over 55 years of age and oncologists working in the public sector reported less stress and anxiety. General well being of clinicians was well preserved even in a highly stressful and anxious situation.

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The psychological effects of unmarried women “a field study on a sample of unmarried women in Algeria”

European Psychiatry ◽

10.1016/j.eurpsy.2017.01.1845 ◽

2017 ◽

Vol 41 (S1) ◽

pp. s902-s902

Author(s):

L. Fekih ◽

B. Mounis

Keyword(s):

Psychological Stress ◽

Negative Impact ◽

Self Esteem ◽

Professional Status ◽

Self Confidence ◽

Common Problems ◽

Competing Interest ◽

The Impact ◽

Late Stages ◽

Confidence Scale

BackgroundThe present research was designed to determine the psychological stress as experienced by unmarried women in the education sector, and how to help them to discover the meaning of their presence in the framework, innovation and achievement, art, science, comprehension, love and adaptation in life.AimThis research aims to identify the various problems and mental disorders that unmarried women suffering from, and to determine the differences between unmarried women in terms of the psychological problems resulting from “unmarried” in: ages, kind and professional status.MethodThe method used in this research is purely descriptive following the collected data from the sample of 200 unmarried women. The tools that were used in this research as follow: Self-Confidence Scale, Psychological Stress Scale, “List of Information Collection for unmarried women”; we proceeded with some statistical techniques.ResultsThe findings of this research were:– emotional problems are the most common problems experienced by unmarried women;– the present study indicates the presence of depressive symptoms in 17%, which can evolve toward psychotic depression as dysthymia (loss of interest in daily activities, hopelessness, low self-esteem, self-criticism, trouble concentrating and trouble making decisions, effectiveness and productivity, avoidance of social activities, feelings of guilt and worries over the past, insomnia…);– the impact of unmarried on late stages have more negative impact, and psychological effect on them was more severe and the greatest harm.ConclusionThe advancement of women in the age without marriage or “unmarried women” is origin of psychological stress and low self-confidence.Dissclosure of interestThe authors have not supplied their declaration of competing interest.

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COVID-19, Mast Cells, Cytokine Storm, Psychological Stress, and Neuroinflammation

The Neuroscientist ◽

10.1177/1073858420941476 ◽

2020 ◽

Vol 26 (5-6) ◽

pp. 402-414 ◽

Cited By ~ 11

Author(s):

Duraisamy Kempuraj ◽

Govindhasamy Pushpavathi Selvakumar ◽

Mohammad Ejaz Ahmed ◽

Sudhanshu P. Raikwar ◽

Ramasamy Thangavel ◽

...

Keyword(s):

Mast Cells ◽

Psychological Stress ◽

Cell Activation ◽

Cell Damage ◽

Neurovascular Unit ◽

Stress Disorders ◽

Mast Cell Activation ◽

Severe Illness ◽

High Morbidity ◽

Cytokine Storm

Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new pandemic infectious disease that originated in China. COVID-19 is a global public health emergency of international concern. COVID-19 causes mild to severe illness with high morbidity and mortality, especially in preexisting risk groups. Therapeutic options are now limited to COVID-19. The hallmark of COVID-19 pathogenesis is the cytokine storm with elevated levels of interleukin-6 (IL-6), IL-1β, tumor necrosis factor-alpha (TNF-α), chemokine (C-C-motif) ligand 2 (CCL2), and granulocyte-macrophage colony-stimulating factor (GM-CSF). COVID-19 can cause severe pneumonia, and neurological disorders, including stroke, the damage to the neurovascular unit, blood-brain barrier disruption, high intracranial proinflammatory cytokines, and endothelial cell damage in the brain. Mast cells are innate immune cells and also implicated in adaptive immune response, systemic inflammatory diseases, neuroinflammatory diseases, traumatic brain injury and stroke, and stress disorders. SARS-CoV-2 can activate monocytes/macrophages, dendritic cells, T cells, mast cells, neutrophils, and induce cytokine storm in the lung. COVID-19 can activate mast cells, neurons, glial cells, and endothelial cells. SARS-CoV-2 infection can cause psychological stress and neuroinflammation. In conclusion, COVID-19 can induce mast cell activation, psychological stress, cytokine storm, and neuroinflammation.

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Stress-Induced Mast Cell Activation in Glabrous and Hairy Skin

Mediators of Inflammation ◽

10.1155/2014/105950 ◽

2014 ◽

Vol 2014 ◽

pp. 1-9 ◽

Cited By ~ 25

Author(s):

Constantin Căruntu ◽

Daniel Boda ◽

Sorin Musat ◽

Ana Căruntu ◽

Eugen Mandache

Keyword(s):

Mast Cell ◽

Mast Cells ◽

Cell Activation ◽

Prolonged Exposure ◽

Mast Cell Degranulation ◽

Mast Cell Activation ◽

Glabrous Skin ◽

Stress Exposure ◽

Hairy Skin ◽

The Impact

Mast cells play a key role in modulation of stress-induced cutaneous inflammation. In this study we investigate the impact of repeated exposure to stress on mast cell degranulation, in both hairy and glabrous skin. Adult male Wistar rats were randomly divided into four groups: Stress 1 day(n=8), Stress 10 days(n=7), Stress 21 days(n=6), and Control(n=8). Rats in the stress groups were subjected to 2 h/day restraint stress. Subsequently, glabrous and hairy skin samples from animals of all groups were collected to assess mast cell degranulation by histochemistry and transmission electron microscopy. The impact of stress on mast cell degranulation was different depending on the type of skin and duration of stress exposure. Short-term stress exposure induced an amplification of mast cell degranulation in hairy skin that was maintained after prolonged exposure to stress. In glabrous skin, even though acute stress exposure had a profound stimulating effect on mast cell degranulation, it diminished progressively with long-term exposure to stress. The results of our study reinforce the view that mast cells are active players in modulating skin responses to stress and contribute to further understanding of pathophysiological mechanisms involved in stress-induced initiation or exacerbation of cutaneous inflammatory processes.

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Associations between APOE Variants and Metabolic Traits and the Impact of Psychological Stress

PLoS ONE ◽

10.1371/journal.pone.0015745 ◽

2011 ◽

Vol 6 (1) ◽

pp. e15745 ◽

Cited By ~ 8

Author(s):

Sofia I. Iqbal Kring ◽

John Barefoot ◽

Beverly H. Brummett ◽

Stephen H. Boyle ◽

Ilene C. Siegler ◽

...

Keyword(s):

Psychological Stress ◽

Metabolic Traits ◽

The Impact

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HYSTERECTOMY IS ASSOCIATED WITH POSTMENOPAUSAL BODY COMPOSITION CHARACTERISTICS

Journal of Biosocial Science ◽

10.1017/s0021932000000377 ◽

2000 ◽

Vol 32 (1) ◽

pp. 37-46 ◽

Cited By ~ 4

Author(s):

SYLVIA KIRCHENGAST ◽

DORIS GRUBER ◽

MICHAEL SATOR ◽

JOHANNES HUBER

Keyword(s):

Body Composition ◽

Weight Gain ◽

Bone Mass ◽

Psychological Stress ◽

Stress Factors ◽

Hormonal Changes ◽

Fat Tissue ◽

Abdominal Region ◽

The Impact ◽

Composition Characteristics

The impact of hysterectomy without oophorectomy and with no malignant purpose on body composition and postmenopausal weight gain was tested in 184 Viennese females aged between 47 and 57 years (mean 52·9). Hysterectomized women were significantly heavier than those who experienced a spontaneous menopause (controls). The amount of fat tissue, especially in the abdominal region, was significantly higher in hysterectomized women. Furthermore, they were reported to have experienced a significantly higher weight gain since menopause (9·1 versus 6·0 kg). No significant differences in bone mass were found. Psychological stress factors and hormonal changes following hysterectomy are discussed as possible causes of these differences.

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Mast cells regulate myofilament calcium sensitization and heart function after myocardial infarction

Journal of Experimental Medicine ◽

10.1084/jem.20160081 ◽

2016 ◽

Vol 213 (7) ◽

pp. 1353-1374 ◽

Cited By ~ 53

Author(s):

Anta Ngkelo ◽

Adèle Richart ◽

Jonathan A. Kirk ◽

Philippe Bonnin ◽

Jose Vilar ◽

...

Keyword(s):

Myocardial Infarction ◽

Mast Cells ◽

Cardiac Function ◽

Cardiac Remodeling ◽

Molecular Mechanisms ◽

Troponin I ◽

Heart Function ◽

Ischemic Disease ◽

Cardiomyocyte Contractility ◽

The Impact

Acute myocardial infarction (MI) is a severe ischemic disease responsible for heart failure and sudden death. Inflammatory cells orchestrate postischemic cardiac remodeling after MI. Studies using mice with defective mast/stem cell growth factor receptor c-Kit have suggested key roles for mast cells (MCs) in postischemic cardiac remodeling. Because c-Kit mutations affect multiple cell types of both immune and nonimmune origin, we addressed the impact of MCs on cardiac function after MI, using the c-Kit–independent MC-deficient (Cpa3Cre/+) mice. In response to MI, MC progenitors originated primarily from white adipose tissue, infiltrated the heart, and differentiated into mature MCs. MC deficiency led to reduced postischemic cardiac function and depressed cardiomyocyte contractility caused by myofilament Ca2+ desensitization. This effect correlated with increased protein kinase A (PKA) activity and hyperphosphorylation of its targets, troponin I and myosin-binding protein C. MC-specific tryptase was identified to regulate PKA activity in cardiomyocytes via protease-activated receptor 2 proteolysis. This work reveals a novel function for cardiac MCs modulating cardiomyocyte contractility via alteration of PKA-regulated force–Ca2+ interactions in response to MI. Identification of this MC-cardiomyocyte cross-talk provides new insights on the cellular and molecular mechanisms regulating the cardiac contractile machinery and a novel platform for therapeutically addressable regulators.

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