Adverse effects of two pharmaceuticals acetaminophen and oxytetracycline on life cycle parameters, oxidative stress, and defensome system in the marine rotifer Brachionus rotundiformis

2018 ◽  
Vol 204 ◽  
pp. 70-79 ◽  
Author(s):  
Jun Chul Park ◽  
Deok-Seo Yoon ◽  
Eunjin Byeon ◽  
Jung Soo Seo ◽  
Un-Ki Hwang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Life Cycle ◽  
Adverse Effects ◽  
Brachionus Rotundiformis ◽  
Marine Rotifer

scholarly journals Molecular functions of ASK family in diseases caused by stress-induced inflammation and apoptosis

2020 ◽  
Author(s):  
Kazuki Kojima ◽  
Hidenori Ichijo ◽  
Isao Naguro
Keyword(s):  
Oxidative Stress ◽  
Endoplasmic Reticulum ◽  
Adverse Effects ◽  
Er Stress ◽  
Inflammatory Diseases ◽  
Family Members ◽  
Disease States ◽  
Molecular Functions ◽  
Critical Responses ◽  
Proper Response

Summary VCells are constantly exposed to various types of stress, and disruption of the proper response lead to a variety of diseases. Among them, inflammation and apoptosis are important examples of critical responses and should be tightly regulated, as inappropriate control of these responses is detrimental to the organism. In several disease states, these responses are abnormally regulated, with adverse effects. Apoptosis signal-regulating kinase (ASK) family members are stress-responsive kinases that regulate inflammation and apoptosis after a variety of stimuli, such as oxidative stress and endoplasmic reticulum (ER) stress. In this review, we summarize recent reports on the ASK family in terms of their involvement in inflammatory diseases, focusing on upstream stimuli that regulate ASK family members.

scholarly journals First person – Natalí Delorme and Leonardo Zamora

Biology Open ◽  
2021 ◽  
Vol 10 (12) ◽  
Keyword(s):  
Oxidative Stress ◽  
Life Cycle ◽  
New Zealand ◽  
Stress Response ◽  
Marine Invertebrates ◽  
Early Career ◽  
New Method ◽  
First Person ◽  
Early Career Researchers ◽  
Selection Of

ABSTRACT First Person is a series of interviews with the first authors of a selection of papers published in Biology Open, helping early-career researchers promote themselves alongside their papers. Natalí Delorme and Leonardo Zamora are co-first authors on ‘ A new method to localise and quantify oxidative stress in live juvenile mussels’, published in BiO. They are both researchers in the laboratory of Serean Adams at the Cawthron Institute, Nelson, New Zealand. Natalí's research interests centre around ecophysiology of marine invertebrates, particularly on the organisms' stress response. Leonardo is investigating the biology of commercially, ecologically and culturally relevant marine invertebrates throughout their life cycle.

scholarly journals Type I toxin-dependent generation of superoxide affects the persister life cycle of Escherichia coli

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Daniel Edelmann ◽  
Bork A. Berghoff
Keyword(s):  
Oxidative Stress ◽  
Escherichia Coli ◽  
Life Cycle ◽  
Type I ◽  
Oxygen Species ◽  
Reactive Oxygen Species Formation ◽  
Species Formation ◽  
Genes Encoding ◽  
Oxidative Challenge ◽  
Detailed Work

Abstract Induction of growth stasis by bacterial toxins from chromosomal toxin-antitoxin systems is suspected to favor formation of multidrug-tolerant cells, named persisters. Recurrent infections are often attributed to resuscitation and regrowth of persisters upon termination of antibiotic therapy. Several lines of evidence point to oxidative stress as a crucial factor during the persister life cycle. Here, we demonstrate that the membrane-depolarizing type I toxins TisB, DinQ, and HokB have the potential to provoke reactive oxygen species formation in Escherichia coli. More detailed work with TisB revealed that mainly superoxide is formed, leading to activation of the SoxRS regulon. Deletion of the genes encoding the cytoplasmic superoxide dismutases SodA and SodB caused both a decline in TisB-dependent persisters and a delay in persister recovery upon termination of antibiotic treatment. We hypothesize that expression of depolarizing toxins during the persister formation process inflicts an oxidative challenge. The ability to counteract oxidative stress might determine whether cells will survive and how much time they need to recover from dormancy.

scholarly journals The degree of oxidative stress is associated with major adverse effects after lung resection: A prospective study

2006 ◽  
Vol 29 (4) ◽  
pp. 591-595 ◽  
Author(s):  
Panagiotis Misthos ◽  
Stylianos Katsaragakis ◽  
Dimitrios Theodorou ◽  
Nikolaos Milingos ◽  
Ioannis Skottis
Keyword(s):  
Oxidative Stress ◽  
Adverse Effects ◽  
Prospective Study ◽  
Lung Resection ◽  
A Prospective Study

Developmental and Full‐Life Cycle Exposures to Guanylurea and Guanylurea–Metformin Mixtures Results in Adverse Effects on Japanese Medaka ( Oryzias latipes )

2019 ◽  
Vol 38 (5) ◽  
pp. 1023-1028 ◽  
Author(s):  
Erin Ussery ◽  
Kristin N. Bridges ◽  
Zacharias Pandelides ◽  
Andrea E. Kirkwood ◽  
John Guchardi ◽  
...  
Keyword(s):  
Life Cycle ◽  
Adverse Effects ◽  
Oryzias Latipes ◽  
Japanese Medaka ◽  
Full Life Cycle ◽  
Full Life

scholarly journals Chronic and Acute Toxicities of Aflatoxins: Mechanisms of Action

2020 ◽  
Vol 17 (2) ◽  
pp. 423 ◽  
Author(s):  
Noreddine Benkerroum
Keyword(s):  
Oxidative Stress ◽  
Risk Factors ◽  
Adverse Effects ◽  
Mechanisms Of Action ◽  
Additive Effects ◽  
Hepatitis Viruses ◽  
Mechanisms Of Toxicity ◽  
Adverse Health Effects ◽  
Relative Contribution ◽  
And Control

There are presently more than 18 known aflatoxins most of which have been insufficiently studied for their incidence, health-risk, and mechanisms of toxicity to allow effective intervention and control means that would significantly and sustainably reduce their incidence and adverse effects on health and economy. Among these, aflatoxin B1 (AFB1) has been by far the most studied; yet, many aspects of the range and mechanisms of the diseases it causes remain to be elucidated. Its mutagenicity, tumorigenicity, and carcinogenicity—which are the best known—still suffer from limitations regarding the relative contribution of the oxidative stress and the reactive epoxide derivative (Aflatoxin-exo 8,9-epoxide) in the induction of the diseases, as well as its metabolic and synthesis pathways. Additionally, despite the well-established additive effects for carcinogenicity between AFB1 and other risk factors, e.g., hepatitis viruses B and C, and the hepatotoxic algal microcystins, the mechanisms of this synergy remain unclear. This study reviews the most recent advances in the field of the mechanisms of toxicity of aflatoxins and the adverse health effects that they cause in humans and animals.

scholarly journals Antioxidant modulation of nevirapine induced hepatotoxicity in rats

2015 ◽  
Vol 8 (1) ◽  
pp. 8-14
Author(s):  
Olufunsho Awodele ◽  
Temidayo Popoola ◽  
Kunle Rotimi ◽  
Victor Ikumawoyi ◽  
Wahab Okunowo
Keyword(s):  
Oxidative Stress ◽  
Vitamin E ◽  
Adverse Effects ◽  
Vitamin C ◽  
Histopathological Examination ◽  
Protective Effects ◽  
Blood Cell Count ◽  
Blood Samples ◽  
Cervical Dislocation ◽  
Related Mortality

AbstractHIV/AIDS related mortality has been dramatically reduced by the advent of antiretroviral therapy (ART). However, ART presents with associated adverse effects. One of such adverse effects is hepatotoxicity observed with nevirapine (NVP) containing ART. Since previous studies showed that NVP hepatotoxicity may be due to oxidative stress via generation of oxidative radicals, this study sought to evaluate the protective effects of antioxidants in alleviating NVP induced hepatotoxicity. Rats were divided into 6 groups with 8 animals per group and received doses of the antioxidants jobelyn (10.7 mg/kg/day), vitamin C (8 mg/kg/day), vitamin E (5 mg/kg/day) and/or NVP (6 mg/kg/day) for 60 days. The animals were sacrificed on day 61 by cervical dislocation, blood samples were collected for biochemical and hematological examination. The liver of the sacrificed animals was weighed and subjected to histopathological examination. There was a statistically significant (p<0.05) elevation in MDA level observed in the NVP group as compared with control. The results further showed non-significant decreases in the levels of MDA in the NVP plus antioxidant groups, except vitamin C, when compared with the NVP alone group. Vitamin E and Vitamin E plus C treated groups showed significantly (p<0.05) higher levels of SOD, CAT and GSH. The results also showed statistically significantly (p<0.05) lower levels of ALT and AST in the antioxidant treated groups There was an observed significantly (p<0.05) higher level of TP and urea in the antioxidant treated rats. A significantly (p<0.05) higher white blood cell count was observed in the antioxidant groups. Histopathological assessment of the liver extracted from the rats showed no visible pathology across the groups. Observations from this study suggest a potentially positive modulatory effect of antioxidants and may be indicative for the inclusion of antioxidants in nevirapine containing ART.

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