scholarly journals Enhanced peripheral blood miR-324-5p is associated with the risk of metabolic syndrome by suppressing ROCK1

2020 ◽  
Vol 1865 (8) ◽  
pp. 158727
Author(s):  
Jun Guo ◽  
Chunxiao Yang ◽  
Yajun Lin ◽  
Gang Hu ◽  
Jie Wei ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Peripheral Blood

Low THRB (thyroid hormone receptor beta) Promoter Methylation Levels in Peripheral Blood Leukocytes Induced By Systematic Inflammation Are Involved in Low Thyroid Hormone Function in Metabolic Syndrome

Hypertension ◽  
2021 ◽  
Author(s):  
Bing Cui ◽  
Xiao Xiao ◽  
Jin’e Wang ◽  
Hongrui Wang ◽  
Cunjin Wu ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Thyroid Hormone ◽  
Promoter Methylation ◽  
Peripheral Blood ◽  
Thyroid Hormone Receptor ◽  
Oral Treatment ◽  
Methylation Status ◽  
Peripheral Blood Leukocytes ◽  
Blood Leukocytes ◽  
A Genome

Abnormal thyroid hormone (TH) function has been observed in all components of metabolic syndrome (MetS), but the mechanisms remain unclear. Altered genomic methylation status is closely related to MetS. Our aim was to determine whether methylation regulation in TH function–related genes is involved in MetS. In a small strictly selected cohort, low TH function was observed in MetS group, as well as lower THRB promoter methylation levels in peripheral blood leukocytes in a genome-wide methylation screening by Illumina 450K beadchip. The results of beadchip assay were then confirmed by Sequenom MassARRAY. Low THRB promoter methylation levels and low TH function in MetS were confirmed in another big-size validation cohort. Lower methylation levels were associated with higher THRB expression in peripheral blood leukocytes, and altered THRB promoter methylation status influenced its promoter activity and expression. In the MetS rat models constructed by high fat and high fructose diet, lower TH function was also observed, as well as lower Thrb promoter methylation levels. Furthermore, systematic inflammation observed in MetS was found to induce decreased THRB promoter methylation levels as well as corresponding THRB expression. Additionally, oral treatment with a physiological T3 dose mitigated hypertension and insulin resistance and partially alleviated hepatic steatosis and adipocyte hypertrophy in MetS rats. Low methylation levels of THRB promoter in peripheral blood leukocytes induced by systematic inflammation were involved in low TH function in MetS, whereas low TH function deteriorates MetS. This might serve as a novel therapeutic target of MetS.

scholarly journals An Isocaloric Nordic Diet Modulates RELA and TNFRSF1A Gene Expression in Peripheral Blood Mononuclear Cells in Individuals with Metabolic Syndrome—A SYSDIET Sub-Study

Nutrients ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 2932 ◽  
Author(s):  
Stine M. Ulven ◽  
Kirsten B. Holven ◽  
Amanda Rundblad ◽  
Mari C. W. Myhrstad ◽  
Lena Leder ◽  
...  
Keyword(s):  
Gene Expression ◽  
Metabolic Syndrome ◽  
Peripheral Blood Mononuclear Cells ◽  
Peripheral Blood ◽  
Mononuclear Cells ◽  
Expression Profiles ◽  
Control Diet ◽  
Peripheral Blood Mononuclear ◽  
Nordic Diet ◽  
Blood Mononuclear Cells

A healthy dietary pattern is associated with a lower risk of metabolic syndrome (MetS) and reduced inflammation. To explore this at the molecular level, we investigated the effect of a Nordic diet (ND) on changes in the gene expression profiles of inflammatory and lipid-related genes in peripheral blood mononuclear cells (PBMCs) of individuals with MetS. We hypothesized that the intake of an ND compared to a control diet (CD) would alter the expression of inflammatory genes and genes involved in lipid metabolism. The individuals with MetS underwent an 18/24-week randomized intervention to compare a ND with a CD. Eighty-eight participants (66% women) were included in this sub-study of the larger SYSDIET study. Fasting PBMCs were collected before and after the intervention and changes in gene expression levels were measured using TaqMan Array Micro Fluidic Cards. Forty-eight pre-determined inflammatory and lipid related gene transcripts were analyzed. The expression level of the gene tumor necrosis factor (TNF) receptor superfamily member 1A (TNFRSF1A) was down-regulated (p = 0.004), whereas the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) subunit, RELA proto-oncogene, was up-regulated (p = 0.016) in the ND group compared to the CD group. In conclusion, intake of an ND in individuals with the MetS may affect immune function.

scholarly journals Subnormal Peripheral Blood Leukocyte Counts Are Related to the Lowest Prevalence and Incidence of Metabolic Syndrome: Tianjin Chronic Low-Grade Systemic Inflammation and Health Cohort Study

2014 ◽  
Vol 2014 ◽  
pp. 1-12 ◽  
Author(s):  
Shaomei Sun ◽  
Hongmei Wu ◽  
Qing Zhang ◽  
Chongjin Wang ◽  
Yinting Guo ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Cohort Study ◽  
Peripheral Blood ◽  
Peripheral Blood Leukocyte ◽  
Cox Proportional Hazards ◽  
Low Grade ◽  
Cross Sectional ◽  
Inflammatory Status ◽  
Leukocyte Counts ◽  
Blood Leukocyte

Few studies have assessed the relationship between a subnormal inflammatory status and metabolic syndrome (MS). We therefore designed a cross-sectional and 5-year cohort study to evaluate how a subnormal peripheral blood leukocyte count is related to MS. Participants were recruited from Tianjin Medical University General Hospital-Health Management Centre. Both a baseline cross-sectional (n=46,179) and a prospective assessment (n=13,061) were performed. Participants without a history of MS were followed up for 5 years. Leukocyte counts and MS components were assessed at baseline and yearly during the follow-up. Adjusted logistic and Cox proportional hazards regression models were used to assess relationships between the categories of leukocyte counts and MS. The subnormal leukocyte counts group (1,100–3,900 cells/mm3) had the lowest prevalence and incidence of MS. The odds ratio and hazard ratio (95% confidence interval) of the highest leukocyte counts were 1.98 (1.57–2.49) and 1.50 (1.22–1.84) (bothPfor trend <0.0001), respectively, when compared to the subnormal leukocyte counts group after adjusting for potential confounders. This study has shown that subnormal leukocyte counts are independently related to the lowest prevalence and incidence of MS. The findings suggest that it is necessary to restudy and discuss the clinical or preventive value of subnormal leukocyte counts.

LONGEVITY-ASSOCIATED GENES IN CIRCULATING PERIPHERAL BLOOD MONONUCLEAR CELL PREDICT METABOLIC SYNDROME

2011 ◽  
Vol 29 ◽  
pp. e391-e392
Author(s):  
G. Ceolotto ◽  
S. Vigili De Kreutzenberg ◽  
G P. Fadini ◽  
A. Cattelan ◽  
F. Stella ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Peripheral Blood Mononuclear Cell ◽  
Mononuclear Cell ◽  
Peripheral Blood ◽  
Peripheral Blood Mononuclear

scholarly journals Metabolic Disease Risk Alters Circulating Peripheral Blood Mononuclear Cell microRNAs in Response to A High Glycemic Meal

Proceedings ◽  
2019 ◽  
Vol 8 (1) ◽  
pp. 30
Author(s):  
Farha Ramzan ◽  
Randall F. D’Souza ◽  
Brenan R. Durainayagam ◽  
Amber M. Milan ◽  
James F. Markworth ◽  
...  
Keyword(s):  
Metabolic Disease ◽  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Peripheral Blood Mononuclear Cell ◽  
Mononuclear Cell ◽  
Peripheral Blood ◽  
Disease Risk ◽  
Peripheral Blood Mononuclear ◽  
The Metabolic Syndrome ◽  
Metabolic Disease Risk

Background: High glycemic diets have been shown to exacerbate the risk of cardio-metabolicdisease in individuals with pre-existing disease risk, including obesity and insulin resistance,common to the Metabolic Syndrome (MetS). [...]

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