Layered structures of hydrophobically modified chitosan derivatives

A series of N,O-acylated chitosan derivatives were emulsified with different fatty acids. Hydrophobically modified chitosan derivatives were expected to exhibit self-assembly behaviour resulting in micelle formation. Several parameters of the oil-in-water emulsification process were investigated: mixing method, speed and duration, volume oil phase and addition of modifiers. Their influence on micellar Z-average diameter, size distribution and Zeta potential was analysed based on dynamic light scattering measurements. There were various relations between the hydrodynamic behaviour of chitosan derivatives, their chemical structure and the process parameters. Additionally, the obtained micelles could serve as active compound carriers because they encapsulated two model substances, namely ibuprofen and α-tocopherol.

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Enhanced flocculation of oil-in-water emulsions by hydrophobically modified chitosan derivatives

Colloids and Surfaces A Physicochemical and Engineering Aspects ◽

10.1016/j.colsurfa.2005.09.036 ◽

2006 ◽

Vol 275 (1-3) ◽

pp. 168-176 ◽

Cited By ~ 96

Author(s):

Svetlana Bratskaya ◽

Valentin Avramenko ◽

Simona Schwarz ◽

Irina Philippova

Keyword(s):

Chitosan Derivatives ◽

Modified Chitosan ◽

Hydrophobically Modified ◽

Oil In Water

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Hydrophobically Modified Chitosan Gauze for Control of Massive Hemorrhage

10.21236/ada629307 ◽

2016 ◽

Author(s):

Mayur Narayan

Keyword(s):

Massive Hemorrhage ◽

Modified Chitosan ◽

Hydrophobically Modified

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Antibacterial Activity of N,O-Acylated Chitosan Derivative

Polymers ◽

10.3390/polym13010107 ◽

2020 ◽

Vol 13 (1) ◽

pp. 107

Author(s):

Agnieszka Piegat ◽

Anna Żywicka ◽

Agata Niemczyk ◽

Agata Goszczyńska

Keyword(s):

Escherichia Coli ◽

Antibacterial Activity ◽

Chitosan Derivative ◽

Modified Chitosan ◽

Microdilution Method ◽

Hydrophobically Modified ◽

Mechanism Of Interaction ◽

H Pylori ◽

Living Bacteria ◽

Antibacterial Potential

The antibacterial activity of N,O-acylated chitosan derivative with linoleic acid (CH_LA) was tested by disc and well diffusion, agar impregnation and microdilution methods against Staphylococcus aureus, Escherichia coli and Helicobacter pylori strains. Hydrophobically modified chitosan (HMC) was expected to exhibit enhanced antibacterial activity and specific mucin interactions. Although diffusion tests have not indicated the antibacterial potential of chitosan (CH) or CH_LA, the results of the microdilution method demonstrated that tested polymers significantly reduced the amount of living bacteria cells in different concentrations depending on the microorganism. Additionally, CH_LA was characterized by enhanced antibacterial activity compared to CH, which may suggest a different mechanism of interaction with S. aureus and H. pylori. Furthermore, the UV-VIS analysis revealed that the amphiphilic character of derivative led to strong CH_LA–mucin interactions. The study proved the high potential of CH_LA in antibacterial applications, especially for the gastrointestinal tract.

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Hydrophobically modified chitosan nanoliposomes for intestinal drug delivery

International Journal of Nanomedicine ◽

10.2147/ijn.s166901 ◽

2018 ◽

Vol Volume 13 ◽

pp. 5837-5848 ◽

Cited By ~ 11

Author(s):

M Gulrez Zariwala ◽

Harshada Bendre ◽

Anatoliy Markiv ◽

Sebastien Farnaud ◽

Derek Renshaw ◽

...

Keyword(s):

Drug Delivery ◽

Modified Chitosan ◽

Hydrophobically Modified

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Concepts for Developing Physical Gels of Chitosan and of Chitosan Derivatives

Gels ◽

10.3390/gels4030067 ◽

2018 ◽

Vol 4 (3) ◽

pp. 67 ◽

Cited By ~ 16

Author(s):

Pasquale Sacco ◽

Franco Furlani ◽

Gaia de Marzo ◽

Eleonora Marsich ◽

Sergio Paoletti ◽

...

Keyword(s):

Molecular Weight ◽

Electrostatic Interactions ◽

Chitosan Derivatives ◽

Modified Chitosan ◽

Physical Chemical ◽

Degree Of Acetylation ◽

Potential Applications ◽

Low Toxicity ◽

Physical Interactions ◽

Biomedical Field

Chitosan macro- and micro/nano-gels have gained increasing attention in recent years, especially in the biomedical field, given the well-documented low toxicity, degradability, and non-immunogenicity of this unique biopolymer. In this review we aim at recapitulating the recent gelling concepts for developing chitosan-based physical gels. Specifically, we describe how nowadays it is relatively simple to prepare networks endowed with different sizes and shapes simply by exploiting physical interactions, namely (i) hydrophobic effects and hydrogen bonds—mostly governed by chitosan chemical composition—and (ii) electrostatic interactions, mainly ensured by physical/chemical chitosan features, such as the degree of acetylation and molecular weight, and external parameters, such as pH and ionic strength. Particular emphasis is dedicated to potential applications of this set of materials, especially in tissue engineering and drug delivery sectors. Lastly, we report on chitosan derivatives and their ability to form gels. Additionally, we discuss the recent findings on a lactose-modified chitosan named Chitlac, which has proved to form attractive gels both at the macro- and at the nano-scale.

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Using Chitosan or Chitosan Derivatives in Cancer Therapy

Polysaccharides ◽

10.3390/polysaccharides2040048 ◽

2021 ◽

Vol 2 (4) ◽

pp. 795-816

Author(s):

Md Salman Shakil ◽

Kazi Mustafa Mahmud ◽

Mohammad Sayem ◽

Mahruba Sultana Niloy ◽

Sajal Kumar Halder ◽

...

Keyword(s):

Drug Delivery ◽

Cancer Therapy ◽

Anticancer Agents ◽

Chitosan Nanoparticles ◽

Chemotherapeutic Drugs ◽

Chitosan Derivatives ◽

Drug Delivery Vehicles ◽

Modified Chitosan ◽

Therapeutic Benefits ◽

Delivery Vehicles

Cancer is one of the major causes of death worldwide. Chemotherapeutic drugs have become a popular choice as anticancer agents. Despite the therapeutic benefits of chemotherapeutic drugs, patients often experience side effects and drug resistance. Biopolymers could be used to overcome some of the limitations of chemotherapeutic drugs, as well as be used either as anticancer agents or drug delivery vehicles. Chitosan is a biocompatible polymer derived from chitin. Chitosan, chitosan derivatives, or chitosan nanoparticles have shown their promise as an anticancer agent. Additionally, functionally modified chitosan can be used to deliver nucleic acids, chemotherapeutic drugs, and anticancer agents. More importantly, chitosan-based drug delivery systems improved the efficacy, potency, cytotoxicity, or biocompatibility of these anticancer agents. In this review, we will investigate the properties of chitosan and chemically tuned chitosan derivatives, and their application in cancer therapy.

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