Targeting translation: a promising strategy for anticancer metallodrugs

The political divide is characterized by liberals and conservatives who hold strong prejudice against each other. Here we introduce one possible strategy for reducing political prejudice: political inclusion. We define political inclusion as receiving a fair chance to voice one’s opinions in a discussion of political topics with political outgroup members. This strategy may reduce political prejudice by inducing perceptions of the political outgroup as fair and respectful; however, such a strategy may also highlight conflicting attitudes and worldviews, thereby further exacerbating prejudice. In three preregistered studies (total N = 799), we test if political inclusion reduces or increases prejudice toward the political outgroup. Specifically, political inclusion was manipulated with either an imagined scenario (Study 1) or a concurrent experience in an ostensible online political discussion (Studies 2 & 3). Across all studies, participants who were politically included by political outgroup members reported reduced prejudice toward their outgroup compared to participants in a neutral control condition (Cohen’s d [-0.27, -0.50]). This effect was mediated by perceptions of the political outgroup as fairer and less dissimilar in their worldviews. Our results indicate that political discussions that are politically inclusive do not cause additional prejudice via worldview conflict, but instead give others a feeling of being heard. It is a promising strategy to reduce political prejudice.

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Yield and chlorophyll index in cabbage in function of enhanced-efficiency nitrogen fertilizers and urea

Scientific Electronic Archives ◽

10.36560/1312020997 ◽

2020 ◽

Vol 13 (2) ◽

pp. 6

Author(s):

J. J. Frazão ◽

A. R. Silva ◽

F. H. M. Salgado ◽

R. A. Flores ◽

E. P. F. Brasil

Keyword(s):

Nitrogen Fertilizers ◽

N Losses ◽

N Sources ◽

Promising Strategy ◽

Applied Dose ◽

Coated Urea ◽

Chlorophyll Index ◽

Polymer Coated Urea ◽

N Rates ◽

And Control

The increase of the efficiency of the nitrogen fertilization promotes reduction of the applied dose and decreases the losses of nitrogen (N) to the environment. The objective of this work was to evaluate the yield and the relative chlorophyll index (IRC) in cabbage crop under cover fertilization, using enhanced-efficiency nitrogen fertilizers, compared to urea, in variable doses. The experimental design was randomized blocks in a 3x4+1 factorial scheme (three sources, four rates and control), with four replications. The N sources used were: common urea (U), urea treated with urease inhibitor NBPT® (UN) and Kimcoat® polymer coated urea (UK). The N rates used were 0, 40, 80, 160 and 320 kg ha-1, divided in two fertilizations at 20 and 40 days after transplantation. Up to 160 kg ha-1 of N, there was no difference between N sources and N rates for both yield and RCI. The enhanced-efficiency N sources (UN and UK) promoted higher averages compared to common urea, possibly due to the higher N losses from common urea. Thus, the use of urease inhibitors or polymers associated with urea is a promising strategy to improve cabbage yield, as well as reducing N losses to the environment.

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Chinese Medicine Protein and Peptide in Gene and Cell Therapy

Current Protein and Peptide Science ◽

10.2174/1389203719666180612082432 ◽

2019 ◽

Vol 20 (3) ◽

pp. 251-264 ◽

Cited By ~ 1

Author(s):

Yinlu Feng ◽

Zifei Yin ◽

Daniel Zhang ◽

Arun Srivastava ◽

Chen Ling

Keyword(s):

Chinese Medicine ◽

Cell Therapy ◽

Future Research ◽

The Past ◽

Promising Strategy ◽

Wide Range ◽

New Directions ◽

Gene And Cell Therapy ◽

Proteins And Peptides

The success of gene and cell therapy in clinic during the past two decades as well as our expanding ability to manipulate these biomaterials are leading to new therapeutic options for a wide range of inherited and acquired diseases. Combining conventional therapies with this emerging field is a promising strategy to treat those previously-thought untreatable diseases. Traditional Chinese medicine (TCM) has evolved for thousands of years in China and still plays an important role in human health. As part of the active ingredients of TCM, proteins and peptides have attracted long-term enthusiasm of researchers. More recently, they have been utilized in gene and cell therapy, resulting in promising novel strategies to treat both cancer and non-cancer diseases. This manuscript presents a critical review on this field, accompanied with perspectives on the challenges and new directions for future research in this emerging frontier.

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Bioremediation as a promising strategy for microplastics removal in wastewater treatment plants

Marine Pollution Bulletin ◽

10.1016/j.marpolbul.2020.111252 ◽

2020 ◽

Vol 156 ◽

pp. 111252

Author(s):

Paula Masiá ◽

Daniel Sol ◽

Alba Ardura ◽

Amanda Laca ◽

Yaisel J. Borrell ◽

...

Keyword(s):

Wastewater Treatment ◽

Wastewater Treatment Plants ◽

Promising Strategy

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Oncolytic Virus Immunotherapy: Showcasing Impressive Progress in Special Issue II

Biomedicines ◽

10.3390/biomedicines9060663 ◽

2021 ◽

Vol 9 (6) ◽

pp. 663

Author(s):

Zong-Sheng Guo

Keyword(s):

Cancer Immunotherapy ◽

Oncolytic Virus ◽

Advanced Stage ◽

Special Issue ◽

Promising Strategy

Cancer immunotherapy has recently become the most promising strategy for hard-to-treat, advanced-stage malignancies [...]

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Porous scaffolds with the structure of an interpenetrating polymer network made by gelatin methacrylated nanoparticle-stabilized high internal phase emulsion polymerization targeted for tissue engineering

RSC Advances ◽

10.1039/d1ra03333f ◽

2021 ◽

Vol 11 (37) ◽

pp. 22544-22555

Author(s):

Atefeh Safaei-Yaraziz ◽

Shiva Akbari-Birgani ◽

Nasser Nikfarjam

Keyword(s):

Tissue Engineering ◽

Extracellular Matrix ◽

Cell Growth ◽

Polymer Network ◽

Synthetic Polymers ◽

Tissue Scaffolds ◽

Interpenetrating Polymer Network ◽

Porous Scaffolds ◽

Promising Strategy ◽

Internal Phase

The interlacing of biopolymers and synthetic polymers is a promising strategy to fabricate hydrogel-based tissue scaffolds to biomimic a natural extracellular matrix for cell growth.

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Detecting apoptosis as a clinical endpoint for proof of a clinical principle

Ophthalmologica ◽

10.1159/000513584 ◽

2020 ◽

Author(s):

Piero Zollet ◽

Timothy E.Yap ◽

M Francesca Cordeiro

Keyword(s):

Drug Development ◽

Therapeutic Response ◽

Imaging Techniques ◽

Brain Diseases ◽

Promising Strategy ◽

Sight Loss ◽

Apoptosis Detection ◽

Novel Therapeutic Strategies

The transparent eye media represent a window through which to observe changes occurring in the retina during pathological processes. In contrast to visualising the extent of neurodegenerative damage that has already occurred, imaging an active process such as apoptosis has the potential to report on disease progression and therefore the threat of irreversible functional loss in various eye and brain diseases. Early diagnosis in these conditions is an important unmet clinical need to avoid or delay irreversible sight loss. In this setting, apoptosis detection is a promising strategy with which to diagnose, provide prognosis, and monitor therapeutic response. Additionally, monitoring apoptosis in vitro and in vivo has been shown to be valuable for drug development in order to assess the efficacy of novel therapeutic strategies both in the pre-clinical and clinical setting. Detection of Apoptosing Retinal Cells (DARC) technology is to date the only tool of its kind to have been tested in clinical trials, with other new imaging techniques under investigation in the fields of neuroscience, ophthalmology and drug development. We summarize the transitioning of techniques detecting apoptosis from bench to bedside, along with the future possibilities they encase.

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