Analytical method for the identification and assay of 12 phthalates in cosmetic products: Application of the ISO 12787 international standard “Cosmetics–Analytical methods–Validation criteria for analytical results using chromatographic techniques”

2012 ◽  
Vol 1253 ◽  
pp. 144-153 ◽  
Author(s):  
Pascal Gimeno ◽  
Annie-Françoise Maggio ◽  
Claudine Bousquet ◽  
Audrey Quoirez ◽  
Corinne Civade ◽  
...  
Keyword(s):  
Analytical Method ◽  
Analytical Methods ◽  
Cosmetic Products ◽  
International Standard ◽  
Chromatographic Techniques ◽  
Analytical Results ◽  
Validation Criteria

Information content of the determinations of the amount of an analyte

1988 ◽  
Vol 53 (12) ◽  
pp. 3021-3028 ◽  
Author(s):  
Karel Eckschlager ◽  
Jiří Fusek
Keyword(s):  
Reference Material ◽  
Information Content ◽  
Analytical Method ◽  
Analytical Signal ◽  
Divergence Measure ◽  
Analytical Results

It is shown how the information content expressed in terms of the extended divergence measure I(r; p, p0) depends on the amount of the component to be determined when homoscedastic and heteroscedastic dependences of the analytical signal on the amount of the analyte are distinguished. The importance of the accuracy is pointed out, with which the amount of the analyte is known in a reference material employed for testing a particular analytical method. Rules are set, the maintaining of which is aimed at avoiding the origin of null information content of analytical results.

Spectrographic Analysis of Cast Iron Using Fused Buttons

1971 ◽  
Vol 25 (3) ◽  
pp. 342-344 ◽  
Author(s):  
John P. Cummings ◽  
Ronald H. Hall ◽  
Ronald J. Plenzler
Keyword(s):  
Weight Loss ◽  
Cast Iron ◽  
High Voltage ◽  
Analytical Method ◽  
White Cast Iron ◽  
Inert Atmosphere ◽  
Spectrographic Analysis ◽  
Analytical Results ◽  
Good Homogeneity

This paper presents an analytical method for the determination of minor metals in white cast iron fused buttons. This method enables the measurement of metals in cast iron with rapidity and excellent analytical results. Buttons of 40 g appear to be ideal but smaller button samples can be tolerated. The fused buttons have good homogeneity, very slight weight loss, and no significant change in composition. Metal cast spectrochemical samples are analyzed in an inert atmosphere utilizing a high voltage spark.

Developments in mycotoxin analysis: an update for 2010-2011

2012 ◽  
Vol 5 (1) ◽  
pp. 3-30 ◽  
Author(s):  
G. Shephard ◽  
F. Berthiller ◽  
P. Burdaspal ◽  
C. Crews ◽  
M. Jonker ◽  
...  
Keyword(s):  
Analytical Method ◽  
Analytical Methods ◽  
Method Development ◽  
Rapid Development ◽  
Ergot Alkaloids ◽  
Alternaria Toxins ◽  
Research Publications ◽  
Mycotoxin Analysis ◽  
The Subject ◽  
Conventional Methods

This review highlights developments in mycotoxin analysis and sampling over a period between mid-2010 and mid-2011. It covers the major mycotoxins: aflatoxins, Alternaria toxins, ergot alkaloids, fumonisins, ochratoxin, patulin, trichothecenes, and zearalenone. Analytical methods for mycotoxins continue to be developed and published. Despite much interest in immunochemical methods and in the rapid development of LC-MS methodology, more conventional methods, sometimes linked to novel clean-up protocols, have also been the subject of research publications over the above period. Occurrence of mycotoxins falls outside the main focus of this review; however, where relevant to analytical method development, this has been mentioned.

A Review: Method Development Validation and Degradation Studies of some Anticancer Drugs

2021 ◽  
pp. 5443-5448
Author(s):  
Punna Venkateshwarlu ◽  
Mehul M. Patel
Keyword(s):  
Liquid Chromatography ◽  
Anticancer Drugs ◽  
Analytical Method ◽  
Analytical Methods ◽  
Bioanalytical Methods ◽  
Method Development ◽  
Estimation Methods ◽  
Simultaneous Estimation ◽  
Pharmaceutical Dosage Forms ◽  
Stability Indicating

This article reviews the various analytical methods reported so far in the literature for the determination of stability and impurity profile the lenalidomide and palbociclib anti cancer drugs in single or combination with other drugs in bulk, pharmaceutical dosage forms, biological fluids, stability indicating and impurity profiling methods. The analytical methods used for the estimation of lenalidomide and palbociclib anticancer drugs reviewed in this paper includes ultraviolet spectrophotometry,high performance liquid chromatography (HPLC) ,ultra performance liquid chromatography (UPLC) ,liquid chromatography-mass spectrometry (LC-MS) and electrophoresis. This review focus on the effect of all chromatographic parameters so as to provide as fast, reliable and cost effective methodology of testing. Method development is the process of proving that analytical method is acceptable for use to measure the concentration of active pharmaceutical ingredient in a specific compound dosage form which must be validated to provide reliable data for regulatory submissions. This reviewed is mainly on analytical method development and validation, stability indicating methods, simultaneous estimation methods and bioanalytical methods. The review covers the time period from 2007 to 2019 during which analytical methods including all types of spectrophotometric and chromatographic techniques were reported. The Review covers lenalidomide and palbociclib API and formulation analytical and bioanalytical methods.

scholarly journals Dimensioning a Call Center: Simulation or Queue Theory?

2009 ◽  
Vol 2 (2) ◽  
pp. 34 ◽  
Author(s):  
Marco Aurélio Carino Bouzada
Keyword(s):  
Analytical Method ◽  
Analytical Methods ◽  
Call Center ◽  
Experimental Approach ◽  
Call Centers ◽  
Experimental Methods ◽  
New Approach ◽  
Alternative Methodology ◽  
Queue Theory ◽  
Set Up

The objective of this paper is to establish a dichotomy - opposing analytical methods (such as Queue Theory) to experimental methods (such as Simulation) and discussing their adequateness to complex operations - set up in the matter of dimensioning the handling capacity of a large brazilian call centers company. The literature related to the application of such methods at call centers is reviewed, and the way the question is treated nowadays by the company is described. Then an experimental approach is suggested to be implemented as an alternative methodology to deal with the issue, instead of the analytical method in use. The results obtained are used to justify the adequacy of the experimental approach to the modern call centers operation, as long as it is possible to have the model closer to reality. The main implication points to a better understanding of the operation achieved with the new approach

scholarly journals Synthesis of Deuterated Surrogate Standards for the Analysis of Legally Regulated Substances in Cosmetics

2020 ◽  
Author(s):  
Fariña Beatriz ◽  
Carlos González ◽  
Manuel Lolo ◽  
F. Javier Sardina
Keyword(s):  
European Union ◽  
Continuous Improvement ◽  
Analytical Methods ◽  
Raw Materials ◽  
Synthetic Methods ◽  
The European Union ◽  
Cosmetic Products ◽  
Musk Xylene ◽  
Harmful Substances ◽  
Musk Ambrette

<p>The presence of harmful substances in cosmetic products is regulated in most countries. In the European Union the Regulation (EC) No. 1223/2009 lays down the requirements for the marketing of cosmetic products. Among others, important families of compounds restricted in the Regulation are musks, allergenic fragrances and phthalates. To ensure product safety, improved analytical methods capable of reliably and reproducibly detecting the presence of traces of prohibited and/or restricted ingredients in raw materials and finished products are required. </p> <p>For the continuous improvement of the reliability of the analytical methods developed to check the compliance of cosmetic products with the Regulation, the use of appropriate surrogate standards or contaminants (substances that are added to the samples to be analyzed to establish the recovery and the reproducibility of the quantification of the analytes) are of utmost importance. One of the best kinds of surrogate standards are isotopically labeled analogs of the analytes of interest. In this work, several synthetic methods have been developed to prepare isotopically labeled analogs of atranol, chloroatranol, di-n-octylphthalate, musk xylene, and musk ambrette, which are restricted substances in cosmetic articles.</p>

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