The diagnostic value of apolipoprotein E in pediatric patients with invasive bacterial infections

2012 ◽  
Vol 45 (3) ◽  
pp. 215-218 ◽  
Author(s):  
Chuanqing Wang ◽  
Yi Wang ◽  
Aimin Wang ◽  
Pan Fu ◽  
Yi Yang
Keyword(s):  
Apolipoprotein E ◽  
Bacterial Infections ◽  
Pediatric Patients ◽  
Diagnostic Value

scholarly journals Ceftazidime as initial therapy for suspected bacterial infections in hospitalized pediatric patients.

1984 ◽  
Vol 26 (3) ◽  
pp. 318-321 ◽  
Author(s):  
M D Reed ◽  
C A O'Brien ◽  
S C Aronoff ◽  
J D Klinger ◽  
J L Blumer
Keyword(s):  
Bacterial Infections ◽  
Pediatric Patients ◽  
Initial Therapy

scholarly journals Usefulness of procalcitonin (PCT), C-reactive protein (CRP), and white blood cell (WBC) levels in the differential diagnosis of acute bacterial, viral, and mycoplasmal respiratory tract infections in children

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yang Li ◽  
Lanfang Min ◽  
Xin Zhang
Keyword(s):  
Differential Diagnosis ◽  
Respiratory Tract ◽  
Bacterial Infection ◽  
Bacterial Infections ◽  
Respiratory Tract Infections ◽  
Respiratory Infections ◽  
Diagnostic Value ◽  
Significant Difference ◽  
Group A ◽  
Tract Infections

Abstract Background There is a lack of studies comparing PCT, CRP and WBC levels in the differential diagnosis of acute bacterial, viral, and mycoplasmal respiratory tract infections. It is necessary to explore the correlation between above markers and different types of ARTI. Methods 108 children with confirmed bacterial infection were regarded as group A, 116 children with virus infection were regarded as group B, and 122 children with mycoplasmal infection were regarded as group C. The levels of PCT, CRP and WBC of the three groups were detected and compared. Results The levels of PCT, CRP and WBC in group A were significantly higher than those in groups B and C (p < 0.05). The positive rate of combined detection of PCT, CRP and WBC was significant higher than that of single detection. There was no significant difference in PCT, CRP and WBC levels between the group of G+ bacterial infection and G− bacterial infection (p > 0.05). ROC curve results showed that the AUC of PCT, CRP and WBC for the diagnosis of bacterial respiratory infections were 0.65, 0.55, and 0.58, respectively. Conclusions PCT, CRP and WBC can be combined as effective indicators for the identification of acute bacterial or no-bacterial infections in children. The levels of PCT and CRP have higher differential diagnostic value than that of WBC in infection, and the combined examination of the three is more valuable in clinic.

Unreliability of Radiographic Diagnosis of Septic Hip in Children

PEDIATRICS ◽  
1984 ◽  
Vol 74 (1) ◽  
pp. 118-120
Author(s):  
Frank M. Volberg ◽  
Thomas E. Sumner ◽  
Jon S. Abramson ◽  
Patricia H. Winchester
Keyword(s):  
Bacterial Infections ◽  
Pediatric Patients ◽  
Radiographic Findings ◽  
Radiographic Diagnosis ◽  
Joint Aspiration ◽  
Lateral Subluxation

The radiographs of 19 pediatric patients with aspiration-proven bacterial infections of the hip were analyzed. The hip radiograph was abnormal in all neonates showing lateral subluxation. The radiograph was negative in eight of ten children more than 1 year of age. It is emphasized that children with suspected septic hip require immediate joint aspiration regardless of radiographic findings.

scholarly journals Cerebrospinal fluid neopterin as a biomarker of neuroinflammatory diseases

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Marta Molero-Luis ◽  
Didac Casas-Alba ◽  
Gabriela Orellana ◽  
Aida Ormazabal ◽  
Cristina Sierra ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Discriminant Analysis ◽  
Bacterial Infections ◽  
Pediatric Patients ◽  
Canonical Discriminant Analysis ◽  
Control Group ◽  
Csf Biomarkers ◽  
Molecular Testing ◽  
Respiratory Pathogens

Abstract The elevation of neopterin in cerebrospinal fluid (CSF) has been reported in several neuroinflammatory disorders. However, it is not expected that neopterin alone can discriminate among different neuroinflammatory etiologies. We conducted an observational retrospective and case–control study to analyze the CSF biomarkers neopterin, total proteins, and leukocytes in a large cohort of pediatric patients with neuroinflammatory disorders. CSF samples from 277 subjects were included and classified into four groups: Viral meningoencephalitis, bacterial meningitis, acquired immune-mediated disorders, and patients with no-immune diseases (control group). CSF neopterin was analyzed with high-performance liquid chromatography. Microbiological diagnosis included bacterial CSF cultures and several specific real-time polymerase chain reactions. Molecular testing for multiple respiratory pathogens was also included. Antibodies against neuronal and glial proteins were tested. Canonical discriminant analysis of the three biomarkers was conducted to establish the best discriminant functions for the classification of the different clinical groups. Model validation was done by biomarker analyses in a new cohort of 95 pediatric patients. CSF neopterin displayed the highest values in the viral and bacterial infection groups. By applying canonical discriminant analysis, it was possible to classify the patients into the different groups. Validation analyses displayed good results for neuropediatric patients with no-immune diseases and for viral meningitis patients, followed by the other groups. This study provides initial evidence of a more efficient approach to promote the timely classification of patients with viral and bacterial infections and acquired autoimmune disorders. Through canonical equations, we have validated a new tool that aids in the early and differential diagnosis of these neuroinflammatory conditions.

scholarly journals Vancomycin Dosage and Its Association with Clinical Outcomes in Pediatric Patients with Gram-Positive Bacterial Infections

2020 ◽  
Vol Volume 13 ◽  
pp. 685-695
Author(s):  
Sooyoung Shin ◽  
Hyun Joo Jung ◽  
Sang-Min Jeon ◽  
Young-Joon Park ◽  
Jung-Woo Chae ◽  
...  
Keyword(s):  
Clinical Outcomes ◽  
Bacterial Infections ◽  
Pediatric Patients ◽  
Gram Positive ◽  
Vancomycin Dosage

Bacterial infections in pediatric patients during early post liver transplant period: A prospective study in Iran

2018 ◽  
Vol 21 (1) ◽  
pp. e13001 ◽  
Author(s):  
Gholamreza Pouladfar ◽  
Zahra Jafarpour ◽  
Seyed Ali Malek Hosseini ◽  
Mohammad Firoozifar ◽  
Razieh Rasekh ◽  
...  
Keyword(s):  
Prospective Study ◽  
Liver Transplant ◽  
Bacterial Infections ◽  
Pediatric Patients ◽  
A Prospective Study

scholarly journals Hyponatremia in Infectious Diseases—A Literature Review

2020 ◽  
Vol 17 (15) ◽  
pp. 5320 ◽  
Author(s):  
Anna L. Królicka ◽  
Adrianna Kruczkowska ◽  
Magdalena Krajewska ◽  
Mariusz A. Kusztal
Keyword(s):  
Bacterial Infections ◽  
Infection Type ◽  
Sodium Concentration ◽  
Diagnostic Value ◽  
Community Acquired Pneumonia ◽  
Human Organism ◽  
Diagnostic Role ◽  
Concentration Threshold ◽  
Meta Analyses ◽  
Common Infections

Hyponatremia is one of the most common water–electrolyte imbalances in the human organism. A serum sodium concentration threshold of less than 135 mmol/L is diagnostic for hyponatremia. The disorder is usually secondary to various diseases, including infections. Our review aims to summarize the diagnostic value and impact of hyponatremia on the prognosis, length of the hospitalization, and mortality among patients with active infection. The scientific literature regarding hyponatremia was reviewed using PubMed, ClinicalKey, and Web of Science databases. Studies published between 2011 and 2020 were screened and eligible studies were selected according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) statement and specific inclusion criteria. The most common infections that were associated with hyponatremia were viral and bacterial infections, including COVID-19 (coronavirus disease 2019). The etiology varied according to the infection site, setting and patient cohort it concerned. In several studies, hyponatremia was associated with prolonged hospitalization, worse outcomes, and higher mortality rates. Hyponatremia can also play a diagnostic role in differentiating pathogens that cause a certain infection type, as it was observed in community-acquired pneumonia. Although many mechanisms leading to hyponatremia have already been described, it is impossible with any certainty to ascribe the etiology of hyponatremia to any of them.

scholarly journals Diagnostic Value of Serum Procalcitonin in Patients with Convulsion in Emergency Department, an Observational Study

Antibiotics ◽  
2020 ◽  
Vol 9 (10) ◽  
pp. 683
Author(s):  
Hisashi Murakami ◽  
Hiromu Naraba ◽  
Takashi Gondo ◽  
Masaki Mochizuki ◽  
Hidehiko Nakano ◽  
...  
Keyword(s):  
Emergency Department ◽  
Bacterial Infection ◽  
Likelihood Ratio ◽  
Bacterial Infections ◽  
Care Center ◽  
Positive Likelihood Ratio ◽  
Diagnostic Value ◽  
Control Group ◽  
Diagnostic Values ◽  
Group Members

Procalcitonin (PCT), a widely used biomarker for bacterial infections, is sometimes measured in convulsion patients to distinguish bacterial infections including bacterial meningitis. However, serum PCT elevation is reported in several other conditions. This study assessed the diagnostic value of serum PCT concentrations in convulsion patients. This study examined a convulsion group: patients admitted to our critical care center during April 2018 through September 2019 via the emergency department presenting with convulsions. Randomly sampled patients admitted without convulsions were categorized as a non-convulsion group. Serum PCT analysis was performed with consideration of whether or not the patient had an infection. Diagnostic values of serum PCT for bacterial infection were evaluated for convulsion and non-convulsion patients using the positive likelihood ratio of PCT. This study found 84 patients as eligible for the convulsion group; 1:2 matched 168 control patients were selected as non-convulsion group members. The positive likelihood ratio for bacterial infection was found to be significantly lower in the convulsion group than in the control group (1.94 vs. 2.65) when setting the positive cut-off for PCT as 0.5 ng/mL. Convulsion patients had a higher PCT value. The positive likelihood ratio for patients without bacterial infection was lower.

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