The usefulness of advanced lipid and oxidative stress testing for diagnosis and management of low HDL-cholesterol phenotype: A case report

Background: Pterocarpus santalinoides stem bark is commonly used in Cameroonian medicine to treat many diseases including hypertension. Thus, this study was aimed to evaluate preventive effects of aqueous extract of Pterocarpus santalinoides (AEPS) stem bark on NG-Nitro-L-arginine-methyl ester (LNAME)-induced hypertension in rat. Methods: Normotensive rats received L-NAME (25 mg/kg intraperitoneally) concomitantly with AEPS (50, 100 and 200 mg/kg) or captopril (20 mg/kg) orally during 3 weeks. At the end of experimental period, arterial pressure and heart rate were recorded by invasive method. After sacrifice, blood, aorta and heart were harvested for biochemical analysis on homogenate. Results: Intraperitoneal injection of L-NAME induced in rat a significant increase (p < 0.001; p < 0.01; p < 0.05) of blood pressure, heart rate, malondialdehyde, total cholesterol, triglycerides, LDL-cholesterol, hepatic and renal markers functions. L-NAME also decreased significantly (p < 0.001; p < 0.01; p < 0.05) the levels of HDL-cholesterol, nitrites, glutathione, superoxide dismutase and catalase activities as compared to control rats. The AEPS prevented significantly the increase (p < 0.001) of hemodynamic parameters induced by L-NAME and various modifications of biochemical parameters (lipid profile, hepatic and renal markers functions) and oxidative stress markers evaluated. Conclusion: This study shows that the aqueous extract of Pterocarpus santalinoides prevents hypertension, dyslipidemia and oxidative stress induced by L-NAME in rat by attenuating endothelial dysfunction, liver and kidney’s damages

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A normotriglyceridemic, low HDL-cholesterol phenotype is characterised by elevated oxidative stress and HDL particles with attenuated antioxidative activity

Atherosclerosis ◽

10.1016/j.atherosclerosis.2005.03.001 ◽

2005 ◽

Vol 182 (2) ◽

pp. 277-285 ◽

Cited By ~ 81

Author(s):

Anatol Kontush ◽

Eliana Cotta de Faria ◽

Sandrine Chantepie ◽

M. John Chapman

Keyword(s):

Oxidative Stress ◽

Antioxidative Activity ◽

Hdl Cholesterol ◽

Low Hdl

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Lipid profile, apolipoprotein A-I and oxidative stress in professional footballers, sedentary individuals, and their relatives

Arquivos Brasileiros de Endocrinologia & Metabologia ◽

10.1590/s0004-27302011000200004 ◽

2011 ◽

Vol 55 (2) ◽

pp. 121-126 ◽

Cited By ~ 7

Author(s):

Aline Margioti Zanella ◽

Marcelo Arruda Nakazone ◽

Marcela Augusta Souza Pinhel ◽

Dorotéia Rossi Silva Souza

Keyword(s):

Oxidative Stress ◽

Physical Activity ◽

Physical Exercise ◽

Lipid Profile ◽

Ldl Cholesterol ◽

Hdl Cholesterol ◽

Beneficial Effects ◽

Apolipoprotein A ◽

And Oxidative Stress ◽

Cholesterol Fraction

OBJECTIVE: To evaluate whether lipid profile (LP), apolipoprotein A-1 (apo A-I) and malondialdehyde (MDA) have any relationship with physical exercise by comparing the groups of footballers (FG) with sedentary individuals (CG) and their relatives (RFG and RCG). SUBJECTS AND METHODS: Twenty individuals from FG and CG, 60 from RFG, and 57 from RCG were studied. RESULTS: FG showed lower levels of total cholesterol (119.5 ± 37.9 mg/dL), LDL-cholesterol fraction (53.6 ± 30.3), apo A-I (116.7 ± 11.9), and higher level of HDL-cholesterol fraction (HDLc) (49.7 ± 8.5) compared to RFG (148.3 ± 36.9, P = 0.02; 82.4 ± 37.7, P < 0.01; 124.6 ± 10.2, P = 0.03; and 42.7 ± 7.7, P < 0.01; respectively). Moreover, FG had reduced levels of MDA (101.0 ± 77.0 ng/mL) compared to CG (290.0 ± 341.0, P = 0.03) and RFG (209.9 ± 197.5, P = 0.04). CONCLUSIONS: These results suggest an association between physical exercise and lower levels of MDA in FG. Physical activity seems to promote beneficial effects on the LP regardless of the genetic influence considering HDLc levels.

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A case report of a diabetic woman with very low HDL cholesterol

Journal of Clinical Lipidology ◽

10.1016/j.jacl.2010.01.003 ◽

2010 ◽

Vol 4 (2) ◽

pp. 133-135

Author(s):

Leila Chaychi ◽

William B. Kinlaw ◽

Bela F. Asztalos ◽

Ernest J. Schaefer

Keyword(s):

Case Report ◽

Hdl Cholesterol ◽

Diabetic Woman ◽

Low Hdl

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Insulin-Leptin Axis, Cardiometabolic Risk and Oxidative Stress in Elderly with Metabolic Syndrome

Experimental and Clinical Endocrinology & Diabetes ◽

10.1055/s-0043-123825 ◽

2018 ◽

Vol 126 (07) ◽

pp. 445-452 ◽

Cited By ~ 6

Author(s):

Daniela Gradinaru ◽

Husseina Khaddour ◽

Denisa Margina ◽

Anca Ungurianu ◽

Claudia Borsa ◽

...

Keyword(s):

Oxidative Stress ◽

Metabolic Syndrome ◽

Uric Acid ◽

Resistance Index ◽

Hdl Cholesterol ◽

Elderly Subjects ◽

Control Group ◽

Oxidative Stress Biomarkers ◽

The Metabolic Syndrome ◽

And Oxidative Stress

AbstractInsulin and leptin have an overlapping anorexigenic action as well as opposite effects on glucose and lipid metabolism. The study focuses on the biochemical and clinical relevance of new indices of insulin-leptin axis utilized in the study of the relationships between leptinemia, insulin sensitivity and oxidative stress, in elderly subjects with metabolic syndrome. We conducted clinical studies on elderly people with metabolic syndrome versus control subjects by creating new insulin-adipogenic indices, namely Insulin-to-Leptin Ratio (ILR) and Insulin-Adipogenic Resistance index (IAR-index). Inflammation and oxidative stress biomarkers evaluated were the high-sensitivity C-reactive protein (hsCRP), the advanced oxidation protein products (AOPP), and the serum antioxidant capacity measured as ferric reducing antioxidant potential (FRAP). The metabolic syndrome group showed significantly (p<0.01) lower levels of ILR and not significant (p=0.09) higher values of IAR-index, as compared to the control group. In metabolic syndrome subjects, the IAR-index was significantly positively correlated with uric acid (r=0.313, p<0.05), FRAP (r=0.347, p<0.05) and AOPP (r=0.677, p<0.01), and negatively correlated with HDL-cholesterol (r=− 0.340, p<0.05) as well as with the ratio FRAP/uric acid (r=− 0.315, p<0.05). ILR and IAR-index reflected the biological state of adipose and pancreatic β-cells and seem to depict the adipo-insular axis status related to metabolic and oxidative stress better than individual markers. Therefore, ILR and IAR-index could represent integrated high-potential biomarkers for disease and patient stratification.

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Can monocyte to HDL cholesterol ratio and monocyte to lymphocyte ratio be markers for inflammation and oxidative stress in patients with vitiligo? A preliminary study

Archives of Dermatological Research ◽

10.1007/s00403-020-02129-3 ◽

2020 ◽

Author(s):

Abdullah Demirbaş ◽

Ömer Faruk Elmas ◽

Mustafa Atasoy ◽

Ümit Türsen ◽

Torello Lotti

Keyword(s):

Oxidative Stress ◽

Hdl Cholesterol ◽

Cholesterol Ratio ◽

Lymphocyte Ratio ◽

Preliminary Study ◽

And Oxidative Stress

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Relationship Between C-Reactive Protein and Atherosclerotic Risk Factors and Oxidative Stress Markers Among Young Persons 10–18 Years Old

Clinical Chemistry ◽

10.1373/clinchem.2006.073668 ◽

2007 ◽

Vol 53 (3) ◽

pp. 456-464 ◽

Cited By ~ 37

Author(s):

Roya Kelishadi ◽

Mohsen Sharifi ◽

Alireza Khosravi ◽

Khosrow Adeli

Keyword(s):

Oxidative Stress ◽

Blood Pressure ◽

Metabolic Syndrome ◽

Young People ◽

Hdl Cholesterol ◽

Oxidative Stress Markers ◽

C Reactive Protein ◽

Reactive Protein ◽

Stress Markers ◽

And Oxidative Stress

AbstractBackground: This study was undertaken to determine the association of serum C-reactive protein (CRP) with generalized and abdominal obesity, body fat composition, the metabolic syndrome, and oxidative stress markers among young people.Methods: We conducted a population-based study of 512 young people, aged 10–18 years. We obtained anthropometric and blood pressure measurements. Fasting blood sugar, total cholesterol (TC), HDL-cholesterol, triglycerides, CRP, malondialdehyde (MDA), and conjugated diene (CDE) were quantified. LDL-cholesterol (LDL-C) was calculated for samples with TG ≤4.52 mmol/LResults: Mean triglycerides, waist and hip circumferences, percentage body fat, subcutaneous fat, and systolic blood pressure increased significantly with increasing body mass index (BMI). In contrast, the mean LDL and TC were higher in underweight than normal weight individuals, and then increased significantly from normal to higher BMI categories. Mean HDL cholesterol significantly decreased with increasing BMI. Overall, CRP, MDA, and CDE were significantly correlated with measures of abdominal obesity. Serum CRP, MDA, and CDE significantly increased in the upper quartiles of waist circumference. Study participants with higher CRP concentrations were more likely to have metabolic syndrome and high oxidative stress markers.Conclusion: We found a significant positive association between CRP and oxidative stress markers in healthy young people, as well as an increase in these markers in the upper quartiles of waist circumference, but not BMI. Oxidative stress and CRP may interact in the early inflammatory processes of atherosclerosis.

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