In this paper studied the impact of the partial replacement of the cement by self-cure polymer (polymethyl methacrylate PMMA) in different ratios on the compressive strength, flexural strength and microstructural analysis, five ratios of cement replacement (1%, 3%, 5%, 7%, and 9%) by PMMA, these tests have been performed after curing at an early age (7days) and standard age (28days). The preparation of the mortar has been performed with the use of 1:2 cement to the sand ratio by weight, with (0.5) water to binder ratio and polymer to self-cure monomer (methyl methacrylate MMA) ratio 2:1. Results have shown that the flexural and the compressive strengths of mortars have been increased with increasing the ratio of the replacement (1%, 3%, 5%) and then decreased at replacement ratio (7% and 9%). The best results of the new cement mortar were reached at the partial replacement of cement with 5% of PMMA were recorded enhancement of compressive strength15.8% at an early age and 24.4% for standard age and enhancement of flexural strength 16.8% at an early age and 19.4% for standard age, from scanning electron microscopy SEM analysis observed the PMMA filling the pores and form more homogeneous microstructure in G32 as compared with the microstructure of G1.