scholarly journals Management of targeted therapies in cancer patients with chronic kidney disease, or on haemodialysis: An Associazione Italiana di Oncologia Medica (AIOM)/Societa’ Italiana di Nefrologia (SIN) multidisciplinary consensus position paper

2019 ◽  
Vol 140 ◽  
pp. 39-51 ◽  
Author(s):  
Nicola Silvestris ◽  
Antonella Argentiero ◽  
Laura Cosmai ◽  
Camillo Porta ◽  
Loreto Gesualdo ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Cancer Patients ◽  
Targeted Therapies ◽  
Position Paper

Thrombosis and kidney disease in cancer: comorbidities defining a very high risk patient: A position paper from the Cancer & the Kidney International Network

2018 ◽  
Vol 2 (2-3) ◽  
pp. 37-49 ◽  
Author(s):  
Vincent Launay-Vacher ◽  
Florian Scotté ◽  
Hanno Riess ◽  
Neil Ashman ◽  
Philip McFarlane ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Cancer Patients ◽  
Working Group ◽  
High Risk Patient ◽  
Position Paper ◽  
International Network ◽  
Direct Anticoagulants ◽  
Special Working ◽  
Special Working Group

Cancer & the Kidney International Network was created in 2014. The aim was to improve the management of cancer patients by developing clinical and scientific knowledge on the main topic of cancer and the kidney. Therefore, the Cancer & the Kidney International Network created a special working group: the Thrombosis, Kidney Disease, and Cancer working Group. The first step of this force was to produce a position paper on this topic by investigating the association of chronic kidney disease and venous thromboembolism in cancer patients, focusing particularly on the anticoagulant management of patients presenting these three comorbidities. The use of low-molecular-weight heparins, vitamin K agonists and oral direct anticoagulants in cancer patients with chronic kidney disease was reviewed.

scholarly journals Management of dyslipidaemia in patients with chronic kidney disease: a position paper endorsed by the Italian Society of Nephrology

2020 ◽  
Vol 33 (3) ◽  
pp. 417-430 ◽  
Author(s):  
Roberto Pontremoli ◽  
Vincenzo Bellizzi ◽  
Stefano Bianchi ◽  
Roberto Bigazzi ◽  
Valeria Cernaro ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Position Paper ◽  
Italian Society

Baseline chronic kidney disease is associated with toxicity and survival in patients treated with targeted therapies for metastatic renal cell carcinoma

2015 ◽  
Vol 26 (8) ◽  
pp. 866-871 ◽  
Author(s):  
François-Xavier Nouhaud ◽  
Christian Pfister ◽  
Guillaume Defortescu ◽  
Anthony Giwerc ◽  
David Charbit ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Renal Cell Carcinoma ◽  
Kidney Disease ◽  
Cell Carcinoma ◽  
Metastatic Renal Cell Carcinoma ◽  
Targeted Therapies ◽  
Renal Cell

scholarly journals The Impact of COVID-19 Pandemic in Portuguese Cancer Patients: A Retrospective Study

2021 ◽  
Vol 18 (16) ◽  
pp. 8552
Author(s):  
Aurea Lima ◽  
Hugo Sousa ◽  
Amanda Nobre ◽  
Ana Luisa Faria ◽  
Manuela Machado
Keyword(s):  
Chronic Kidney Disease ◽  
Retrospective Study ◽  
Kidney Disease ◽  
Cancer Patients ◽  
Cardiac Disease ◽  
Severe Disease ◽  
Clinicopathological Characteristics ◽  
Increased Risk ◽  
Immunosuppressed Patients ◽  
The Impact

Literature reports that SARS-CoV-2 infection in cancer patients may be associated with higher severity and mortality, nevertheless the knowledge is limited. We aimed to describe patients’ demographic characteristics and COVID-19 disease outcomes in Portuguese cancer patients. We conducted a retrospective study in a cohort of cancer patients diagnosed with COVID-19. A total of 127 individuals were included: 46.5% males and 53.5% females, with a median age of 72 years. Clinicopathological characteristics were used in univariate and multivariable logistic regression analyses to estimate odds ratios for each variable with outcomes adjusting for potential confounders. Our cohort revealed that 84.3% of patients had more than one risk factor for severe disease rather than cancer. In total, 36.2% of patients were admitted to the Department of Internal Medicine, 14.2% developed severe disease, 1.6% required Intensive Care Unit, and mortality was observed in 11.8%. Severe COVID-19 disease was associated with unfit (ECOG PS > 2) patients (p = 0.009; OR = 6.39; 95% CI: 1.60–25.59), chronic kidney disease (p = 0.004; OR = 20.7; 95% CI: 2.64–162.8), immunosuppression (p < 0.001; OR = 10.3; 95% CI: 2.58–41.2), and presence of respiratory symptoms at diagnosis (p = 0.033; OR = 5.05; 95% CI: 1.14–22.4). Increased risk for mortality was associated with unfit patients (p = 0.036; OR = 4.22; 95% CI: 1.10–16.3), cardiac disease (p = 0.003; OR = 8.26; 95% CI: 2.03–33.6) and immunosuppression (p = 0.022; OR = 5.06; 95% CI: 1.27–20.18). Our results demonstrated that unfit and immunosuppressed patients, with chronic kidney disease and cardiac disease, have, respectively, an increased risk for severe disease and mortality related to COVID-19. Hence, this study provides important information on risk factors for severe COVID-19 disease and associated mortality in a Portuguese cancer population.

scholarly journals Long-Term Outcomes of Pulmonary Resection for Lung Cancer Patients with Chronic Kidney Disease

2019 ◽  
Vol 43 (12) ◽  
pp. 3249-3258 ◽  
Author(s):  
Yoko Yamamoto ◽  
Ryu Kanzaki ◽  
Takashi Kanou ◽  
Naoko Ose ◽  
Soichiro Funaki ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Cancer Patients ◽  
Pulmonary Resection ◽  
Long Term Outcomes ◽  
Lung Cancer Patients

A single-center study of cancer and chemotherapy-induced kidney disease.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e13062-e13062
Author(s):  
Abu-Sayeef Mirza ◽  
Sarah Mushtaq ◽  
Revati Reddy ◽  
Mina Mousa ◽  
Chandrashekar Bohra ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Cancer Patients ◽  
Kidney Cancer ◽  
Kinase Inhibitors ◽  
Retrospective Chart Review ◽  
Chemotherapeutic Agents ◽  
Cancer Center ◽  
P Value ◽  
Renal Outcomes

e13062 Background: It is clinically understood that chronic kidney disease (CKD) and cancer are interrelated. Yet, few studies measure how renal outcomes vary according to common malignancies and common therapeutic agents. We report the incidence and the nature of CKD among cancer patients from a single institution. Methods: A retrospective chart review of cancer patients managed in the onconephrology clinic at the Moffitt Cancer Center from 05/01/2015 to 07/31/2016 was conducted. Patients with acute or chronic kidney disease secondary to a malignancy or side effect of chemotherapy were included in this study. Renal function outcomes were recorded at three-month follow-up intervals from the 15-month duration. Results: Out of the total 88 patients with median age of 68 years, 63 patients were diagnosed with chronic kidney disease, whereas the remaining had acute kidney injury. Kidney cancer and multiple myeloma represented the largest proportion with 12 patients each. Patients with kidney cancer had a mean creatinine of (2.35, 1.74) mg/dl compared to patients without kidney cancer with creatinine (1.97, 1.07) mg/dl. Abdominal cancers had the highest proportion of chronic kidney disease (84.21%) whereas 81.48% of patients with genitourinary cancers had chronic kidney disease. Patients prescribed tyrosine kinase inhibitors had a lower average estimated glomerular filtration rate (28.37, 9.86) mL/min/1.73 m2 compared to other chemotherapeutic agents, though this was a weakly significant relationship (p-value = 0.07). Similar renal outcomes according to malignancy and chemotherapy are reported. Conclusions: This group of patients demonstrated the frequency of chronic kidney disease differs depending on the type of malignancy or chemotherapy. A multidisciplinary approach involving oncologists and nephrologists should be adopted to prevent further renal damage from cancer and its therapies.

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