Modeling epigenetic modifications under multiple treatment conditions

By the application of cognitive technique, aversive stimulus and positive nonverbal reinforcement, an attempt was made to control thumb-sucking behavior of a school girl in a Grade 4 classroom. During the first baseline period, thumb-sucking occurred on the average 63% a class-session but decreased on an average of 12% after treatment. With reinstatement of baseline conditions, it rose to an average of 54%, but after second experimental phase decreased to a mean of 5.1%. No recurrence appeared during the last days. Use of multiple treatment conditions limited interpretations.

Download Full-text

multiDE: a dimension reduced model based statistical method for differential expression analysis using RNA-sequencing data with multiple treatment conditions

BMC Bioinformatics ◽

10.1186/s12859-016-1111-9 ◽

2016 ◽

Vol 17 (1) ◽

Cited By ~ 3

Author(s):

Guangliang Kang ◽

Li Du ◽

Hong Zhang

Keyword(s):

Statistical Method ◽

Differential Expression ◽

Rna Sequencing ◽

Expression Analysis ◽

Differential Expression Analysis ◽

Reduced Model ◽

Sequencing Data ◽

Multiple Treatment ◽

Model Based ◽

Treatment Conditions

Download Full-text

Bang for Your Buck: A Single-Case Experimental Design Study of Practice Amount and Distribution in Treatment for Childhood Apraxia of Speech

Journal of Speech Language and Hearing Research ◽

10.1044/2019_jslhr-s-18-0212 ◽

2019 ◽

Vol 62 (9) ◽

pp. 3160-3182 ◽

Cited By ~ 4

Author(s):

Edwin Maas ◽

Christina Gildersleeve-Neumann ◽

Kathy Jakielski ◽

Nicolette Kovacs ◽

Ruth Stoeckel ◽

...

Keyword(s):

Single Case ◽

Evidence Base ◽

Distributed Practice ◽

Single Subject ◽

Single Subject Design ◽

Apraxia Of Speech ◽

Childhood Apraxia Of Speech ◽

Opposite Pattern ◽

Massed Practice ◽

Treatment Conditions

Purpose The aim of this study was to examine 2 aspects of treatment intensity in treatment for childhood apraxia of speech (CAS): practice amount and practice distribution. Method Using an alternating-treatments single-subject design with multiple baselines, we compared high versus low amount of practice, and massed versus distributed practice, in 6 children with CAS. Conditions were manipulated in the context of integral stimulation treatment. Changes in perceptual accuracy, scored by blinded analysts, were quantified with effect sizes. Results Four children showed an advantage for high amount of practice, 1 showed an opposite effect, and 1 showed no condition difference. For distribution, 4 children showed a clear advantage for massed over distributed practice post treatment; 1 showed an opposite pattern, and 1 showed no clear difference. Follow-up revealed a similar pattern. All children demonstrated treatment effects (larger gains for treated than untreated items). Conclusions High practice amount and massed practice were associated with more robust speech motor learning in most children with CAS, compared to low amount and distributed practice, respectively. Variation in effects across children warrants further research to determine factors that predict optimal treatment conditions. Finally, this study adds to the evidence base supporting the efficacy of integral stimulation treatment for CAS. Supplemental Material https://doi.org/10.23641/asha.9630599

Download Full-text

Maximizing Outcomes in Group Treatment of Aphasia: Lessons Learned From a Community-Based Center

Perspectives on Neurophysiology and Neurogenic Speech and Language Disorders ◽

10.1044/nnsld24.3.100 ◽

2014 ◽

Vol 24 (3) ◽

pp. 100-105 ◽

Cited By ~ 1

Author(s):

Darlene Williamson

Keyword(s):

Group Treatment ◽

Treatment Protocol ◽

Lessons Learned ◽

Group Program ◽

Community Based ◽

Multiple Treatment ◽

Use Of Technology ◽

Communication Impairments ◽

Treatment Settings

Given the potential of long term intervention to positively influence speech/language and psychosocial domains, a treatment protocol was developed at the Stroke Comeback Center which addresses communication impairments arising from chronic aphasia. This article presents the details of this program including the group purposes and principles, the use of technology in groups, and the applicability of a group program across multiple treatment settings.

Download Full-text

Optimal Experimental Design With Nesting of Persons in Organizations

Zeitschrift für Psychologie ◽

10.1027/2151-2604/a000143 ◽

2013 ◽

Vol 221 (3) ◽

pp. 145-159 ◽

Cited By ~ 1

Author(s):

Gerard J. P. van Breukelen

Keyword(s):

Repeated Measures ◽

Optimal Number ◽

Health Centers ◽

Randomized Experiments ◽

Optimal Sample ◽

Treatment Conditions ◽

Sampling Cost ◽

Nested Designs ◽

Simple Equations ◽

Number Of Individuals

This paper introduces optimal design of randomized experiments where individuals are nested within organizations, such as schools, health centers, or companies. The focus is on nested designs with two levels (organization, individual) and two treatment conditions (treated, control), with treatment assignment to organizations, or to individuals within organizations. For each type of assignment, a multilevel model is first presented for the analysis of a quantitative dependent variable or outcome. Simple equations are then given for the optimal sample size per level (number of organizations, number of individuals) as a function of the sampling cost and outcome variance at each level, with realistic examples. Next, it is explained how the equations can be applied if the dependent variable is dichotomous, or if there are covariates in the model, or if the effects of two treatment factors are studied in a factorial nested design, or if the dependent variable is repeatedly measured. Designs with three levels of nesting and the optimal number of repeated measures are briefly discussed, and the paper ends with a short discussion of robust design.

Download Full-text