Nanoporous metal organic frameworks as hybrid polymer–metal composites for drug delivery and biomedical applications

2017 ◽  
Vol 22 (4) ◽  
pp. 625-637 ◽  
Author(s):  
Sarwar Beg ◽  
Mahfoozur Rahman ◽  
Atul Jain ◽  
Sumant Saini ◽  
Patrick Midoux ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Metal Organic Frameworks ◽  
Hybrid Polymer ◽  
Metal Composites ◽  
Nanoporous Metal ◽  
Polymer Metal ◽  
Metal Organic

scholarly journals Recent Trends in Covalent and Metal Organic Frameworks for Biomedical Applications

Nanomaterials ◽  
2018 ◽  
Vol 8 (11) ◽  
pp. 916 ◽  
Author(s):  
Georges Chedid ◽  
Ali Yassin
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Materials Science ◽  
High Surface ◽  
Metal Organic Frameworks ◽  
Great Promise ◽  
Surface Areas ◽  
Metal Organic ◽  
New Type ◽  
Recent Trends

Materials science has seen a great deal of advancement and development. The discovery of new types of materials sparked the study of their properties followed by applications ranging from separation, catalysis, optoelectronics, sensing, drug delivery and biomedicine, and many other uses in different fields of science. Metal organic frameworks (MOFs) and covalent organic frameworks (COFs) are a relatively new type of materials with high surface areas and permanent porosity that show great promise for such applications. The current study aims at presenting the recent work achieved in COFs and MOFs for biomedical applications, and to examine some challenges and future directions which the field may take. The paper herein surveys their synthesis, and their use as Drug Delivery Systems (DDS), in non-drug delivery therapeutics and for biosensing and diagnostics.

Chiral Nanoporous Metal-Organic Frameworks with High Porosity as Materials for Drug Delivery

2011 ◽  
Vol 23 (47) ◽  
pp. 5629-5632 ◽  
Author(s):  
Chun-Yi Sun ◽  
Chao Qin ◽  
Chun-Gang Wang ◽  
Zhong-Min Su ◽  
Shuang Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Metal Organic Frameworks ◽  
High Porosity ◽  
Nanoporous Metal ◽  
Metal Organic

Selenium-Containing Polymer@Metal-Organic Frameworks Nanocomposites as an Efficient Multiresponsive Drug Delivery System

2016 ◽  
Vol 27 (6) ◽  
pp. 1605465 ◽  
Author(s):  
Weiqiang Zhou ◽  
Lu Wang ◽  
Feng Li ◽  
Weina Zhang ◽  
Wei Huang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Metal Organic Frameworks ◽  
Polymer Metal ◽  
Metal Organic

Recent advances in Fe-MOF compositions for in biomedical applications

2021 ◽  
Vol 28 ◽  
Author(s):  
Yuyu Zhong ◽  
Weicong Liu ◽  
Congying Rao ◽  
Baohong Li ◽  
Xiaoxiong Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Porous Materials ◽  
Antibacterial Agent ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Biomedical Application ◽  
Metal Organic Frameworks ◽  
Medical Applications ◽  
Future Perspectives ◽  
Metal Organic

Background: To date, a number of new and attractive materials have been applied in drug delivery systems (DDDs) to improve the efficiency of the treatment of cancers. Some problems like low stability, toxicity, and weak ability of targeting have hampered most of the materials for further applications in biomedicine. MIL(MIL = Materials of Institute Lavoisier), as a typical subclass of metal-organic frameworks (MOFs), owns more advantages than other subclass MOFs, such as better biodegradability and lower cytotoxicity. However, until now, systematic conclusions and analyses of Fe-based MIL on medical applications are rare, even though the majority of documents have discussed one research branch of the porous materials MOFs. Discussion: In this review, we're going to focus mainly on the latest studies of applications, including bioimaging, biosensing, and antibacterial and drug delivery on Fe-based MIL. The existing shortcomings and future perspectives of the rapidly growing biomedical applications of Fe-based MIL materials addressing dosage and loading strategies issues are also discussed briefly.. Further studies with the use of different therapies will be of great interest. Conclusion: This article reviews the Fe-based MOFs design and biomedical application, including biosensing, bioimaging, antibacterial agent, and drug delivery in recent years.

Recent Advances in Metal-Organic Frameworks as Anticancer Drug Delivery Systems: A Review.

2021 ◽  
Vol 21 ◽  
Author(s):  
Abdollah Karami ◽  
Omnia Mohamed ◽  
Ahmed Ahmed ◽  
Ghaleb A. Husseini ◽  
Rana Sabouni
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Metal Organic Frameworks ◽  
Delivery Systems ◽  
Stimuli Responsive ◽  
Anticancer Drug Delivery ◽  
Advantages And Disadvantages ◽  
Metal Organic

Background: Metal-organic frameworks (MOFs), as attractive hybrid crystalline porous materials, are increasingly being investigated in biomedical applications owing to their exceptional properties, including high porosity, ultrahigh surface areas, tailorable composition and structure, and tunability and surface functionality. Of interest in this review is the design and development of MOFbased drug delivery systems (DDSs) that have excellent biocompatibility, good stability under physiological conditions, high drug loading capacity, and controlled/targeted drug release. Objective: This review highlights the latest advances in MOFs as anticancer drug delivery systems (DDSs) along with insights on their design, fabrication, and performance under different stimuli that are either internal or external. The synthesis methods of MOFs, along with their advantages and disadvantages, are briefly discussed. The emergence of multifunctional MOF-based theranostic platforms is also discussed. Finally, the future challenges facing the developments of MOFs in the field of drug delivery are discussed. Methods: The review was prepared by carrying out a comprehensive literature survey using relevant work published in various scientific databases. Results: Novel MOFs in biomedical applications, especially in drug delivery, have shown great potentials. MOF-based DDSs can be classified into normal (non-controllable) DDSs, stimuli-responsive DDSs, and theranostic platforms. The normal DDSs are pristine MOFs loaded with MOFs and offer little to no control over the drug delivery. Stimuli-responsive DDSs offer better spatiotemporal control over the drug release by responding to either endogenous (pH, redox, ions, ATP) or exogenous stimuli (light, magnetism, US, pressure, temperature). The theranostic platforms combine stimuli-responsive drug delivery with diagnostic imaging functionality, paving the road for imaging-guided drug delivery. Conclusion: This review presented a summary of the various methods utilized in MOF synthesis along with the advantages and disadvantages of each method. Furthermore, the review highlighted and discussed the latest developments in the field of MOF-based DDSs and theranostic platforms. The review is focused on the characteristics of MOF-based DDSs, the encapsulation of different anticancer drugs as well as their stimuli-responsive release.

scholarly journals MIL-53 (Al) metal-organic frameworks as potential drug carriers

2021 ◽  
Vol 2058 (1) ◽  
pp. 012015
Author(s):  
O Yu Griaznova ◽  
I V Zelepukin ◽  
G V Tikhonowski ◽  
V N Kolokolnikov ◽  
S M Deyev
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Drug Loading ◽  
High Surface ◽  
Metal Organic Frameworks ◽  
High Surface Area ◽  
Drug Carriers ◽  
Microwave Assisted Synthesis ◽  
Promising Candidate ◽  
Metal Organic

Abstract One of the challenges of the medicine is to improve the chemical stability of drugs and to prevent their premature biodegradation before reaching the therapeutic target. Various nanoparticles were used to solve this problem, but low drug loading efficiency limited their biomedical applications. Metal organic frameworks are promising candidates for drug delivery since they have extremely high surface area and regular porosity. In this study, we prepared high-crystalline MIL-53 frameworks based on aluminium and 2-aminoterephtalic acid by microwave-assisted synthesis and evaluated their properties as drug carriers. Drug loading of chemotherapeutic and diagnostic molecules of different nature riches value of 34% by particle weight, significantly higher than those of other reported solid nanoparticles. Therefore, our results make MIL-53 (Al) frameworks promising candidate for drug delivery.

scholarly journals Metal-Organic Frameworks and Their Composites Towards Biomedical Applications

2021 ◽  
Vol 8 ◽  
Author(s):  
Yana Ma ◽  
Xianglong Qu ◽  
Cui Liu ◽  
Qiuran Xu ◽  
Kangsheng Tu
Keyword(s):  
Drug Delivery ◽  
Contrast Agents ◽  
Biomedical Applications ◽  
Metal Organic Frameworks ◽  
Therapeutic Agents ◽  
Metal Organic ◽  
Targeting Strategy

Owing to their unique features, including high cargo loading, biodegradability, and tailorability, metal–organic frameworks (MOFs) and their composites have attracted increasing attention in various fields. In this review, application strategies of MOFs and their composites in nanomedicine with emphasis on their functions are presented, from drug delivery, therapeutic agents for different diseases, and imaging contrast agents to sensor nanoreactors. Applications of MOF derivatives in nanomedicine are also introduced. Besides, we summarize different functionalities related to MOFs, which include targeting strategy, biomimetic modification, responsive moieties, and other functional decorations. Finally, challenges and prospects are highlighted about MOFs in future applications.

scholarly journals Development of biological metal–organic frameworks designed for biomedical applications: from bio-sensing/bio-imaging to disease treatment

2020 ◽  
Vol 2 (9) ◽  
pp. 3788-3797 ◽  
Author(s):  
Huai-Song Wang ◽  
Yi-Hui Wang ◽  
Ya Ding
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Metal Organic Frameworks ◽  
Disease Treatment ◽  
Metal Organic ◽  
Bio Imaging

This review introduces biological metal–organic frameworks (bio-MOFs) designed and prepared using biological ligands for bio-sensing, bio-imaging, and drug delivery.

scholarly journals Biomedical Applications of Metal−Organic Frameworks for Disease Diagnosis and Drug Delivery: A Review

Nanomaterials ◽  
2022 ◽  
Vol 12 (2) ◽  
pp. 277
Author(s):  
Miral Al Sharabati ◽  
Rana Sabouni ◽  
Ghaleb A. Husseini
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Chemical Engineering ◽  
Metal Organic Frameworks ◽  
Disease Diagnosis ◽  
Inorganic Materials ◽  
Synthesis Methods ◽  
High Porosity ◽  
Wide Range ◽  
Metal Organic

Metal−organic frameworks (MOFs) are a novel class of porous hybrid organic−inorganic materials that have attracted increasing attention over the past decade. MOFs can be used in chemical engineering, materials science, and chemistry applications. Recently, these structures have been thoroughly studied as promising platforms for biomedical applications. Due to their unique physical and chemical properties, they are regarded as promising candidates for disease diagnosis and drug delivery. Their well-defined structure, high porosity, tunable frameworks, wide range of pore shapes, ultrahigh surface area, relatively low toxicity, and easy chemical functionalization have made them the focus of extensive research. This review highlights the up-to-date progress of MOFs as potential platforms for disease diagnosis and drug delivery for a wide range of diseases such as cancer, diabetes, neurological disorders, and ocular diseases. A brief description of the synthesis methods of MOFs is first presented. Various examples of MOF-based sensors and DDSs are introduced for the different diseases. Finally, the challenges and perspectives are discussed to provide context for the future development of MOFs as efficient platforms for disease diagnosis and drug delivery systems.

Combined experimental and theoretical insight into the drug delivery of nanoporous metal–organic frameworks

RSC Advances ◽  
2015 ◽  
Vol 5 (104) ◽  
pp. 85606-85612 ◽  
Author(s):  
Jiaping Wang ◽  
Juncheng Jin ◽  
Fumei Li ◽  
Baohong Li ◽  
Jianqiang Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Molecular Level ◽  
Load Capacity ◽  
Metal Organic Frameworks ◽  
Void Space ◽  
Drug Load ◽  
Nanoporous Metal ◽  
Metal Organic ◽  
Theoretical Insight ◽  
Insight Into

The comparison between calculated drug load values and some molecular level properties indicates the existence of a relationship between the void space of material and drug load capacity.

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