scholarly journals Biomedical Applications of Metal−Organic Frameworks for Disease Diagnosis and Drug Delivery: A Review

Nanomaterials ◽  
2022 ◽  
Vol 12 (2) ◽  
pp. 277
Author(s):  
Miral Al Sharabati ◽  
Rana Sabouni ◽  
Ghaleb A. Husseini
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Chemical Engineering ◽  
Metal Organic Frameworks ◽  
Disease Diagnosis ◽  
Inorganic Materials ◽  
Synthesis Methods ◽  
High Porosity ◽  
Wide Range ◽  
Metal Organic

Metal−organic frameworks (MOFs) are a novel class of porous hybrid organic−inorganic materials that have attracted increasing attention over the past decade. MOFs can be used in chemical engineering, materials science, and chemistry applications. Recently, these structures have been thoroughly studied as promising platforms for biomedical applications. Due to their unique physical and chemical properties, they are regarded as promising candidates for disease diagnosis and drug delivery. Their well-defined structure, high porosity, tunable frameworks, wide range of pore shapes, ultrahigh surface area, relatively low toxicity, and easy chemical functionalization have made them the focus of extensive research. This review highlights the up-to-date progress of MOFs as potential platforms for disease diagnosis and drug delivery for a wide range of diseases such as cancer, diabetes, neurological disorders, and ocular diseases. A brief description of the synthesis methods of MOFs is first presented. Various examples of MOF-based sensors and DDSs are introduced for the different diseases. Finally, the challenges and perspectives are discussed to provide context for the future development of MOFs as efficient platforms for disease diagnosis and drug delivery systems.

Recent advances in the design of inorganic and nano-clay particles for the treatment of brain disorders

2021 ◽  
Author(s):  
Francesca Persano ◽  
Svetlana Batasheva ◽  
Gölnur Fakhrullina ◽  
Giuseppe Gigli ◽  
Stefano Leporatti ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Silica Nanoparticles ◽  
Biomedical Applications ◽  
Inorganic Materials ◽  
Brain Disorders ◽  
Clay Particles ◽  
Recent Advances ◽  
Wide Range ◽  
Nano Clay

Inorganic materials, in particular nanoclays and silica nanoparticles, have attracted enormous attention due to their versatile and tuneable properties, making them ideal candidates for a wide range of biomedical applications, such as drug delivery.

scholarly journals Recent Trends in Covalent and Metal Organic Frameworks for Biomedical Applications

Nanomaterials ◽  
2018 ◽  
Vol 8 (11) ◽  
pp. 916 ◽  
Author(s):  
Georges Chedid ◽  
Ali Yassin
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Materials Science ◽  
High Surface ◽  
Metal Organic Frameworks ◽  
Great Promise ◽  
Surface Areas ◽  
Metal Organic ◽  
New Type ◽  
Recent Trends

Materials science has seen a great deal of advancement and development. The discovery of new types of materials sparked the study of their properties followed by applications ranging from separation, catalysis, optoelectronics, sensing, drug delivery and biomedicine, and many other uses in different fields of science. Metal organic frameworks (MOFs) and covalent organic frameworks (COFs) are a relatively new type of materials with high surface areas and permanent porosity that show great promise for such applications. The current study aims at presenting the recent work achieved in COFs and MOFs for biomedical applications, and to examine some challenges and future directions which the field may take. The paper herein surveys their synthesis, and their use as Drug Delivery Systems (DDS), in non-drug delivery therapeutics and for biosensing and diagnostics.

Chiral Nanoporous Metal-Organic Frameworks with High Porosity as Materials for Drug Delivery

2011 ◽  
Vol 23 (47) ◽  
pp. 5629-5632 ◽  
Author(s):  
Chun-Yi Sun ◽  
Chao Qin ◽  
Chun-Gang Wang ◽  
Zhong-Min Su ◽  
Shuang Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Metal Organic Frameworks ◽  
High Porosity ◽  
Nanoporous Metal ◽  
Metal Organic

scholarly journals Recent Developments in the Synthesis and Applications of Metal Organic Framework: A Concise Review

2021 ◽  
Vol 33 (5) ◽  
pp. 956-962
Author(s):  
Chandan Adhikari ◽  
Rehana Farooq
Keyword(s):  
Drug Delivery ◽  
Porous Materials ◽  
Electrochemical Sensors ◽  
Metal Organic Framework ◽  
Metal Organic Frameworks ◽  
Inorganic Materials ◽  
Synthetic Methods ◽  
Concise Review ◽  
Metal Organic ◽  
Organic Framework

Metal organic frameworks (MOFs) are one of those compounds which have drawn attention in various applications due to their several interesting properties like tunable shape, size, pore size, easy functionalization, high surface area, pore volume, etc. Metal organic frameworks due to their uniform structures, tunable porosity, wide variety and stability on various topology, geometry, dimension and chemical functions of the molecular network give a remarkable structural diversity in comparison to other porous materials. This enables scientists to handle numerous framework structures, porosity and functionality effectively. The unique structural architecture and tunable properties of MOF’s makes them an interesting hybrid material consisting of organic and inorganic materials. MOF can be randomly constructed like Lego bricks and superior in terms of versatility in comparisson to other porous materials. A number of MOFs containing a wide variety of metal e.g. zinc, copper, iron, aluminium, magnesium, chromium, zirconium, gadolinium, manganese are gaining rapid growth in commercial markets for gas storage, adsorption, separation and catalytic applications. This concise review emphasizes various synthetic methods e.g. solvothermal process, hydrothermal synthesis, electrochemical synthesis, microwave synthesis, sonochemical synthesis, mechanochemical synthesis, of metal organic framework developed in the last few decades. It also addresses various applications of metal organic framework e.g. hydrogen storage, gas adsorption, drug delivery systems and bioimaging agents, biocatalysts, biosensors, electrochemical sensors, etc. It also comments on various challenges and futuristic applications of metal organic frameworks in various field e.g. liquid wate management, gaseous waste management, sunlight assisted catalysis, water purification, building materials, electronic devices, battery technologies, targeted drug delivery, solar cells, etc. of science and technology in coming decades.

Recent advances in Fe-MOF compositions for in biomedical applications

2021 ◽  
Vol 28 ◽  
Author(s):  
Yuyu Zhong ◽  
Weicong Liu ◽  
Congying Rao ◽  
Baohong Li ◽  
Xiaoxiong Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Porous Materials ◽  
Antibacterial Agent ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Biomedical Application ◽  
Metal Organic Frameworks ◽  
Medical Applications ◽  
Future Perspectives ◽  
Metal Organic

Background: To date, a number of new and attractive materials have been applied in drug delivery systems (DDDs) to improve the efficiency of the treatment of cancers. Some problems like low stability, toxicity, and weak ability of targeting have hampered most of the materials for further applications in biomedicine. MIL(MIL = Materials of Institute Lavoisier), as a typical subclass of metal-organic frameworks (MOFs), owns more advantages than other subclass MOFs, such as better biodegradability and lower cytotoxicity. However, until now, systematic conclusions and analyses of Fe-based MIL on medical applications are rare, even though the majority of documents have discussed one research branch of the porous materials MOFs. Discussion: In this review, we're going to focus mainly on the latest studies of applications, including bioimaging, biosensing, and antibacterial and drug delivery on Fe-based MIL. The existing shortcomings and future perspectives of the rapidly growing biomedical applications of Fe-based MIL materials addressing dosage and loading strategies issues are also discussed briefly.. Further studies with the use of different therapies will be of great interest. Conclusion: This article reviews the Fe-based MOFs design and biomedical application, including biosensing, bioimaging, antibacterial agent, and drug delivery in recent years.

Expanding the NUIG MOF Family: synthesis and characterization of new MOFs for selective CO2 adsorption, metal ion removal from aqueous systems, and drug delivery applications

2021 ◽  
Author(s):  
Meghan Winterlich ◽  
Darragh McHugh ◽  
Evan O'Toole ◽  
Katerina Skordi ◽  
Ciaran O'Malley ◽  
...  
Keyword(s):  
Metal Ion ◽  
Biomedical Applications ◽  
Co2 Adsorption ◽  
Metal Organic Frameworks ◽  
Synthesis And Characterization ◽  
Metal Ion Removal ◽  
Ion Removal ◽  
Wide Range ◽  
Metal Organic

Metal organic frameworks (MOFs) have attracted considerable attention in recent years due to their use in a wide range of environmental, industrial and biomedical applications. The employment of benzophenone-4,4’-dicarboxylic acid...

scholarly journals Designing Magnetic NanoMOFs for Biomedicine: Current Trends and Applications

2020 ◽  
Vol 6 (3) ◽  
pp. 39
Author(s):  
Mariangela Oggianu ◽  
Noemi Monni ◽  
Valentina Mameli ◽  
Carla Cannas ◽  
Suchithra Ashoka Sahadevan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Magnetic Properties ◽  
Metal Organic Frameworks ◽  
High Porosity ◽  
Targeted Chemotherapy ◽  
Clinical Use ◽  
Crucial Step ◽  
Current Trends ◽  
Metal Organic ◽  
Shape Of Particles

Metal–organic frameworks (MOFs) have shown a great potential in biomedicine due to their promising applications in different fields, including drug delivery, thermometry, theranostics etc. In this context, the development of magnetic sub-micrometric or nanometric MOFs through miniaturization approaches of magnetic MOFs up to the nanoscale still represents a crucial step to fabricate biomedical probes, especially in the field of theranostic nanomedicine. Miniaturization processes have to be properly designed to tailor the size and shape of particles and to retain magnetic properties and high porosity in the same material, fundamental prerequisites to develop smart nanocarriers integrating simultaneously therapeutic and contrast agents for targeted chemotherapy or other specific clinical use. An overview of current trends on the design of magnetic nanoMOFs in the field of biomedicine, with particular emphasis on theranostics and bioimaging, is herein envisioned.

Nanoporous metal organic frameworks as hybrid polymer–metal composites for drug delivery and biomedical applications

2017 ◽  
Vol 22 (4) ◽  
pp. 625-637 ◽  
Author(s):  
Sarwar Beg ◽  
Mahfoozur Rahman ◽  
Atul Jain ◽  
Sumant Saini ◽  
Patrick Midoux ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Metal Organic Frameworks ◽  
Hybrid Polymer ◽  
Metal Composites ◽  
Nanoporous Metal ◽  
Polymer Metal ◽  
Metal Organic

Gender-Dependent Reproductive Toxicity of Copper Metal-Organic Frameworks and Attenuation by Surface Modification

Nanoscale ◽  
2021 ◽  
Author(s):  
Xiaotian Ji ◽  
Yousheng Mo ◽  
Haishan Li ◽  
Wanling Zhao ◽  
Aiqi Zhong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Surface Modification ◽  
Reproductive System ◽  
Metal Organic Frameworks ◽  
Reproductive Toxicity ◽  
Disease Diagnosis ◽  
Copper Metal ◽  
Diagnosis And Therapy ◽  
Metal Organic

Metal-organic frameworks (MOFs) as promising materials have been widely used in drug delivery, disease diagnosis and therapy, however, their effects on reproductive system remains unknown, which hinders their further clinical...

scholarly journals Metal-Organic Frameworks for Drug Delivery Applications

2021 ◽  
pp. 139-170
Author(s):  
Doaa Ahmed Ghareeb ◽  
Nessma Magdy Nasr
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Drug Delivery Systems ◽  
Metal Organic Frameworks ◽  
Stimuli Responsive ◽  
Surface Areas ◽  
Wide Range ◽  
Metal Organic ◽  
Delivery Vehicles ◽  
Structural Aspects

Metal-organic frameworks (MOFs) are based on metals and organic linkers; they possess large surface areas, suitable pore size and shape, wide range of chemical composition, and functionalized pore surface, which enable them for possible applications as delivery vehicles for therapeutic agents. The challenges include not only the development of new solids but also continuous improvements in the formulation and processing of the materials, including modifying the morphology and shape of the frameworks to fit the proposed applications of drug delivery. This chapter discussed enormous MOF-based stimuli responsive drug delivery systems, and considerable achievements have been made as a new avenue for drug delivery, their structural aspects, their applications in the controlled release of the drugs, and future view for development of drug controlled release researches using MOFs. Among the properties that must be developed and approved are the materials' toxicology, stability, their reproducibility of manufacture of MOFs in body's liquid, and pharmacokinetics of drug-loaded MOFs.

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