Early Prediction of Non-response to Anti-depressive Treatment with an Easy-to-use Electrophysiological Index Dynamics

2017 ◽  
Vol 41 (S1) ◽  
pp. S145-S145
Author(s):  
S. Yariv ◽  
G. Shahaf ◽  
B. Bloch ◽  
A. Reshef ◽  
Y. Bloch
Keyword(s):  
Single Channel ◽  
Severe Depression ◽  
Response To Treatment ◽  
Healthy Controls ◽  
Multiple Channels ◽  
Proof Of Concept ◽  
Treatment Interventions ◽  
Major Significance ◽  
Treatment Onset ◽  
Frequent Sampling

IntroductionThe evaluation of response to pharmacological treatment in MDD requires 6–8 weeks. Therefore, the ability to predict response, and especially lack of response to treatment, as early as possible after treatment onset or change, is of major significance. Many studies demonstrated significant results regarding the ability to use EEG and ERP markers. However, these markers are derived from long EEG/ERP samples, often from multiple channels, which render them impractical for frequent sampling.MethodsWe developed a new electrophysiological attention-related marker from a single channel (2 electrodes) and 1 minute samples. This work presents an initial evaluation of the ability to harness this marker, for early differentiation between responders and non-responders to anti-depressive treatment, in 26 patients with various levels of depression and heterogeneous treatment interventions and 10 healthy controls. Subjects who initiated treatment for depression were followed clinically through their Hamilton depression scores as well as their EEG activity twice a week for a period of 8 weeks. Any acceptable anti-depressive treatment been included. The improvement in Hamilton scores at the end of 8 weeks used to discriminate responders and non-responders.ResultsWithin two weeks, we could differentiate between non-responders and responders to anti-depressive treatment, with absolute discrimination between subjects with moderate to severe depression, and with 0.71 sensitivity and 0.96 specificity within the whole depressed subjects.ConclusionsThis is a proof of concept for an easy to use, cheap and quick marker for the lack of respond to anti-depressive treatment within two weeks of anti-depressive treatment.

scholarly journals AB1034 DEPRESSION AND ANXIETY IN FAMILIAL MEDITERRANEAN FEVER

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1808.2-1809
Author(s):  
D. Karatas ◽  
Z. Öztürk ◽  
D. Cekic ◽  
Z. Yuertsever ◽  
Ü. Erkorkmaz ◽  
...  
Keyword(s):  
Familial Mediterranean Fever ◽  
Severe Depression ◽  
Anxiety And Depression ◽  
Control Group ◽  
Healthy Controls ◽  
Depression And Anxiety ◽  
Mild Depression ◽  
Moderate Depression ◽  
Mediterranean Fever

Background:Familial Mediterranean Fever (FMF) is a hereditary autoinflammatory disease characterized by recurrent attacks of fever, peritonitis, pleuritis, arthritis, and skin eruption (1). It is shown by studies that chronic diseases like diabetes mellitus, chronic heart disease, hypertension which other than inflammatory – rheumatologic disease increase depression and anxiety (2). There are a few studies evaluating depression and anxiety in FMF patients, and these results are conflicting (3,4).Objectives:To assess the frequency of depression and anxiety in patients with Familial Mediterranean Fever (FMF)Methods:In this study, 77 FMF patients aged 18 and over who were followed up in Sakarya University Education and Research Hospital, Department of Rheumatology, and 78 healthy volunteers aged 18 and over as thecontrol group. Beck depression scale and Beck anxiety scale were used to depression and anxiety, respectively. Beck’sdepression scale was evaluated as 9 and below normal, 10-16 mild depression, 17-29 moderate depression, 30-63 severe depression. Beck anxiety scale was evaluated as 0-8 normal, 8-15 mild anxiety, 16-25 moderate anxiety, 26 and above severe anxiety.FMF disease severity was determined by Pras scoring.Results:The study group, comprised 77 diagnosed with FMF with a meanage of 37.18 and a control group comprised of 78 healthy controls (C) with a meanage of 35.32 (p=0,058). İn studygroup (P) %63.6, control group (C) %53.8 as female. %36.4 of thestudy group(C), %46.2 of the control group are male. (p=0,216). The prevalence of depression was significantly higher in FMF patients compared to the control group (in order P;C: normal %24,7; %47,4, mild depression: %40.3; %26.9, moderate depression %26; %19.2, severe depression %11.7; %6.4 p<0.015). Similarly in depression results; the prevalence of anxiety was significantly higher in FMF patients compared to the control group (in order P;C normal %23,4; %57.7, mild anxiety %26; %20.5, moderate anxiety %26; %15.4, severe anxiety %24.4; %6.4 p<0,001). Depression status was not correlated with FMF disease severity (p=0.645). A correlation was found between FMF severity and anxiety which it is which was found statistically significant (p=0.005).There was no relationship between erythrocyte sedimentation rate and C-reactive protein with depression and anxiety.Conclusion:Both anxiety and depression frequency are increased in FMF patients compared to healthy controls.References:[1]Livneh A, Langevitz P, Zemer D et al. (1997) Criteria for the diagnosis of familial Mediterranean fever. Arthritis Rheum 40 (10), 1879–85.[2]Alonso J, Ferrer M, Gandek B, Ware JE Jr, Aaronson NK, Mosconi P, Rasmussen NK, Bullinger M, Fukuhara S, Kaasa S, Leplège A, IQOLA Project Group (2004) Health-related quality of life associated with chronic conditions in eight countries: results from the International Quality of Life Assessment (IQOLA) Project. Qual Life Res 13:283–298[3]Makay B, Emiroglu N, Unsal E (2010) Depression andanxiety in children and adolescents with familial Mediterranean fever. Clin Rheumatol 29, 375–9.[4]Giese A, Ornek A, Kilic L, Kurucay M, Sendur S. N., Lainka E, Henning B. F. Anxiety and depression in adult patients with familialMediterranean fever: a study comparing patients living in Germany and Turkey. International Journal of Rheumatic Diseases 2017; 20: 2093–2100Disclosure of Interests:None declared

scholarly journals Generalization of the model-independent Laurent–Pietarinen single-channel pole-extraction formalism to multiple channels

2016 ◽  
Vol 755 ◽  
pp. 452-455 ◽  
Author(s):  
Alfred Švarc ◽  
Mirza Hadžimehmedović ◽  
Hedim Osmanović ◽  
Jugoslav Stahov ◽  
Lothar Tiator ◽  
...  
Keyword(s):  
Single Channel ◽  
Multiple Channels ◽  
Model Independent

scholarly journals Abnormal gastric slow waves in patients with functional dyspepsia assessed by multichannel electrogastrography

2001 ◽  
Vol 280 (6) ◽  
pp. G1370-G1375 ◽  
Author(s):  
Xuemei Lin ◽  
Jiande Z. Chen
Keyword(s):  
Wave Propagation ◽  
Functional Dyspepsia ◽  
Slow Wave ◽  
Single Channel ◽  
Slow Waves ◽  
Lower Percentage ◽  
Healthy Controls ◽  
Fasting State ◽  
Gastric Slow Wave ◽  
Gastric Slow Waves

The aim of this study was to utilize multichannel electrogastrography to investigate whether patients with functional dyspepsia had impaired propagation or coordination of gastric slow waves in the fasting state compared with healthy controls. The study was performed in 10 patients with functional dyspepsia and 11 healthy subjects. Gastric myoelectrical activity was measured by using surface electrogastrography with a specially designed four-channel device. The study was performed for 30 min or more in the fasting state. Special computer programs were developed for the computation of the propagation and coupling of the gastric slow wave. It was found that, compared with the healthy controls, the patients showed a significantly lower percentage of slow wave propagation (58.0 ± 8.9 vs. 89.9 ± 2.6%, P < 0.002) and a significantly lower percentage of slow wave coupling (46.9 ± 4.4 vs. 61.5 ± 6.9%, P < 0.04). In addition, the patients showed inconsistencies in the frequency and regularity of the gastric slow wave among the four-channel electrogastrograms (EGGs). It was concluded that patients with functional dyspepsia have impaired slow wave propagation and coupling. Multichannel EGG has more information than single-channel EGG for the detection of gastric myoelectrical abnormalities.

A Controlled Comparison of Cognitive—Behaviour Therapy, Diazepam and Placebo in the Management of Generalized Anxiety

1989 ◽  
Vol 17 (1) ◽  
pp. 1-14 ◽  
Author(s):  
K. G. Power ◽  
D. W. A. Jerrom ◽  
R. J. Simpson ◽  
M. J. Mitchell ◽  
V. Swanson
Keyword(s):  
Cognitive Behaviour Therapy ◽  
Psychological Treatment ◽  
Subsequent Treatment ◽  
Self Report ◽  
Response To Treatment ◽  
Generalized Anxiety ◽  
Behaviour Therapy ◽  
Treatment Interventions ◽  
Group Response ◽  
Cognitive Behaviour

Generalized anxiety patients were randomly allocated to Cognitive-Behaviour Therapy, Diazepam or Placebo and managed in a primary care setting. Treatments were balanced for degree of psychologist/patient contact. A range of outcome measures, including patient self report, psychologist assessor and general practitioner ratings were used. Large variations within group response to treatment emerged. At the end of active treatment the superiority of Cognitive-Behaviour Therapy was suggested. Post-study psychotropic prescription and psychological treatment was assessed at a 12-month follow-up. The Cognitive-Behaviour group revealed the lowest incidence of subsequent treatment interventions.

Clinical Evaluation of High Weekly Intravenous Doses of Methotrexate in Advanced Oropharyngeal Carcinoma

1970 ◽  
Vol 56 (5) ◽  
pp. 259-268 ◽  
Author(s):  
Giuseppe M. de Palo ◽  
Mario De Lena ◽  
Roberto Molinari ◽  
Antonio Cunsolo ◽  
Silvio Monfardini ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Side Effects ◽  
Intravenous Administration ◽  
Renal Toxicity ◽  
Severe Depression ◽  
Response To Treatment ◽  
Oropharyngeal Carcinoma ◽  
Intraarterial Infusion ◽  
Intravenous Injections ◽  
Duration Of Response

Methotrexate (MTX) was given by weekly rapid intravenous injections to 27 patients with inoperable oropharyngeal carcinoma. 9 cases were untreated while 18 had received radiotherapy or chemotherapy before administration of MTX. In 20 cases the dose was 40 mg/m2/week (patients over 50 years) and in 7 cases 60 mg/m2/week (table 1). In responsive patients, maintenance treatment was given at the dose of 15 mg/m2 every 4 days either orally or intramuscularly. 23 cases were adequately evaluable, i.e. they received treatment for a minimum of 3 weeks. Response to treatment was evaluated according to Karnofsky's scale. Considering only category 1 regressions, 11/16 (75%) patients adequately treated with 40 mg/m2 showed objective improvement and respectively 4/7 (57%) given 60 mg/m*. 8 out of 15 cases (41%) with category 1 response showed a regression greater than 50%. The mean duration of response for category 1 patients was 3.5 months, while the longest regression lasted 9 months (table 2). 18 patients had one or more side effects: 9 had oral lesions or gastroenteritis, 12 bone marrow depression, 3 hepatic and 1 renal toxicity. One patient died from hepatic and renal toxicity; in the remaining cases the side effects were quickly reversible (table 3). The percent regression rate for category 1 response and its average duration obtained with intravenous MTX seems comparable to intraarterial infusion (table 4). Systemic toxicity seems also comparable (table 5). Furthermore, intravenous administration obviates the typical local complications occurring with intra-arterial treatment and therapy can be given also at outpatients. For this reason, intravenous administration of MTX is preferred to intra-arterial infusion in the control of primary inoperable oropharyngeal carcinomas, provided no severe depression of liver, kidney and bone marrow is present.

scholarly journals Identification of a novel autoantigen eukaryotic initiation factor 3 associated with polymyositis

Rheumatology ◽  
2019 ◽  
Vol 59 (5) ◽  
pp. 1026-1030 ◽  
Author(s):  
Zoe Betteridge ◽  
Hector Chinoy ◽  
Jiri Vencovsky ◽  
John Winer ◽  
Kiran Putchakayala ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Indirect Immunofluorescence ◽  
Mass Spectrometry Analysis ◽  
Initiation Factor ◽  
Response To Treatment ◽  
Healthy Controls ◽  
Eukaryotic Initiation Factor ◽  
Favourable Response ◽  
Cell Extracts ◽  
Cytoplasmic Complex

Abstract Objectives To describe the prevalence and clinical associations of autoantibodies to a novel autoantigen, eukaryotic initiation factor 3 (eIF3), detected in idiopathic inflammatory myositis. Methods Sera or plasma from 678 PM patients were analysed for autoantigen specificity by radio-labelled protein immunoprecipitation (IPP). Samples immunoprecipitating the same novel autoantigens were further analysed by indirect immunofluorescence and IPP using pre-depleted cell extracts. The autoantigen was identified through a combination of IPP and MALDI-TOF mass spectrometry, and confirmed using commercial antibodies and IPP-western blots. Additional samples from patients with DM (668), DM-overlap (80), PM-overlap (191), systemic sclerosis (150), systemic lupus erythematosus (200), Sjogren’s syndrome (40), rheumatoid arthritis (50) and healthy controls (150) were serotyped by IPP as disease or healthy controls. Results IPP revealed a novel pattern in three PM patients (0.44%) that was not found in disease-specific or healthy control sera. Indirect immunofluorescence demonstrated a fine cytoplasmic speckled pattern for all positive patients. Mass spectrometry analysis of the protein complex identified the target autoantigen as eIF3, a cytoplasmic complex with a role in the initiation of translation. Findings were confirmed by IPP-Western blotting. The three anti-eIF3-positive patients had no history of malignancy or interstitial lung disease, and had a favourable response to treatment. Conclusion We report a novel autoantibody in 0.44% of PM patients directed against a cytoplasmic complex of proteins identified as eIF3. Although our findings need further confirmation, anti-eIF3 appears to correlate with a good prognosis and a favourable response to treatment.

Depression influences the EDI scores in anorexia nervosa patients

2003 ◽  
Vol 18 (3) ◽  
pp. 119-123 ◽  
Author(s):  
Chantal Bizeul ◽  
Jean Marcel Brun ◽  
Daniel Rigaud
Keyword(s):  
Anorexia Nervosa ◽  
Depressive Symptoms ◽  
Major Depression ◽  
Young Women ◽  
Interpersonal Relations ◽  
Severe Depression ◽  
Body Image Dissatisfaction ◽  
Control Group ◽  
Healthy Controls ◽  
Severity Of Depression

AbstractAimTo study the influence of the severity of depression on the eating disorder’s inventory (EDI) scores in anorexia nervosa (AN) patients.MethodsWe compared by variance analysis the EDI scores from three groups of AN patients: 55 patients having a major depression (as assessed by a Beck’s depression inventory (BDI) ≥ 16); 77 patients having a less severe depression (BDI < 16); 32 patients with mild or non-existent depression (BDI ≤ 7) and the EDI scores from a control group of 29 French healthy young women.ResultsHigher EDI scores were elicited in the more severely depressed AN patients than in the less- or non-depressed AN patients (P < 0.01). In non-depressed AN patients, none of the scores was different from those of the control group. This was particularly true for the scores “Slimness wish”, “bulimia”, “body image dissatisfaction”, “perfectionism” and “fear of maturity”. The non-depressed restrictive AN patients had no score which differ from healthy controls.DiscussionsThe present results suggested that the EDI scores are clearly influenced by the severity of depression. Among the psychopathological and behavioural traits assessed with the EDI, only a few were not related to depressive symptoms: “feeling of inefficiency” and “distrust in interpersonal relations”.

Superposition properties of independent ion channels

1989 ◽  
Vol 238 (1291) ◽  
pp. 155-170 ◽  
Keyword(s):  
Ion Channels ◽  
Sojourn Time ◽  
Single Channel ◽  
Stochastic Modelling ◽  
Multiple Channels ◽  
Channel Activity ◽  
Channel System ◽  
Distributional Properties ◽  
Multichannel Systems ◽  
Selection Of

Membrane patches usually contain several ion channels of a given type. However, most of the stochastic modelling on which data analysis (in particular, estimation of kinetic constants) is currently based, relates to a single channel rather than to multiple channels. Attempts to circumvent this problem experimentally by recording under conditions where channel activity is low are restrictive and can introduce bias; moreover, possibly important information on how multichannel systems behave will be missed. We have extended existing theory to multichannel systems by applying results from point process theory to derive some distributional properties of the various types of sojourn time that occur when a given number of channels are open in a system containing a specified number of independent channels in equilibrium. Separate development of properties of a single channel and the superposition of several such independent channels simplifies the presentation of known results and extensions. To illustrate the general theory, particular attention is given to the types of sojourn time that occur in a two channel system; detailed expressions are presented for a selection of models, both Markov and non-Markov.

scholarly journals Renal Resistive Index in Patients with Septic Shock: Changes in the Renal Resistive Index as a Parameter of Tissue Perfusion in the Assessment of Response to Treatment during Resuscitation of Patients with Septic Shock; a Prospective Observational Study

2021 ◽  
Author(s):  
Hamed Aminiahidashti ◽  
Mohammad Sazgar ◽  
Fatemeh Jahanian ◽  
Soroush Niksalehi ◽  
Iraj Golikhatir
Keyword(s):  
Septic Shock ◽  
Observational Study ◽  
Prospective Observational Study ◽  
Resistive Index ◽  
Tissue Perfusion ◽  
Response To Treatment ◽  
Renal Resistive Index ◽  
P Value ◽  
Volume Assessment ◽  
Treatment Onset

Abstract BackgroundSeptic shock, a complication characterized by altered tissue perfusion, is associated with high mortality if left untreated. Renal resistive index (RRI) reflects changes in intrarenal perfusion. Therefore, the present study aimed at investigating changes in RRI during resuscitation of patients with septic shock and evaluating its relationship with other micro- and macrociculatory perfusion parameters.MethodsThe present prospective observational study was performed on all patients referring to the emergency department intensive care unit (ED-ICU) diagnosed with septic shock from July 2018 to September 2019. Demographic characteristics of the study subjects were recorded and their hemodynamic, paraclinical, and RRI values were measured at three time points of on arrival, and 30 and 120 minutes and six hours after admission, by ultrasound.ResultsA total of 109 subjects entered data analysis; their mean age was 67.62 ± 14.67 years, of which 65 (59.1) were male. The RRI values were 0.71 ± 0.27, on arrival, at 30 and 0.70 ± 0.1 on 60 minutes, at six hours after treatment onset, respectively, showing that RRI values decreased during the study, which was statistically significant (P-value= 0.00). ConclusionA decrease in RRI value during resuscitation is associated with an increase in MAP in patients with septic shock. Accordingly, RRI can be used as an indicator of microcirculatory perfusion in the treatment process and volume assessment of patients with septic shock.

scholarly journals Depression, Anxiety, and Suicide Risk Among Ugandan Youth in Vocational Training

2021 ◽  
Author(s):  
Badru Bukenya ◽  
Rogers Kasirye ◽  
Joanne Lunkuse ◽  
Moses Kinobi ◽  
Sylvanna M. Vargas ◽  
...  
Keyword(s):  
Vocational Training ◽  
Suicide Risk ◽  
Attempted Suicide ◽  
Severe Depression ◽  
Anxiety And Depression ◽  
Treatment Interventions ◽  
Governmental Organization ◽  
Female Youth ◽  
Prevalence Of Depression ◽  
Severe Anxiety

Abstract Background: The current study examines the prevalence of depression, anxiety, suicide risk, and PTSD in Ugandan youth (13-25 years) attending vocational training programs.Methods: Youth from five urban (n=224 females, 81 males) and four rural (n=153 females only) vocational training centers operated by a non-governmental organization completed demographic and mental health questionnaires.Results: Nearly half of the youth reported moderate or severe depression and/or anxiety. More than half reported anxiety and depression-related impairment. Nearly a quarter of youth had considered or attempted suicide. More than half screened positive on the PC-PTSD screen. Rural female youth reported the most food insecurity (56.9%), trafficking (37.9%), severe depression (35.9%), depression-related impairment (56.9%), severe anxiety (26.1%), and anxiety-related impairment (55.6%).Conclusions: Results from this study suggest that Ugandan youth have exceedingly high rates of depression, anxiety, suicide risk, and probable PTSD. Rural female youth may be especially at risk. Relevant treatment interventions are needed that can be adapted to youth in vocational training centers.

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