Desalination of seawater has played an important role in many arid regions in the world. There are many methods for desalination of seawater, such as MED, MSF, RO, ED, TVC, and MVC, etc. Different methods have different advantages and disadvantages. In the present work, a new method for desalination of seawater with steam-ejector refrigeration plant was introduced. The main purpose of the new method is a hybrid plant of TVC and steam-ejector refrigeration. In the hybrid circle, no other energy was need. When the steam-ejector refrigeration plant is working, the seawater as cooling water is introduced into evaporator of TVC and evaporates. The vapor getting in TVC is extracted by a second steam-ejector, together with the active steam, is used as source of heat for desalination. The main advantage of this hybrid plant is that part of the heat energy of cooling water in refrigeration is reused. Comparing with other distillation method desalination of seawater, the energy consumption is much less. Especially on marine usage, the advantage is clear.