Preparation, characterization, and in vitro bioactivity study of glutaraldehyde crosslinked chitosan/poly(vinyl alcohol)/ascorbic acid-MWCNTs bionanocomposites

2020 ◽  
Vol 144 ◽  
pp. 389-402 ◽  
Author(s):  
Shadpour Mallakpour ◽  
Shima Rashidimoghadam
Keyword(s):  
Ascorbic Acid ◽  
Vinyl Alcohol ◽  
Poly Vinyl Alcohol ◽  
In Vitro Bioactivity ◽  
Crosslinked Chitosan

scholarly journals Synthesis of poly(vinyl alcohol) — hydroxyapatite composites and characterization of their bioactivity

2013 ◽  
Vol 11 (9) ◽  
pp. 1403-1411 ◽  
Author(s):  
Zuzana Balgová ◽  
Martin Palou ◽  
Jaromír Wasserbauer ◽  
Jana Kozánková
Keyword(s):  
Vinyl Alcohol ◽  
Sol Gel ◽  
Calcium Nitrate ◽  
Weight Percent ◽  
Poly Vinyl Alcohol ◽  
Aqueous Environment ◽  
Calcium Nitrate Tetrahydrate ◽  
In Vitro Bioactivity ◽  
Before And After

AbstractAbstract A series of poly(vinyl alcohol) membranes reinforced with hydroxyapatite in various weight percent — 0%, 10%, 20%, 30%, 40% and 50% were prepared. Hydroxyapatite was prepared by a sol-gel procedure using diammonium hydrogen phosphate and calcium nitrate tetrahydrate as starting materials in an alkaline aqueous environment and then mixed with a solution of poly(vinyl alcohol), which was prepared by dissolving it in water at 85°C. The different mixtures were cast in a mould and evaporated for 7 days at a temperature of 30°C to obtain 1 mm thin membranes. FTIR spectroscopy was used to identify the different functional groups in the composites. The surface morphology was examined using a scanning electron microscope. In vitro bioactivity tests in Simulated Blood Fluid were performed for up to 28 days, especially for the membrane containing 50 wt.% HA. SEM was used to characterise the surface microstructure of biocomposite membranes before and after soaking in SBF. It was observed that the formation of clusters in membranes increases with increasing amount of HA. The clusters are formed due to agglomeration and crystal growth of HA particles during drying of the membranes. The in vitro bioactivity was found to increase with soaking time of biocomposite materials in simulated blood fluid. Graphical abstract

scholarly journals Dual Network Composites of Poly(vinyl alcohol)-Calcium Metaphosphate/Alginate with Osteogenic Ions for Bone Tissue Engineering in Oral and Maxillofacial Surgery

2021 ◽  
Vol 8 (8) ◽  
pp. 107
Author(s):  
Lilis Iskandar ◽  
Lucy DiSilvio ◽  
Jonathan Acheson ◽  
Sanjukta Deb
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Vinyl Alcohol ◽  
Maxillofacial Surgery ◽  
Bone Defects ◽  
Bone Tissue Regeneration ◽  
Poly Vinyl Alcohol ◽  
Oral And Maxillofacial Surgery

Despite considerable advances in biomaterials-based bone tissue engineering technologies, autografts remain the gold standard for rehabilitating critical-sized bone defects in the oral and maxillofacial (OMF) region. A majority of advanced synthetic bone substitutes (SBS’s) have not transcended the pre-clinical stage due to inferior clinical performance and translational barriers, which include low scalability, high cost, regulatory restrictions, limited advanced facilities and human resources. The aim of this study is to develop clinically viable alternatives to address the challenges of bone tissue regeneration in the OMF region by developing ‘dual network composites’ (DNC’s) of calcium metaphosphate (CMP)—poly(vinyl alcohol) (PVA)/alginate with osteogenic ions: calcium, zinc and strontium. To fabricate DNC’s, single network composites of PVA/CMP with 10% (w/v) gelatine particles as porogen were developed using two freeze–thawing cycles and subsequently interpenetrated by guluronate-dominant sodium alginate and chelated with calcium, zinc or strontium ions. Physicochemical, compressive, water uptake, thermal, morphological and in vitro biological properties of DNC’s were characterised. The results demonstrated elastic 3D porous scaffolds resembling a ‘spongy bone’ with fluid absorbing capacity, easily sculptable to fit anatomically complex bone defects, biocompatible and osteoconductive in vitro, thus yielding potentially clinically viable for SBS alternatives in OMF surgery.

scholarly journals Multifunctional Coatings for Robotic Implanted Device

2019 ◽  
Vol 20 (20) ◽  
pp. 5126 ◽  
Author(s):  
Caterina Cristallini ◽  
Serena Danti ◽  
Bahareh Azimi ◽  
Veronika Tempesti ◽  
Claudio Ricci ◽  
...  
Keyword(s):  
Acrylic Acid ◽  
Vinyl Alcohol ◽  
Soft Tissues ◽  
Functional Characterization ◽  
Titanium Substrate ◽  
Repair Process ◽  
Chemical Imaging ◽  
In Vitro Cytotoxicity ◽  
Poly Vinyl Alcohol

The objective of this study was the preparation and physico-chemical, mechanical, biological, and functional characterization of a multifunctional coating for an innovative, fully implantable device. The multifunctional coating was designed to have three fundamental properties: adhesion to device, close mechanical resemblance to human soft tissues, and control of the inflammatory response and tissue repair process. This aim was fulfilled by preparing a multilayered coating based on three components: a hydrophilic primer to allow device adhesion, a poly(vinyl alcohol) hydrogel layer to provide good mechanical compliance with the human tissue, and a layer of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) fibers. The use of biopolymer fibers offered the potential for a long-term interface able to modulate the release of an anti-inflammatory drug (dexamethasone), thus contrasting acute and chronic inflammation response following device implantation. Two copolymers, poly(vinyl acetate-acrylic acid) and poly(vinyl alcohol-acrylic acid), were synthetized and characterized using thermal analysis (DSC, TGA), Fourier transform infrared spectroscopy (FT-IR chemical imaging), in vitro cell viability, and an adhesion test. The resulting hydrogels were biocompatible, biostable, mechanically compatible with soft tissues, and able to incorporate and release the drug. Finally, the multifunctional coating showed a good adhesion to titanium substrate, no in vitro cytotoxicity, and a prolonged and controlled drug release.

Tailoring the in vitro characteristics of poly(vinyl alcohol)-nanohydroxyapatite composite scaffolds for bone tissue engineering

2016 ◽  
Vol 36 (8) ◽  
pp. 771-784 ◽  
Author(s):  
Tejinder Kaur ◽  
Arunachalam Thirugnanam ◽  
Krishna Pramanik
Keyword(s):  
Mechanical Strength ◽  
Vinyl Alcohol ◽  
Contact Angle Measurement ◽  
Angle Measurement ◽  
Poly Vinyl Alcohol ◽  
Apatite Formation ◽  
Composite Scaffolds ◽  
Alizarin Red ◽  
Casting Technique

Abstract Poly(vinyl alcohol) reinforced with nanohydroxyapatite (PVA-nHA) composite scaffolds were developed by varying the nHA (1%, 2%, 3%, 4%, and 5%, w/v) composition in the PVA matrix by solvent casting technique. The developed composite scaffolds were characterized using scanning electron microscopy (SEM), X-ray powder diffraction (XRD), attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy, and contact angle measurement. The stability of the composite scaffolds in physiological environment was evaluated by swelling and degradation studies. Further, these composite scaffolds were tested for in vitro bioactivity, hemolysis, biocompatibility, and mechanical strength. SEM micrographs showed a homogenous distribution of nHA (3%, w/v) in the PVA matrix. XRD and ATR-FTIR analysis confirmed no phase contamination and the existence of the chemical bond between PVA-nHA at approximately 2474 cm-1. PVA-nHA composite scaffolds with 3% (w/v) concentration of nHA showed nominal swelling and degradation behavior with good mechanical strength. The mechanical strength and degradation properties of the scaffold above 3% (w/v) of nHA was found to deteriorate, which is due to the agglomeration of nHA. The in vitro bioactivity and hemolysis studies showed improved apatite formation and hemocompatibility of the developed scaffolds. In vitro cell adhesion, proliferation, alkaline phosphatase activity, and Alizarin red S staining confirmed the biocompatibility of the composite scaffolds.

A novel poly (vinyl alcohol)-aided ZnO/Fe2O3 nanocomposite as an ascorbic acid sensor

2021 ◽  
Vol 32 (6) ◽  
pp. 7778-7790
Author(s):  
Buzuayehu Abebe ◽  
Enyew Amare Zereffa ◽  
H. C. Ananda Murthy ◽  
C. R. Ravikumar
Keyword(s):  
Ascorbic Acid ◽  
Vinyl Alcohol ◽  
Poly Vinyl Alcohol ◽  
Ascorbic Acid Sensor

scholarly journals The Design, Characterization and Antibacterial Activity of Heat and Silver Crosslinked Poly(Vinyl Alcohol) Hydrogel Forming Dressings Containing Silver Nanoparticles

Nanomaterials ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 96
Author(s):  
John Jackson ◽  
Helen Burt ◽  
Dirk Lange ◽  
In Whang ◽  
Robin Evans ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Antibacterial Activity ◽  
Silver Nitrate ◽  
Vinyl Alcohol ◽  
Unmet Need ◽  
Chemical Characterization ◽  
Wound Dressings ◽  
Poly Vinyl Alcohol ◽  
Burn Wound

The prompt treatment of burn wounds is essential but can be challenging in remote parts of Africa, where burns from open fires are a constant hazard for children and suitable medical care may be far away. Consequently, there is an unmet need for an economical burn wound dressing with a sustained antimicrobial activity that might be manufactured locally at low cost. This study describes and characterizes the novel preparation of a silver nitrate-loaded/poly(vinyl alcohol) (PVA) film. Using controlled heating cycles, films may be crosslinked with in situ silver nanoparticle production using only a low heat oven and little technical expertise. Our research demonstrated that heat-curing of PVA/silver nitrate films converted the silver to nanoparticles. These films swelled in water to form a robust, wound-compatible hydrogel which exhibited controlled release of the antibacterial silver nanoparticles. An optimal formulation was obtained using 5% (w/w) silver nitrate in PVA membrane films that had been heated at 140 °C for 90 min. Physical and chemical characterization of such films was complemented by in vitro studies that confirmed the effective antibacterial activity of the released silver nanoparticles against both gram positive and negative bacteria. Overall, these findings provide economical and simple methods to manufacture stable, hydrogel forming wound dressings that release antibiotic silver over prolonged periods suitable for emergency use in remote locations.

Pore Size Distribution and Blend Composition Affect In Vitro Prevascularized Bone Matrix Formation on Poly(Vinyl Alcohol)/Gelatin Sponges

2017 ◽  
Vol 302 (11) ◽  
pp. 1700300 ◽  
Author(s):  
Jose Gustavo De la Ossa ◽  
Luisa Trombi ◽  
Delfo D'Alessandro ◽  
Maria Beatrice Coltelli ◽  
Lorenzo Pio Serino ◽  
...  
Keyword(s):  
Pore Size Distribution ◽  
Pore Size ◽  
Size Distribution ◽  
Vinyl Alcohol ◽  
Bone Matrix ◽  
Poly Vinyl Alcohol ◽  
Blend Composition

Poly(Vinyl Alcohol) Enhances Acetylation of Ascorbic Acid in Superparamagnetic Graphene Oxide Nanoparticles Ultrasonically Complexed with Acetylsalicylic Acid

2020 ◽  
Vol 2 (8) ◽  
pp. 3663-3673
Author(s):  
Anastasia Tkach ◽  
Uladzimir Fiadosenka ◽  
Aliaksandr Burko ◽  
Hanna Bandarenka ◽  
Anna Matsukovich ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Graphene Oxide ◽  
Acetylsalicylic Acid ◽  
Vinyl Alcohol ◽  
Poly Vinyl Alcohol ◽  
Oxide Nanoparticles

scholarly journals PREPARATION AND CHARACTERIZATION OF POLY (VINYL ALCOHOL)–POLY (VINYL PYRROLIDONE) MUCOADHESIVE BUCCAL PATCHES FOR DELIVERY OF LIDOCAINE HCL

2018 ◽  
Vol 10 (1) ◽  
pp. 115 ◽  
Author(s):  
Napaphak Jaipakdee ◽  
Thaned Pongjanyakul ◽  
Ekapol Limpongsa
Keyword(s):  
Vinyl Alcohol ◽  
Vinyl Pyrrolidone ◽  
Poly Vinyl Alcohol ◽  
Scanning Calorimetry ◽  
X Ray ◽  
Casting Technique ◽  
In Vitro Permeation ◽  
Lidocaine Hcl ◽  
Poly Vinyl Pyrrolidone

Objective: The objectives of this study were to prepare and characterize a buccal mucoadhesive patch using poly (vinyl alcohol) (PVA), poly (vinyl pyrrolidone) (PVP) as a mucoadhesive matrix, Eudragit S100 as a backing layer, and lidocaine HCl as a model drug.Methods: Lidocaine HCl buccal patches were prepared using double casting technique. Molecular interactions in the polymer matrices were studied using attenuated total reflectance-fourier transform infrared spectroscopy (ATR-FTIR), differential scanning calorimetry (DSC) and X-ray diffractometry. Mechanical and mucoadhesive properties were measured using texture analyzer. In vitro permeation of lidocaine HCl from the patch was conducted using Franz diffusion cell.Results: Both of the free and lidocaine HCl patches were smooth and transparent, with good flexibility and strength. ATR-FTIR, DSC and X-ray diffractometry studies confirmed the interaction of PVA and PVP. Mechanical properties of matrices containing 60% PVP were significantly lower than those containing 20% PVP (*P<0.05). Mucoadhesive properties had a tendency to decrease with the concentration of PVP in the patch. The patch containing 60% PVP had significantly lower muco-adhesiveness than those containing 20% PVP (*P<0.05). In vitro permeation revealed that the pattern of lidocaine HCl permeation started with an initial fast permeation, followed by a slower permeation rate. The initial permeation fluxes follow the zero-order model of which rate was not affected by the PVP concentrations in the PVA/PVP matrix.Conclusion: Mucoadhesive buccal patches fabricated with PVA/PVP were successfully prepared. Incorporation of PVP in PVA/PVP matrix affected the strength of polymeric matrix and mucoadhesive property of patches.

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