Protective effects of Polygonatum kingianum polysaccharides and aqueous extract on uranium-induced toxicity in human kidney (HK-2) cells

2022 ◽  
Author(s):  
Wenjing Li ◽  
Libing Yu ◽  
Bo Fu ◽  
Jian Chu ◽  
Chun Chen ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Human Kidney ◽  
Protective Effects

Protective effects of Houttuynia cordata aqueous extract in mice consuming a high saturated fat diet

2013 ◽  
Vol 4 (2) ◽  
pp. 322-327 ◽  
Author(s):  
Ming-cheng Lin ◽  
Pei-chun Hsu ◽  
Mei-chin Yin
Keyword(s):  
Aqueous Extract ◽  
Saturated Fat ◽  
Protective Effects ◽  
Houttuynia Cordata

scholarly journals HEPATOPROTECTIVE AND NEPHROPROTECTIVE EFFECTS OF THE AQUEOUS EXTRACT OF TURMERIC (CURCUMA LONGA) IN RIFAMPICIN AND ISONIAZID-INDUCED HEPATOTOXICITY AND NEPHROTOXICITY IN RATS

2019 ◽  
pp. 293-298
Author(s):  
MAHDI M THUAWAINI ◽  
MAWAHIB B GASIM AL-FARHAAN ◽  
KARIMA F ABBAS
Keyword(s):  
Aqueous Extract ◽  
Total Bilirubin ◽  
Curcuma Longa ◽  
Albino Rats ◽  
Histopathological Study ◽  
Protective Effects ◽  
Significant Elevation ◽  
Liver And Kidney ◽  
Histopathological Studies ◽  
Kidney Functions

Objectives: The present study was designed to estimate the influences of oral administration of aqueous extract of turmeric (Curcuma longa) in hepatotoxicity and nephrotoxicity induced in rats by isoniazid and rifampicin (RIF) for 4 weeks. Influences were determined through the estimation of liver and kidney functions and histopathological changes. Materials and Methods: A total of 48 male albino rats were randomly divided into six groups: Normal control, INH+RIF treated rats, Turmeric aqueous extract 100 mg/kg treated rats, Turmeric aqueous extract 100 mg/kg + INH and RIF treated rats, Turmeric aqueous extract 200 mg/kg treated rats, Turmeric aqueous extract 200 mg/kg+ INH and RIF treated rats. Turmeric aqueous extract and INH + RIF (50 mg/kg bwpo, daily) were given for 4 weeks. Liver and kidney function markers (aspartate transaminase [AST], alanine transaminase [ALT], alanine phosphatase [ALP], bilirubin, blood urea, and creatinine) were determined enzymatically. In addition, tissues of liver and kidney were quickly separated and fixed in 10% formalin and subjected to histopathological studies. Statistical analysis was carried out using t-test. Results: The aqueous extract of turmeric (at a dose of 100 and 200 mg/kg bw, p.o. daily ) showed hepato- and reno-protective effects in hepato- and reno- toxicity induced by RIF and INH in rats. Significant elevation of serum ALT, AST, ALP, total bilirubin, creatinine, urea, and total protein, due to RIF and INH treatment, were significantly decreased. The histopathological study further confirmed the biochemical results. Conclusion: Results of the present study indicated that turmeric has hepatoprotective and renoprotective action against RIF- and INH-induced hepatic and renal injury in rats.

scholarly journals Macro- and Microelement Content and Other Properties of Chaenomeles japonica L. Fruit and Protective Effects of Its Aqueous Extract on Hepatocyte Metabolism

2017 ◽  
Vol 178 (2) ◽  
pp. 327-337 ◽  
Author(s):  
Irena Baranowska-Bosiacka ◽  
Beata Bosiacka ◽  
Julita Rast ◽  
Izabela Gutowska ◽  
Jolanta Wolska ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Protective Effects ◽  
Hepatocyte Metabolism ◽  
Microelement Content

scholarly journals Protective Effects of Aqueous Extract of Sempervivum tectorum L (Crassulaceae) on Aluminium-Induced Oxidative Stress in Rat Blood

2014 ◽  
Vol 13 (2) ◽  
pp. 179 ◽  
Author(s):  
M Florin ◽  
T Alexandra ◽  
SL Gabriela ◽  
CT Romeo ◽  
G Corina ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Aqueous Extract ◽  
Protective Effects ◽  
Rat Blood

scholarly journals Cardioprotective Effect of Ajwa Date Aqueous Extract on Doxorubicin-Induced Toxicity in Rats

2018 ◽  
Vol 11 (3) ◽  
pp. 1521-1536 ◽  
Author(s):  
Meaad F. Sabbah ◽  
Fawzia Alshubali ◽  
Othman A. S. Baothman ◽  
Mazin A. Zamzami ◽  
Lobna Shash ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Aqueous Extract ◽  
Chemotherapeutic Agents ◽  
Male Rats ◽  
Control Group ◽  
Dna Integrity ◽  
Protective Effects ◽  
Cardiac Enzymes ◽  
Group Iii ◽  
Group I

Doxorubicin (DOX) is one of the most potent and widely used chemotherapeutic agents to treat several malignancies. However, the clinical use of DOX is seriously restricted due to its acute and chronic cardiotoxic side effects This study investigated the protective effect of (Ajwa) date aqueous extract (AJDAE) against doxorubicin-induced cardiotoxicity in rats. Sixty Wister albino male rats (150-200 gms.) were comprised in our study and divided into six equal groups: group I (untreated control), group II, group III, rats were orally received AJDAE (0.75 & 1.5 gm/ kg.bw) respectively, for 4 weeks, rats of groups IV, V and VI were intraperitoneally injected with one dose of doxorubicin (5 mg/kg.bw) at the end of the 4th week of the study to induce cardiotoxicity, rats of groups V & VI were orally received AJDAE (0.75 & 1.5 gm/ kg.bw) respectively. Cardiac enzymes, lipid profile, SOD, GR, GST, GPx, CAT and MDA in rats’ hearts homogenate, urinary 8OHdG as well as DNA integrity and histopathological changes were investigated in all studied rats.Oral administration of AJDAE (0.75 & 1.5 gm/ kg.bw) attenuated the cardiotoxicity of DOX, improved the cardiac enzymes, lipid profile, reduced the urinary 8OHdG and prohibited the depletion of endogenous antioxidants and suppressed lipid peroxidation (MDA). Moreover, AJDAE enhanced DNA integrity. Histological findings showed that AJDAE (0.75 & 1.5 gm/ kg.bw) administration reduced cardiomyocytes alterations, congestion, edema and the intense cellular stress exerted on myocardial fibers as well as restored the cardiomyocytes architecture. Our data showed that AJDAE obviously resulted in protective effects against DOX-induced cardiotoxicity in rat’s heart. It can be concluded that Ajwa date offers a considerable protection against DOX-induced cardiotoxicity.

scholarly journals Effect of Trigonella Foenum against Ethylene Diamine Tetra Acetic Acid induced Nephrotoxicity in Male Albino Rats

2020 ◽  
Vol 1 (1) ◽  
pp. 32-43
Author(s):  
A I Barakat ◽  
EH Radwan
Keyword(s):  
Creatinine Clearance ◽  
Aqueous Extract ◽  
Renal Damage ◽  
Kidney Tissue ◽  
Free Radical Scavenger ◽  
Albino Rats ◽  
Radical Scavenger ◽  
Protective Agent ◽  
Protective Effects ◽  
Oxidative Stress Biomarkers

Background Nephrotoxicity is a complication due to the effect of some toxic chemicals on kidney. Current study planned to screen the effect of Trigonella foenumaqueous seeds extracts on EDTA induced nephrotoxicity. Trigonella foenum known for its various medicinal properties is also a natural antioxidant and a free radical scavenger with no documented evidence as a nephron-protective agent. Objective To investigate the protective effects of aqueous seed extracts of Trigonella foenum. Material and Methods The present study was used 40 male albino rats (Rattus albinus) with weight of (150 ± 10) g with divided into four groups: control gp; EDTA gp (95 mg/kg); Trigonella foenum gp (500 mg/kg) and EDTA + Trigonella f oenum gp by gastric tube daily for 4 weeks. Blood urea, creatinine, GFR, creatinine clearance, MDA and GPx analyses and microscopic examination of kidney were performed. Results In the present study, Blood samples were taken from all groups and concentration of serum urea, creatinine, GFR, Creatinine clearance, MDA and GPx were determined. Histopathological observations were observed in kidney tissue. Data were analyzed using analysis of variance (ANOVA). EDTA induced an increase in urea and creatinine as well as there was a decrease in the concentration of GFR and creatinine clearance. The level of MDA was increase while the concentration of GPx was decrease in the serum of EDTA group. The aqueous extracts of Trigonella seeds significantly prevented renal damage by normalizing increased levels of renal markers. The correction of oxidative stress biomarkers was consistent with amelioration of the histopathological changes induced by EDTA. Hence, it is suggested that ameliorative effect of aqueous extract of Trigonella foenumagainst EDTA induced nephrotoxicity. Conclusion The present data suggest that aqueous extract of Trigonella foenum exhibits reno-protective effect in EDTA induced renal damage.

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