Association of early adulthood weight and subsequent weight change with cardiovascular diseases: Findings from REACTION study

2021 ◽  
Author(s):  
Yuanyue Zhu ◽  
Ruizhi Zheng ◽  
Chunyan Hu ◽  
Guijun Qin ◽  
Bin Wang ◽  
...  
Keyword(s):  
Cardiovascular Diseases ◽  
Weight Change ◽  
Early Adulthood ◽  
Reaction Study

Relationship of Weight Change Patterns From Young to Middle Adulthood With Incident Cardiovascular Diseases

2020 ◽  
Author(s):  
Mengyi Liu ◽  
Zhuxian Zhang ◽  
Chun Zhou ◽  
Panpan He ◽  
Yuanyuan Zhang ◽  
...  
Keyword(s):  
Cardiovascular Diseases ◽  
Young Adulthood ◽  
Weight Change ◽  
Later Life ◽  
Normal Weight ◽  
Self Report ◽  
Middle Adulthood ◽  
Health And Nutrition ◽  
First Occurrence ◽  
Relationship Of

Abstract Context The effect of weight change patterns on cardiovascular diseases (CVD) remains uncertain. Objective We aim to examine the relation of weight change patterns and absolute weight change from young adulthood to midlife with incident CVD. Design Retrospective cohort study. Setting National Health and Nutrition Examination Survey 1999-2016. Participants A total of 20 715 US adults aged 40 through 79 with recalled weight at young adulthood (25 years) and midlife (10 years before baseline). Main Outcome Measure CVD status was determined by self-report of a prior diagnosis, and age at diagnosis was used to establish time of CVD onset. CVD events was defined as the first occurrence of a congestive heart failure, coronary heart disease, angina pectoris, heart attack, or stroke. Results After 9.76 years of follow-up, compared with participants who remained at normal weight, those in maximum overweight, changing from nonobese to obese, changing from obese to nonobese, maintaining obesity between young and middle adulthood had a 39% (hazard ratio [HR], 1.39; 95% confidence interval [CI], 1.19-1.62), 93% (HR, 1.93; 95% CI, 1.64-2.28), 125% (HR, 2.25; 95% CI, 1.29-3.94), and 132% (HR, 2.32; 95% CI, 1.68-3.20) higher risk of CVD, respectively. In addition, compared with weight change within 2.5 kg, weight gain ≥ 10.0 kg was associated with higher risk of CVD. Conclusions Both nonobese to obese, obese to nonobese, and stable obese from young to middle adulthood were associated with increased risks of CVD. The findings emphasize the importance of maintaining normal weight throughout the adulthood for preventing CVD in later life.

scholarly journals Relations of body weight status in early adulthood and weight changes until middle age with metabolic syndrome in the Chinese population

2017 ◽  
Vol 4 (11) ◽  
pp. 4011
Author(s):  
Liancheng Zhao ◽  
Huanhuan Liu ◽  
Long Zhou ◽  
Ying Li ◽  
Min Guo ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Body Weight ◽  
Weight Gain ◽  
Weight Change ◽  
Chinese Population ◽  
Weight Status ◽  
Early Adulthood ◽  
Weight Changes ◽  
Body Weight Status ◽  
Increased Risk

Background: The evidences for the relationship between long-term weight gain and metabolic syndrome (MetS) in Chinese population were limited. Therefore, this study aims to explore the association of body weight status in early adulthood and weight changes with MetS.Methods: Data from China Multicenter Collaborative Study of Cardiovascular Epidemiology including 12808 participants aged 35–59 were used. Participants were surveyed for cardiovascular risk factors and a self-reported weight at age 25, which was defined as early adulthood. Weight change was calculated as the difference between baseline weight and early adulthood weight. MetS was defined according to AHA/NHLBI definition in 2009. Multivariate logistic regression model was used to examine the association between early adulthood weight status, weight change and MetS.Results: Mean age of participants was 46.7 years, including 6134 men and 6674 women. The overall prevalence of MetS was 21.8%. After adjusted for age, sex and other confounding factors, both BMI at 25 age and weight gain were positively associated with the risk of MetS. Being overweight (BMI, 24–27.9 kg m-2) or obese (BMI ≥28 kg m-2) at early adulthood was related to an increased risk of MetS, the odds ratio (OR) and 95%confidence interval (CI) was 3.24 (2.82–3.72) and 13.31 (8.72–20.31). In addition, weight gain was also associated with higher risk of MetS (P for trend<0.01).Conclusions: Overweight and obesity in early adulthood and weight gain were both independently related to an increased risk of MetS in the middle-aged Chinese men and women. 

Weight Change from Early to Middle Adulthood and Incident Asthma Later in Life: A Retrospective Cohort Study

2020 ◽  
Author(s):  
Tao Wang ◽  
Yunping Zhou ◽  
Nan Kong ◽  
Jianzhong Zhang ◽  
Guo Cheng ◽  
...  
Keyword(s):  
Cohort Study ◽  
Weight Gain ◽  
Weight Change ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Early Adulthood ◽  
Adult Onset ◽  
Middle Adulthood ◽  
Hazard Ratios ◽  
Incident Asthma

Abstract Background: Data describing the effects of weight change across adulthood on asthma are important for the prevention of asthma. This study aimed to investigate the association between weight change from early to middle adulthood and risk of incident asthma.Methods: Using data from the National Health and Nutrition Examination Survey (NHANES), we performed a nationally retrospective cohort study of the U.S. general population. A total of 20 771 people aged 40-74 years with recalled weight at young and middle adulthood were included in the cohort. Hazard ratios relating weight change to incident asthma over 10 years of follow-up were calculated using Cox models adjusting for covariates.Results: Compared with participants with stable non-obesity between young and middle adulthood, the hazard ratios of incident asthma were 1.63 (95% confidence interval 1.29 to 2.07) for weight gain (non-obesity to obesity), 1.41 (0.97 to 2.05) for stable obesity, and 1.21 (0.41 to 3.62) for weight loss (obesity to non-obesity). In addition, participants who gained more than 20 kg had a hazard ratio of 1.53 (1.15 to 2.03), compared with those whose weight had remained stable. When stratified by sex, the association between weight gain and incident asthma was seen only in females. Population attributable fraction calculations estimated that 10.2% of adult-onset asthma could be averted, if all those who were non-obesity at early adulthood could prevent weight gain by midlife. Conclusion: The findings implied that maintaining normal weight across adulthood, especially preventing weight gain in early adulthood, was important for preventing adult-onset asthma.

scholarly journals Prepregnancy and Early Adulthood Body Mass Index and Adult Weight Change in Relation to Fetal Loss

2014 ◽  
Vol 124 (4) ◽  
pp. 662-669 ◽  
Author(s):  
Audrey J. Gaskins ◽  
Janet W. Rich-Edwards ◽  
Daniela S. Colaci ◽  
Myriam C. Afeiche ◽  
Thomas L. Toth ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Weight Change ◽  
Early Adulthood ◽  
Fetal Loss ◽  
Adult Weight

scholarly journals Association of Weight Loss from Early to Middle Adulthood and Incident Hypertension Risk Later in Life

Nutrients ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2622
Author(s):  
Yunping Zhou ◽  
Tao Wang ◽  
Xin Yin ◽  
Yun Sun ◽  
Wei Jie Seow
Keyword(s):  
Weight Loss ◽  
Weight Gain ◽  
Weight Change ◽  
Lower Risk ◽  
Cox Regression ◽  
Early Adulthood ◽  
Later Life ◽  
Normal Weight ◽  
Middle Adulthood ◽  
Incident Hypertension

Background: The effect of obesity in early adulthood and weight loss on incident hypertension in older age has not been well characterized. This study aimed to examine the association of weight loss from young adulthood to midlife with risk of incident hypertension later in life. Methods: We performed a retrospective cohort study using data from the National Health and Nutrition Examination Survey (NHANES). Five weight change groups were categorized: stable normal, weight loss, weight gain, maximum overweight and stable obese. The hazard ratios (HRs) and 95% confidence intervals (CIs) of the association between weight change and risk of hypertension in later life were estimated using Cox regression models. Results: Compared with participants who maintained normal weight, the stable obese, weight gain, maximum overweight and weight loss groups exhibited significantly higher risks of incident hypertension, with HR of 3.28 (95% CI = 2.71 to 3.96), 2.93 (95% CI = 2.62 to 3.28), 1.76 (95% CI = 1.55 to 2.00) and 1.97 (95% CI = 1.17 to 3.31), respectively. We also observed a lower risk among those in the weight loss group (HR = 0.60, 95% CI = 0.35 to 1.02) compared with those who were stable obese. Conclusions: Weight loss from early to middle adulthood was associated with lower risk of incident hypertension as compared to those who stayed obese and higher risk of incident hypertension as compared to those who maintained normal weight. Thus, maintaining normal weight throughout adulthood may be important for the primary prevention of hypertension.

scholarly journals Body mass index at early adulthood, subsequent weight change and cancer incidence and mortality

2014 ◽  
Vol 135 (12) ◽  
pp. 2900-2909 ◽  
Author(s):  
Xuesong Han ◽  
June Stevens ◽  
Kimberly P. Truesdale ◽  
Patrick T. Bradshaw ◽  
Anna Kucharska-Newton ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Cancer Incidence ◽  
Weight Change ◽  
Early Adulthood ◽  
Incidence And Mortality
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