From bed sores to skin failure: Linguistic and conceptual confusion in the field of skin and tissue integrity

Objetivo: conhecer o perfil de Diagnósticos de Enfermagem em mulheres nutrizes atendidas no Banco de Leite Humano. Metodologia: estudo descritivo, com 30 mulheres atendidas no Banco de Leite Humano entre doadoras e não doadoras. Os dados foram coletados nos meses de março a maio de 2012. A análise se deu por meio de estatística descritiva. Resultados: os diagnósticos foram descritos para dois grupos: Não doadoras: Disposição para conhecimento melhorado (100,0%), Risco de infecção (80,9%), Integridade Tissular prejudicada (80,9%), Padrão de sono prejudicado (76,1%), Conhecimento deficiente (66,6%), Ansiedade (52,3%); Em Doadoras: Padrão de sono prejudicado (77,7%) e Ansiedade (55,5%). Conclusão: a taxonomia diagnóstica encontra-se de acordo com a população estudada. Validou-se a necessidade do uso dessa tecnologia como um sistema padrão de linguagem.Descritores: Bancos de leite; Diagnóstico de enfermagem; Cuidados de enfermagem; Saúde da mulher; Aleitamento materno.NURSING DIAGNOSIS IDENTIFIED IN WOMEN AT THE HUMAN MILK BANKObjective: to know the profile of Nursing Diagnosis in women hosted in the Human Milk Bank. Methodology: descriptive study, with 30 women attended at the Human Milk Bank between donors and no donors. Data were collected from March to May 2012. The analysis was done through simple descriptive statistics. Results: diagnosis were described for two groups: No donors: Readiness for enhanced knowledge (100.0%), Risk for infection (80.9%), Impaired tissue integrity (80.9%), Disturbed sleep pattern (76.1%), Deficient knowledge (66.6%), Anxiety (52.3%); In Donors: Disturbed sleep pattern (77.7%) and Anxiety (55.5%). Conclusion: the diagnostic taxonomy is in agreement with the studied population. The need to use this technology as a standard language system was validated.Descriptors: Milk banks; Nursing diagnosis; Nursing care; Women’s health; Breastfeeding.ENFERMERÍA DE DIAGNÓSTICO IDENTIFICADOS EN MUJERES ASISTIDA EN BANCO DE LECHE HUMANAObjetivo: conocer el perfil de los diagnósticos de enfermería de las mujeres dio la bienvenida al Banco de Leche Humana. Metodology: estúdio descriptivo, con 30 mujeres atendidas enel Banco de Leche Humana entre los donantes y no donantes. Los datos fueron recolectados entre marzo y mayo de 2012. El análisis se realizó utilizando estadísticas descriptivas simples. Resultados: los diagnósticos han sido descritos por dos grupos: No donantes: Disposición para mejorar los conocimientos (100%), Riesgo de infección (80,9%), Deterioro de la integridade cutánea (80,9%), Trastorno del patrón de sueño (76, 1%), Conocimientos deficientes (66,6%), Ansiedad (52,3%); Em Donantes: Trastorno del patrón de sueño (77,7%) y Ansiedad (55,5%). Conclusión: la taxonomía diagnóstica es función de la población estudiada. Han verificado la necesidad de la utilización de esta tecnología como un sistema estándar de lenguaje.Descriptores: Bancos de leche; Diagnóstico de enfermería; Atención de enfermería; Salud de lamujer; Lactancia materna.

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Concluding Summary

10.1093/oso/9780198809524.003.0010 ◽

2018 ◽

Author(s):

Carrie Figdor

Keyword(s):

Social Sciences ◽

External Factors ◽

Cognitive Capacity ◽

Human Cognition ◽

Conceptual Foundation ◽

The Social ◽

New Research ◽

Internal And External Factors ◽

Conceptual Confusion

Chapter 10 provides a summary of the argument of the book. It elaborates some of the benefits of Literalism, such as less conceptual confusion and an expanded range of entities for research that might illuminate human cognition. It motivates distinguishing the questions of whether something has a cognitive capacity from whether it is intuitively like us. It provides a conceptual foundation for the social sciences appropriate for the increasing role of modeling in these sciences. It also promotes convergence in terms of the roles of internal and external factors in explaining both human and nonhuman behavior. Finally, it sketches some of the areas of new research that it supports, including group cognition and artificial intelligence.

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Episiotomy: the biomechanical impact of multiple small incisions during a normal vaginal delivery

Interface Focus ◽

10.1098/rsfs.2019.0027 ◽

2019 ◽

Vol 9 (5) ◽

pp. 20190027 ◽

Cited By ~ 1

Author(s):

Dulce Oliveira ◽

Maria Vila Pouca ◽

João Ferreira ◽

Teresa Mascarenhas

Keyword(s):

Pelvic Floor ◽

Pelvic Floor Dysfunction ◽

Levator Ani ◽

Symphysis Pubis ◽

Pelvic Floor Muscles ◽

Point Of View ◽

Normal Vaginal Delivery ◽

Tissue Integrity ◽

Levator Trauma ◽

Reaction Forces

Childbirth-related injuries are one of the main causes of pelvic floor dysfunction. To attempt to avoid serious tears during delivery, an episiotomy can be performed. In this study, we intended to investigate the biomechanical performance of the pelvic floor muscles after performing different episiotomies using a physics-based computational model which includes the pelvic floor muscles and the fetus. Previous biomechanical studies have analysed the mechanical effects of single incisions of different lengths; in this study, we intend to analyse the implications of multiple small incisions, evaluating the reaction forces, the stress on the muscles and the loss of tissue integrity sustained by the pelvic floor. The obtained results predict that an episiotomy delivery reduces the likelihood of macroscopic levator trauma by decreasing the stress on the region of insertion of the rectal area of the levator ani in the symphysis pubis . From the mechanical point of view, multiple incisions do not bring benefits compared to larger incisions. However, nothing can be ascertained about the clinical benefit of such an approach.

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Silicon dioxide nanoparticles induced neurobehavioral impairments by disrupting microbiota–gut–brain axis

Journal of Nanobiotechnology ◽

10.1186/s12951-021-00916-2 ◽

2021 ◽

Vol 19 (1) ◽

Author(s):

Jun Diao ◽

Yinyin Xia ◽

Xuejun Jiang ◽

Jingfu Qiu ◽

Shuqun Cheng ◽

...

Keyword(s):

Gut Microbiota ◽

Health Risk ◽

Silicon Dioxide ◽

Spatial Learning And Memory ◽

Rrna Gene ◽

Silicon Dioxide Nanoparticles ◽

Potential Health ◽

Specific Chemical ◽

Memory Impairments ◽

Tissue Integrity

Abstract Background Silicon dioxide nanoparticles (SiO2NPs) are widely used as additive in the food industry with controversial health risk. Gut microbiota is a new and hot topic in the field of nanotoxicity. It also contributes a novel and insightful view to understand the potential health risk of food-grade SiO2NPs in children, who are susceptible to the toxic effects of nanoparticles. Methods In current study, the young mice were orally administrated with vehicle or SiO2NPs solution for 28 days. The effects of SiO2NPs on the gut microbiota were detected by 16S ribosomal RNA (rRNA) gene sequencing, and the neurobehavioral functions were evaluated by open field test and Morris water maze. The level of inflammation, tissue integrity of gut and the classical indicators involved in gut–brain, gut–liver and gut–lung axis were all assessed. Results Our results demonstrated that SiO2NPs significantly caused the spatial learning and memory impairments and locomotor inhibition. Although SiO2NPs did not trigger evident intestinal or neuronal inflammation, they remarkably damaged the tissue integrity. The microbial diversity within the gut was unexpectedly enhanced in SiO2NPs-treated mice, mainly manifested by the increased abundances of Firmicutes and Patescibacteria. Intriguingly, we demonstrated for the first time that the neurobehavioral impairments and brain damages induced by SiO2NPs might be distinctively associated with the disruption of gut–brain axis by specific chemical substances originated from gut, such as Vipr1 and Sstr2. Unapparent changes in liver or lung tissues further suggested the absence of gut–liver axis or gut–lung axis regulation upon oral SiO2NPs exposure. Conclusion This study provides a novel idea that the SiO2NPs induced neurotoxic effects may occur through distinctive gut–brain axis, showing no significant impact on either gut–lung axis or gut–liver axis. These findings raise the exciting prospect that maintenance and coordination of gastrointestinal functions may be critical for protection against the neurotoxicity of infant foodborne SiO2NPs.

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Is a diluted seawater-based solution safe and effective on human nasal epithelium?

European Archives of Oto-Rhino-Laryngology ◽

10.1007/s00405-020-06527-1 ◽

2021 ◽

Author(s):

Song Huang ◽

Samuel Constant ◽

Barbara De Servi ◽

Marisa Meloni ◽

Amina Saaid ◽

...

Keyword(s):

Wound Repair ◽

Wound Closure ◽

Isotonic Saline ◽

Nasal Epithelium ◽

Mucin Secretion ◽

Nasal Irrigation ◽

Tissue Integrity ◽

Human Nasal Epithelium ◽

Pre Treatment

Abstract Purpose Nasal irrigation is an effective method for alleviating several nasal symptoms and regular seawater-based nasal irrigation is useful for maintaining nasal hygiene which is essential for appropriate functioning of the nose and for preventing airborne particles including some pollutants, pathogens, and allergens from moving further in the respiratory system. However, safety studies on seawater-based nasal irrigation are scarce. In this study, the safety and efficacy of a diluted isotonic seawater solution (Stérimar Nasal Hygiene, SNH) in maintaining nasal homeostasis were evaluated in vitro. Methods Safety was assessed by measuring tissue integrity via transepithelial electrical resistance (TEER). Efficacy was measured by mucociliary clearance (MCC), mucin secretion, and tissue re-epithelization (wound repair) assays. All assays were performed using a 3D reconstituted human nasal epithelium model. Results In SNH-treated tissues, TEER values were statistically significantly lower than the untreated tissues; however, the values were above the tissue integrity limit. SNH treatment significantly increased MCC (88 vs. 36 µm/s, p < 0.001) and mucin secretion (1717 vs. 1280 µg/ml, p < 0.001) as compared to untreated cultures. Faster wound closure profile was noted upon pre-SNH treatment as compared to classical isotonic saline solution pre-treatment (90.5 vs. 50.7% wound closure 22 h after wound generation). Conclusion SNH did not compromise the integrity of the nasal epithelium in vitro. Furthermore, SNH was effective for removal of foreign particles through MCC increase and for enhancing wound repair on nasal mucosa.

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Effect of Lipopolysaccharides (LPS) and Lipoteichoic acid (LTA) on the Inflammatory Response in Rumen Epithelial Cells (REC) and the Impact of LPS on Claw Explants

Animals ◽

10.3390/ani11072058 ◽

2021 ◽

Vol 11 (7) ◽

pp. 2058

Author(s):

Nicole Reisinger ◽

Dominik Wendner ◽

Nora Schauerhuber ◽

Elisabeth Mayer

Keyword(s):

Epithelial Cells ◽

Inflammatory Response ◽

Structural Integrity ◽

Animal Health ◽

Lipoteichoic Acid ◽

Local Inflammatory Response ◽

Tissue Integrity ◽

Separation Force ◽

The Impact ◽

Rumen Epithelial Cells

Endotoxins play a crucial role in ruminant health due to their deleterious effects on animal health. The study aimed to evaluate whether LPS and LTA can induce an inflammatory response in rumen epithelial cells. For this purpose, epithelial cells isolated from rumen tissue (RECs) were stimulated with LPS and LTA for 1, 2, 4, and 24 h. Thereafter, the expression of selected genes of the LPS and LTA pathway and inflammatory response were evaluated. Furthermore, it was assessed whether LPS affects inflammatory response and structural integrity of claw explants. Therefore, claw explants were incubated with LPS for 4 h to assess the expression of selected genes and for 24 h to evaluate tissue integrity via separation force. LPS strongly affected the expression of genes related to inflammation (NFkB, TNF-α, IL1B, IL6, CXCL8, MMP9) in RECs. LTA induced a delayed and weaker inflammatory response than LPS. In claw explants, LPS affected tissue integrity, as there was a concentration-dependent decrease of separation force. Incubation time had a strong effect on inflammatory genes in claw explants. Our data suggest that endotoxins can induce a local inflammatory response in the rumen epithelium. Furthermore, translocation of LPS might negatively impact claw health.

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Application of Levine’s Model in Nursing Care of Patient with Diabetic Foot: A Case Study

Journal of A Sustainable Global South ◽

10.24843/jsgs.2020.v04.i01.p02 ◽

2020 ◽

Vol 4 (1) ◽

pp. 6

Author(s):

Ida Ayu Agung Laksmi ◽

Heri Kristianto ◽

Tony Suharsono

Keyword(s):

Nursing Care ◽

Diabetic Foot ◽

Single Case ◽

Hemodynamic Instability ◽

Design Data ◽

Tissue Integrity ◽

Damage Tissue ◽

Conservation Problem ◽

Conservation Model

Diabetic foot is such a life threatening condition for people with Diabetes Mellitus which it can be result in hemodynamic instability and loss of consciousness. In order to improve quality of nursing care in patient with diabetic foot, nurses should apply a nursing model approach. Levine conservation theoretical model is one of comprehensive model theory that can be applied in patients with critical diabetic foot in Emergency Department (ED). This case study describes a nursing care using Levine's Conservation Model to care for a patient with diabetic foot. This study was a case study with a single case design. Data were collected using physical assessment, written communications with the patient, interviews patient family members, and observing the patient during intensive care in the ED of Lawang General Hospital on December 21th, 2015. Levine's Conservation Model used as the nursing guideline successfully identified patient issues including ineffective breathing pattern as a major priority of energy conservation problem and damage tissue integrity as a problem of structural conservation. Both of conservation problem were caused by patient's personal integrity conservation maladaptive that caused by ineffective therapeutic regimen management. Levine’s conservation model is useful to investigate nursing problem and applicable to solve the emergency condition of damage tissue integrity in patients with diabetic foot. Index Terms— diabetic foot, nursing care, levine’s conservation model.

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