Minimal reduction type and the Kazhdan-Lusztig map

Spaceflight-associated neuro-ocular syndrome (SANS) involves unilateral or bilateral optic disc edema, widening of the optic nerve sheath, and posterior globe flattening. Owing to posterior globe flattening, it is hypothesized that microgravity causes a disproportionate change in intracranial pressure (ICP) relative to intraocular pressure. Countermeasures capable of reducing ICP include thigh cuffs and breathing against inspiratory resistance. Owing to the coupling of central venous pressure (CVP) and intracranial pressure, we hypothesized that both ICP and CVP will be reduced during both countermeasures. In four male participants (32 ± 13 yr) who were previously implanted with Ommaya reservoirs for treatment of unrelated clinical conditions, ICP was measured invasively through these ports. Subjects were healthy at the time of testing. CVP was measured invasively by a peripherally inserted central catheter. Participants breathed through an impedance threshold device (ITD, −7 cmH2O) to generate negative intrathoracic pressure for 5 min, and subsequently, wore bilateral thigh cuffs inflated to 30 mmHg for 2 min. Breathing through an ITD reduced both CVP (6 ± 2 vs. 3 ± 1 mmHg; P = 0.02) and ICP (16 ± 3 vs. 12 ± 1 mmHg; P = 0.04) compared to baseline, a result that was not observed during the free breathing condition (CVP, 6 ± 2 vs. 6 ± 2 mmHg, P = 0.87; ICP, 15 ± 3 vs. 15 ± 4 mmHg, P = 0.68). Inflation of the thigh cuffs to 30 mmHg caused no meaningful reduction in CVP in all four individuals (5 ± 4 vs. 5 ± 4 mmHg; P = 0.1), coincident with minimal reduction in ICP (15 ± 3 vs. 14 ± 4 mmHg; P =0.13). The application of inspiratory resistance breathing resulted in reductions in both ICP and CVP, likely due to intrathoracic unloading.

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Digitally Patterned Mesoporous Carbon Nanostructures of Colorless Polyimide for Transparent and Flexible Micro-Supercapacitor

Energies ◽

10.3390/en14092547 ◽

2021 ◽

Vol 14 (9) ◽

pp. 2547

Author(s):

Hyeonwoo Kim ◽

Suwon Hwang ◽

Taeseung Hwang ◽

Jung Bin In ◽

Junyeob Yeo

Keyword(s):

Carbon Nanostructures ◽

Specific Area ◽

Bending Test ◽

Chemical Compositions ◽

Carbon Structure ◽

Carbon Structures ◽

Direct Laser ◽

Mechanical Bending ◽

Minimal Reduction ◽

High Flexibility

Here, we demonstrate the fabrication of a flexible and transparent micro-supercapacitor (MSC), using colorless polyimide (CPI) via a direct laser writing carbonization (DLWC) process. The focused laser beam directly carbonizes the CPI substrate and generates a porous carbon structure on the surface of the CPI substrate. Fluorine, which is one of the chemical compositions of CPI, can enhance the specific area and the conductivity of the carbon electrode by creating micropores in carbon structures during carbonization. Thus, the fabricated carbonized CPI-based MSC shows enhanced specific capacitance (1.20 mF at 10 mV s−1) and better transmittance (44.9%) compared to the conventional PI-based MSC. Additionally, the fabricated carbonized CPI-based MSC shows excellent cyclic performance with minimal reduction (<~10%) in 3000 cycles and high capacitance retention under mechanical bending test conditions. Due to its high flexibility, transparency, and capacitance, we expect that carbonized CPI-based MSC can be further applied to various flexible and transparent applications.

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Stability of dronabinol capsules when stored frozen, refrigerated, or at room temperature

American Journal of Health-System Pharmacy ◽

10.2146/ajhp150501 ◽

2016 ◽

Vol 73 (14) ◽

pp. 1088-1092 ◽

Cited By ~ 3

Author(s):

Michael F. Wempe ◽

Alan Oldland ◽

Nancy Stolpman ◽

Tyree H. Kiser

Keyword(s):

High Performance ◽

Room Temperature ◽

Oxidative Degradation ◽

Storage Condition ◽

Sesame Oil ◽

Forced Degradation ◽

Product Packaging ◽

Time Points ◽

The Stability ◽

Minimal Reduction

Abstract Purpose Results of a study to determine the 90-day stability of dronabinol capsules stored under various temperature conditions are reported. Methods High-performance liquid chromatography (HPLC) with ultraviolet (UV) detection was used to assess the stability of dronabinol capsules (synthetic delta-9-tetrahydrocannabinol [Δ9-THC] mixed with high-grade sesame oil and other inactive ingredients and encapsulated as soft gelatin capsules) that were frozen, refrigerated, or kept at room temperature for three months. The dronabinol capsules remained in the original foil-sealed blister packs until preparation for HPLC–UV assessment. The primary endpoint was the percentage of the initial Δ9-THC concentration remaining at multiple designated time points. The secondary aim was to perform forced-degradation studies under acidic conditions to demonstrate that the HPLC–UV method used was stability indicating. Results The appearance of the dronabinol capsules remained unaltered during frozen, cold, or room-temperature storage. Regardless of storage condition, the percentage of the initial Δ9-THC content remaining was greater than 97% for all evaluated samples at all time points over the three-month study. These experimental data indicate that the product packaging and the sesame oil used to formulate dronabinol capsules efficiently protect Δ9-THC from oxidative degradation to cannabinol; this suggests that pharmacies can store dronabinol capsules in nonrefrigerated automated dispensing systems, with a capsule expiration date of 90 days after removal from the refrigerator. Conclusion Dronabinol capsules may be stored at room temperature in their original packaging for up to three months without compromising capsule appearance and with minimal reduction in Δ9-THC concentration.

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Structural basis of muscle O2 diffusing capacity: evidence from muscle function in situ

Journal of Applied Physiology ◽

10.1152/jappl.2000.88.2.560 ◽

2000 ◽

Vol 88 (2) ◽

pp. 560-566 ◽

Cited By ~ 68

Author(s):

Russell T. Hepple ◽

Michael C. Hogan ◽

Creed Stary ◽

Donald E. Bebout ◽

Odile Mathieu-Costello ◽

...

Keyword(s):

Gastrocnemius Muscle ◽

Capillary Density ◽

Structural Basis ◽

Diffusing Capacity ◽

Diffusion Distance ◽

Short Term ◽

Cross Sectional ◽

Intact Organism ◽

Minimal Reduction

Although evidence for muscle O2 diffusion limitation of maximal O2 uptake has been found in the intact organism and isolated muscle, its relationship to diffusion distance has not been examined. Thus we studied six sets of three purpose-bred littermate dogs (aged 10–12 mo), with 1 dog per litter allocated to each of three groups: control (C), exercise trained for 8 wk (T), or left leg immobilized for 3 wk (I). The left gastrocnemius muscle from each animal was surgically isolated, pump-perfused, and electrically stimulated to peak O2 uptake at three randomly applied levels of arterial oxygenation [normoxia, arterial[Formula: see text]([Formula: see text]) 77 ± 2 (SE) Torr; moderate hypoxia, [Formula: see text]: 33 ± 1 Torr; and severe hypoxia, [Formula: see text]: 22 ± 1 Torr]. O2 delivery (ml ⋅ min−1 ⋅ 100 g− 1) was kept constant among groups for each level of oxygenation, with O2 delivery decreasing with decreasing [Formula: see text]. O2extraction (%) was lower in I than T or C for each condition, but calculated muscle O2 diffusing capacity (Dm[Formula: see text]) per 100 grams of muscle was not different among groups. After the experiment, the muscle was perfusion fixed in situ, and a sample from the midbelly was processed for microscopy. Immobilized muscle showed a 45% reduction of muscle fiber cross-sectional area ( P < 0.05), and a resulting 59% increase in capillary density ( P < 0.05) but minimal reduction in capillary-to-fiber ratio (not significant). In contrast, capillarity was not significantly different in T vs. C muscle. The results show that a dramatically increased capillary density (and reduced diffusion distance) after short-term immobilization does not improve Dm[Formula: see text] in heavily working skeletal muscle.

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A Pilot Study on Efficacy of Vishakalpa (Shwetra lepa) in Shwetra (Vitiligo)

International Journal of Ayurvedic Medicine ◽

10.47552/ijam.v11i4.1727 ◽

2020 ◽

Vol 11 (4) ◽

pp. 747-753

Author(s):

Akhilesh Deshmukh ◽

Nilima Wadnerwar ◽

Apurva Gaikwad

Keyword(s):

Pilot Study ◽

Social Stigma ◽

The Body ◽

Local Application ◽

Newly Diagnosed ◽

Marital Problems ◽

Before And After ◽

Potent Drug ◽

Minimal Reduction ◽

Shape And Size

Shwetra (Vitiligo) is a skin disease which takes longer time to cure. It affects the external beauty of the body causing social stigma, shyness, loss of confidence, fear of comments marital problems, etc. The disease needs repeated shodhana and regular internal and external shaman chikitsa for longer duration. Objectives: To study the efficacy of Vishakalpa (Shwetra lepa) alone in the management of Shwetra and to provide a potent drug for sure and quick relief from Shwetra (vitiligo), this pilot study was carried out. Material and methods: Shwetra lepa was prepared and used as local application in 15 patients having newly diagnosed patches of vitiligo. The changes in shape, size and number of patches and VETI score was assessed before and after treatment. The data was analyzed with the help of parametric and non parametric tests. Results: Though there was no significant change in VETI score, minimal reduction in shape and size of patches, daha and kandu was observed with Shwetra lepa vati. Conclusion: One month study duration for local application of Shwetra lepa vati and sample size was found to be insufficient to prove the efficacy of Shwetra lepa. Hence it is recommended that Shwetra lepa should be used alone for longer period up to 6 to 9 months or it can be used along with repeated shodhana and continuous shamana chikitsa for 2 to 6 months for effective results.

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A simple criterion to design optimal non-pharmaceutical interventions for mitigating epidemic outbreaks

Journal of The Royal Society Interface ◽

10.1098/rsif.2020.0803 ◽

2021 ◽

Vol 18 (178) ◽

Author(s):

Marco Tulio Angulo ◽

Fernando Castaños ◽

Rodrigo Moreno-Morton ◽

Jorge X. Velasco-Hernández ◽

Jaime A. Moreno

Keyword(s):

Disease Transmission ◽

Reproduction Number ◽

Contact Rate ◽

Simple Criterion ◽

Societal Costs ◽

Public Events ◽

Maximum Decrease ◽

Minimal Reduction ◽

Theoretical Results ◽

Pharmaceutical Interventions

For mitigating the COVID-19 pandemic, much emphasis is made on implementing non-pharmaceutical interventions to keep the reproduction number below one. However, using that objective ignores that some of these interventions, like bans of public events or lockdowns, must be transitory and as short as possible because of their significant economic and societal costs. Here, we derive a simple and mathematically rigorous criterion for designing optimal transitory non-pharmaceutical interventions for mitigating epidemic outbreaks. We find that reducing the reproduction number below one is sufficient but not necessary. Instead, our criterion prescribes the required reduction in the reproduction number according to the desired maximum of disease prevalence and the maximum decrease of disease transmission that the interventions can achieve. We study the implications of our theoretical results for designing non-pharmaceutical interventions in 16 cities and regions during the COVID-19 pandemic. In particular, we estimate the minimal reduction of each region’s contact rate necessary to control the epidemic optimally. Our results contribute to establishing a rigorous methodology to design optimal non-pharmaceutical intervention policies for mitigating epidemic outbreaks.

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Reduction numbers and Hilbert polynomials of ideals in higher dimensional CohenMacaulay local rings

Mathematical Proceedings of the Cambridge Philosophical Society ◽

10.1017/s0305004100075149 ◽

1992 ◽

Vol 111 (1) ◽

pp. 47-56 ◽

Cited By ~ 4

Author(s):

Yinghwa Wu

Keyword(s):

Local Ring ◽

Residue Field ◽

Primary Ideal ◽

Local Rings ◽

Hilbert Polynomials ◽

Higher Dimensional ◽

Reduction Number ◽

Minimal Reduction ◽

System Of Parameters

Throughout, (R, m) will denote a d-dimensional CohenMacaulay (CM for short) local ring having an infinite residue field and I an m-primary ideal in R. Recall that an ideal J I is said to be a reduction of I if Ir+1 = JIr for some r 0, and a reduction J of I is called a minimal reduction of I if J is generated by a system of parameters. The concepts of reduction and minimal reduction were first introduced by Northcott and Rees12. If J is a reduction of I, define the reduction number of I with respect to J, denoted by rj(I), to be min {r 0 Ir+1 = JIr}. The reduction number of I is defined as r(I) = min {rj(I)J is a minimal reduction of I}. The reduction number r(I) is said to be independent if r(I) = rj(I) for every minimal reduction J of I.

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The critical weed-free period in glyphosate-resistant soybean in Ontario is similar to previous estimates using glyphosate-susceptible soybean

Canadian Journal of Plant Science ◽

10.1139/cjps-2018-0049 ◽

2019 ◽

Vol 99 (4) ◽

pp. 437-443

Author(s):

Nader Soltani ◽

Robert E. Nurse ◽

Amit J. Jhala ◽

Peter H. Sikkema

Keyword(s):

Growth Stage ◽

Field Experiments ◽

Yield Loss ◽

Growth Stages ◽

Weed Species ◽

Weed Biomass ◽

Weed Density ◽

Weed Interference ◽

Beginning Of Flowering ◽

Minimal Reduction

A study consisting of 13 field experiments was conducted during 2014–2016 in southwestern Ontario and southcentral Nebraska (Clay Center) to determine the effect of late-emerging weeds on the yield of glyphosate-resistant soybean. Soybean was maintained weed-free with glyphosate (900 g ae ha−1) up to the VC (cotyledon), V1 (first trifoliate), V2 (second trifoliate), V3 (third trifoliate), V4 (fourth trifoliate), and R1 (beginning of flowering) growth stages, after which weeds were allowed to naturally infest the soybean plots. The total weed density was reduced to 24%, 63%, 67%, 72%, 76%, and 92% in Environment 1 (Exeter, Harrow, and Ridgetown) when soybean was maintained weed-free up to the VC, V1, V2, V3, V4, and R1 soybean growth stages, respectively. The total weed biomass was reduced by 33%, 82%, 95%, 97%, 97%, and 100% in Environment 1 (Exeter, Harrow, and Ridgetown) and 28%, 100%, 100%, 100%, 100%, and 100% in Environment 2 (Clay Center) when soybean was maintained weed-free up to the VC, V1, V2, V3, V4, and R1 stages, respectively. The critical weed-free periods for a 2.5%, 5%, and 10% yield loss in soybean were the V1–V2, VC–V1, and VC–V1 soybean stages in Environment 1 (Exeter, Harrow, and Ridgetown) and V2–V3, V2–V3, and V1–V2 soybean stages in Environment 2 (Clay Center), respectively. For the weed species evaluated, there was a minimal reduction in weed biomass (5% or less) when soybean was maintained weed-free beyond the V3 soybean growth stage. These results shows that soybean must be maintained weed-free up to the V3 growth stage to minimize yield loss due to weed interference.

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Esthetic rehabilitation of anterior teeth with different thicknesses of porcelain laminate veneers: An 8-year follow-up clinical evaluation

European Journal of Dentistry ◽

10.4103/ejd.ejd_241_17 ◽

2018 ◽

Vol 12 (04) ◽

pp. 590-593 ◽

Cited By ~ 2

Author(s):

Tassiana Cançado Melo Sá ◽

Monize Ferreira Figueiredo de Carvalho ◽

Julio Celso M. de Sá ◽

Claudia Silami Magalhães ◽

Allyson Nogueira Moreira ◽

...

Keyword(s):

Excellent Result ◽

Clinical Report ◽

Invasive Treatment ◽

Minimum Thickness ◽

Anterior Teeth ◽

Tooth Preparation ◽

Minimal Reduction ◽

And Function ◽

Laminate Veneers

ABSTRACTThis clinical report describes an 8-year follow-up evaluation using different thicknesses of porcelain laminate veneers of diastema and malformed anterior teeth. Minimally invasive treatment with no preparation or minimal reduction options could be considered and chosen based on the characteristics of each case. Laminate veneers with or without reduction can offer an excellent result regarding esthetics and function. Despite its failure without reduction, this treatment is indicated because it can be applied regardless of the structure of the teeth. At first, no tooth preparation with rotatory instruments was performed, and porcelain laminates of minimum thickness were made for the four maxillary anterior teeth. After 6 years, the adhesive interfaces were stained, and the patient was unsatisfied with the esthetics of her smile. Therefore, at that time, the professional decided to prepare the anterior teeth for porcelain laminate veneers. Diastema closure and/or correction of malformed anterior teeth using porcelain laminate veneers is a viable option for the clinician because it restores esthetic harmony. The patient was very pleased with the new laminate veneers.

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