scholarly journals Strengthening epithelial barriers through modulation of the histone code in allergic diseases—a novel approach for preventing the atopic march?

2020 ◽  
Vol 146 (3) ◽  
pp. 515-517
Author(s):  
Jörg Tost
Keyword(s):  
Allergic Diseases ◽  
Histone Code ◽  
Atopic March ◽  
Novel Approach ◽  
Epithelial Barriers

scholarly journals Principles of complementary food introduction in atopic dermatitis

2021 ◽  
Vol 5 (6) ◽  
pp. 421-426
Author(s):  
A.S. Botkina ◽  
◽  
M.I. Dubrovskaya ◽  
Keyword(s):  
Atopic Dermatitis ◽  
Allergic Diseases ◽  
Elimination Diet ◽  
Complementary Food ◽  
Childhood Nutrition ◽  
Atopic March ◽  
Special Diet ◽  
Starting Point ◽  
Keywords Atopic Dermatitis ◽  
Early Childhood Nutrition

Atopic dermatitis (AD) is one of the most common inflammatory skin disorders. In most patients, AD is a starting point for developing other atopic diseases, e.g., food allergy, allergic diseases of the gastrointestinal tract, allergic rhinitis, and asthma known under the umbrella of "atopic march". In addition to genetic predisposition, various environmental factors are essential for the development of this dermatosis. In young children, food is the most relevant factor. This paper discusses principles of the selection of complementary food, techniques, and terms of its introduction. Prolonging of breastfeeding, the adequate introduction of complementary food, and personified nutrition program prevent the atopic march. The authors highlight that there is no special diet for atopic dermatitis. Meanwhile, food should be safe, low allergy, and balanced to provide a child with essential macro-and micronutrients. In addition, the paper addresses the utility and validity of an elimination diet which should be prescribed only in established food sensitization and used under the control o f a specialist. KEYWORDS: atopic dermatitis, atopic march, infancy, early childhood, nutrition, complementary foods, prevention. FOR CITATION: Botkina A.S., Dubrovskaya M.I. Principles of complementary food introduction in atopic dermatitis. Russian Medical Inquiry. 2021;5(6):421–426 (in Russ.). DOI: 10.32364/2587-6821-2021-5-6-421-426.

scholarly journals Significance of the epidermal barrier and sensitisation to household allergens to the development of atopic march for primary prevention

2018 ◽  
Vol 17 (2) ◽  
pp. 114-120
Author(s):  
E. E. Varlamov ◽  
A. N. Pampura ◽  
A. N. Asmanov
Keyword(s):  
Allergic Rhinitis ◽  
Early Childhood ◽  
Atopic Dermatitis ◽  
Primary Prevention ◽  
Bronchial Asthma ◽  
Allergic Diseases ◽  
The State ◽  
Older Age ◽  
Epidermal Barrier ◽  
Atopic March

Atopic march is a variant flowing of atopia that begins in early childhood as atopic dermatitis, then developinto other allergic diseases (bronchial asthma, allergic rhinitis) at an older age. The state of the epidermal barrier and sensitization to inhaled allergens are considered as predictors for the development of atopic march. Data on the importance of these factors in the development of atopic march and information about possible approaches to prevention are presented in this article.

scholarly journals Melatonin prevents allergic airway inflammation in epicutaneously sensitized mice

2021 ◽  
Author(s):  
Xudong Liu ◽  
Yuchao Zhang ◽  
Yaolin Ren ◽  
Jinquan Li
Keyword(s):  
Oxidative Stress ◽  
Airway Hyperresponsiveness ◽  
Molecular Mechanisms ◽  
Allergic Airway Inflammation ◽  
Allergic Diseases ◽  
Pathological Process ◽  
Histopathological Changes ◽  
Atopic March ◽  
Stress Markers ◽  
Successful Establishment

Purpose: The pathological process of atopic dermatitis (AD) progressing into other types of allergic diseases such as asthma and allergic rhinitis during the first several years of life is often referred to as the atopic march. Although the phenomenon of atopic march has been recognized for decades, how asthma stems from AD is still not fully understood, confounding a universal strategy to effectively protect people from the atopic march. Methods: We established experimental atopic march mice by first inducing allergic dermatitis with 0.5% fluorescein isothiocyante applied to the skin, followed by an OVA airway challenge. In addition, by examining serum immunoglobulin concentrations, airway cytokines, the levels of oxidative stress markers, histopathological changes in lung tissue and airway hyperresponsiveness, we were able to validate the successful establishment of the model. Furthermore, by detecting the attenuating effects of melatonin (MT) and the levels of oxidative stress in the atopic march mice, we explored the potential molecular mechanisms involved in the development of atopic march. Results: By successfully establishing an experimental atopic march mouse model, we were able to demonstrate that overproduction of oxidative stress in the lung significantly upregulated the activation of NF-κB signaling pathways causing TSLP release, which further promotes the development of atopic march. Conclusions: To mitigate the development of the atopic march, antioxidants such as MT may be imperative to inhibit NF-κB activation in the lung, especially after the onset of AD.

scholarly journals Eosinophil microRNAs Play a Regulatory Role in Allergic Diseases Included in the Atopic March

2020 ◽  
Vol 21 (23) ◽  
pp. 9011
Author(s):  
Émile Bélanger ◽  
Anne-Marie Madore ◽  
Anne-Marie Boucher-Lafleur ◽  
Marie-Michelle Simon ◽  
Tony Kwan ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Immunoglobulin E ◽  
Clinical Manifestations ◽  
Skin Barrier ◽  
Allergic Diseases ◽  
Forced Expiratory Volume ◽  
Inflammatory Reactions ◽  
Atopic March ◽  
History Of

(1) Background: The atopic march is defined by the increased prevalence of allergic diseases after atopic dermatitis onset. In fact, atopic dermatitis is believed to play an important role in allergen sensitization via the damaged skin barrier, leading to allergic diseases such as allergic asthma and allergic rhinitis. The eosinophil, a pro-inflammatory cell that contributes to epithelial damage, is one of the various cells recruited in the inflammatory reactions characterizing these diseases. Few studies were conducted on the transcriptome of this cell type and even less on their specific microRNA (miRNA) profile, which could modulate pathogenesis of allergic diseases and clinical manifestations post-transcriptionally. Actually, their implication in allergic diseases is not fully understood, but they are believed to play a role in inflammation-related patterns and epithelial cell proliferation. (2) Methods: Next-generation sequencing was performed on RNA samples from eosinophils of individuals with atopic dermatitis, atopy, allergic rhinitis and asthma to obtain differential counts of primary miRNA (pri-miRNA); these were also analyzed for asthma-related phenotypes such as forced expiratory volume in one second (FEV1), immunoglobulin E (IgE) and provocative concentration of methacholine inducing a 20% fall in forced expiratory volume in 1 s (PC20) levels, as well as FEV1 to forced vital capacity (FEV1/FVC) ratio. (3) Results: Eighteen miRNAs from eosinophils were identified to be significantly different between affected individuals and unaffected ones. Based on counts from these miRNAs, individuals were then clustered into groups using Ward’s method on Euclidian distances. Groups were found to be explained by asthma diagnosis, familial history of respiratory diseases and allergic rhinitis as well as neutrophil counts. (4) Conclusions: The 18 differential miRNA counts for the studying phenotypes allow a better understanding of the epigenetic mechanisms underlying the development of the allergic diseases included in the atopic march.

OR.75. Reduction of Serum IgE by Depletion of the IgE B Cell Lineage- A Novel Approach for the Treatment of Allergic Diseases

2009 ◽  
Vol 131 ◽  
pp. S31
Author(s):  
Hans Brightbill ◽  
Surinder Jeet ◽  
Zhonghua Lin ◽  
Donghong Yan ◽  
Meijuan Zhou ◽  
...  
Keyword(s):  
B Cell ◽  
Cell Lineage ◽  
Allergic Diseases ◽  
Serum Ige ◽  
Novel Approach

scholarly journals A case of atopic dermatitis with a severe resistant course in adult patient with atopic march

2020 ◽  
Vol 17 (2) ◽  
pp. 69-73
Author(s):  
Galiya M. Tusupbekova ◽  
Aigul A. Syzdykova ◽  
Botagoz M. Davletova
Keyword(s):  
Atopic Dermatitis ◽  
Adult Patient ◽  
Clinical Symptoms ◽  
Clinical Manifestations ◽  
Allergic Diseases ◽  
Atopic Disease ◽  
Significant Others ◽  
Natural Course ◽  
Atopic March ◽  
Typical Sequence

Introduction. The atopic march is the natural course of development of atopy symptoms. It is characterized by a typical sequence of development of clinical symptoms of atopic disease, when some symptoms become more significant, others are recede. Timely allergological diagnostics with the identification of causal allergens allows to preventor suspend the atopic march. Purpose of the study was to demonstrate the stages of the atopic march formation and clinical manifestations of atopy, the importance of on timely detection of causal allergens, the capability of modern diagnostics and treatment of severe resistant forms of allergic diseases.

The allergic march and early diagnosis, treatment and prevention of allergic diseases

2001 ◽  
Vol 58 (5) ◽  
pp. 262-265 ◽  
Author(s):  
Roger Lauener ◽  
P. Eigenmann
Keyword(s):  
Early Diagnosis ◽  
Allergic Diseases ◽  
Medikamentöse Behandlung ◽  
Atopic March ◽  
Präventive Maßnahmen ◽  
Allergische Erkrankungen ◽  
Treatment And Prevention ◽  
Allergic March

Allergische Erkrankungen weisen eine charakteristische Eigenschaft auf: in verschiedenen Lebensabschnitten des Kindes zeigen sie sich unter verschiedenen Gesichtern. Dieser typische zeitliche Ablauf, bei der atopische Kinder mit zunehmendem Alter aus einer allergischen Erkrankung «herauswachsen», dann aber an der nächsten Form einer Allergie erkranken, wird als allergischer Marsch («allergic march, atopic march») oder als Allergiekarriere bezeichnet. Verschiedene Informationen können dazu beitragen, die Kinder früh zu erkennen, die gefährdet sind, den allergischen Marsch durchzumachen. So haben die Kinder, die bereits früh im Säuglingsalter gegen bestimmte Allergene sensibilisiert sind, bei denen die Sensibilisierung über längere Zeit nachgewiesen werden kann, und die an einer atopischen Dermatitis leiden, ein hohes Risiko, später an allergischem Asthma zu erkranken. Es stellt sich die Frage, inwiefern man durch präventive Maßnahmen oder früh einsetzende Therapien diesen «Marsch durch die allergischen Krankheiten» aufhalten oder zumindest verlangsamen kann. Zuverlässige Mittel, um im Sinne der Primärprävention jegliche Manifestation der atopischen Konstitution schon im Ansatz verhindern zu können, stehen zur Zeit nicht zur Verfügung. Hingegen können ein sorgfältiger Ernährungsaufbau im Säuglingsalter und Maßnahmen zur Hausstaubsanierung dazu beitragen, den Verlauf der Allergiekarriere günstig zu beeinflussen. Bei ausgewählten, ganz besonders belasteten Patienten kann eine früh beginnende und über lange Zeit durchgeführte medikamentöse Behandlung erwogen werden.

CRIC3, a chemokine receptor inactivator as a novel approach in the treatment of allergic diseases

2003 ◽  
Vol 111 (2) ◽  
pp. S278
Author(s):  
J. Elsner ◽  
I. Hartung ◽  
R. Bäder ◽  
S.E. Escher ◽  
N. Spodsberg ◽  
...  
Keyword(s):  
Chemokine Receptor ◽  
Allergic Diseases ◽  
Novel Approach

scholarly journals Current Insights into Atopic March

Children ◽  
2021 ◽  
Vol 8 (11) ◽  
pp. 1067
Author(s):  
Mitsuru Tsuge ◽  
Masanori Ikeda ◽  
Naomi Matsumoto ◽  
Takashi Yorifuji ◽  
Hirokazu Tsukahara
Keyword(s):  
Oxidative Stress ◽  
Environmental Pollutants ◽  
Skin Barrier ◽  
Allergic Diseases ◽  
Barrier Dysfunction ◽  
Atopic March ◽  
Inflammatory Conditions ◽  
And Oxidative Stress ◽  
Type 2 Inflammation

The incidence of allergic diseases is increasing, and research on their epidemiology, pathophysiology, and the prevention of onset is urgently needed. The onset of allergic disease begins in infancy with atopic dermatitis and food allergy and develops into allergic asthma and allergic rhinitis in childhood; the process is defined as “atopic march”. Atopic march is caused by multiple immunological pathways, including allergen exposure, environmental pollutants, skin barrier dysfunction, type 2 inflammation, and oxidative stress, which promote the progression of atopic march. Using recent evidence, herein, we explain the involvement of allergic inflammatory conditions and oxidative stress in the process of atopic march, its epidemiology, and methods for prevention of onset.

scholarly journals Modern Outlooks on «Atopic March» Secondary Prevention Capabilities in Children with Atopic Dermatitis

2020 ◽  
Vol 19 (6) ◽  
pp. 514-519
Author(s):  
Nikolay N. Murashkin ◽  
Leyla S. Namazova-Baranova ◽  
Roman A. Ivanov ◽  
Dmitri V. Fedorov ◽  
Eduard T. Ambarchian ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Inflammatory Process ◽  
Inflammatory Diseases ◽  
Allergic Diseases ◽  
Disease Course ◽  
Therapeutic Approaches ◽  
Atopic March ◽  
Gradual Development ◽  
Severity Of The Disease

Atopic dermatitis (AD) is one of the most common inflammatory diseases of childhood, and it is the first one in gradual development of allergic diseases, also known as «atopic march». Sensitization establishment during the AD uncontrolled course is associated with the high risk of developing of serious allergic pathologies, increase in the severity of the disease course, and patients’ quality of life reduction. Thereby, it is crucial to achieve quick jugulation of the inflammatory process in case of severe AD with early onset of disease. This article shows modern therapeutic approaches to disease control in children.

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