The allergic march and early diagnosis, treatment and prevention of allergic diseases

2001 ◽  
Vol 58 (5) ◽  
pp. 262-265 ◽  
Author(s):  
Roger Lauener ◽  
P. Eigenmann
Keyword(s):  
Early Diagnosis ◽  
Allergic Diseases ◽  
Medikamentöse Behandlung ◽  
Atopic March ◽  
Präventive Maßnahmen ◽  
Allergische Erkrankungen ◽  
Treatment And Prevention ◽  
Allergic March

Allergische Erkrankungen weisen eine charakteristische Eigenschaft auf: in verschiedenen Lebensabschnitten des Kindes zeigen sie sich unter verschiedenen Gesichtern. Dieser typische zeitliche Ablauf, bei der atopische Kinder mit zunehmendem Alter aus einer allergischen Erkrankung «herauswachsen», dann aber an der nächsten Form einer Allergie erkranken, wird als allergischer Marsch («allergic march, atopic march») oder als Allergiekarriere bezeichnet. Verschiedene Informationen können dazu beitragen, die Kinder früh zu erkennen, die gefährdet sind, den allergischen Marsch durchzumachen. So haben die Kinder, die bereits früh im Säuglingsalter gegen bestimmte Allergene sensibilisiert sind, bei denen die Sensibilisierung über längere Zeit nachgewiesen werden kann, und die an einer atopischen Dermatitis leiden, ein hohes Risiko, später an allergischem Asthma zu erkranken. Es stellt sich die Frage, inwiefern man durch präventive Maßnahmen oder früh einsetzende Therapien diesen «Marsch durch die allergischen Krankheiten» aufhalten oder zumindest verlangsamen kann. Zuverlässige Mittel, um im Sinne der Primärprävention jegliche Manifestation der atopischen Konstitution schon im Ansatz verhindern zu können, stehen zur Zeit nicht zur Verfügung. Hingegen können ein sorgfältiger Ernährungsaufbau im Säuglingsalter und Maßnahmen zur Hausstaubsanierung dazu beitragen, den Verlauf der Allergiekarriere günstig zu beeinflussen. Bei ausgewählten, ganz besonders belasteten Patienten kann eine früh beginnende und über lange Zeit durchgeführte medikamentöse Behandlung erwogen werden.

THE ROLE OF PHAGE THERAPY IN THE FORMATION OF THE INTESTINAL MICROECOSYSTEM

2020 ◽  
pp. 183-191
Author(s):  
Gladkov S.F. ◽  
Perevoshchikova N.K. ◽  
Chernykh N.S. ◽  
Pichugina Yu.S. ◽  
Surkova M.A.
Keyword(s):  
Intestinal Microbiota ◽  
Allergic Diseases ◽  
Evidence Base ◽  
Immunological Tolerance ◽  
Convincing Evidence ◽  
Selective Decontamination ◽  
Genetic Characteristics ◽  
Treatment And Prevention ◽  
Intestinal Infections ◽  
The Individual

The current adverse situation associated with the presence of a pandemic of allergic diseases is due to the lack of a scientifically based concept of treatment and prevention. The increased interest of researchers from different countries in the formation of immunological tolerance by modeling the intestinal microbiota is of high importance. Methods of influence on the microbial communities of the child's intestine should be as delicate as possible, taking into account the individual genetic characteristics of the microecosystem and the possibility of anaphylaxis. Until now, probiotic drugs have been widely used to correct dysbiosis, but data is gradually accumulating that there is no convincing evidence base for their use for the treatment and prevention of atopy. The use of bacteriophages is very relevant and one of the promising, actively studied areas of correction of intestinal biocenosis today, which are an alternative to antibiotic and probiotic medications. Selective decontamination of representatives of opportunistic flora, as the main factor in the implementation of the atopic phenotype, makes it possible to preserve and accelerate the formation of a unique and individual composition of the intestinal microbiota of the child, which can form an immunoregulatory balance. More than a century of experience in the use of bacteriophages indicates the safety of their use. Today, bacteriophages are actively used in various fields of practical medicine − obstetrics-gynecology, perinatology, urology, pediatric otorhinolaryngology, in the treatment of purulent-septic and intestinal infections. In some cases, bacteriophages are very effective against antibiotic-resistant pathogens. The active personalized use of bacteriophages in real clinical practice will make it possible to solve a number of serious, long-standing health problems in the Russian Federation and to win a world priority in this direction.

Climate change and its impact on the development of allergic diseases

2021 ◽  
Vol 17 (4) ◽  
pp. 7-18
Author(s):  
Evgeniya V. Nazarova
Keyword(s):  
Air Pollution ◽  
Respiratory System ◽  
Forest Fires ◽  
Negative Impact ◽  
Allergic Diseases ◽  
Developed Countries ◽  
Dust Storms ◽  
International Studies ◽  
Treatment And Prevention ◽  
Earth Temperature

Since the middle of the twentieth century, there has been a widespread increase in the prevalence of allergic diseases, especially in developed countries. Much attention is paid to the changing climate and its influence on the development of allergies, mainly of the respiratory system. In many countries, studies are intensifying to study the relationship of various weather phenomena, air pollution, Earth temperature with the course of certain allergic diseases of the respiratory tract. Global strategies for the treatment and prevention of allergic diseases are being developed. This review provides data from international studies demonstrating the negative impact on human health and the development of allergic diseases of the respiratory system, in particular asthma: a global rise in Earth temperature, air pollution, dust storms, forest fires, dampness in rooms and atmospheric mold, thunderstorms and floods.

On the importance of psychological factors in allergic diseases in children

1999 ◽  
Vol 80 (3) ◽  
pp. 219-221
Author(s):  
I. S. Aron ◽  
A. M. Potemkin
Keyword(s):  
Allergic Disease ◽  
Psychological Factors ◽  
Allergic Diseases ◽  
First Year ◽  
Childhood Diseases ◽  
Treatment And Prevention ◽  
Prevention And Treatment ◽  
First Year Of Life

Allergic diseases account for 20-25% in the overall structure of all morbidity in Russia [5]. The problem of prevention and treatment of allergic diseases in children is especially urgent, because allergic diseases occupy a leading place in the structure of childhood diseases. According to A.M. Potemkina, treatment and prevention of allergic diseases in children are most effective in the first three years of life. In children of the first year of life, monoallergy prevails, that is, one allergic disease (85%).

scholarly journals Potential of the Antibody Against cis–Phosphorylated Tau in the Early Diagnosis, Treatment, and Prevention of Alzheimer Disease and Brain Injury

2016 ◽  
Vol 73 (11) ◽  
pp. 1356 ◽  
Author(s):  
Kun Ping Lu ◽  
Asami Kondo ◽  
Onder Albayram ◽  
Megan K. Herbert ◽  
Hekun Liu ◽  
...  
Keyword(s):  
Brain Injury ◽  
Alzheimer Disease ◽  
Early Diagnosis ◽  
Phosphorylated Tau ◽  
Treatment And Prevention

Correlation between severity of migraine attacks and IgE level in peripheral blood

2016 ◽  
Vol 40 (3) ◽  
Author(s):  
Maryam Hassanpour Moghadam ◽  
Hamidreza Ardalani ◽  
Alireza Alehashemi ◽  
Mahboobeh Adami Dehkordi ◽  
Mojtaba Meshkat
Keyword(s):  
Inflammatory Mediators ◽  
Peripheral Blood ◽  
Migraine Headache ◽  
Clinical Symptoms ◽  
Allergic Sensitization ◽  
Allergic Diseases ◽  
University Hospital ◽  
Migraine Headaches ◽  
Treatment And Prevention ◽  
Significant Difference

Abstract: The correlation between allergic diseases and migraine is partially due to a better understanding of inflammatory mediators with vasoactive function that play an important role in these diseases. This study aimed to evaluate the correlation between allergic sensitization and severity of migraine.: This study was carried out on 212 patients who suffered from migraine headache in a university hospital in Mashhad, Iran. All of these patients were evaluated for allergic rhinitis (AR) by measuring the IgE level in peripheral blood and assessing the clinical symptoms of AR. Prevalence of AR in migraine patients and degree of allergic sensitization was assessed in this study.: The prevalence of AR in migraine patients was 78.30%. Total IgE levels in the peripheral blood in migraine patients with AR were found to be significantly (p<0.0001) higher than those without migraines. There was a significant difference between severity of AR (higher level of IgE) and severity of migraine attacks (p<0.0001), but there was not any significant difference between severity of AR and other factors.: We propose that inflammatory mediators play a key role in triggering migraine attacks. Thus, effective treatment of AR in migraine patients plays an important role in treatment and prevention of migraine headaches.

scholarly journals Principles of complementary food introduction in atopic dermatitis

2021 ◽  
Vol 5 (6) ◽  
pp. 421-426
Author(s):  
A.S. Botkina ◽  
◽  
M.I. Dubrovskaya ◽  
Keyword(s):  
Atopic Dermatitis ◽  
Allergic Diseases ◽  
Elimination Diet ◽  
Complementary Food ◽  
Childhood Nutrition ◽  
Atopic March ◽  
Special Diet ◽  
Starting Point ◽  
Keywords Atopic Dermatitis ◽  
Early Childhood Nutrition

Atopic dermatitis (AD) is one of the most common inflammatory skin disorders. In most patients, AD is a starting point for developing other atopic diseases, e.g., food allergy, allergic diseases of the gastrointestinal tract, allergic rhinitis, and asthma known under the umbrella of "atopic march". In addition to genetic predisposition, various environmental factors are essential for the development of this dermatosis. In young children, food is the most relevant factor. This paper discusses principles of the selection of complementary food, techniques, and terms of its introduction. Prolonging of breastfeeding, the adequate introduction of complementary food, and personified nutrition program prevent the atopic march. The authors highlight that there is no special diet for atopic dermatitis. Meanwhile, food should be safe, low allergy, and balanced to provide a child with essential macro-and micronutrients. In addition, the paper addresses the utility and validity of an elimination diet which should be prescribed only in established food sensitization and used under the control o f a specialist. KEYWORDS: atopic dermatitis, atopic march, infancy, early childhood, nutrition, complementary foods, prevention. FOR CITATION: Botkina A.S., Dubrovskaya M.I. Principles of complementary food introduction in atopic dermatitis. Russian Medical Inquiry. 2021;5(6):421–426 (in Russ.). DOI: 10.32364/2587-6821-2021-5-6-421-426.

scholarly journals PATHOGENETIC APPROACH TO EARLY DIAGNOSIS OF MILD NEURO-ORTHOPEDIC PATHOLOGY IN CHILDREN

2020 ◽  
Vol 76 (4) ◽  
pp. 106-109
Author(s):  
M.E. Winderlich ◽  
◽  
N.B. Schekolova ◽  
Keyword(s):  
Differential Diagnosis ◽  
Early Diagnosis ◽  
Children And Adolescents ◽  
Research Methods ◽  
Musculoskeletal System ◽  
Spinal Deformity ◽  
Foot Placement ◽  
Pelvic Bones ◽  
Timely Diagnosis ◽  
Treatment And Prevention

216 children and adolescents from 3 months to 17 years with mild neuroorthopedic pathology – torticollis, abnormal foot placement, flat-valgus feet, posture disorders, scoliosis, shortening of the limb were examined. The etiological factors of Natal trauma and the pathogenesis of torticollis formation were determined with confirmation by instrumental research methods. During the growth of the child, there is a progression of neuroorthopedic pathology in the form of scoliotic spinal deformity with a misalignment of the pelvic bones due to an asymmetric flat-valgus installation of the feet. The program for differential diagnosis and prevention of mild neuroorthopedic disorders was developed depending on the age of children. It is shown, that the leading link in the pathogenesis of neuroorthopedic pathology is natal trauma. Timely diagnosis, treatment and prevention of disorders of the musculoskeletal system will prevent the formation of pathology in various age periods.

scholarly journals Allergy and obesity in children: is there any link?

2021 ◽  
pp. 17-26
Author(s):  
Natalia Begievna Migacheva ◽  
Dariia Alekseevna Rakcheeva ◽  
Olga Viktorovna Skvortsova ◽  
Evgeniia Gennadevna Mikhailova
Keyword(s):  
Mutual Influence ◽  
Pediatric Population ◽  
Allergic Diseases ◽  
Current Data ◽  
Steady Increase ◽  
Laboratory Studies ◽  
Prevention Strategies ◽  
Causal Factors ◽  
Treatment And Prevention ◽  
Obesity In Children

The steady increase in the prevalence of non-communicable diseases in the population, including obesity and allergic diseases, dictates the need to study both common causal factors and mechanisms of their development, and to search for new effective treatment and prevention strategies. However the resultsof epidemiologic, clinical and laboratory studies are still inconclusive, especially in pediatric population. In this review we present and discuss current data that may help to understand the possible relationship and mechanisms of mutual influence of allergy and obesity in children.

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