Single-nucleotide polymorphism in the human TIA1 gene interacts with stressful life events to predict the development of pathological anxiety symptoms in a Swedish population

AbstractThe current study investigated the longitudinal relationships among behavioral inhibition (BI), life events, and anxiety in a sample of 102 BI children and 100 behaviorally uninhibited (BUI) children aged 3 to 4 years. Children's parents completed questionnaires on BI, stressful life events, and anxiety symptoms, and were administered a diagnostic interview three times in a 5-year period. In line with our hypotheses, negative life events, particularly negative behavior-dependent life events (i.e., life events that are related to the children's own behaviors), and the impact of negative life events were predictive of increases in subsequent anxiety symptoms, the likelihood of having an anxiety disorder, and increased number of anxiety diagnoses over the 5-year follow-up period. Experiencing more positive, behavior-independent life events decreased the risk of being diagnosed with an anxiety disorder. Furthermore, differences were found in life events between BI and BUI children. That is, BI children experienced fewer positive and specifically positive behavior-dependent life events, and the impact of these positive life events was also lower in BI children than in BUI children. However, BI did not interact with life events in the prediction of anxiety problems as hypothesized. Therefore, this study seems to indicate that BI and life events act as additive risk factors in the development of anxiety problems.

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Swedish Population Substructure Revealed by Genome-Wide Single Nucleotide Polymorphism Data

PLoS ONE ◽

10.1371/journal.pone.0016747 ◽

2011 ◽

Vol 6 (2) ◽

pp. e16747 ◽

Cited By ~ 24

Author(s):

Elina Salmela ◽

Tuuli Lappalainen ◽

Jianjun Liu ◽

Pertti Sistonen ◽

Peter M. Andersen ◽

...

Keyword(s):

Single Nucleotide Polymorphism ◽

Population Substructure ◽

Single Nucleotide Polymorphism Data ◽

Nucleotide Polymorphism ◽

Swedish Population ◽

Single Nucleotide ◽

Genome Wide ◽

Polymorphism Data

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Stressful Life Events, Worry, and Rumination Predict Depressive and Anxiety Symptoms in Young Adolescents

Journal of Child and Adolescent Psychiatric Nursing ◽

10.1111/jcap.12102 ◽

2015 ◽

Vol 28 (1) ◽

pp. 35-42 ◽

Cited By ~ 43

Author(s):

Cara C. Young ◽

Mary S. Dietrich

Keyword(s):

Life Events ◽

Stressful Life Events ◽

Anxiety Symptoms ◽

Stressful Life ◽

Young Adolescents

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Depressive and Anxiety Symptoms, Dysfunctional Attitudes and Social Aspects in Irritable Bowel Syndrome and Inflammatory Bowel Disease

The International Journal of Psychiatry in Medicine ◽

10.2190/pm.37.3.a ◽

2007 ◽

Vol 37 (3) ◽

pp. 245-255 ◽

Cited By ~ 49

Author(s):

Zoltán Kovács ◽

Ferenc Kovács

Keyword(s):

Social Support ◽

Life Events ◽

Healthy Subjects ◽

Stressful Life Events ◽

Anxiety Symptoms ◽

Dysfunctional Attitudes ◽

Stressful Life ◽

Inflammatory Bowel ◽

And Gender ◽

Irritable Bowel

Objective: Biopsychosocial models for both organic and functional gastrointestinal (GI) disorders have been described in the recent literature. The objective of this study was to give further data to this model by assessing stressful life events, social support, psychopathological symptoms, and dysfunctional attitudes in irritable bowel syndrome (IBS), inflammatory bowel disease (IBD) and healthy subjects. Method: Age- and gender-matched IBS and IBD patients presenting at a tertiary care gastroenterological center completed self-reported questionnaires on stressful life events, social support, depressive and anxiety symptoms and dysfunctional attitudes. For comparative purposes, data from an age- and gender-matched healthy control group were obtained. Results: No significant differences were found between the groups regarding stressful life events and social support. Both patient groups had higher depressive and anxiety symptoms compared to healthy subjects, and IBS patients had higher depressive scores compared to IBD patients. IBS patients had more dysfunctional attitudes compared to both IBD and healthy subjects, while IBD and healthy subjects did not differ on dysfunctional attitudes. Conclusions: GI patient status is associated with depressive and anxiety symptoms, in addition IBS patients have more severe depressive symptoms and depressogenic dysfunctional attitudes. The fact that functional GI patients are characterized by more severe psychological, but not social parameters, supports the hypothesis that IBS might be related to the range of depressive disorders.

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Comorbid Depressive and Anxiety Symptoms and Their Correlates Among 93,078 Multiethnic Adults in Southwest China

Frontiers in Public Health ◽

10.3389/fpubh.2021.783687 ◽

2021 ◽

Vol 9 ◽

Author(s):

Qiaolan Liu ◽

Pingcuo Wangqing ◽

Yangji Baima ◽

Songmei Wang ◽

Zhuozhi Shen ◽

...

Keyword(s):

Depressive Symptoms ◽

Ethnic Groups ◽

Chronic Diseases ◽

Life Events ◽

Stressful Life Events ◽

Southwest China ◽

Well Being ◽

Anxiety Symptoms ◽

Stressful Life ◽

Multiethnic Populations

Background: Depressive symptoms and anxiety symptoms commonly coexist and severely increases the disease burden worldwide. Little is known about the patterns and correlates of comorbid depressive and anxiety symptoms among the multiethnic populations of China.Methods: This population-based study investigated the comprehensive associations of comorbid depressive and anxiety symptoms with lifestyles, stressful life events, chronic diseases, and physical and mental well-being among 93,078 participants (37,193 men, 55,885 women) aged 30–79 years across seven ethnic groups in Southwest China. Multivariable logistic regression models were used to estimate associations.Results: Overall, 2.9% (2.1% in men and 3.5% in women) participants had comorbid depressive and anxiety symptoms; there was considerable heterogeneity among multiethnic populations. Participants with chronic diseases were more likely to have comorbidity than those without them; people with rheumatic heart disease reported the highest risk, with an odds ratio (OR) of 6.25 and 95% confidence interval (CI) of 4.06–9.62. Having experienced 3 or more stressful life events (OR, 8.43, 95% CI: 7.27–9.77), very poor self-rated health status (OR, 33.60, 95%CI: 25.16–44.87), and very unsatisfied life (OR, 33.30, 95% CI: 23.73–46.74) had strong positive associations with comorbid depressive symptoms and anxiety symptoms, with a dose-response relationship (P < 0.05). High frequency of physical activity had negative associations. All the associations were stronger than depressive symptoms alone or anxiety symptoms alone.Conclusions: Our findings emphasize the need to focus on the vulnerable ethnic groups with comorbid depressive and anxiety symptoms, ultimate for help early prevention and improvement of health equity in the underdevelopment and high urbanization areas.

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Coexisting Psychiatric Problems and Stressful Life Events in Adults With Symptoms of ADHD—A Large Swedish Population-Based Study of Twins

Journal of Attention Disorders ◽

10.1177/1087054710376909 ◽

2010 ◽

Vol 16 (1) ◽

pp. 13-22 ◽

Cited By ~ 48

Author(s):

Bettina Friedrichs ◽

Wilmar Igl ◽

Henrik Larsson ◽

Jan-Olov Larsson

Keyword(s):

Life Events ◽

Adult Adhd ◽

Stressful Life Events ◽

Population Based ◽

Stressful Life ◽

Swedish Population ◽

Compulsive Disorder ◽

Increased Risk ◽

Significant Difference ◽

Psychiatric Problems

Objective: To explore the associations of subtypes of adult ADHD with other psychiatric problems, stressful life events, and sex differences. Method: Odds ratios were calculated using information from 17,899 participants from a population-based survey of adult twins born in Sweden between 1959 and 1985. Results: Symptoms of attention deficit hyperactivity disorder (ADHD) were associated with an increased risk for symptoms of (odds ratio [95% confidence interval]): generalized anxiety disorder (5.6 [4.3; 6.5]), major depression (2.8 [2.4; 3.2]), bipolar disorder (8.0 [5.1; 12.6]), obsessive-compulsive disorder (3.9 [3.1; 4.9]), and alcohol dependence (2.6 [2.2; 3.1]). Symptoms of ADHD were found to be associated with an increased risk for stressful life events (1.8 [1.3; 2.4]). No significant difference in comorbidity was observed between the two sexes. Conclusion: Both women and men with ADHD are at increased risk for symptoms of other psychiatric disorders. They are also at increased risk for stressful life events.

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Monoaminergic Multilocus Genetic Variants Interact with Stressful Life Events in Predicting Changes in Adolescent Anxiety Symptoms: A One-year Longitudinal Study

Journal of Youth and Adolescence ◽

10.1007/s10964-021-01496-y ◽

2021 ◽

Vol 50 (11) ◽

pp. 2194-2207

Author(s):

Cong Cao ◽

Kexin Sun ◽

Lili Cao ◽

Feifei Li

Keyword(s):

Longitudinal Study ◽

Life Events ◽

Genetic Variants ◽

Stressful Life Events ◽

Anxiety Symptoms ◽

Stressful Life ◽

Adolescent Anxiety ◽

One Year

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Are Stressful Life Events Causally Related to the Severity of Obsessive-Compulsive Symptoms? A Monozygotic Twin Difference Study

European Psychiatry ◽

10.1016/j.eurpsy.2014.11.008 ◽

2015 ◽

Vol 30 (2) ◽

pp. 309-316 ◽

Cited By ~ 20

Author(s):

P. Vidal-Ribas ◽

A. Stringaris ◽

C. Rück ◽

E. Serlachius ◽

P. Lichtenstein ◽

...

Keyword(s):

Depressive Symptoms ◽

Life Events ◽

Stressful Life Events ◽

Stressful Life ◽

Obsessive Compulsive ◽

Swedish Population ◽

Obsessive Compulsive Symptoms ◽

Family Disruption ◽

Wide Range ◽

The Impact

AbstractTraumatic or stressful life events have long been hypothesized to play a role in causing or precipitating obsessive-compulsive symptoms but the impact of these environmental factors has rarely been investigated using genetically informative designs. We tested whether a wide range of retrospectively-reported stressful life events (SLEs) influence the lifetime presence and severity of obsessive-compulsive symptoms (OCS) in a large Swedish population-based cohort of 22,084 twins. Multiple regression models examined whether differences in SLEs within twin pairs were significantly associated with differences in OCS. In the entire sample (i.e., both monozygotic [MZ] and dizygotic twin pairs), two SLEs factors, “abuse and family disruption” and “sexual abuse”, were significantly associated with the severity of OCS even after controlling for depressive symptoms. Other SLEs factors were either not associated with OCS (“loss”, “non-sexual assault”) or were no longer associated with OCS after controlling for depression (“illness/injury”). Within MZ pair analyses, which effectively control for genetic and shared environmental effects, showed that only the “abuse and family disruption” factor remained independently related to within-pair differences in OCS severity, even after controlling for depressive symptoms. Despite being statistically significant, the magnitude of the associations was small; “abuse and family disruption” explained approximately 3% of the variance in OCS severity. We conclude that OCS are selectively associated with certain types of stressful life events. In particular, a history of interpersonal abuse, neglect and family disruption may make a modest but significant contribution to the severity of OCS. Further replication in longitudinal cohorts is essential before causality can be firmly established.

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