scholarly journals A systematic investigation on flavonoids, catechin, β-sitosterol and lignin glycosides from Saraca asoca (ashoka) having anti-cancer & antioxidant properties with no side effect

2022 ◽  
Vol 99 (1) ◽  
pp. 100293
Author(s):  
S. Rehan Ahmad ◽  
Pritha Ghosh
Keyword(s):  
Side Effect ◽  
Antioxidant Properties ◽  
Systematic Investigation ◽  
Saraca Asoca ◽  
Anti Cancer

Identification of Anti-cancer Peptides Based on Multi-classifier System

2020 ◽  
Vol 22 (10) ◽  
pp. 694-704 ◽  
Author(s):  
Wanben Zhong ◽  
Bineng Zhong ◽  
Hongbo Zhang ◽  
Ziyi Chen ◽  
Yan Chen
Keyword(s):  
Machine Learning ◽  
Side Effect ◽  
Learning Models ◽  
Normal Cells ◽  
Classifier System ◽  
Prediction Rate ◽  
Anti Cancer ◽  
Feature Information ◽  
Machine Learning Models ◽  
Better Than

Aim and Objective: Cancer is one of the deadliest diseases, taking the lives of millions every year. Traditional methods of treating cancer are expensive and toxic to normal cells. Fortunately, anti-cancer peptides (ACPs) can eliminate this side effect. However, the identification and development of new anti Materials and Methods: In our study, a multi-classifier system was used, combined with multiple machine learning models, to predict anti-cancer peptides. These individual learners are composed of different feature information and algorithms, and form a multi-classifier system by voting. Results and Conclusion: The experiments show that the overall prediction rate of each individual learner is above 80% and the overall accuracy of multi-classifier system for anti-cancer peptides prediction can reach 95.93%, which is better than the existing prediction model.

Dermatological side effects of immunotherapy drugs and targeted cancer therapies: Importance of dermatology and oncology collaboration

2020 ◽  
pp. 107815522097062
Author(s):  
Uğur Çelik ◽  
Ertuğrul H Aydemir ◽  
Burhan Engin ◽  
Muazzez Ç Oba ◽  
Mesut Yılmaz ◽  
...  
Keyword(s):  
Side Effects ◽  
Outpatient Clinic ◽  
Targeted Therapies ◽  
Side Effect ◽  
Common Side Effect ◽  
Cancer Therapies ◽  
Anti Cancer ◽  
Targeted Cancer Therapies ◽  
Dermatological Side Effects ◽  
Skin Side Effects

Introduction Novel anti-cancer drugs such as targeted cancer therapies and immune check-point inhibitors (ICIs) have adverse events, especially concerning the skin. The aim of this study is to report an overview of the commonly consulted dermatological side effects of ICIs and targeted cancer therapies in clinical practice, along with their management. Methods In this single-center study, we evaluated consecutive oncological patients who were referred from the oncology outpatient clinic to the dermatology outpatient clinic due to skin side effects of ICIs and targeted therapies. All patients were examined and treated at the same day of referral by experienced dermatologists. Patient characteristics, clinical findings, diagnostic workups and treatments were retrieved from outpatient records. Results Sixty three patients were enrolled. Most common diagnoses were lung carcinoma, melanoma and colon carcinoma. Fifty patients (79%) were using targeted therapies while 13 (21%) were using ICIs. Xerosis was the most common side effect (44%), followed by acneiform rash, paronychia, eczema and pruritus. Majority of the side effects were grade 2 and 3. Psoriasis was a common side effect of ICIs. One patient had a newly developed dysplastic nevus on vemurafenib treatment. Oncological treatment was not withheld in any of the patients. Conclusions This study revealed the most commonly consulted skin side effects of novel anti-cancer drugs and their management in daily practice. We underlie the importance of collaborative work of oncology and dermatology professionals as early management of cutaneous side effects of targeted therapies and ICIs improves patient outcomes.

scholarly journals Seaweeds

2020 ◽  
Vol 5 (4) ◽  
pp. 315-322
Author(s):  
A. K. Pandey ◽  
O. P. Chauhan ◽  
A. D. Semwal
Keyword(s):  
Folk Medicine ◽  
Antioxidant Properties ◽  
Chemical Properties ◽  
Brand Names ◽  
Terrestrial Plants ◽  
Frozen Foods ◽  
Sulphated Polysaccharides ◽  
Food Properties ◽  
Anti Cancer ◽  
Pharmaceutical Industries

Seaweeds are microalgae growing in coastal regions and resistant to salinity. Seaweeds are rich resources of natural nutrients some of which cannot be obtained from terrestrial plants. Bioactive compounds of seaweeds such as sulphated polysaccharides, peptides, minerals, phlorotannins, carotenoids and sulfolipids have proven health benefits against various diseases. Traditionally, seaweeds are used as folk medicine for treating diseases like goiter, wounds, burns, rashes, inflammation, diabetes and also gaining attention of pharmaceutical industries due to their anti-cancer, anti-aging, anti-angiogenesis, anti-bacterial, anti-viral and antioxidant properties. Seaweeds polysaccharides have wide applications in foods as well as in pharmaceutical industry due to their bio-chemical properties such as stabilizer, emulsifier and gelling property. In food industry, seaweed polysaccharides are used as a functional ingredient in many products such as frozen foods, ice-cream, jam, jelly, beverages etc. Several commercial food preparations from seaweeds are also available in the market such as sea salt, nori snack wasabi, pink rock salt, seaweed thins toasted coconuts, crunchy seaweed chips, raw unroasted seaweed under different brand names. The present review is a compilation of nutritional, pharmacological and food properties of seaweeds along with its potential towards development of functional foods.

scholarly journals Synergistic Effect of Acoustic and Vacuum Drying to Antioxidant Attributes of Cordyceps militaris

2020 ◽  
pp. 18-22
Author(s):  
Minh Phuoc Nguyen
Keyword(s):  
Synergistic Effect ◽  
Product Quality ◽  
Synergistic Effects ◽  
Antioxidant Properties ◽  
Cordyceps Militaris ◽  
Water Evaporation ◽  
Vacuum Drying ◽  
Processing Temperature ◽  
Anti Cancer ◽  
Anti Oxidant

Acoustic drying allows the utilization of lower temperatures than conventional methodology in the drying process. Vacuum drying is one of the most energy demanding processes. Water evaporation also takes place at lower temperatures under vacuum and hence the product processing temperature can be significantly lower, offering higher product quality. Cordyceps militaris is a well-known entamophagus fungus with wonderful health benefits such as adaptogenic, aphrodisiac, anti-oxidant, anti-aging, neuroprotective, nootropic, immunomodulatory, anti-cancer and hepatoprotective role by its phytochemical constituents. This study focused on the synergistic effects of acoustic and vacuum drying on antioxidant properties of Cordyceps militaris. We noticed that acoustic drying at power 800 W in frequency 40kHz combined with vacuum drying at pressure -0.8 bar were suitable for dehydration of this valuable material. From this approach, a combination of acoustic and vacuum drying created a synergistic effect consuming less energy than single drying method because it can be performed at low temperature while maintaining the product quality and wholesomeness. Moisture content is partly removed by acoustic drying and further dehydration in a vacuum dryer to reduce moisture to a stable level.

scholarly journals The effect of anti-cancer and anti-tuberculosis treatments in lung cancer patients with active tuberculosis: a retrospective analysis

2020 ◽  
Author(s):  
MEI CHAI ◽  
Qingming Shi
Keyword(s):  
Lung Cancer ◽  
Cancer Patients ◽  
Side Effect ◽  
Treatment Completion ◽  
Completion Rate ◽  
Karnofsky Performance Score ◽  
Lung Cancer Patients ◽  
Control Subjects ◽  
Tb Treatment ◽  
Anti Cancer

Abstract Background Lung tuberculosis (TB) and lung cancer have a complex relationship. Data concerning TB treatment in lung cancer patients are still incomplete. The aim of this study was to investigate the effects of anti-cancer and anti-tuberculosis treatments in lung cancer patients with active lung TB. Methods In a retrospective cohort study, lung cancer patients with active lung TB were identified between January 2013 and December 2016. Age- and sex-matched lung cancer patients without tuberculosis were selected as control subjects. Anti-cancer and anti-tuberculosis treatments were administered according to the national guidelines. The clinical courses and responses of lung cancer patients with and without active lung TB were examined and compared.Results A total of 31 consecutive lung cancer patients were diagnosed with active lung TB. Fifty-one lung cancer patients without TB were enrolled as control subjects. Most patients in the two groups were elderly, had advanced non-small cell lung cancer and had tumor burdens. The anti-cancer treatment completion rate and response rate were not different between two group (87.1% in TB treatment patients vs. 92.2% in lung cancer patients; 77.4% in TB treatment patients vs. 88.2% in lung cancer patients, respectively). The anti-tuberculosis treatment completion rate and success rate was 87.1% and 80.7%. The median survival times were not different between two groups (52 weeks in TB treatment patients vs. 57 weeks in lung cancer patients). The change in Karnofsky performance score was also not different between two groups. The most common side effect in TB treatment patients was liver injury (61.3%). The most serious side effect in TB treatment patients was leukocyte deficiency (9.7% in Grade 3). Both of side effects mentioned above were not different between two groups. Conclusion Both anti-cancer and anti-tuberculosis treatments can be safely and effectively administered in lung cancer patients with active lung TB. Attention should be paid to the risk of tuberculosis in lung cancer patients in TB high-burden countries.

scholarly journals The effect of anti-cancer and anti-tuberculosis treatments in lung cancer patients with active tuberculosis: a retrospective analysis

2020 ◽  
Author(s):  
Mei Chai (Former Corresponding Author) ◽  
Qingming Shi(New Corresponding Author)
Keyword(s):  
Lung Cancer ◽  
Cancer Patients ◽  
Side Effect ◽  
Treatment Completion ◽  
Completion Rate ◽  
Karnofsky Performance Score ◽  
Lung Cancer Patients ◽  
Control Subjects ◽  
Tb Treatment ◽  
Anti Cancer

Abstract Background Lung tuberculosis (TB) and lung cancer have a complex relationship. Data concerning TB treatment in lung cancer patients are still incomplete. The aim of this study was to investigate the effects of anti-cancer and anti-tuberculosis treatments in lung cancer patients with active lung TB. Methods In a retrospective cohort study, lung cancer patients with active lung TB were identified between January 2013 and December 2016. Age- and sex-matched lung cancer patients without tuberculosis were selected as control subjects. Anti-cancer and anti-tuberculosis treatments were administered according to the national guidelines. The clinical courses and responses of lung cancer patients with and without active lung TB were examined and compared. Results A total of 31 consecutive lung cancer patients were diagnosed with active lung TB. Fifty-one lung cancer patients without TB were enrolled as control subjects. Most patients in the two groups were elderly, had advanced non-small cell lung cancer and had tumor burdens. The anti-cancer treatment completion rate and response rate were not different between two group (87.1% in TB treatment patients vs. 92.2% in lung cancer patients; 77.4% in TB treatment patients vs. 88.2% in lung cancer patients, respectively). The anti-tuberculosis treatment completion rate and success rate was 87.1% and 80.7%. The median survival times were not different between two groups (52 weeks in TB treatment patients vs. 57 weeks in lung cancer patients). The change in Karnofsky performance score was also not different between two groups. The most common side effect in TB treatment patients was liver injury (61.3%). The most serious side effect in TB treatment patients was leukocyte deficiency (9.7% in Grade 3). Both of side effects mentioned above were not different between two groups. Conclusion Both anti-cancer and anti-tuberculosis treatments can be safely and effectively administered in lung cancer patients with active lung TB. Attention should be paid to the risk of tuberculosis in lung cancer patients in TB high-burden countries.

scholarly journals PEG-rhG-CSF Use Reduces Glucose Level Significantly in Cancer Patients Receiving Chemotherapy

2020 ◽  
Vol 4 (6) ◽  
Author(s):  
Shasha Cui ◽  
Xinqiang Liu ◽  
Dayan Zhang ◽  
Lu Zhang ◽  
Ying Wang
Keyword(s):  
Cancer Patients ◽  
Cancer Chemotherapy ◽  
Side Effect ◽  
Fasting Blood Glucose ◽  
Time Interval ◽  
Glucose Levels ◽  
Significant Difference ◽  
Anti Cancer ◽  
Chemotherapy Induced Neutropenia ◽  
Mean Glucose

Background: In patients receiving anti-cancer chemotherapy, polyethylene glycolated recombinant human granulocyte-colony stimulating factor (PEG-rhG-CSF) was used for prophylaxis of chemotherapy-induced neutropenia. However, the side effect of PEG-rhG-CSF use on fasting blood glucose (FBG) level remains unclear. Materials and Methods: Cancer patients receiving chemotherapy and PEG-rhG-CSF were enrolled in our study. Baseline glucose (Glucose 1) was measured before PEG-rhG-CSF use, a second FBG test (Glucose 2) was performed after PEG-rhG-CSF use. Mean glucose levels were compared using t test. Results: The time interval between PEG-rhG-CSF use and the second glucose test was 2.4±1.5 days. The mean Glucose 1 was 5.18±0.53 mmol/L, and Glucose 2 was 3.80±1.13 mmol/L. Statistical analysis showed a significant difference between Glucose 1 and 2 existed (P<0.001). Conclusion: Our study identifies a hypoglycemic side effect of PEG-rhG-CSF occurs in cancer patients undergoing anti-cancer chemotherapy. Our results highlight the caution required when using PEG-rhG-CSF for prophylaxis of chemotherapy-induced neutropenia.

scholarly journals ISOLATION AND CHEMICAL CHARACTERIZATION OF VOLATILE OILS OF CENTRATHERUM ANTHELMINTICUM AND CITRUS AURANTIFOLIA

2019 ◽  
Vol 1 (1) ◽  
pp. 06-09
Author(s):  
Shweta Srivastava
Keyword(s):  
Essential Oils ◽  
Antioxidant Properties ◽  
Chemical Characterization ◽  
Volatile Oil ◽  
Daily Consumption ◽  
Citrus Aurantifolia ◽  
Anti Cancer ◽  
Anti Oxidant ◽  
Centratherum Anthelminticum

Introduction: Centratherum anthelminticum is an ethnomedicinal plant in India and a common ingredient in Ayurvedic formulations. The pharmacological effects of C. anthelminticum ranges from anti-oxidant, anti-diabetic, anti-microbial to recently found anti-cancer activity. Citrus aurantifolia (Rutaceae) is mainly used in daily consumption, in many cultural cuisines, and in juice production. It is widely used because of its antibacterial, anticancer, antidiabetic, antifungal, anti-hypertensive, anti-inflammation, anti-lipidemia, and antioxidant properties. Objective: To isolate and identify the compounds in the essential oils from the seeds of C. anthelminticum Kuntz and peels of C. aurantifolia (Christm.) swingle collected from the Delhi NCR region. Materials and Methods: The essential oils from seeds of C. anthelminticum Kuntz and peels of C. aurantifolia were extracted by steam distillation and analyzed by gas chromatograph and gas chromatography–mass spectrometer. Results: Chemical characterization of the volatile oil and seeds of C. anthelminticum Kuntz showed that the oil is greenish and semi viscous. The major component of the oil was found to be beta-caryophyllene (64.43%), beta-pinene (9.81%), alpha-humulene (4.64%), caryophyllene oxide (2.24%), gamma-elemene (1.73%), limonene (1.48%) and myrecene (0.11%). Whereas the major constituents of volatile oil from peels of C. aurantifolia comprises of twenty nine components viz.  sesquiterpne alcohols (20.68%) including  Globulol, Hurmularel, 6 - dien - 3 - ol. (-) -Spathulenol, ledol,alpha-bisabolol, - (-) Spathulenol and Sesquíterpene esters (20.68%), caryophyllene, alpha- Farnesene, alpha-Caryophylline, gamma -elemene, gamma-.neoclovene, monoterpene alcohol (13.79%). Conclusion: The present study revealed the chemical composition of essential oils of both the drugs under study which can be used as references in the food, pharmaceutical and cosmetic industries.

scholarly journals The effect of anti-cancer and anti-tuberculosis treatments in lung cancer patients with active tuberculosis: a retrospective analysis

BMC Cancer ◽  
2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Mei Chai ◽  
Qingming Shi
Keyword(s):  
Lung Cancer ◽  
Cancer Patients ◽  
Side Effect ◽  
Treatment Completion ◽  
Completion Rate ◽  
Karnofsky Performance Score ◽  
Lung Cancer Patients ◽  
Control Subjects ◽  
Tb Treatment ◽  
Anti Cancer

Abstract Background Lung tuberculosis (TB) and lung cancer have a complex relationship. Data concerning TB treatment in lung cancer patients are still incomplete. The aim of this study was to investigate the effects of anti-cancer and anti-tuberculosis treatments in lung cancer patients with active lung TB. Methods In a retrospective cohort study, lung cancer patients with active lung TB were identified between January 2013 and December 2016. Age- and sex-matched lung cancer patients without tuberculosis were selected as control subjects. Anti-cancer and anti-tuberculosis treatments were administered according to the national guidelines. The clinical courses and responses of lung cancer patients with and without active lung TB were examined and compared. Results A total of 31 consecutive lung cancer patients were diagnosed with active lung TB. Fifty-one lung cancer patients without TB were enrolled as control subjects. Most patients in the two groups were elderly, had advanced non-small cell lung cancer and had tumor burdens. The anti-cancer treatment completion rate and response rate were not different between two group (87.1% in TB treatment patients vs. 92.2% in lung cancer patients, 77.4% in TB treatment patients vs. 88.2% in lung cancer patients, respectively). The anti-tuberculosis treatment completion rate and success rate was 87.1 and 80.7%. The median survival times were not different between two groups (52 weeks in TB treatment patients vs. 57 weeks in lung cancer patients). The change in Karnofsky performance score was also not different between two groups. The most common side effect in TB treatment patients was liver injury (61.3%). The most serious side effect in TB treatment patients was leukocyte deficiency (9.7% in Grade 3). Both of side effects mentioned above were not different between two groups. Conclusion Both anti-cancer and anti-tuberculosis treatments can be safely and effectively administered in lung cancer patients with active lung TB. Attention should be paid to the risk of tuberculosis in lung cancer patients in TB high-burden countries.

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