PEG-rhG-CSF Use Reduces Glucose Level Significantly in Cancer Patients Receiving Chemotherapy

Background: In patients receiving anti-cancer chemotherapy, polyethylene glycolated recombinant human granulocyte-colony stimulating factor (PEG-rhG-CSF) was used for prophylaxis of chemotherapy-induced neutropenia. However, the side effect of PEG-rhG-CSF use on fasting blood glucose (FBG) level remains unclear. Materials and Methods: Cancer patients receiving chemotherapy and PEG-rhG-CSF were enrolled in our study. Baseline glucose (Glucose 1) was measured before PEG-rhG-CSF use, a second FBG test (Glucose 2) was performed after PEG-rhG-CSF use. Mean glucose levels were compared using t test. Results: The time interval between PEG-rhG-CSF use and the second glucose test was 2.4±1.5 days. The mean Glucose 1 was 5.18±0.53 mmol/L, and Glucose 2 was 3.80±1.13 mmol/L. Statistical analysis showed a significant difference between Glucose 1 and 2 existed (P<0.001). Conclusion: Our study identifies a hypoglycemic side effect of PEG-rhG-CSF occurs in cancer patients undergoing anti-cancer chemotherapy. Our results highlight the caution required when using PEG-rhG-CSF for prophylaxis of chemotherapy-induced neutropenia.

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Blood Glucose Levels on Beagle (Canis familiaris) in Kenagarian Mungo, Luak District Lima Puluh Kota West Sumatra

Jurnal Medika Veterinaria ◽

10.21157/j.med.vet..v9i2.3489 ◽

2015 ◽

Vol 9 (2) ◽

Author(s):

Afrio Arisman ◽

Sugito Sugito ◽

Zuhrawati Zuhrawati ◽

M. Hasan ◽

Abdul Harris ◽

...

Keyword(s):

Blood Glucose ◽

Fasting Blood Glucose ◽

Test Results ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Significant Difference ◽

West Sumatra ◽

The Difference ◽

Hunting Frequency ◽

Mean Glucose

This research aimed to determine glucose levels of beagle which is maintained by Sports Association of Pig Hunting (PORBI) in Kenagarian Mungo Sub-district Luak District Lima Puluh Kota, West Sumatra. Blood samples were collected from 20 beagles. Blood sampling was performed during fasting time and two hours postprandial. Data were analyzed with analysis of Chisquare (x2). The results showed that mean glucose level in the fasting state beagle was 63.45±11.84 mg /dl and two hours postprandial was 93.45±12.52 mg/dl. The test results showed statistically significant differences (P<0.05) postprandial, hunting frequency and multivitamin injection on blood glucose levels. The test results showed no statistically significant difference (P>0.05) between the frequency of feeding and supplementary feeding on blood glucose levels. Conclusion average blood glucose levels beagle still in the normal range. There is a difference in blood glucose between two hours postprandial with a fasting blood glucose levels and the difference between the hunting frequency and giving multivitamins injection on blood glucose levels and there was no difference on blood glucose levels between the frequency feeding, and supplemental feeding.Key words: beagle, glucose levels, hunting, multivitamins

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KADAR GLUKOSA DARAH ANJING PEMBURU (Canis familiaris) DI KENAGARIAN MUNGO KECAMATAN LUAK KABUPATEN LIMA PULUH KOTA PROVINSI SUMATERA BARAT (Blood Glucose Levels on Beagle (Canis familiaris) in Kenagarian Mungo, Luak District Lima Puluh Kota West Sumatera)

Jurnal Medika Veterinaria ◽

10.21157/j.med.vet..v9i2.3982 ◽

2015 ◽

Vol 9 (2) ◽

Author(s):

Afrio Arisman ◽

Sugito Sugito ◽

Zuhrawati N.A ◽

M Hasan ◽

Abdul Harris ◽

...

Keyword(s):

Blood Glucose ◽

Fasting Blood Glucose ◽

Canis Familiaris ◽

Test Results ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Significant Difference ◽

The Difference ◽

Hunting Frequency ◽

Mean Glucose

This research aimed to determine glucose levels of beagle maintained by Sports Association of Pig Hunting (PORBI) in Kenagarian Mungo Sub-district Luak District Lima Puluh Kota, West Sumatera. Blood samples were collected from 20 beagles. Blood sampling was performed during fasting time and two hours postprandial. Data were analyzed with analysis of Chisquare (x2). The results showed that mean glucose level in the fasting state beagle was 63.45±11.84 mg/dl and two hours postprandial was 93.45±12.52 mg/dl. The statistical test results showed no significant difference (P>0.05) between the frequency of feeding and supplementary feeding on blood glucose levels. To conclude, the average of beagle blood glucose levels is still in normal range. There is a difference in blood glucose between two hours postprandial and a fasting blood glucose levels and the difference between hunting frequency and giving multivitamins injection on blood glucose levels, but there was no difference on blood glucose levels between the frequency feeding and supplemental feeding.Key words: beagle, glucose levels, hunting, multivitamins

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UJI AKTIVITAS ANTIDIABETES EKSTRAK ETANOL BUAH CABAI MERAH ( Capsicum annuum L. ) TERHADAP MENCIT PUTIH JANTAN

SCIENTIA : Jurnal Farmasi dan Kesehatan ◽

10.36434/scientia.v9i1.221 ◽

2019 ◽

Vol 9 (1) ◽

pp. 86 ◽

Cited By ~ 1

Author(s):

Zulkarni Zulkarni

Keyword(s):

Blood Glucose ◽

Capsicum Annuum ◽

Fasting Blood Glucose ◽

Ethanol Extract ◽

Negative Control ◽

Control Group ◽

Glucose Levels ◽

Capsicum Annuum L ◽

Blood Glucose Levels ◽

Significant Difference

This Research was conducted to determine the effect of ethanol extract from red chilli (Capsicum annuum L)in lowering blood glucose levels of hyperglycemic male white mices. This study used 30 malewhitemices and divided into 6 groups: negative control group, the positive control group, the treatmentgroup withdosage of 200 mg / kgweight, 400 mg / kgwieght, 600 mg / kg weight and a comparison group with glibenclamide with dosage of 5 mg / kgweightadministered orally for 21 days. The level of fasting blood glucose was checked 6 days after dexamethasone induced, and after the ethanol extract of red chilies on day 7th, 14th, and 21st. The data was analyzed statistically with one –way and two-way Anova by usingSPSS16 program and proceed with the test Duncan to look the significant difference between treatments. The results showed that the ethanol extract from red chilies with a dosage of 200mg / kgweight, 400mg / kgweight, 600 mg / kgweight showed the effect in lowering blood sugar levels in male white mices hyperglycemia significantly (p <0.05). The duration ethanol extract of red chili affected blood glucose levels. The most effective duration in lowering blood glucose levels is the administration of a preparation within 21 days.

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Increased Small Dense LDL and Decreased Paraoxonase Enzyme Activity Reveals Formation of an Atherogenic Risk in Streptozotocin-Induced Diabetic Guinea Pigs

Journal of Diabetes Research ◽

10.1155/2013/860190 ◽

2013 ◽

Vol 2013 ◽

pp. 1-8 ◽

Cited By ~ 5

Author(s):

Mutay Aslan ◽

Filiz Ozcan ◽

Ertan Kucuksayan

Keyword(s):

Guinea Pigs ◽

Polyacrylamide Gel Electrophoresis ◽

Fasting Blood Glucose ◽

Cholesterol Acyltransferase ◽

Density Lipoprotein ◽

Hdl Cholesterol ◽

Pon1 Activity ◽

Small Dense Ldl ◽

Glucose Levels ◽

Significant Difference

This study aimed to investigate LDL subfraction distribution as well as serum cholesteryl ester transfer protein (CETP), lecithin-cholesterol acyltransferase (LCAT), and paraoxonase (PON1) activity in streptozotocin-induced diabetic guinea pigs.Materials/Methods. Guinea pigs were given a single intraperitoneal (ip) injection of streptozotocin (STZ) and animals having fasting blood glucose levels greater than 200 mg/dl, were considered diabetic. Protein levels of LCAT and CETP were determined via ELISA. Paraoxonase activity was measured kinetically by the formation of phenol while LDL subfraction analysis was done by disc polyacrylamide gel electrophoresis.Results. Plasma glucose and high-density lipoprotein (HDL) cholesterol were significantly increased while total cholesterol and LDL cholesterol were significantly decreased in diabetic guinea pigs compared to controls. LDL subfraction analysis revealed a significant decrease in nonatherogenic LDL-2 subfraction and a significant increase in atherogenic LDL-4 subfraction in diabetic guinea pigs compared to controls. Plasma CETP and PON1 levels were significantly decreased while LCAT showed no significant difference in diabetic guinea pigs compared to controls.Conclusion. Decreased non-atherogenic LDL-1, LDL-2 subfractions, increased small dense LDL-4 subfraction, and decreased PON1 activity, reveals formation of an atherogenic risk in diabetic guinea pigs. Decrease in CETP levels supports the observed increase in HDL cholesterol levels in diabetic guinea pigs.

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Red dragon fruit (Hylocereus spp.) peel marmalade effectively improve blood glucose and lipid profile of hypercholesterolemic wistar rats

JURNAL GIZI INDONESIA ◽

10.14710/jgi.9.1.61-67 ◽

2020 ◽

Vol 9 (1) ◽

pp. 61-67

Author(s):

Natalia Desy Putriningtyas ◽

Intan Permatasari ◽

Dita Oktaviani ◽

Anastasia Servia Raha ◽

Siti Wahyuningsih

Keyword(s):

Blood Glucose ◽

Functional Food ◽

Wistar Rats ◽

Fasting Blood Glucose ◽

Control Group ◽

Fruit Peel ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Dragon Fruit ◽

Significant Difference

Background: Polyphenols, antioxidants, dietary fiber, and vitamin contained in the red dragon fruit peel. Red dragon fruit peel can be processed into marmalade. Red dragon fruit peel marmalade has the potential to be a functional food. Functional food is food that has a physiological function based on scientific studies.Objectives: The objective of this study is to analyze the effect of red dragon fruit peel marmalade on fasting blood glucose levels, HDL, LDL, and triglycerides levels of hypercholesterolemic Wistar rats.Methods: This study used a pre-&post-test control group design. Hypercholesterolemic male Wistar rats were randomly assigned into five groups. Hypercholesterolemia was induced by 1% cholesterol powder and 0.5% cholic acid for two weeks. All groups received standard chow. Samples were grouped into five groups: K-; K+; K1 (0.94 g/kg b.wt/day); K2 (1.41 g/kg b.wt/day); K3 (1.88 g/kg b.wt/day). The intervention was carried out for 28 days. GDP level was measured using the GOD-PAP. HDL, LDL, and triglyceride were analyzed with spectrophotometry. GDP, HDL, LDL, and triglyceride levels were measured twice before fasting. A paired t-test and one-way ANOVA were used to analyze the data.Results: The result showed that K-; K1; K2; K3 had a significant difference between groups before and after the intervention (p<0.05). Red dragon fruit peel Marmalade was able to reduce the levels of GDP, LDL, triglycerides, and increase HDL (p <0.05).Conclusion: Red dragon fruit peel marmalade reduced fasting blood glucose levels, LDL, triglyceride levels, and increased HDL levels of hypercholesterolemic Wistar rats.

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The effect of anti-cancer and anti-tuberculosis treatments in lung cancer patients with active tuberculosis: a retrospective analysis

10.21203/rs.2.13039/v5 ◽

2020 ◽

Author(s):

MEI CHAI ◽

Qingming Shi

Keyword(s):

Lung Cancer ◽

Cancer Patients ◽

Side Effect ◽

Treatment Completion ◽

Completion Rate ◽

Karnofsky Performance Score ◽

Lung Cancer Patients ◽

Control Subjects ◽

Tb Treatment ◽

Anti Cancer

Abstract Background Lung tuberculosis (TB) and lung cancer have a complex relationship. Data concerning TB treatment in lung cancer patients are still incomplete. The aim of this study was to investigate the effects of anti-cancer and anti-tuberculosis treatments in lung cancer patients with active lung TB. Methods In a retrospective cohort study, lung cancer patients with active lung TB were identified between January 2013 and December 2016. Age- and sex-matched lung cancer patients without tuberculosis were selected as control subjects. Anti-cancer and anti-tuberculosis treatments were administered according to the national guidelines. The clinical courses and responses of lung cancer patients with and without active lung TB were examined and compared.Results A total of 31 consecutive lung cancer patients were diagnosed with active lung TB. Fifty-one lung cancer patients without TB were enrolled as control subjects. Most patients in the two groups were elderly, had advanced non-small cell lung cancer and had tumor burdens. The anti-cancer treatment completion rate and response rate were not different between two group (87.1% in TB treatment patients vs. 92.2% in lung cancer patients; 77.4% in TB treatment patients vs. 88.2% in lung cancer patients, respectively). The anti-tuberculosis treatment completion rate and success rate was 87.1% and 80.7%. The median survival times were not different between two groups (52 weeks in TB treatment patients vs. 57 weeks in lung cancer patients). The change in Karnofsky performance score was also not different between two groups. The most common side effect in TB treatment patients was liver injury (61.3%). The most serious side effect in TB treatment patients was leukocyte deficiency (9.7% in Grade 3). Both of side effects mentioned above were not different between two groups. Conclusion Both anti-cancer and anti-tuberculosis treatments can be safely and effectively administered in lung cancer patients with active lung TB. Attention should be paid to the risk of tuberculosis in lung cancer patients in TB high-burden countries.

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The effect of anti-cancer and anti-tuberculosis treatments in lung cancer patients with active tuberculosis: a retrospective analysis

10.21203/rs.2.13039/v2 ◽

2020 ◽

Author(s):

Mei Chai (Former Corresponding Author) ◽

Qingming Shi(New Corresponding Author)

Keyword(s):

Lung Cancer ◽

Cancer Patients ◽

Side Effect ◽

Treatment Completion ◽

Completion Rate ◽

Karnofsky Performance Score ◽

Lung Cancer Patients ◽

Control Subjects ◽

Tb Treatment ◽

Anti Cancer

Abstract Background Lung tuberculosis (TB) and lung cancer have a complex relationship. Data concerning TB treatment in lung cancer patients are still incomplete. The aim of this study was to investigate the effects of anti-cancer and anti-tuberculosis treatments in lung cancer patients with active lung TB. Methods In a retrospective cohort study, lung cancer patients with active lung TB were identified between January 2013 and December 2016. Age- and sex-matched lung cancer patients without tuberculosis were selected as control subjects. Anti-cancer and anti-tuberculosis treatments were administered according to the national guidelines. The clinical courses and responses of lung cancer patients with and without active lung TB were examined and compared. Results A total of 31 consecutive lung cancer patients were diagnosed with active lung TB. Fifty-one lung cancer patients without TB were enrolled as control subjects. Most patients in the two groups were elderly, had advanced non-small cell lung cancer and had tumor burdens. The anti-cancer treatment completion rate and response rate were not different between two group (87.1% in TB treatment patients vs. 92.2% in lung cancer patients; 77.4% in TB treatment patients vs. 88.2% in lung cancer patients, respectively). The anti-tuberculosis treatment completion rate and success rate was 87.1% and 80.7%. The median survival times were not different between two groups (52 weeks in TB treatment patients vs. 57 weeks in lung cancer patients). The change in Karnofsky performance score was also not different between two groups. The most common side effect in TB treatment patients was liver injury (61.3%). The most serious side effect in TB treatment patients was leukocyte deficiency (9.7% in Grade 3). Both of side effects mentioned above were not different between two groups. Conclusion Both anti-cancer and anti-tuberculosis treatments can be safely and effectively administered in lung cancer patients with active lung TB. Attention should be paid to the risk of tuberculosis in lung cancer patients in TB high-burden countries.

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Minimally Invasive Versus Open Surgery for Radical Hysterectomy Followed By Adjuvant Radiotherapy in Intermediate- or High-Risk Early-Stage Cancer of The Cervix: A Retrospective Study

10.21203/rs.3.rs-830000/v1 ◽

2021 ◽

Author(s):

Qi-ying Zhang ◽

Zi Liu ◽

Ya-li Wang ◽

Jing Zhang ◽

Wen Li ◽

...

Keyword(s):

Risk Factors ◽

Cervical Cancer ◽

High Risk ◽

Minimally Invasive ◽

Cancer Patients ◽

Radical Hysterectomy ◽

Early Stage ◽

Time Interval ◽

Significant Difference ◽

The Impact

Abstract Background Postoperative radiotherapy (RT) or chemoradiotherapy (CRT) improves outcomes of cervical cancer patients with risk factors. Minimally invasive surgery (MIS) has an inferior survival than open radical hysterectomy (ORH), however, the impact of MIS on postoperative RT remains uncertain. The study compared the impacts of MIS versus ORH on delivering of adjuvant RT or CRT for intermediate- or high-risk early-stage cervical cancer. Methods Data on stage IB1-IIA2 patients who underwent radical hysterectomy and postoperative RT/CRT in our institution, from 2014 to 2017, were retrospectively collected. Patients with high or intermediate-risk factors who met the Sedlis criteria received postoperative pelvic external beam radiotherapy (50Gy/25f) with platinum-based chemotherapy (0–6 cycles) according to guidelines. Disease-free survival (DFS) and overall survival (OS) were compared in the two surgical groups. Results One hundred and twenty-nine patients eligible for the study (68 in ORH; 61 in MIS groups) had similar clinicopathologic features except for the stage (highest in MIS was IB1; IIA1 in ORH) and presence of lymph vascular space invasion (higher in MIS group). The median time interval from surgery to chemotherapy and to RT was shorter in the MIS group. Three-year DFS and OS were similar in both groups. Further sub-analysis indicated that the DFS and OS in intermediate/high-risk groups had no significant difference. Cox-multivariate analyses found that tumor size > 4 cm and time interval from surgery to RT beyond seven weeks were adverse independent prognostic factors for DFS. Conclusions In early-stage (IB1-IIA2) cervical cancer patients with intermediate or high-risk factors who received postoperative RT or CRT, no matter they received ORH or MIS as their primary treatment, the DFS and OS had no significant difference, despite TI from surgery to postoperative adjuvant therapy being shorter in the MIS group than ORH.

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Differences in glucose level between right arm and left arm using continuous glucose monitors

Digital Health ◽

10.1177/2055207620970342 ◽

2020 ◽

Vol 6 ◽

pp. 205520762097034

Author(s):

Nicole Kim ◽

Kevin Pham ◽

Allen Shek ◽

Jeremy Lim ◽

Xiaohan Liu ◽

...

Keyword(s):

Glucose Level ◽

Skin Irritation ◽

Glucose Monitoring ◽

Target Range ◽

Glucose Levels ◽

Significant Difference ◽

Freestyle Libre ◽

The Right ◽

Mean Glucose ◽

Time In Target Range

Background Continuous glucose monitoring (CGM) measures interstitial glucose levels through a sensor with a thin filament inserted under the skin. It is customary for patients to rotate sensor application sites between arms to minimize skin irritation. However, there is limited data regarding the degree of inter-arm differences with CGM technology. Methods Self-proclaimed right-handed (n = 5) and left-handed (n = 5) participants, regardless of concurrent comorbidities, were enrolled for CGM. Participants wore a FreeStyle Libre Pro sensor on each arm for a maximum of 14 days. Muscle mass and body fat analysis was conducted using a multi-frequency segmental body composition analyzer. Glucose levels from both arms were time-matched with the first 12 hours eliminated from analysis. Mean glucose and time in target range were compared between readings from the right and left arm. Results A total of 9830 paired glucose levels were included for analysis. In all participants (n = 10), mean glucose on the right arm was 89.1 mg/dL (SD, 19.9) and 85.3 mg/dL (SD, 19.3) on the left arm (P < 0.001). Glucose was out of target range (70-180 mg/dL) for 12.7% of the time in the right arm compared to 18.5% in the left arm (P < 0.001). Conclusions In a group of 10 nondiabetic and diabetic adults, there was a statistically significant difference in CGM readings between the right and left arms. Time in target range may differ based on arm selection when using a CGM. Arm dominance did not explain the inter-arm glucose level discordance.

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Effect of interval between diagnosis of advanced cancer and cessation of active anti-cancer treatment on survival in terminally ill cancer patients

Journal of Clinical Oncology ◽

10.1200/jco.2009.27.15_suppl.e20630 ◽

2009 ◽

Vol 27 (15_suppl) ◽

pp. e20630-e20630

Author(s):

Y. Kim ◽

J. Lee ◽

W. Choi ◽

J. Park ◽

H. Kim ◽

...

Keyword(s):

Prognostic Factors ◽

Cancer Treatment ◽

Cancer Patients ◽

Advanced Cancer ◽

Performance Status ◽

Terminally Ill ◽

Time Interval ◽

Terminally Ill Cancer Patients ◽

Terminal Stage ◽

Anti Cancer

e20630 Background: Although various prognostic factors have been proposed to predict survival in terminally ill cancer patients, accurate prognostication is still a challenging task for oncologists. The objective of this study was to evaluate whether the time interval between diagnosis of advanced cancer and cessation of active anti-cancer treatment (ATP; active treatment period) can predict survival in terminally ill cancer patients. Methods: We prospectively evaluated 79 patients with advanced (recurrent or metastatic) cancer who were determined as terminal stage, namely cessation of active anti-cancer treatment and transition to palliative care, by attending oncologists. ATP and other known prognostic factors including clinical symptoms and signs, performance status, laboratory tests, and clinical prediction of survival (CPS) were analyzed. Results: Of the 79 patients, 46 were male (58%) and 33 were female (42%) with a median age of 60 years (range, 21–82). Median overall survival after being diagnosed with advanced cancer was 11.6 months (95% confidence interval (CI), 8.02–15.18), and survival after being determined as terminal stage was 1.9 months (95% CI, 1.38–2.42). According to 3 ATP categories (< 3months, 3–12 months, and >12 months), terminal stage survival were 1.0 month, 1.8 months, and 3.6 months, respectively (p=0.002). On multivariate analysis, short ATP, non-colorectal cancer, fatigue, and Karnofsky performance status less than 50 were significantly associated with a poor prognosis. Conclusions: Our study suggests that ATP is an independent prognostic factor for survival in terminally ill cancer patients who cannot receive active anti-cancer treatment anymore. Future prognostic models should include ATP as a prognostic variable. No significant financial relationships to disclose.

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