Amino-modified carbon dots as a functional platform for drug delivery: load-release mechanism and cytotoxicity

The development of innovative drug delivery systems, versatile to different drug characteristics with better effectiveness and safety, has always been in high demand. Chitosan, an aminopolysaccharide, derived from natural chitin biomass, has received much attention as one of the emerging pharmaceutical excipients and drug delivery entities. Chitosan and its derivatives can be used for direct compression tablets, as disintegrant for controlled release or for improving dissolution. Chitosan has been reported for use in drug delivery system to produce drugs with enhanced muco-adhesiveness, permeation, absorption and bioavailability. Due to filmogenic and ionic properties of chitosan and its derivative(s), drug release mechanism using microsphere technology in hydrogel formulation is particularly relevant to pharmaceutical product development. This review highlights the suitability and future of chitosan in drug delivery with special attention to drug loading and release from chitosan based hydrogels. Extensive studies on the favorable non-toxicity, biocompatibility, biodegradability, solubility and molecular weight variation have made this polymer an attractive candidate for developing novel drug delivery systems including various advanced therapeutic applications such as gene delivery, DNA based drugs, organ specific drug carrier, cancer drug carrier, etc.

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pH and redox dual-sensitive drug delivery system constructed based on fluorescent carbon dots

RSC Advances ◽

10.1039/d0ra09164b ◽

2021 ◽

Vol 11 (5) ◽

pp. 2656-2663

Author(s):

Boye Zhang ◽

Qianqian Duan ◽

Yi Li ◽

Jianming Wang ◽

Wendong Zhang ◽

...

Keyword(s):

Drug Delivery ◽

Controlled Release ◽

Cancer Cells ◽

Fluorescence Imaging ◽

Drug Delivery System ◽

Delivery System ◽

Carbon Dots ◽

Ph Responsive ◽

Charge Reversal ◽

Fluorescent Carbon Dots

The system is pH-responsive and redox-controlled release. And the charge reversal and size transitions of the system can enhance the targeted ability. Moreover, the system can recognize the cancer cells by the fluorescence imaging.

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Dried Molasses as a Direct Compression Matrix for Oral Controlled Release Drug Delivery II: Release Mechanism and Characteristics of Theophylline from a Molasses-Hpmc Matrix

Drug Development and Industrial Pharmacy ◽

10.3109/03639048909058527 ◽

1989 ◽

Vol 15 (5) ◽

pp. 705-718 ◽

Cited By ~ 3

Author(s):

Samuel D. Uko-nne ◽

Robert W. Mendes ◽

Sunil S. Jambhekar

Keyword(s):

Drug Delivery ◽

Controlled Release ◽

Release Mechanism ◽

Direct Compression ◽

Release Drug

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Fluorescence resonance energy transfer monitoring of pH-responsive doxorubicin release from carbon dots/aptamer functionalized magnetic mesoporous silica

Nanomedicine ◽

10.2217/nnm-2020-0410 ◽

2021 ◽

Author(s):

Abolghasem Abbasi Kajani ◽

Masoud Ayatollahi Mehrgardi

Keyword(s):

Drug Delivery ◽

Energy Transfer ◽

Fluorescence Resonance Energy Transfer ◽

Carbon Dots ◽

Drug Loading ◽

Resonance Energy Transfer ◽

Resonance Energy ◽

Spectroscopic Techniques ◽

Ph Responsive ◽

Fluorescence Resonance

Aim: To develop a novel theranostic nanoplatform for simultaneous fluorescent monitoring and stimuli-triggered drug delivery. Materials & methods: Different microscopic and spectroscopic techniques were used for the characterization of nanocarriers. MCF-7 and human umbilical vein endothelial cell lines were cultured and treated with different doses of doxorubicin-loaded nanocarriers. The cell viability and drug release were studied using MTT assay and fluorescence microscopy. Results: Biocompatible and mono-disperse nanocarriers represent hollow and mesoporous structures with the calculated surface area of 552.83 m2.g-1, high magnetic activity (12.6 emu.g-1), appropriate colloidal stability and high drug loading capacity (up to 61%). Conclusion: Taxane-based carbon dots act as the pH-responsive gatekeepers for the controlled release of doxorubicin into cancer cells and provide a fluorescence resonance energy transfer system for real-time monitoring of drug delivery.

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β‐Cyclodextrin‐Decorated Carbon Dots Serve as Nanocarriers for Targeted Drug Delivery and Controlled Release

ChemNanoMat ◽

10.1002/cnma.201800528 ◽

2019 ◽

Vol 5 (4) ◽

pp. 479-487 ◽

Cited By ~ 6

Author(s):

Ting Yang ◽

Jing‐Li Huang ◽

Yi‐Ting Wang ◽

An‐Qi Zheng ◽

Yang Shu ◽

...

Keyword(s):

Drug Delivery ◽

Controlled Release ◽

Targeted Drug Delivery ◽

Carbon Dots ◽

Targeted Drug

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Glutathione-mediated mesoporous carbon as a drug delivery nanocarrier with carbon dots as a cap and fluorescent tracer

Nanotechnology ◽

10.1088/0957-4484/27/35/355102 ◽

2016 ◽

Vol 27 (35) ◽

pp. 355102 ◽

Cited By ~ 18

Author(s):

Yang Zhang ◽

Lu Han ◽

Yue Zhang ◽

Yan-Qin Chang ◽

Xu-Wei Chen ◽

...

Keyword(s):

Drug Delivery ◽

Carbon Dots ◽

Mesoporous Carbon ◽

Fluorescent Tracer

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Photoluminescent F-doped carbon dots prepared by ring-opening reaction for gene delivery and cell imaging

RSC Advances ◽

10.1039/c7ra13607b ◽

2018 ◽

Vol 8 (11) ◽

pp. 6053-6062 ◽

Cited By ~ 19

Author(s):

Tian-Ying Luo ◽

Xi He ◽

Ji Zhang ◽

Ping Chen ◽

Yan-Hong Liu ◽

...

Keyword(s):

Drug Delivery ◽

Gene Delivery ◽

Carbon Dots ◽

Ring Opening ◽

Cell Imaging ◽

Imaging Agents ◽

Ring Opening Reaction ◽

Doped Carbon Dots

Carbon dots (CDs) are photoluminescent nanoparticles with distinctive properties, having great potential in nano-biomaterial systems such as gene/drug delivery vectors and cell imaging agents.

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