Amomum villosum Lour. fruit extract ameliorates high-fat diet-induced body mass gain and adipogenic pathways in C57BL/6 mice

This study aimed to investigate the effects of interval and continuous training on the body mass gain and adiposity levels of rats fed a high-fat diet. Forty-eight male Sprague-Dawley rats were randomly divided into two groups, standard diet and high-fat diet, and received their respective diets for a period of four weeks without exercise stimuli. After this period, the animals were randomly divided into six groups (n=8): control standard diet (CS), control high-fat diet (CH), continuous training standard diet (CTS), continuous training high-fat diet (CTH), interval training standard diet (ITS), and interval training high-fat diet (ITH). The interval and continuous training consisted of a swimming exercise performed over eight weeks. CH rats had greater body mass gain, sum of adipose tissues mass, and lower serum high density lipoprotein values than CS. The trained groups showed lower values of feed intake, caloric intake, body mass gain, and adiposity levels compared with the CH group. No significant differences were observed between the trained groups (CTS versus ITS and CTH versus ITH) on body mass gains and adiposity levels. In conclusion, both training methodologies were shown to be effective in controlling body mass gain and adiposity levels in high-fat diet fed rats.

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Flavanol supplementation protects against obesity-associated increases in systemic interleukin-6 levels without inhibiting body mass gain in mice fed a high-fat diet

Nutrition Research ◽

10.1016/j.nutres.2019.03.011 ◽

2019 ◽

Vol 66 ◽

pp. 32-47 ◽

Cited By ~ 3

Author(s):

Laura E. Griffin ◽

Dane W. Fausnacht ◽

Jessica L. Tuzo ◽

Adele K. Addington ◽

Kathryn C. Racine ◽

...

Keyword(s):

Body Mass ◽

Interleukin 6 ◽

High Fat Diet ◽

Mass Gain ◽

High Fat ◽

Body Mass Gain

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Overexpression of the gene encoding neurosecretory protein GL precursor prevents excessive fat accumulation in the adipose tissue of mice fed a long-term high-fat diet

10.1101/2021.07.25.453688 ◽

2021 ◽

Author(s):

Keisuke Fukumura ◽

Yuki Narimatsu ◽

Shogo Moriwaki ◽

Eiko Iwakoshi-Ukena ◽

Megumi Furumitsu ◽

...

Keyword(s):

Adipose Tissue ◽

Glucose Tolerance ◽

Feeding Behavior ◽

Body Mass ◽

High Fat Diet ◽

Mass Gain ◽

Oral Glucose ◽

High Fat ◽

Fat Accumulation

We previously identified a novel small hypothalamic protein, neurosecretory protein GL (NPGL), which induces feeding behavior and fat accumulation in rodents depending on their diet. In the present study, we explored the effects of NPGL on feeding behavior and energy metabolism in mice placed on a long-term high-fat diet with 60% calories from fat (HFD 60). Overexpression of the NPGL precursor gene (Npgl) over 18 weeks increased food intake and body mass. The weekly body mass gain of Npgl-overexpressing mice was higher than that of controls until 7 weeks from induction of overexpression, after which it ceased to be so. Oral glucose tolerance tests showed that Npgl overexpression maintained glucose tolerance and increased blood insulin levels, and intraperitoneal insulin tolerance tests showed that it maintained insulin sensitivity. At the experimental endpoint, Npgl overexpression was associated with increased mass of the perirenal white adipose tissue (WAT) and decreased mass of the epididymal WAT (eWAT), resulting in little effect on the total WAT mass. These results suggest that under long-term HFD 60 feeding, Npgl overexpression may play a role in avoiding metabolic disturbance both by accelerating energy storage and by suppressing excess fat accumulation in certain tissues, such as the eWAT.

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Methionine restriction plus overload improves skeletal muscle and metabolic health in old mice on a high fat diet

Scientific Reports ◽

10.1038/s41598-021-81037-6 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Anandini Swaminathan ◽

Andrej Fokin ◽

Tomas Venckūnas ◽

Hans Degens

Keyword(s):

Skeletal Muscle ◽

Glucose Tolerance ◽

Muscle Mass ◽

Body Mass ◽

High Fat Diet ◽

Control Diet ◽

Metabolic Health ◽

High Fat ◽

Methionine Restriction ◽

Old Mice

AbstractMethionine restriction (MR) has been shown to reduce the age-induced inflammation. We examined the effect of MR (0.17% methionine, 10% kCal fat) and MR + high fat diet (HFD) (0.17% methionine, 45% kCal fat) on body mass, food intake, glucose tolerance, resting energy expenditure, hind limb muscle mass, denervation-induced atrophy and overload-induced hypertrophy in young and old mice. In old mice, MR and MR + HFD induced a decrease in body mass. Muscle mass per body mass was lower in old compared to young mice. MR restored some of the HFD-induced reduction in muscle oxidative capacity. The denervation-induced atrophy of the m. gastrocnemius was larger in animals on MR than on a control diet, irrespective of age. Old mice on MR had larger hypertrophy of m. plantaris. Irrespective of age, MR and MR + HFD had better glucose tolerance compared to the other groups. Young and old mice on MR + HFD had a higher resting VO2 per body mass than HFD group. Mice on MR and MR + HFD had a resting respiratory quotient closer to 0.70, irrespective of age, indicating an increased utilization of lipids. In conclusion, MR in combination with resistance training may improve skeletal muscle and metabolic health in old age even in the face of obesity.

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Effects of neurosecretory protein GL on food intake and fat accumulation under different dietary nutrient compositions in rats

Bioscience Biotechnology and Biochemistry ◽

10.1093/bbb/zbab064 ◽

2021 ◽

Author(s):

Keisuke Fukumura ◽

Kenshiro Shikano ◽

Yuaki Narimatsu ◽

Eiko Iwakoshi-Ukena ◽

Megumi Furumitsu ◽

...

Keyword(s):

Food Intake ◽

Feeding Behavior ◽

Body Mass ◽

Mass Gain ◽

Chow Diet ◽

Tissue Mass ◽

Fat Accumulation ◽

Intracerebroventricular Infusion ◽

Body Mass Gain ◽

Sucrose Diet

Abstract We recently identified a novel hypothalamic small protein, named neurosecretory protein GL (NPGL), which is involved in energy homeostasis in birds and mammals. However, whether the action of NPGL is influenced by nutritional composition remains unknown. Thus, we investigated the effect of chronic intracerebroventricular infusion of NPGL for 13 days on feeding behavior and body mass gain under a normal chow diet (NC), high-fat diet, high-sucrose diet (HSD), and medium-fat/medium-sucrose diet (MFSD) in rats. NPGL stimulated food intake of NC and MFSD, especially during the light period. By contrast, NPGL decreased body mass gain under NC and increased total white adipose tissue mass in HSD- and MFSD-fed rats. These data suggest that the effects of NPGL on feeding behavior, body mass gain, and fat accumulation depend on nutrient type. Among them, sucrose in diets seems to contribute to fat accumulation elicited by NPGL.

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The ameliorative effect of the Pyracantha fortuneana (Maxim.) H. L. Li extract on intestinal barrier dysfunction through modulating glycolipid digestion and gut microbiota in high fat diet-fed rats

Food & Function ◽

10.1039/c9fo01599j ◽

2019 ◽

Vol 10 (10) ◽

pp. 6517-6532 ◽

Cited By ~ 5

Author(s):

Hang Xu ◽

Chunfang Zhao ◽

Yutian Li ◽

Ruiyu Liu ◽

Mingzhang Ao ◽

...

Keyword(s):

Gut Microbiota ◽

High Fat Diet ◽

Intestinal Barrier ◽

High Fat ◽

Barrier Dysfunction ◽

Fruit Extract ◽

Intestinal Barrier Dysfunction ◽

Beneficial Effects ◽

Obese Rats ◽

Ameliorative Effect

Pyracantha fortuneana fruit extract (PFE) exhibits beneficial effects on IBF in association with the modulation of glycolipid digestion and gut microbiota in HFD-fed obese rats.

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Jamun ( Eugenia jambolana Lam.) Fruit Extract Prevents Obesity by Modulating the Gut Microbiome in High‐Fat‐Diet‐Fed Mice

Molecular Nutrition & Food Research ◽

10.1002/mnfr.201801307 ◽

2019 ◽

Vol 63 (9) ◽

pp. 1801307 ◽

Cited By ~ 12

Author(s):

Jialin Xu ◽

Tingting Liu ◽

Yuanyuan Li ◽

Wei Liu ◽

Zhanjun Ding ◽

...

Keyword(s):

Gut Microbiome ◽

High Fat Diet ◽

High Fat ◽

Fruit Extract ◽

Eugenia Jambolana

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Supplementation of a Fermented Soybean Extract Reduces Body Mass and Prevents Obesity in High Fat Diet-Induced C57BL/6J Obese Mice

Preventive Nutrition and Food Science ◽

10.3746/pnf.2016.21.3.187 ◽

2016 ◽

Vol 21 (3) ◽

pp. 187-196 ◽

Cited By ~ 3

Author(s):

Jae Yeon Lee ◽

Adithan Aravinthan ◽

Young Shik Park ◽

Kyo Yeol Hwang ◽

Su-Il Seong ◽

...

Keyword(s):

Body Mass ◽

High Fat Diet ◽

Obese Mice ◽

High Fat ◽

Fermented Soybean ◽

Soybean Extract

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Hydration status of Greco-Roman wrestlers in an authentic precompetition situation

Applied Physiology Nutrition and Metabolism ◽

10.1139/apnm-2012-0334 ◽

2013 ◽

Vol 38 (6) ◽

pp. 621-625 ◽

Cited By ~ 9

Author(s):

Vahur Ööpik ◽

Saima Timpmann ◽

Andres Burk ◽

Innar Hannus

Keyword(s):

Specific Gravity ◽

Body Mass ◽

Urine Osmolality ◽

Mass Gain ◽

The Body ◽

Urine Specific Gravity ◽

Hydration Status ◽

Greco Roman ◽

Reduced Body ◽

Body Mass Gain

We assessed the urinary indexes of hydration status of Greco-Roman wrestlers in an authentic precompetition situation at the time of official weigh-in (OWI). A total of 51 of 89 wrestlers competing in the Estonian Championship in 2009 donated a urine sample. Questionnaire responses revealed that 27 wrestlers (body mass losers (BMLs)) reduced body mass before the competition, whereas 24 wrestlers (those who do not lose body mass (n-BMLs)) did not. In 42 wrestlers, values of urine specific gravity ≥1.020 and urine osmolality ≥700 mOsmol·kg−1 revealed a hypohydrated status. The prevalence of hypohydration in the BMLs (96%) was higher than in the n-BMLs (67%) (χ2 = 7.68; p < 0.05). The prevalence of serious hypohydration (urine specific gravity >1.030) was 5.3 times greater (χ2 = 8.32; p < 0.05) in the BMLs than in the n-BMLs. In the BMLs, the extent of body mass gain during the 16-h recovery (2.5 ± 1.2 kg) was associated (r = 0.764; p < 0.05) with self-reported precompetition body mass loss (4.3 ± 2.0 kg) and exceeded the body mass gain observed in the n-BMLs (0.7 ± 1.2 kg; p < 0.05). We conclude that hypohydration is prevalent among Greco-Roman wrestlers at the time of OWI. The prevalence of hypohydration and serious hypohydration is especially high among wrestlers who are accustomed to reducing body mass before competition. These results suggest that an effective rehydration strategy is needed for Olympic-style wrestlers, and that changes in wrestling rules should be considered to reduce the prevalence of harmful body mass management behaviours.

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