Polyunsaturated fatty acid intake and lung function in a regional Australian population: A cross-sectional study with a nested case-control analysis

AbstractLong-Chain Polyunsaturated Fatty Acid (LCPUFA) is essential throughout pregnancy, since deficiency of LPUFA may linked to obstetrical complications. This study aimed to investigate LCPUFA status in severe preeclampsia and preterm birth. A cross sectional study was conducted in 104 pregnant women, which divided into normal pregnancy, severe preeclampsia and preterm birth groups. Serum percentage and concentration of total LCPUFA, omega-3, alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), omega-6, linoleic acid (LA), and arachidonic acid (AA) were measured using gas chromatography/mass spectrometry. Receiver operating characteristic (ROC), bivariate and multivariate analysis were performed. Severe preeclampsia showed the highest concentration of total PUFA and the lowest DHA percentage, with significantly higher Omega-6/Omega-3 ratio (p = 0.004) and lower omega-3 index (p < 0.002) compared to control. Preterm birth showed the least omega-3 concentrations, with significantly low omega-6 derivates (LA (p = 0.014) and AA (p = 0.025)) compared to control. LCPUFA parameters have shown to increase the risk in both conditions, particularly ALA ≤ 53 µmol/L in preeclampsia with OR 5.44, 95%CI 1.16–25.42 and preterm birth with OR 4.68, 95%CI 1.52–14.38. These findings suggest that severe preeclampsia and preterm birth have an imbalance in LCPUFA status.

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The association of blood non-esterified fatty acid, saturated fatty acids, and polyunsaturated fatty acids levels with mild cognitive impairment in Chinese population aged 35–64 years: a cross-sectional study

Nutritional Neuroscience ◽

10.1080/1028415x.2019.1610606 ◽

2019 ◽

pp. 1-13 ◽

Cited By ~ 1

Author(s):

Rong Fan ◽

Lei Zhao ◽

Bing-jie Ding ◽

Rong Xiao ◽

Wei-wei Ma

Keyword(s):

Fatty Acids ◽

Cognitive Impairment ◽

Fatty Acid ◽

Mild Cognitive Impairment ◽

Polyunsaturated Fatty Acids ◽

Chinese Population ◽

Saturated Fatty Acids ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional

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Plasma fatty acid profile is related to cognitive function in obese Chinese populations (35–64 years): A cross‐sectional study

Food Science & Nutrition ◽

10.1002/fsn3.1738 ◽

2020 ◽

Vol 8 (9) ◽

pp. 4773-4781

Author(s):

Qi Duan ◽

Rong Fan ◽

Ruqing Lei ◽

Weiwei Ma ◽

Bingjie Ding

Keyword(s):

Fatty Acid ◽

Cognitive Function ◽

Fatty Acid Profile ◽

Cross Sectional Study ◽

Plasma Fatty Acid ◽

Sectional Study ◽

Cross Sectional ◽

Chinese Populations ◽

Plasma Fatty Acid Profile

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Relationship between Dietary n-6 Fatty Acid Intake and Hypertension: Effect of Glycated Hemoglobin Levels

Nutrients ◽

10.3390/nu10121825 ◽

2018 ◽

Vol 10 (12) ◽

pp. 1825 ◽

Cited By ~ 5

Author(s):

Haruki Nakamura ◽

Akinori Hara ◽

Hiromasa Tsujiguchi ◽

Thao Thi Thu Nguyen ◽

Yasuhiro Kambayashi ◽

...

Keyword(s):

Blood Pressure ◽

Fatty Acids ◽

Fatty Acid ◽

Confidence Interval ◽

Odds Ratio ◽

Glycated Hemoglobin ◽

Cross Sectional Study ◽

Fatty Acid Intake ◽

Cross Sectional ◽

Acid Intake

The relationship between dietary n-6 fatty acids and hypertension is not clear. The metabolic products of n-6 fatty acids include those that control blood pressure, such as prostaglandin and thromboxane, and that differ depending on the extent of glucose tolerance. This cross-sectional study investigated the association of dietary n-6 fatty acid intake on hypertension, and the effects of glycated hemoglobin (HbA1c) value in 633 Japanese subjects aged 40 years and older. Dietary intake was measured using a validated brief self-administered diet history questionnaire. We defined hypertension as the use of antihypertensive medication or a blood pressure of 140/90 mmHg. The prevalence of hypertension was 55.3%. A high n-6 fatty acids intake inversely correlated with hypertension in subjects with HbA1c values less than 6.5% (odds ratio, 0.857; 95% confidence interval, 0.744 to 0.987). On the contrary, in subjects with an HbA1c value of 6.5% or higher, the n-6 fatty acids intake was significantly associated with hypertension (odds ratio, 3.618; 95% confidence interval, 1.019 to 12.84). Regular dietary n-6 fatty acid intake may contribute to the prevention and treatment of hypertension in a healthy general population. By contrast, in subjects with diabetes, regular n-6 fatty acids intake may increase the risk of hypertension.

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