Sport-related differences in biomarkers of bone resorption and cartilage degradation in endurance athletes

ABSTRACT Background The present study aimed prospectively to investigate the effect of a combination of tumour necrosis factor inhibitors and bisphosphonates (TNFi with BP) on bone mineral density (BMD) and bone and cartilage biomarkers compared to that of BP alone at 1 year in patients with rheumatoid arthritis (RA). Methods Two groups of patients with RA and osteoporosis were enrolled. One group (37 patients) had already received BP, while the other group (37 patients) had already received TNFi with BP. The serum bone resorption and formation markers, cartilage markers, BMD in the lumbar spine, femoral neck, and distal radius were prospectively investigated at the beginning of the study and at 6 and 12 months. Results The percentages of change recorded for the various assessment categories were as follows in the TNFi with BP group: (1) tartrate-resistant acid phosphatase-5b had significantly decreased and osteocalcin had increased; (2) matrix metalloproteinase-3 and cartilage oligomeric matrix protein had significantly decreased; and (3) each BMD did not differ significantly between the groups. Conclusion Our data suggested that TNFi with BP therapy not only suppressed cartilage degradation and bone resorption but also increased bone formation; however, this treatment did not affect the BMD at 1 year.

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284 AN ORAL RECOMBINANT FORM OF SALMON CALCITONIN SUPPRESSES BOTH BONE RESORPTION AND CARTILAGE DEGRADATION

Osteoarthritis and Cartilage ◽

10.1016/s1063-4584(08)60328-3 ◽

2008 ◽

Vol 16 ◽

pp. S127

Author(s):

I. Byrjalsen ◽

K. Henriksen ◽

B.J. Riis ◽

M.A. Karsdal ◽

C. Christiansen

Keyword(s):

Bone Resorption ◽

Salmon Calcitonin ◽

Cartilage Degradation ◽

Recombinant Form ◽

And Cartilage

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MIV-711, a highly selective cathepsin K inhibitor, reduces biomarkers of bone resorption and cartilage degradation in healthy subjects

Osteoarthritis and Cartilage ◽

10.1016/j.joca.2014.02.376 ◽

2014 ◽

Vol 22 ◽

pp. S197 ◽

Cited By ~ 5

Author(s):

E. Lindstrom ◽

U. Grabowska ◽

M. Jerling ◽

C. Edenius

Keyword(s):

Bone Resorption ◽

Healthy Subjects ◽

Cathepsin K ◽

Cartilage Degradation ◽

Cathepsin K Inhibitor ◽

And Cartilage

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Urinary collagen crosslinks to monitor bone and cartilage degradation in collagen-induced arthritis in rhesus monkeys

Acta Orthopaedica Scandinavica ◽

10.3109/17453679509157691 ◽

1995 ◽

Vol 66 (sup266) ◽

pp. 202-203 ◽

Cited By ~ 1

Author(s):

Johan M te Koppele ◽

Bert A't Hart

Keyword(s):

Rhesus Monkeys ◽

Cartilage Degradation ◽

Collagen Induced Arthritis ◽

Collagen Crosslinks ◽

And Cartilage

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Emerging Natural-Product-Based Treatments for the Management of Osteoarthritis

Antioxidants ◽

10.3390/antiox10020265 ◽

2021 ◽

Vol 10 (2) ◽

pp. 265

Author(s):

Maria-Luisa Pérez-Lozano ◽

Annabelle Cesaro ◽

Marija Mazor ◽

Eric Esteve ◽

Sabine Berteina-Raboin ◽

...

Keyword(s):

Bone Resorption ◽

Natural Product ◽

Treatment Strategies ◽

Cartilage Degradation ◽

Therapeutic Strategies ◽

Clinical Models ◽

Osteoarthritic Joint ◽

Dietary Components ◽

New Treatment ◽

Review Current

Osteoarthritis (OA) is a complex degenerative disease in which joint homeostasis is disrupted, leading to synovial inflammation, cartilage degradation, subchondral bone remodeling, and resulting in pain and joint disability. Yet, the development of new treatment strategies to restore the equilibrium of the osteoarthritic joint remains a challenge. Numerous studies have revealed that dietary components and/or natural products have anti-inflammatory, antioxidant, anti-bone-resorption, and anabolic potential and have received much attention toward the development of new therapeutic strategies for OA treatment. In the present review, we provide an overview of current and emerging natural-product-based research treatments for OA management by drawing attention to experimental, pre-clinical, and clinical models. Herein, we review current and emerging natural-product-based research treatments for OA management.

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Exosomes derived from miR-126-3p-overexpressing synovial fibroblasts suppress chondrocyte inflammation and cartilage degradation in a rat model of osteoarthritis

Cell Death Discovery ◽

10.1038/s41420-021-00418-y ◽

2021 ◽

Vol 7 (1) ◽

Author(s):

Yan Zhou ◽

Jianghua Ming ◽

Yaming Li ◽

Bochun Li ◽

Ming Deng ◽

...

Keyword(s):

Synovial Fluid ◽

Apoptotic Cell ◽

Synovial Fibroblasts ◽

Cartilage Degeneration ◽

Cartilage Degradation ◽

Exosomal Mirnas ◽

Exosomal Mirna ◽

And Control ◽

And Cartilage

AbstractMicroRNAs (miRNAs) encapsulated within exosomes can serve as essential regulators of intercellular communication and represent promising biomarkers of several aging-associated disorders. However, the relationship between exosomal miRNAs and osteoarthritis (OA)-related chondrocytes and synovial fibroblasts (SFCs) remain to be clarified. Herein, we profiled synovial fluid-derived exosomal miRNAs and explored the effects of exosomal miRNAs derived from SFCs on chondrocyte inflammation, proliferation, and survival, and further assessed their impact on cartilage degeneration in a surgically-induced rat OA model. We identified 19 miRNAs within synovial fluid-derived exosomes that were differentially expressed when comparing OA and control patients. We then employed a microarray-based approach to confirm that exosomal miRNA-126-3p expression was significantly reduced in OA patient-derived synovial fluid exosomes. At a functional level, miRNA-126-3p mimic treatment was sufficient to promote rat chondrocyte migration and proliferation while also suppressing apoptosis and IL-1β, IL-6, and TNF-α expression. SFC-miRNA-126-3p-Exos were able to suppress apoptotic cell death and associated inflammation in chondrocytes. Our in vivo results revealed that rat SFC-derived exosomal miRNA-126-3p was sufficient to suppress the formation of osteophytes, prevent cartilage degeneration, and exert anti-apoptotic and anti-inflammatory effects on articular cartilage. Overall, our findings indicate that SFC exosome‐delivered miRNA-126-3p can constrain chondrocyte inflammation and cartilage degeneration. As such, SFC-miRNA-126-3p-Exos may be of therapeutic value for the treatment of patients suffering from OA.

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Biochemical markers identify influences on bone and cartilage degradation in osteoarthritis - the effect of sex, Kellgren-Lawrence (KL) score, Body Mass Index (BMI), oral salmon calcitonin (sCT) treatment and diurnal variation

BMC Musculoskeletal Disorders ◽

10.1186/1471-2474-11-125 ◽

2010 ◽

Vol 11 (1) ◽

Cited By ~ 51

Author(s):

MA Karsdal ◽

I Byrjalsen ◽

AC Bay-Jensen ◽

K Henriksen ◽

BJ Riis ◽

...

Keyword(s):

Body Mass Index ◽

Diurnal Variation ◽

Body Mass ◽

Salmon Calcitonin ◽

Biochemical Markers ◽

Cartilage Degradation ◽

And Cartilage

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The Effect of a Lower Body Positive Pressure Supported Treadmill Exercise Regime on Systemic Biomarkers of Inflammation and Cartilage Degradation in Individuals with Knee Osteoarthritis: A Pilot Study

International Journal of Kinesiology and Sports Science ◽

10.7575/aiac.ijkss.v.9n.3p18 ◽

2021 ◽

Vol 9 (3) ◽

pp. 18

Author(s):

Stephen Cornish ◽

Jason Peeler

Keyword(s):

Articular Cartilage ◽

Knee Pain ◽

Weight Bearing ◽

Cartilage Degradation ◽

Treadmill Walking ◽

Positive Pressure ◽

Control Group ◽

Knee Oa ◽

And Cartilage

Background: Knee osteoarthritis (OA) has been linked to a chronic low-grade inflammatory response and altered metabolic activity of articular cartilage. Objective: The purpose of this investigation was to evaluate the effectiveness of a 12-week (3 times/week) lower body positive pressure (LBPP) treadmill walking regime on knee pain and systemic biomarkers of inflammation and cartilage degradation. Methods: Sixteen overweight (BMI > 25 kg/m2) knee OA patients were randomized to a LBPP treadmill walking exercise group (N = 7) or non-exercise control group (N = 9). Baseline and 12-week follow-up assessments evaluated the following dependent variables: acute knee pain during full weight bearing treadmill walking; inflammatory biomarkers (C-reactive protein, interleukin-1β, interleukin-6, s100A8/A9, and tumor necrosis factor-α), and catabolic metabolism of articular cartilage (sCOMP). Results: Knee pain at baseline and follow-up remained unchanged for the non-exercise control group (P > 0.05). However, knee pain for the LBPP exercise group was significantly decreased at follow-up (P ≤ 0.05). No differences in the biomarkers of inflammation and cartilage degradation were observed for between and within group comparisons (all P > 0.05). Conclusions: Data suggested that the LBPP supported walking regime could be effectively used to promote regular weight bearing exercise without exacerbation of knee joint pain and did not increase levels of systemic inflammation or catabolic activity of articular cartilage in overweight knee OA patients. This pilot investigation offers important insight regarding the potential role that the LBPP technology could play in facilitating investigations examining the disease modifying effect of exercise on knee OA pathogenesis.

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