25 Mechanism of cell death caused by complex 1 defects in a rat dopaminergic cell line

The aim of this study was to investigate the endpoints related to cell death, either necrosis or apoptosis, induced by four chemicals in the promyelocytic leukemia cell line, HL-60. Cell morphology, DNA fragmentation, cytofluorimetric analysis and oxygen consumption were used to classify the type of cell death observed. In our analysis, we found that not all the selected parameters reproduced the differences observed in the cell death caused by the four chemicals tested. As cell death is a very complex phenomenon, several factors should be taken into account (cell type, exposure time and chemical concentration), if chemicals are to be classified according to differences in the mechanisms more directly involved in cell death.

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Identification of hypoxia-responsive genes in a dopaminergic cell line by subtractive cDNA libraries and microarray analysis

Parkinsonism & Related Disorders ◽

10.1016/s1353-8020(00)00070-5 ◽

2001 ◽

Vol 7 (3) ◽

pp. 273-281 ◽

Cited By ~ 9

Author(s):

D Beitner-Johnson ◽

K Seta ◽

Y Yuan ◽

H.-W Kim ◽

R.T Rust ◽

...

Keyword(s):

Cell Line ◽

Microarray Analysis ◽

Cdna Libraries ◽

Dopaminergic Cell

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Differential effects of antioxidants on amyloid beta- and H2O2-induced cell death in the SHSY-5Y neuronal cell-line

Neuropathology and Applied Neurobiology ◽

10.1046/j.1365-2990.2002.39286_55.x ◽

2002 ◽

Vol 28 (2) ◽

pp. 169-169

Author(s):

C. Shukla ◽

L. D. Plant ◽

Z. Henderson ◽

L. R. Bridges ◽

H. A. Pearson

Keyword(s):

Cell Death ◽

Cell Line ◽

Amyloid Beta ◽

Neuronal Cell ◽

Neuronal Cell Line ◽

Differential Effects

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Effects of tyrosine kinase inhibitors on cell death induced by sodium fluoride and pertussis toxin in the pancreatic β-cell line, RINm5F

British Journal of Pharmacology ◽

10.1038/sj.bjp.0703783 ◽

2001 ◽

Vol 132 (1) ◽

pp. 119-126 ◽

Cited By ~ 13

Author(s):

Jim Elliott ◽

John H B Scarpello ◽

Noel G Morgan

Keyword(s):

Cell Death ◽

Tyrosine Kinase ◽

Cell Line ◽

Tyrosine Kinase Inhibitors ◽

Sodium Fluoride ◽

Pertussis Toxin ◽

Kinase Inhibitors ◽

Pancreatic Β Cell ◽

Β Cell

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Thapsigargin Enhances Cell Death in the Gastrointestinal Stromal Tumor Cell Line, GIST-T1, by Treatment with Imatinib (Glivec)

JOURNAL OF HEALTH SCIENCE ◽

10.1248/jhs.52.110 ◽

2006 ◽

Vol 52 (2) ◽

pp. 110-117 ◽

Cited By ~ 3

Author(s):

Toufeng Jin ◽

Hajime Nakatani ◽

Takahiro Taguchi ◽

Hiroshi Sonobe ◽

Norihito Morimoto ◽

...

Keyword(s):

Cell Death ◽

Tumor Cell ◽

Gastrointestinal Stromal Tumor ◽

Cell Line ◽

Tumor Cell Line ◽

Stromal Tumor

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The mode of cell death associated with cavitation in teratocarcinoma-derived embryoid bodies

Development ◽

10.1242/dev.80.1.63 ◽

1984 ◽

Vol 80 (1) ◽

pp. 63-74

Author(s):

Sheilagh M. Boyd ◽

M. L. Hooper ◽

A. H. Wyllie

Keyword(s):

Cell Death ◽

Cell Line ◽

Embryonal Carcinoma ◽

Carcinoma Cell ◽

Embryoid Bodies ◽

Embryonal Carcinoma Cell ◽

Embryonal Carcinoma Cell Line ◽

Related Cell ◽

Significant Difference ◽

Tissue Modelling

Cell death occurring in embryoid bodies derived from the embryonal carcinoma cell line, PSA4, which undergo cavitation, and in those from the related cell line S2, which do not undergo cavitation, was classified as apoptosis or necrosis by ultrastructural criteria. Both modes of cell death were seen in PSA4 embryoid bodies while apoptosis alone was seen in S2 embryoid bodies. No significant difference was found between PSA4 and S2 embryoid bodies either in apoptotic incidence score or in the spatial distribution of apoptotic events. We therefore conclude that although apoptosis and tissue modelling coexist in PSA4 embryoid bodies, necrosis rather than apoptosis is causally related to formation of the cavity.

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