Role of gene–gene interaction between ADRA2A and SLC6A2 polymorphism to attention system in Korean ADHD children

Clinical aspects, risk factors, results of selective coronary angiography, features of DNA-polymorphism (I/D polymorphism of gene ACE, isoalleles polymorphism gene APOE, SsTI polymorphism gene АРОСЗ, С677Т polymorphism of gene MTHFR, 4a/4b, G894T and T786C polymorphisms eNOs) in 89 women with a various degree of a coronary obstruction. In patients with sings of coronary artery atherosclerosis, familial history i heart disease was observed in most cases (greater degree on a line of mother). The obtained data show the reliable role of allele T, genotype CT gene MTHFRand gene-gene interaction of ACE and MTHFR genes (DD и СС, DD и СТ) in development of i heart disease.

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The role of allelic and nonallelic interactions of genes in the mechanism of heterosis

Faktori eksperimental'noi evolucii organizmiv ◽

10.7124/feeo.v24.1097 ◽

2019 ◽

Vol 24 ◽

pp. 177-182

Author(s):

S. G. Hablak ◽

Ya. A. Abdullaeva ◽

L. O. Ryabovol ◽

Ya. S. Ryabovol

Keyword(s):

First Generation ◽

Gene Interaction ◽

Point Of View ◽

F1 Hybrids ◽

Heterosis Effect ◽

Nonallelic Interactions ◽

F2 Generation ◽

Mutant Lines ◽

Polymeric Interaction

Aim. Studying the heterosis effect from the point of view of allelic and nonallelic gene interaction in F1 hybrids from crossing the arabidopsis ecotypes Col-0 and La-0. Methods. Hybridological method of crossing mutant lines and analysis of the inheritance of the signs of the root system. Results. When plants of different races Col-0 and La-0 cross in the F2 generation, polymeric interaction of genes occurs. In that case splitting in F2 goes in the ratio 15: 1. At the same time, hybrids of the first generation exhibit heterosis, which is manifested in a more powerful development of a rosette of leaves in comparison with the initial forms. Conclusions. The emergence of heterosis in hybrids of the first generation can be explained on the basis of the allelic and nonallelic gene interaction, which creates a favorable combination of genes during hybridization, causing the best manifestation of an economically valuable trait. Keywords: Arabidopsis thaliana (L.) Heynh., heterosis, gene, mutation, race.

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The role of the ameiotic1 gene in the initiation of meiosis and in subsequent meiotic events in maize.

Genetics ◽

10.1093/genetics/135.4.1151 ◽

1993 ◽

Vol 135 (4) ◽

pp. 1151-1166 ◽

Cited By ~ 3

Author(s):

I Golubovskaya ◽

Z K Grebennikova ◽

N A Avalkina ◽

W F Sheridan

Keyword(s):

Meiotic Division ◽

Higher Plants ◽

Gene Interaction ◽

Microtubule Organizing Center ◽

Spindle Fiber ◽

Chromosome Synapsis ◽

Organizing Center ◽

Relationship Of ◽

The Relationship

Abstract Understanding the initiation of meiosis and the relationship of this event with other key cytogenetic processes are major goals in studying the genetic control of meiosis in higher plants. Our genetic and structural analysis of two mutant alleles of the ameiotic1 gene (am1 and am1-praI) suggest that this locus plays an essential role in the initiation of meiosis in maize. The product of the ameiotic1 gene affects an earlier stage in the meiotic sequence than any other known gene in maize and is important for the irreversible commitment of cells to meiosis and for crucial events marking the passage from premeiotic interphase into prophase I including chromosome synapsis. It appears that the period of ameiotic1 gene function in meiosis at a minimum covers the interval from some point during premeiotic interphase until the early zygotene stage of meiosis. To study the interaction of genes in the progression of meiosis, several double meiotic mutants were constructed. In these double mutants (i) the ameiotic1 mutant allele was brought together with the meiotic mutation (afd1) responsible for the fixation of centromeres in meiosis; and with the mutant alleles of the three meiotic genes that control homologous chromosome segregation (dv1, ms43 and ms28), which impair microtubule organizing center organization, the orientation of the spindle fiber apparatus, and the depolymerization of spindle filaments after the first meiotic division, respectively; (ii) the afd1 mutation was combined with two mutations (dsy1 and as1) affecting homologous pairing; (iii) the ms43 mutation was combined with the as1, the ms28 and the dv1 mutations; and (iv) the ms28 mutation was combined with the dv1 mutation and the ms4 (polymitotic1) mutations. An analysis of gene interaction in the double mutants led us to conclude that the ameiotic1 gene is epistatic over the afd1, the dv1, the ms43 and the ms28 genes but the significance of this relationship requires further analysis. The afd gene appears to function from premeiotic interphase throughout the first meiotic division, but it is likely that its function begins after the start of the ameiotic1 gene expression. The afd1 gene is epistatic over the two synaptic mutations dsy1 and as1 and also over the dv1 mutation. The new ameiotic*-485 and leptotene arrest*-487 mutations isolated from an active Robertson's Mutator stocks take part in the control of the initiation of meiosis.

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MassArray analysis of genomic susceptibility variants in ovarian cancer

Scientific Reports ◽

10.1038/s41598-020-76491-7 ◽

2020 ◽

Vol 10 (1) ◽

Author(s):

Sonali Verma ◽

Indu Sharma ◽

Varun Sharma ◽

Amrita Bhat ◽

Ruchi Shah ◽

...

Keyword(s):

Ovarian Cancer ◽

Odds Ratio ◽

Gene Interaction ◽

P Value ◽

Nucleotide Polymorphisms ◽

Single Nucleotide ◽

Jammu And Kashmir ◽

Interactive Analysis ◽

Strong Existence

AbstractOvarian cancer (OC), a multifaceted and genetically heterogeneous malignancy is one of the most common cancers among women. The aim of the study is to unravel the genetic factors associated with OC and the extent of genetic heterogeneity in the populations of Jammu and Kashmir (J&K).Using the high throughput Agena MassARRAY platform, present case control study was designed which comprises 200 histopathological confirmed OC patients and 400 age and ethnicity matched healthy controls to ascertain the association of previously reported eleven single nucleotide polymorphisms (SNPs) spread over ten genes (DNMT3A, PIK3CA, FGFR2, GSTP1, ERCC5, AKT1, CASC16, CYP19A1, BCL2 and ERCC1) within the OC population of Jammu and Kashmir, India. The association of each variant was estimated using logistic regression analyses. Out of the 11 SNPs the odds ratio observed for three SNPs; rs2699887 was (1.72 at 95% CI: 1.19–2.48, p = 0.004), rs1695 was (1.87 at 95% CI: 1.28–2.71, p = 0.001), and rs2298881 was (0.66 at 95% CI: 0.46–0.96, p = 0.03) were found significantly associated with the OC after correction with confounding factors i.e. age & BMI. Furthermore, the estimation of interactive analyses was performed and odds ratio observed was 2.44 (1.72–3.47), p value < 0. 001 suggests that there was a strong existence of interplay between the selected genetic variants in OC, which demonstrate that interactive analysis highlights the role of gene–gene interaction that provides an insight among multiple little effects of various polymorphisms in OC.

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The role of gene–gene interaction in the prediction of criminal behavior

Comprehensive Psychiatry ◽

10.1016/j.comppsych.2013.11.005 ◽

2014 ◽

Vol 55 (3) ◽

pp. 483-488 ◽

Cited By ~ 3

Author(s):

Brian B. Boutwell ◽

Scott Menard ◽

J.C. Barnes ◽

Kevin M. Beaver ◽

Todd A. Armstrong ◽

...

Keyword(s):

Criminal Behavior ◽

Gene Interaction

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Role of mitochondrial genetic interactions in determining adaptation to high altitude in human population around the globe

10.1101/2021.06.21.449348 ◽

2021 ◽

Author(s):

Rahul K Verma ◽

Alena Kalyakulina ◽

Ankit Mishra ◽

Mikhail Ivanchenko ◽

Sarika Jalan

Keyword(s):

High Altitude ◽

Human Population ◽

Nadh Dehydrogenase ◽

Gene Interaction ◽

Genetic Networks ◽

Genetic Interactions ◽

High Altitude Adaptation ◽

Evolutionary Forces ◽

Altitude Adaptation

Physiological and haplogroup studies performed to understand high-altitude adaptation in humans are limited to individual genes and polymorphic sites. Due to stochastic evolutionary forces, the frequency of a polymorphism is affected by changes in the frequency of a nearby polymorphism on the same DNA sample making them connected in terms of evolution. Here, first, we provide a method to model these mitochondrial polymorphisms as 'co-mutation networks' for three high-altitude populations, Tibetan, Ethiopian and Andean. Then, by transforming these co-mutation networks into weighted and undirected gene-gene interaction (GGI) networks, we were able to identify functionally enriched genetic interactions ofCYBandCO3genes in Tibetan and Andean populations, while NADH dehydrogenase genes in the Ethiopian population playing a significant role in high altitude adaptation. These co-mutation-based genetic networks provide insights into the role of different sets of genes in high-altitude adaptation human sub-populations.

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Role of a Signalling System in Gene Interaction in Inheritance of Root System Characteristics of <i>Arabidopsis thaliana</i> (L.) Heynh.

Open Journal of Genetics ◽

10.4236/ojgen.2016.63006 ◽

2016 ◽

Vol 06 (03) ◽

pp. 51-60

Author(s):

Sergei Hablak

Keyword(s):

Arabidopsis Thaliana ◽

Root System ◽

Gene Interaction ◽

Signalling System ◽

System Characteristics

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The Evolution and Expression Profiles of EC1 Gene Family during Development in Cotton

Genes ◽

10.3390/genes12122001 ◽

2021 ◽

Vol 12 (12) ◽

pp. 2001

Author(s):

Xinyu Wang ◽

Wei Chen ◽

Jinbo Yao ◽

Yan Li ◽

Akwasi Yeboah ◽

...

Keyword(s):

Gene Family ◽

Plant Species ◽

Potential Role ◽

Expression Profiles ◽

Gene Interaction ◽

Pcr Analysis ◽

Egg Cell ◽

Gene Interaction Networks ◽

Expression Of Genes

Fertilization is essential to sexual reproduction of flowering plants. EC1 (EGG CELL 1) proteins have a conserved cysteine spacer characteristic and play a crucial role in double fertilization process in many plant species. However, to date, the role of EC1 gene family in cotton is fully unknown. Hence, detailed bioinformatics analysis was explored to elucidate the biological mechanisms of EC1 gene family in cotton. In this study, we identified 66 genes in 10 plant species in which a total of 39 EC1 genes were detected from cotton genome. Phylogenetic analysis clustered the identified EC1 genes into three families (I-III) and all of them contain Prolamin-like domains. A good collinearity was observed in the synteny analysis of the orthologs from cotton genomes. Whole-genome duplication was determined to be one of the major impetuses for the expansion of the EC1 gene family during the process of evolution. qRT-PCR analysis showed that EC1 genes were highly expressed in reproductive tissues under multiple stresses, signifying their potential role in enhancing stress tolerance or responses. Additionally, gene interaction networks showed that EC1 genes may be involved in cell stress and response transcriptional regulator in the synergid cells and activate the expression of genes required for pollen tube guidance. Our results provide novel functional insights into the evolution and functional elucidation of EC1 gene family in cotton.

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