scholarly journals Biological roles and therapeutic potential of circular RNAs in osteoarthritis

2021 ◽  
Vol 24 ◽  
pp. 856-867
Author(s):  
Xingjia Mao ◽  
Yanyan Cao ◽  
Zijian Guo ◽  
Linlin Wang ◽  
Chuan Xiang
Keyword(s):  
Therapeutic Potential ◽  
Circular Rnas

scholarly journals Therapeutic Potential of Circular RNAs in Osteosarcoma

2020 ◽  
Vol 10 ◽  
Author(s):  
Ben Wan ◽  
Hao Hu ◽  
Renxian Wang ◽  
Weifeng Liu ◽  
Dafu Chen
Keyword(s):  
Therapeutic Potential ◽  
Circular Rnas

scholarly journals Circular PVT1: an oncogenic non-coding RNA with emerging clinical importance

2019 ◽  
Vol 72 (8) ◽  
pp. 513-519 ◽  
Author(s):  
Jayashree Adhikary ◽  
Sourabrata Chakraborty ◽  
Subhamita Dalal ◽  
Souradip Basu ◽  
Abhijit Dey ◽  
...  
Keyword(s):  
Therapeutic Potential ◽  
Genetic Locus ◽  
Treatment Protocol ◽  
Clinical Importance ◽  
Cancer Cell Line ◽  
Cancer Therapeutics ◽  
Circular Rnas ◽  
Molecular Alteration ◽  
Primary Tumors ◽  
Non Coding Rna

The importance of circular RNAs (circRNAs) in pathological processes like cancer is evident. Among the circRNAs, recent studies have brought circPVT1 under focus as the most potent oncogenic non-coding RNA. Recent studies on various aspects of circPVT1, including its biogenesis, molecular alteration and its probable role in oncogenesis, have been conducted for research and clinical interest. In this review, a first attempt has been made to summarise the available data on circPVT1 from PubMed and other relevant databases with special emphasis on its role in development, progression and prognosis of various malignant conditions. CircPVT1 is derived from the same genetic locus encoding for long non-coding RNA lncPVT1; however, existing literature suggested circPVT1 and lncPVT1 are transcripted independently by different promoters. The interaction between circRNA and microRNA has been highlighted in majority of the few malignancies in which circPVT1 was studied. Besides its importance in diagnostic and prognostic procedures, circPVT1 seemed to have huge therapeutic potential as evident from differential drug response of cancer cell line as well as primary tumors depending on expression level of the candidate. circPVT1 in cancer therapeutics might be promising as a biomarker to make the existing treatment protocol more effective and also as potential target for designing novel therapeutic intervention.

scholarly journals Circular RNAs and Hepatocellular Carcinoma: New Epigenetic Players With Diagnostic and Prognostic Roles

2021 ◽  
Vol 11 ◽  
Author(s):  
Kedeerya Aishanjiang ◽  
Xin-dong Wei ◽  
Yi Fu ◽  
Xinjie Lin ◽  
Yujie Ma ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Hepatocellular Carcinoma ◽  
Closed Loop ◽  
Therapeutic Potential ◽  
Therapeutic Targets ◽  
Circular Rnas ◽  
Diagnosis And Prognosis ◽  
Physiological Processes ◽  
Non Coding Rnas ◽  
Novel Targets

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide. Due to the lack of potent diagnosis and prognosis biomarkers and effective therapeutic targets, the overall prognosis of survival is poor in HCC patients. Circular RNAs (circRNAs) are a class of novel endogenous non-coding RNAs with covalently closed loop structures and implicated in diverse physiological processes and pathological diseases. Recent studies have demonstrated the involvement of circRNAs in HCC diagnosis, prognosis, development, and drug resistance, suggesting that circRNAs may be a class of novel targets for improving HCC diagnosis, prognosis, and treatments. In fact, some artificial circRNAs have been engineered and showed their therapeutic potential in treating HCV infection and gastric cancer. In this review, we introduce the potential of circRNAs as biomarkers for HCC diagnosis and prognosis, as therapeutic targets for HCC treatments and discuss the challenges in circRNA research and chances of circRNA application.

scholarly journals Expanding uncapped translation and emerging function of circular RNA in carcinomas and noncarcinomas

2022 ◽  
Vol 21 (1) ◽  
Author(s):  
Yan Wang ◽  
Chunjie Wu ◽  
Yu Du ◽  
Zhongwei Li ◽  
Minle Li ◽  
...  
Keyword(s):  
Internal Ribosome Entry Site ◽  
Therapeutic Potential ◽  
Circular Rna ◽  
Human Diseases ◽  
Circular Rnas ◽  
Host Proteins ◽  
Entry Site ◽  
Internal Ribosome Entry ◽  
Polysome Profiling ◽  
Translation Mechanism

AbstractCircular RNAs (circRNAs) are classified as noncoding RNAs because they are devoid of a 5’ end cap and a 3’ end poly (A) tail necessary for cap-dependent translation. However, increasing numbers of translated circRNAs identified through high-throughput RNA sequencing overlapping with polysome profiling indicate that this rule is being broken. CircRNAs can be translated in cap-independent mechanism, including IRES (internal ribosome entry site)-initiated pattern, MIRES (m6A internal ribosome entry site) -initiated patterns, and rolling translation mechanism (RCA). CircRNA-encoded proteins harbour diverse functions similar to or different from host proteins. In addition, they are linked to the modulation of human disease including carcinomas and noncarcinomas. CircRNA-related translatomics and proteomics have attracted increasing attention. This review discusses the progress and exclusive characteristics of circRNA translation and highlights the latest mechanisms and regulation of circRNA translatomics. Furthermore, we summarize the extensive functions and mechanisms of circRNA-derived proteins in human diseases, which contribute to a better understanding of intricate noncanonical circRNA translatomics and proteomics and their therapeutic potential in human diseases.

scholarly journals Circular RNAs in depression: Biogenesis, function, expression, and therapeutic potential

2021 ◽  
Vol 137 ◽  
pp. 111244
Author(s):  
Hua Gan ◽  
Yuhe Lei ◽  
Naijun Yuan ◽  
Kairui Tang ◽  
Wenzhi Hao ◽  
...  
Keyword(s):  
Therapeutic Potential ◽  
Circular Rnas ◽  
Function Expression

scholarly journals The Biomarker and Therapeutic Potential of Circular Rnas in Schizophrenia

Cells ◽  
2020 ◽  
Vol 9 (10) ◽  
pp. 2238
Author(s):  
Artem Nedoluzhko ◽  
Natalia Gruzdeva ◽  
Fedor Sharko ◽  
Sergey Rastorguev ◽  
Natalia Zakharova ◽  
...  
Keyword(s):  
Gene Expression ◽  
Rna Binding ◽  
Gene Expression Regulation ◽  
Rna Binding Proteins ◽  
Therapeutic Potential ◽  
Expression Patterns ◽  
Circular Rna ◽  
Circular Rnas ◽  
Cellular Processes ◽  
Non Coding Rna

Circular RNAs (circRNAs) are endogenous, single-stranded, most frequently non-coding RNA (ncRNA) molecules that play a significant role in gene expression regulation. Circular RNAs can affect microRNA functionality, interact with RNA-binding proteins (RBPs), translate proteins by themselves, and directly or indirectly modulate gene expression during different cellular processes. The affected expression of circRNAs, as well as their targets, can trigger a cascade of events in the genetic regulatory network causing pathological conditions. Recent studies have shown that altered circular RNA expression patterns could be used as biomarkers in psychiatric diseases, including schizophrenia (SZ); moreover, circular RNAs together with other cell molecules could provide new insight into mechanisms of this disorder. In this review, we focus on the role of circular RNAs in the pathogenesis of SZ and analyze their biomarker and therapeutic potential in this disorder.

scholarly journals Non-Coding RNAs in Brain Tumors, the Contribution of lncRNAs, circRNAs, and snoRNAs to Cancer Development—Their Diagnostic and Therapeutic Potential

2020 ◽  
Vol 21 (19) ◽  
pp. 7001
Author(s):  
Julia Latowska ◽  
Adriana Grabowska ◽  
Żaneta Zarębska ◽  
Konrad Kuczyński ◽  
Bogna Kuczyńska ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Therapeutic Potential ◽  
Tumor Development ◽  
Circular Rnas ◽  
Human Beings ◽  
Pediatric Solid Tumors ◽  
Current State ◽  
Non Coding Rnas ◽  
Regulatory Rnas ◽  
Unique Cell

Brain tumors are one of the most frightening ailments that afflict human beings worldwide. They are among the most lethal of all adult and pediatric solid tumors. The unique cell-intrinsic and microenvironmental properties of neural tissues are some of the most critical obstacles that researchers face in the diagnosis and treatment of brain tumors. Intensifying the search for potential new molecular markers in order to develop new effective treatments for patients might resolve this issue. Recently, the world of non-coding RNAs (ncRNAs) has become a field of intensive research since the discovery of their essential impact on carcinogenesis. Some of the most promising diagnostic and therapeutic regulatory RNAs are long non-coding RNAs (lncRNAs), circular RNAs (circRNAs), and small nucleolar RNAs (snoRNAs). Many recent reports indicate the important role of these molecules in brain tumor development, as well as their implications in metastasis. In the following review, we summarize the current state of knowledge about regulatory RNAs, namely lncRNA, circRNAs, and snoRNAs, and their impact on the development of brain tumors in children and adults with particular emphasis on malignant primary brain tumors—gliomas and medulloblastomas (MB). We also provide an overview of how these different ncRNAs may act as biomarkers in these tumors and we present their potential clinical implications.

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