Natural medicines for the treatment of fatigue: Bioactive components, pharmacology, and mechanisms

2019 ◽  
Vol 148 ◽  
pp. 104409 ◽  
Author(s):  
Chuanhong Luo ◽  
Xiaorong Xu ◽  
Xichuan Wei ◽  
Wuwen Feng ◽  
Haozhou Huang ◽  
...  
Keyword(s):  
Bioactive Components ◽  
Natural Medicines

scholarly journals Natural Medicines for the Treatment of Epilepsy: Bioactive Components, Pharmacology and Mechanism

2021 ◽  
Vol 12 ◽  
Author(s):  
Li-Ying He ◽  
Mei-Bian Hu ◽  
Ruo-Lan Li ◽  
Rong Zhao ◽  
Lin-Hong Fan ◽  
...  
Keyword(s):  
Epileptic Seizures ◽  
Brain Dysfunction ◽  
Bioactive Components ◽  
Cure Rate ◽  
Sugar Degradation ◽  
Genetic Level ◽  
Low Toxicity ◽  
Natural Drugs ◽  
Glial Cell Proliferation ◽  
Natural Medicines

Epilepsy is a chronic disease that can cause temporary brain dysfunction as a result of sudden abnormal discharge of the brain neurons. The seizure mechanism of epilepsy is closely related to the neurotransmitter imbalance, synaptic recombination, and glial cell proliferation. In addition, epileptic seizures can lead to mitochondrial damage, oxidative stress, and the disorder of sugar degradation. Although the mechanism of epilepsy research has reached up to the genetic level, the presently available treatment and recovery records of epilepsy does not seem promising. Recently, natural medicines have attracted more researches owing to their low toxicity and side-effects as well as the excellent efficacy, especially in chronic diseases. In this study, the antiepileptic mechanism of the bioactive components of natural drugs was reviewed so as to provide a reference for the development of potential antiepileptic drugs. Based on the different treatment mechanisms of natural drugs considered in this review, it is possible to select drugs clinically. Improving the accuracy of medication and the cure rate is expected to compensate for the shortage of the conventional epilepsy treatment drugs.

scholarly journals HPLC/DAD Comparison of Sixteen Bioactive Components between Da-Cheng-Qi Decoction and its Parent Herbal Medicines

2010 ◽  
Vol 5 (6) ◽  
pp. 1934578X1000500
Author(s):  
Fengguo Xu ◽  
Ying Liu ◽  
Rui Song ◽  
Haijuan Dong ◽  
Zunjian Zhang
Keyword(s):  
Herbal Medicines ◽  
Preparation Procedure ◽  
Bioactive Components ◽  
Natural Medicines ◽  
Radix Et Rhizoma Rhei

Differences in the contents of sixteen bioactive components (three tannins, five anthraquinones, six flavonoids and two neolignans) between Da-Cheng-Qi decoction (DCQD) and its three constitutional herbal medicines (Radix et Rhizoma Rhei, Cortex Magnoliae officinalis, and Fructus Aurantii Immaturus) were compared using validated HPLC/DAD methods. The results indicated that there existed some kinds of interactions between these constitutional natural medicines during the DCQD preparation procedure, which could either enhance or depress the extractive rates of bioactive components.

Comparative Study of Contents of Several Bioactive Components in Fruiting Bodies and Mycelia of Culinary-Medicinal Mushrooms

2013 ◽  
Vol 15 (3) ◽  
pp. 315-323 ◽  
Author(s):  
Shin-Yi Lin ◽  
Yu-Kai Chen ◽  
Hui-Tzu Yu ◽  
Gayane S. Barseghyan ◽  
Mikheil D. Asatiani ◽  
...  
Keyword(s):  
Comparative Study ◽  
Fruiting Bodies ◽  
Bioactive Components ◽  
Medicinal Mushrooms

Effect of Culture Time on the Bioactive Components in the Fruit Bodies of Caterpillar Mushroom, Cordyceps militaris CM-H0810 (Ascomycetes)

2019 ◽  
Vol 21 (11) ◽  
pp. 1107-1114
Author(s):  
Lina Zhu ◽  
Hongxia Zhang ◽  
Yangfang Liu ◽  
Jing-Song Zhang ◽  
Xinhua Gao ◽  
...  
Keyword(s):  
Cordyceps Militaris ◽  
Bioactive Components ◽  
Culture Time

Determination of Antioxidant Activities and Bioactive Components of Foeniculum vulgare Mill. (Samonsabar)

2019 ◽  
Vol 30 (3) ◽  
pp. 16-22
Keyword(s):  
Antioxidant Activities ◽  
Biological Activities ◽  
Scientific Information ◽  
Ethanolic Extract ◽  
The Body ◽  
World Health ◽  
Gas Chromatography Mass Spectrometry ◽  
Molecular Formula ◽  
Bioactive Components ◽  
Foeniculum Vulgare

World Health Organization (WHO) estimated that 80% of the population of developing countries use traditional medicines, mostly natural plant products, for their primary health care needs. In the past few decades, the medicinal value of plants has been assumed more important dimension owing largely to the discovery that extracts from plants contain not only primary metabolites but also a diverse array of secondary metabolites with antioxidant potential. Medicinal plants are potential sources of natural compounds with biological activities and therefore attract the attention of researchers worldwide. Antioxidants are vital substances which possess ability to protect the body from damage due to free radical-induced oxidative stress. The purpose of current study was to determine the antioxidant activities and bioactive components of Foeniculum vulgare (fennel) (Samonsabar) seeds by using UV Visible Spectrophotometer (UV-Vis) and Gas Chromatography-Mass Spectrometry (GC-MS). Aqueous extract of fennel seeds showed more antioxidant activity (IC50: 0.28 ug/ml) than ethanolic extract (IC50: 0.83 ug/ml) and comparable to standard antioxidant, ascorbic acid (IC50: 0.59 ug/ml). GC-MS analysis was fruitful in identification of compounds based on peak area, retention time, molecular formula, molecular weight, MS Fragmentions and pharmacological actions. Ten bioactive phytochemical compounds from aqueous extracts and 11 from ethanolic extract of fennel seeds were identified. These findings indicated that fennel seeds are potential to provide preventive properties against oxidative damage. These results will give scientific information for quality control of indigenous drug to herbal medicine users and local practitioners using fennel for different types of ailments

Anti-Inflammatory Properties of Plant Derived Natural Products – A Systematic Review

2019 ◽  
Vol 26 (24) ◽  
pp. 4506-4536 ◽  
Author(s):  
Iris E. Allijn ◽  
René P. Brinkhuis ◽  
Gert Storm ◽  
Raymond M. Schiffelers
Keyword(s):  
Systematic Review ◽  
Natural Products ◽  
Positive Control ◽  
Therapeutic Effects ◽  
Reference Compound ◽  
Individual Molecular Species ◽  
The Past ◽  
Anti Inflammatory ◽  
The Individual ◽  
Natural Medicines

Traditionally, natural medicines have been administered as plant extracts, which are composed of a mixture of molecules. The individual molecular species in this mixture may or may not contribute to the overall medicinal effects and some may even oppose the beneficial activity of others. To better control therapeutic effects, studies that characterized specific molecules and describe their individual activity that have been performed over the past decades. These studies appear to underline that natural products are particularly effective as antioxidants and anti-inflammatory agents. In this systematic review we aimed to identify potent anti-inflammatory natural products and relate their efficacy to their chemical structure and physicochemical properties. To identify these compounds, we performed a comprehensive literature search to find those studies, in which a dose-response description and a positive control reference compound was used to benchmark the observed activity. Of the analyzed papers, 7% of initially selected studies met these requirements and were subjected to further analysis. This analysis revealed that most selected natural products indeed appeared to possess anti-inflammatory activities, in particular anti-oxidative properties. In addition, 14% of the natural products outperformed the remaining natural products in all tested assays and are attractive candidates as new anti-inflammatory agents.

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